المؤلفون: Byun, Hwa Kyung, Chang, Won Ick, Lee, Joo Ho, Park, Chul-Kee, Kim, In Ah, Kim, Chae-Yong, Cho, Jaeho, Kim, Eui Hyun, Chang, Jong Hee, Kang, Seok-Gu, Moon, Ju Hyung, Lee, Sang Hyung, Lee, Jason Joon Bock, Kim, Il Han, Suh, Chang-Ok, Wee, Chan Woo, Yoon, Hong In

المساهمون: Park, Chul-Kee, Kim, In Ah, Kim, Chae-Yong, Lee, Sang Hyung, Kim, Il Han

الوصف: PurposeWe aimed to compare the outcomes of adjuvant radiotherapy (ART) and surveillance in patients with grade 2 meningiomas (MNG2) who underwent surgical resection. Materials and MethodsData from four hospitals, in which patients aged >= 18 years underwent Simpson grade 1-4 surgical resection for newly diagnosed MNG2 between 1998 and 2018, were examined in this multicenter retrospective cohort study. Patients receiving ART with conventional fractionation were compared with those undergoing surveillance. Progression-free survival (PFS), progression/recurrence (P/R) were evaluated. ResultsThis study included 518 patients, 158 of whom received ART. The median follow-up duration was 64.9 months. In the total cohort, ART was independently associated with significantly improved PFS (HR, 0.35; 95% CI, 0.23-0.55; P<0.001) and P/R (HR, 0.30; 95% CI, 0.18-0.48; P<0.001). In the propensity score-matched cohort (n=143 in each group), the 5-year PFS rates were 80.8% and 57.7% (P=0.004), and the 5-year P/R rates were 16.5% and 40.0% (P=0.002) in the ART and surveillance groups, respectively. After gross total resection, the 5-year PFS (85.0% vs. 64.7%; P=0.020) and P/R rates (15.2% vs. 32.0%; P=0.035) were significantly better in the ART group than in the surveillance group. A model for P/R was developed using recursive partitioning analysis with surgical extent, tumor size, and Ki-67 index. ART reduced the risk of P/R in the low- (P=0.069), intermediate- (P=0.044), and high-risk groups (P<0.001). Local control was also significantly enhanced by ART among all the risk groups (all P<0.05). ConclusionsART significantly improved PFS and P/R in patients with MNG2, irrespective of the surgical extent, and can be recommended after gross total resection. A prognostic model may guide decision-making for the use of ART. ; N ; 1

العلاقة: Frontiers in Oncology, Vol.12, p. 877244; https://hdl.handle.net/10371/184966Test; 000827218500001; 2-s2.0-85134202163; 167876

الإتاحة: https://doi.org/10.3389/fonc.2022.877244Test
https://hdl.handle.net/10371/184966Test

المؤلفون: Lee, Joongyo, Lee, Jason Joon Bock, Cha, In‐Ho, Park, Kyung Ran, Lee, Chang Geol

المصدر: Head & Neck ; volume 44, issue 8, page 1816-1824 ; ISSN 1043-3074 1097-0347

الوصف: Background We investigated dental implant outcomes in patients who had previously received radiotherapy (RT) for head and neck malignancies. Methods We reviewed 90 dental implants in 27 patients who received RT for head and neck cancer and received dental implants afterwards. The cumulative implant survival rate (CISR) was calculated. In addition, the implant quality was assessed using “Health Scale for Dental Implants.” Results The CISR at 3 years was 79.6%. The mean radiation dose at the implant site ( D mean ) was identified as an independent prognostic factor for implant survival. No implant failed if D mean was less than 38 Gy. Regarding implant quality, dental implants in grafted bone and D mean were independent risk factors. Conclusions D mean was identified as an independent prognostic factor for implant survival and quality. Dental implants can be safely considered when D mean is lower than 38 Gy.

الإتاحة: https://doi.org/10.1002/hed.27080Test

المؤلفون: Lee, Jason Joon Bock, Lee, Eungman, Choi, Won Hoon, Kim, Jihun, Chang, Kyung Hwan, Kim, Dong Wook, Shin, Han Back, Kim, Tae Hyung, Byun, Hwa Kyung, Cho, Jaeho

المساهمون: Zou, Jennifer Wei

المصدر: PLOS ONE ; volume 17, issue 3, page e0265143 ; ISSN 1932-6203

الوصف: This study aimed to evaluate the quality of low-dose-rate (LDR) prostate brachytherapy (BT) based on treatment-related dosimetric outcomes. Data of 100 patients treated using LDR BT with stranded seeds from November 2012 to November 2017 were collected. The prescription dose for the prostate was 145 Gy. The dose constraints for the preoperative plan were: V100% ≥ 95%, V150% ≤ 60%, V200% ≤ 20% for the prostate; V100% for rectum, ≤ 1 cc; and V200 Gy for urethra, 0.0 cc. Intraoperative real-time dose calculation and postoperative dose distribution analysis on days 0 and 30 were performed. Median dosimetric outcomes on days 0 and 30 respective were: V100% 92.28% and 92.23%, V200% 18.63% and 25.02%, and D90% 150.88 Gy and 151.46 Gy for the prostate; V100% for the rectum, 0.11 cc and 0.22 cc; and V200 Gy for the urethra, 0.00 cc and 0.00 cc, respectively. Twenty patients underwent additional seed implantation to compensate for insufficient dose coverage of the prostate. No loss or substantial migration of seeds or severe toxicity was reported. With stranded seed implantation and intraoperative optimization, appropriate dose delivery to the prostate without excessive dose to the organs at risk could be achieved.

الإتاحة: https://doi.org/10.1371/journal.pone.0265143Test

المؤلفون: Kim, Tae Hyung, Kim, Jin Sung, Yoon, Hong In, Lee, Joongyo, Lee, Jason Joon Bock, Byun, Hwa Kyung, Cho, Yeona, Kim, Yong Bae, Lee, Ik Jae, Kim, Kyung Hwan, Chang, Jee Suk

المساهمون: National Research Foundation of Korea, Eulji University

المصدر: Radiation Oncology ; volume 16, issue 1 ; ISSN 1748-717X

مصطلحات موضوعية: Radiology, Nuclear Medicine and imaging, Oncology

الوصف: Background The COVID-19 pandemic has stripped many medical students worldwide of their right to quality education. In response, we developed hybrid courses involving aspects of both online and in-person teaching for radiation oncology medical student clerkship. Methods We entitled students to customize their own rotation schedule using Google Forms and developed a flipped learning online class, which consisted of at least one video clip on basic knowledge of radiation oncology per day (yonsei-radonc.com). Students were instructed to watch online videos before the next day’s discussion session. Required components of the medical education program (e.g., target drawing, site visits to treatment facilities) were also prepared and conducted in accordance with the appropriate level of social distancing measures. Finally, we conducted questionnaire surveys after the completion of the week-long course and clerkship. Results From March to June 2020, 110 fourth-year medical students undertook a clinical module in our 1-week radiation oncology program course. Each day, students completed the flipped learning prior to meeting with the educator and then participated in the online discussion session and conference. All activities were well performed as scheduled. Students’ motivation was high, as was their overall satisfaction with the course. The students were satisfied with the online contents, flipped learning strategy, and instructors. Conclusions We successfully integrated open and virtual educational platforms to improve access to and satisfaction with student clerkship. In the future “new normal,” minimized face-to-face learning interactions, such as flipped learning, should be actively utilized for medical and other students’ education.

الإتاحة: https://doi.org/10.1186/s13014-021-01927-xTest

المؤلفون: Choi, Seo Hee, Park, So Hyun, Lee, Jason Joon Bock, Baek, Jong Geol, Kim, Jin Sung, Yoon, Hong In

المساهمون: Ministry of Science, Korea through the R&D program

المصدر: Radiation Oncology ; volume 14, issue 1 ; ISSN 1748-717X

مصطلحات موضوعية: Radiology, Nuclear Medicine and imaging, Oncology

الإتاحة: https://doi.org/10.1186/s13014-019-1263-7Test

المؤلفون: Lee, Jason Joon Bock¹ (AUTHOR), Park, Jun Su² (AUTHOR), Hong, Hyun Pyo³ (AUTHOR), Kim, Myung Sub³ (AUTHOR), Koo, Dong-Hoe⁴ (AUTHOR), Lee, Hyebin¹ (AUTHOR) hyebin.lee@samsung.com, Nam, Heerim¹ (AUTHOR) hyebin.lee@samsung.com

المصدر: Journal of Personalized Medicine. Feb2023, Vol. 13 Issue 2, p354. 11p.

مصطلحات موضوعية: *CHEMOEMBOLIZATION, *HEPATOCELLULAR carcinoma, *PROGNOSIS, *PROGRESSION-free survival, *SURVIVAL rate

مستخلص: This study assessed the use of pretreatment albumin–-bilirubin (ALBI) grade as a prognostic factor in patients with hepatocellular carcinoma (HCC) receiving combined transarterial chemoembolization (TACE) and radiotherapy (RT). Patients who underwent RT following TACE between January 2011 and December 2020 were analyzed retrospectively. The survival outcomes of patients in regard to the ALBI grade and Child–Pugh (C–P) classification were evaluated. A total of 73 patients with a median follow-up of 16.3 months were included. Thirty-three (45.2%) and forty patients (54.8%) were categorized into ALBI grades 1 and 2–3, respectively, while sixty-four (87.7%) and nine (12.3%) were C–P classes A and B, respectively (p = 0.003). The median progression-free survival (PFS) and overall survival (OS) for ALBI grade 1 vs. 2–3 were 8.6 months vs. 5.0 months (p = 0.016) and 27.0 months vs. 15.9 months (p = 0.006), respectively. The median PFS and OS for C–P class A vs. B were 6.3 months vs. 6.1 months (p = 0.265) and 24.8 months vs. 19.0 months (p = 0.630), respectively. A multivariate analysis showed that ALBI grades 2–3 were significantly associated with worse PFS (p = 0.035) and OS (p = 0.021). In conclusion, the ALBI grade could be a good prognosticator in HCC patients who were treated with combined TACE-RT. [ABSTRACT FROM AUTHOR]

المؤلفون: Lee, Jason Joon Bock, Suh, Young Joo, Oh, Caleb, Lee, Byung Min, Kim, Jin Sung, Chang, Yongjin, Jeon, Yeong Jeong, Kim, Ji Young, Park, Seong Yong, Chang, Jee Suk

المساهمون: Yonsei University College of Medicine

المصدر: International Journal of Radiation Oncology*Biology*Physics ; volume 114, issue 5, page 1045-1052 ; ISSN 0360-3016

مصطلحات موضوعية: Cancer Research, Radiology, Nuclear Medicine and imaging, Oncology, Radiation

الإتاحة: https://doi.org/10.1016/j.ijrobp.2022.08.042Test
https://api.elsevier.com/content/article/PII:S0360301622031613?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S0360301622031613?httpAccept=text/plainTest

المؤلفون: Lee, Hyebin, Ryu, Han Suk, Park, Hee Chul, Yu, Jeong Il, Yoo, Gyu Sang, Choi, Changhoon, Nam, Heerim, Lee, Jason Joon Bock, Do, In-Gu, Han, Dohyun, Ha, Sang Yun

المصدر: International Journal of Molecular Sciences; Nov2022, Vol. 23 Issue 21, p12923, 11p

مصطلحات موضوعية: MACHINE learning, RECTAL cancer, BIOMARKERS, TREATMENT effectiveness, PROTEOMICS, PROTEIN expression

مستخلص: High-throughput mass-spectrometry-based quantitative proteomic analysis was performed using formalin-fixed, paraffin-embedded (FFPE) biopsy samples obtained before treatment from 13 patients with locally advanced rectal cancer (LARC), who were treated with concurrent chemoradiation therapy (CCRT) followed by surgery. Patients were divided into complete responder (CR) and non-complete responder (nCR) groups. Immunohistochemical (IHC) staining of 79 independent FFPE tissue samples was performed to validate the predictive ability of proteomic biomarker candidates. A total of 3637 proteins were identified, and the expression of 498 proteins was confirmed at significantly different levels (differentially expressed proteins—DEPs) between two groups. In Gene Ontology enrichment analyses, DEPs enriched in biological processes in the CR group included proteins linked to cytoskeletal organization, immune response processes, and vesicle-associated protein transport processes, whereas DEPs in the nCR group were associated with biosynthesis, transcription, and translation processes. Dual oxidase 2 (DUOX2) was selected as the most predictive biomarker in machine learning algorithm analysis. Further IHC validation ultimately confirmed DUOX2 as a potential biomarker for predicting the response of nCR to CCRT. In conclusion, this study suggests that the treatment response to RT may be affected by the pre-treatment tumor microenvironment. DUOX2 is a potential biomarker for the early prediction of nCR after CCRT. [ABSTRACT FROM AUTHOR]

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المؤلفون: Kim, Tae Hyung^1,2 (AUTHOR), Lee, Jason Joon Bock^1,3 (AUTHOR), Cho, Jaeho¹ (AUTHOR) jjhmd@yuhs.ac

المصدر: Cancers. Oct2022, Vol. 14 Issue 19, p4907. 11p.

مصطلحات موضوعية: *PROSTATE tumors treatment, *STATISTICS, *TIME, *CONVALESCENCE, *AGE distribution, *MULTIVARIATE analysis, *PROSTATE, *TREATMENT failure, *RADIATION doses, *RADIOISOTOPE brachytherapy, *PROSTATE-specific antigen, *PROSTATE tumors

مستخلص: Simple Summary: Our study investigated clinical features of prostate-specific antigen (PSA) bounce in patients undergoing brachytherapy. PSA bounce is common and discriminating between large bounces and biochemical failures is very difficult. Therefore, we suggest important points to discriminate between large bounces and biochemical failures. In addition, we aimed to examine the clinical features and details of PSA bounce in patients receiving brachytherapy. Prostate-specific antigen (PSA) bounce is common in patients undergoing 125I brachytherapy (BT), and our study investigated its clinical features. A total of 100 patients who underwent BT were analyzed. PSA bounce and large bounce were defined as an increase of ≥0.2 and ≥2.0 ng/mL above the initial PSA nadir, respectively, with a subsequent decline without treatment. Biochemical failure was defined using the Phoenix definition (nadir +2 ng/mL), except for a large bounce. With a median follow-up of 49 months, 45% and 7% of the patients experienced bounce and large bounce, respectively. The median time to bounce was 24 months, and the median PSA value at the bounce spike was 1.62 ng/mL, a median raise of 0.44 ng/mL compared to the pre-bounce nadir. The median time to bounce recovery was 4 months. The post-bounce nadir was obtained at a median of 36 months after low-dose-rate BT. On univariate analysis, age, the PSA nadir value at 2 years, and prostate volume were significant factors for PSA bounce. The PSA nadir value at 2 years remained significant in multivariate analysis. We should carefully monitor young patients with high prostate volume having a >0.5 PSA nadir value at 2 years for PSA bounce. [ABSTRACT FROM AUTHOR]

المؤلفون: Lee, Jason Joon Bock, Lee, Jeongshim, Yoon, Hong In, Kim, Se Hoon, Cho, Jaeho, Lee, Kyu Sung, Chang, Jong Hee, Suh, Chang-Ok

المصدر: Journal of Neuro-Oncology ; volume 144, issue 2, page 333-341 ; ISSN 0167-594X 1573-7373

مصطلحات موضوعية: Cancer Research, Neurology (clinical), Neurology, Oncology

الإتاحة: https://doi.org/10.1007/s11060-019-03232-wTest