المؤلفون: Vacher, C, Ho, N, Skinner, A, Robinson, J, Freebairn, L, Lee, GY, Iorfino, F, Prodan, A, Song, YJC, Occhipinti, J-A, Hickie, IB

الوصف: The ongoing COVID-19 pandemic has impacted the mental health of populations and highlighted the limitations of mental health care systems. As the trajectory of the pandemic and the economic recovery are still uncertain, decision tools are needed to help evaluate the best interventions to improve mental health outcomes. We developed a system dynamics model that captures causal relationships among population, demographics, post-secondary education, health services, COVID-19 impact, and mental health outcomes. The study was conducted in the Australian state of Victoria. The model was calibrated using historical data and was stratified by age group and by geographic remoteness. Findings demonstrate that the most effective intervention combination includes economic, social, and health sector initiatives. Assertive post-suicide attempt care is the most impactful health sector intervention, but delaying implementation reduces the potency of its impact. Some evidence-based interventions, such as population-wide community awareness campaigns, are projected to worsen mental health outcomes when implemented on their own. Systems modelling offers a powerful decision-support tool to test alternative strategies for improving mental health outcomes in the Victorian context.

العلاقة: pii: ijerph19116470; Vacher, C., Ho, N., Skinner, A., Robinson, J., Freebairn, L., Lee, G. Y., Iorfino, F., Prodan, A., Song, Y. J. C., Occhipinti, J. -A. & Hickie, I. B. (2022). Optimizing Strategies for Improving Mental Health in Victoria, Australia during the COVID-19 Era: A System Dynamics Modelling Study. INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH, 19 (11), https://doi.org/10.3390/ijerph19116470Test.; http://hdl.handle.net/11343/316124Test

الإتاحة: https://doi.org/10.3390/ijerph19116470Test
http://hdl.handle.net/11343/316124Test

المؤلفون: Kim, MS, Chung, BY, Chang, SE, Oh, SH, Ryu, HJ, Kim, DH, Lee, JH, Ko, JY, Kim, JE, Lee, GY, Jeon, J, Choi, H, Roh, MR, Bae, JM, Na, JI, Jung, HJ, Bang, CH, Kim, HS, Lee, SH, Shin, MK, Park, KY, Park, CJ, Choi, M, Yoon, TJ, Suh, KS, Park, YL, Ryoo, YW, Kim, MH, Kim, YC

المساهمون: 105230, Kim, YC

مصطلحات موضوعية: Dermatitis, Allergic Contact, Hair Dyes, Humans, Republic of Korea, Retrospective Studies, Sunscreening Agents

الوصف: Background: Pigmented contact dermatitis (PCD), a rare variant of non-eczematous contact dermatitis, is clinically characterized by sudden-onset brown or grey pigmentation on the face and neck. It is hypothesized to be caused by repeated contact with low levels of allergens. Objectives: This study evaluated the risk of using hair dyes in patients with PCD in Korea. Methods: A total of 1033 PCD patients and 1366 controls from 31 university hospitals were retrospectively recruited. We collected and analysed the data from the patient group, diagnosed through typical clinical findings of PCD and the control group, which comprised age/sex-matched patients who visited the participating hospitals with pre-existing skin diseases other than current allergic disease or PCD. Results: Melasma and photosensitivity were significantly more common in the control group, and a history of contact dermatitis was more common in the PCD group. There were significantly more Fitzpatrick skin type V participants in the PCD group than in the control group. There was no significant difference in sunscreen use between the groups. Using dermatologic medical history, Fitzpatrick skin type and sunscreen use as covariates, we showed that hair dye use carried a higher PCD risk (odds ratio [OR] before adjustment: 2.06, confidence interval [CI]: 1.60–2.65; OR after adjustment: 2.74, CI: 1.88–4.00). Moreover, henna users had a higher risk of PCD (OR before adjustment: 5.51, CI: 4.07–7.47; OR after adjustment: 7.02, CI: 4.59–10.74), indicating a significant increase in the risk of PCD with henna dye use. Contact dermatitis history was more prevalent in henna users than in those using other hair dyes in the PCD group (17.23% vs. 11.55%). Conclusion: Hair dye use is a risk factor for PCD. The risk significantly increased when henna hair dye was used by those with a history of contact dermatitis.

العلاقة: J009269959; http://repository.ajou.ac.kr/handle/201003/32078Test; Journal of the European Academy of Dermatology and Venereology : JEADV, 37(12). : 2543-2549, 2023

الإتاحة: https://doi.org/10.1111/jdv.19395Test
http://repository.ajou.ac.kr/handle/201003/32078Test

المؤلفون: Kim, CJ, Kim, M, Lee, GY, Park, E, Schlenk, EA

المساهمون: 105842, Kim, CJ

مصطلحات موضوعية: Adult, Humans, Medication Adherence, Metabolic Syndrome, Nurse's Role, Pharmaceutical Preparations, meta-analysis, nursing, systematic review

الوصف: Aims and Objectives: To determine the effectiveness of nurse-led interventions on medication adherence, medication knowledge and clinical outcomes in adults taking medication for metabolic syndrome. Background: Despite the significance of interventions designed to improve medication adherence, a systematic review of nurse-led intervention studies for metabolic syndrome is lacking. Design: A systematic review and meta-analysis of randomised controlled trials. Methods: The study was conducted following the PRISMA guidelines checklist. PubMed, EMBASE, PsychINFO, CINAHL, Cochrane CENTRAL and other manual sources were searched in May 2021.The quality assessment was conducted using the Effective Public Health Practice Project Quality Assessment Tool for Quantitative Studies. Comprehensive Meta-Analysis 3.0 was used to calculate the pooled effect sizes with 95% confidence intervals. Results: This review included 20 studies of nurse-led medication adherence interventions in 6017 adults at risk for metabolic syndrome. The pooled effect size using the random effects model indicated that nurse-led interventions had a significantly moderate impact on enhancing medication adherence and medication knowledge and improving selected clinical outcomes of available studies in nurse-led intervention groups compared with control groups. Duration of intervention (median 12 weeks), mode of delivery (group vs. individual) and using multiple strategies influenced outcomes of nurse-led medication adherence interventions. The results revealed that interventions of moderate- to high-quality studies were more likely to show significant improvements in medication adherence than those of low-quality studies. Conclusion: The meta-analyses showed that nurse-led interventions may enhance medication adherence and knowledge and improve clinical outcomes of this population. Relevance to Clinical Practice: The findings may contribute to evidence-based information about nurse-led intervention and its selection of appropriate interventions for ...

العلاقة: J009621067; http://repository.ajou.ac.kr/handle/201003/26205Test; Journal of clinical nursing, 32(15-16). : 5328-5356, 2023

الإتاحة: https://doi.org/10.1111/jocn.16589Test
http://repository.ajou.ac.kr/handle/201003/26205Test

المؤلفون: Oh, J, Park, SY, Lee, GY, Park, JH, Joe, HB

المساهمون: 111154, 104200, 104247, Oh, J, Park, SY, Joe, HB

مصطلحات موضوعية: Adult, Anesthesia, General, Humans, Neuromuscular Blocking Agents, Piperidines, Remifentanil, General anesthesia, I-gel insertion, Remimazolam

الوصف: Background: Remimazolam is a new anesthetic drug developed and is an ultra-short-acting agent with rapid onset and offset. The pharmacology of this drug seems to be ideal for short surgeries eligible for I-gel insertion. Therefore, this study aimed to determine the optimal bolus dose of remimazolam for I-gel insertion when co-administered with remifentanil without neuromuscular blocking agents (NMBAs). Methods: Patients aged 19–65years with American Society of Anesthesiologists physical status I or II scheduled for general anesthesia were enrolled. The first dose of remimazolam was 0.15mg/kg and remifentanil was co-administered at an effect-site concentration (Ce) of 3.0ng/mL. The dose of remimazolam for the following patient was decreased or increased by 0.05mg/kg depending on the success or failure of I-gel insertion in the previous patient. Results: The remimazolam bolus dose required for successful I-gel insertion in 50% of adult patients using modified Dixon’s up-and-down method with remifentanil Ce 3.0ng/mL and no NMBAs was 0.280 ± 0.048mg/kg. Isotonic regression analysis showed that the 50% and 95% effective doses were 0.244 (83% confidence interval [CI] 0.213–0.313) mg/kg and 0.444 (95% CI 0.436–0.448) mg/kg, respectively. The mean time to loss of consciousness (Modified Observer’s Assessment of Alertness/Sedation score < 2) was 52.2s. Three patients (12.0%) showed a reduction in systolic blood pressure of more than 30% from baseline. Conclusions: Selecting the appropriate dose of remimazolam/remifentanil without NMBAs makes it feasible to insert the I-gel. Trial registration: This study protocol was registered at http://cris.nih.go.krTest (KCT0007801, 12th, October, 2022).

العلاقة: J014712253; http://repository.ajou.ac.kr/handle/201003/25293Test; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10018909Test; BMC anesthesiology, 23(1). : 81-81, 2023

الإتاحة: https://doi.org/10.1186/s12871-023-02041-zTest
http://repository.ajou.ac.kr/handle/201003/25293Test
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10018909Test

المؤلفون: Lee, GY, Kim, S, Choi, ST, Song, J-S

المصدر: Abstracts Accepted for Publication

الإتاحة: https://doi.org/10.1136/annrheumdis-2017-eular.4571Test

المؤلفون: Prentice KJ, Saksi J, Robertson LT, Lee GY, Inouye KE, Eguchi K, Lee A, Cakici O, Otterbeck E, Cedillo P, Achenbach P, Ziegler AG, Calay ES, Engin F, Hotamisligil GS

المصدر: Yearbook of Paediatric Endocrinology.

مصطلحات موضوعية: General Economics, Econometrics and Finance

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::bd388d09727e00ffa8c609b19850f2e5Test
https://doi.org/10.1530/ey.19.15.6Test

المؤلفون: Kim, JH, Lee, GY, Lee, HS, Park, SY

المساهمون: 104200, Park, SY

مصطلحات موضوعية: Anesthesia, Antitussive Agents, Benzimidazoles, Cough, Female, Humans, Piperidines, Remifentanil, Sevoflurane, emergence cough, extubation, ramosetron

الوصف: BACKGROUND: Remifentanil reduces cough during extubation. Ramosetron, a 5-HT(3) receptor antagonist, is a potent antiemetic. Regarding the antitussive property of 5-HT receptor agonists, ramosetron can mediate the cough reflex by increasing the remifentanil requirement. This study evaluated the effect of ramosetron on the optimal effect-site concentration (Ce) of remifentanil for preventing emergence cough from sevoflurane anesthesia in female patients. METHODS: Forty-seven randomly selected female patients undergoing laparoscopic cholecystectomy received either ramosetron 0.3 mg (n = 23) or the same volume of normal saline (n = 24) intravenously at the end of surgery. The remifentanil Ce using target-controlled infusion in 50% of patients (EC(50)) and 95% of patients (EC(95)) were assessed using Dixon's up-and-down or isotonic regression method with a bootstrapping approach. RESULTS: Using Dixon's up-and-down method, the EC(50) of remifentanil in the control group (1.33 +/- 0.38 ng/mL) was comparable to that of ramosetron group (1.50 +/- 0.69 ng/mL) (P = 0.615). Using isotonic regression analysis, the EC(50) (83% confidence interval) did not differ between the two groups (1.17 [0.86-1.43] ng/mL and 1.13 [0.68-1.56] ng/mL in control and ramosetron groups). However, the EC(95) (95% confidence interval) was significantly lower in the control group than in the ramosetron group (1.90 [1.45-1.96] ng/mL and 2.92 [2.35-2.97] ng/mL). CONCLUSION: Remifentanil Ce for preventing emergence cough was higher in the ramosetron group than in the control group. It may indicate the lowering effect of ramosetron on the antitussive activity of remifentanil.

العلاقة: J013816128; http://repository.ajou.ac.kr/handle/201003/25146Test; Current pharmaceutical design, 28(16). : 1359-1366, 2022

الإتاحة: https://doi.org/10.2174/1381612828666220412101447Test
http://repository.ajou.ac.kr/handle/201003/25146Test

المؤلفون: Oh, J, Park, SY, Lee, SY, Song, JY, Lee, GY, Park, JH, Joe, HB

المساهمون: 111154, 104200, 101795, 104247, Oh, J, Park, SY, Lee, SY, Joe, HB

مصطلحات موضوعية: Aged, Anesthesia, General, Benzodiazepines, Humans, Hypnotics and Sedatives, Middle Aged, Unconsciousness, General anesthesia, Intravenous anesthesia, Remima-zolam, Vital signs

الوصف: BACKGROUND: Remimazolam is a new ultra short-acting benzodiazepine originally developed as an improved version of midazolam. Recent studies have demonstrated non-inferiority of remimazolam to propofol in general anesthesia. However, to date, few studies have investigated the induction bolus dose of remimazolam required to achieve general anesthesia. We aimed to determine the 95% effective dose (ED95) of remimazolam bolus required to achieve loss of consciousness (LOC) and the appropriate doses for different age groups. METHODS: Patients aged 20-79 years with the American Society of Anesthesiologists physical status of I or II were enrolled in this study. A total of 120 patients were included representing young, middle-aged, and elderly groups. Loss of eyelash reflex and verbal response after the administration of remimazolam was considered successful LOC. The ED95 of remimazolam was determined using a biased coin up-and-down design with sequential allocation and the isotonic regression method. RESULTS: The ED95 of remimazolam for induction of general anesthesia was 0.367 mg/kg (95% CI [0.277, 0.392]) in the young group, 0.369 mg/kg (95% CI [0.266, 0.394]) in the middle-aged group, and 0.249 mg/kg (95% CI [0.199, 0.288]) in the elderly group. During the study period, none of the patients required rescue medications for hypotension or bradycardia. CONCLUSIONS: This study investigated the ED95 of remimazolam bolus for anesthesia induction. The precise dosing of the ED95 can help maintain hemodynamic stability during the induction of anesthesia.

العلاقة: J020056419; http://repository.ajou.ac.kr/handle/201003/24789Test; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9726459Test; Korean journal of anesthesiology, 75(6). : 510-517, 2022

الإتاحة: https://doi.org/10.4097/kja.22331Test
http://repository.ajou.ac.kr/handle/201003/24789Test
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9726459Test

المؤلفون: Lee GY, Yip CC, Yu EC, Man DW

المصدر: Clinical Interventions in Aging, Vol Volume 8, Pp 623-633 (2013)

مصطلحات موضوعية: Alzheimer's disease, memory training, errorless learning, computerized, early dementia, Geriatrics, RC952-954.6

الوصف: Grace Y Lee,1 Calvin CK Yip,2 Edwin CS Yu,3 David WK Man4 1Occupational Therapy Department, Kwai Chung Hospital, 2CY Functional Recovery Services, 3Psychogeriatric Team, Kwai Chung Hospital, 4Department of Rehabilitation Sciences, the Hong Kong Polytechnic University, Hong Kong, People’s Republic of China Background: Improving the situation in older adults with cognitive decline and evidence of cognitive rehabilitation is considered crucial in long-term care of the elderly. The objective of this study was to implement a computerized errorless learning-based memory training program (CELP) for persons with early Alzheimer’s disease, and to compare the training outcomes of a CELP group with those of a therapist-led errorless learning program (TELP) group and a waiting-list control group. Methods: A randomized controlled trial with a single-blind research design was used in the study. Chinese patients with early Alzheimer’s disease screened by the Clinical Dementia Rating (score of 1) were recruited. The subjects were randomly assigned to CELP (n = 6), TELP (n = 6), and waiting-list control (n = 7) groups. Evaluation of subjects before and after testing, and at three-month follow-up was achieved using primary outcomes on the Chinese Mini-Mental State Examination, Chinese Dementia Rating Scale, Hong Kong List Learning Test, and the Brief Assessment of Prospective Memory-Short Form. Secondary outcomes were the Modified Barthel Index, Hong Kong Lawton Instrumental Activities of Daily Living Scale, and Geriatric Depression Scale-Short Form. The data were analyzed using Friedman's test for time effect and the Kruskal-Wallis test for treatment effect. Results: Positive treatment effects on cognition were found in two errorless learning-based memory groups (ie, computer-assisted and therapist-led). Remarkable changes were shown in cognitive function for subjects receiving CELP and emotional/daily functions in those receiving TELP. Conclusion: Positive changes in the cognitive function of Chinese patients with early Alzheimer's disease were initially found after errorless training through CELP. Further enhancement of the training program is recommended. Keywords: Alzheimer’s disease, memory training, errorless learning, computerized, early dementia

وصف الملف: electronic resource

العلاقة: https://www.dovepress.com/evaluation-of-a-computer-assisted-errorless-learning-based-memory-trai-peer-reviewed-article-CIATest; https://doaj.org/toc/1178-1998Test

الوصول الحر: https://doaj.org/article/6e64fc67e41a4ea884caf87da52d84e1Test

المؤلفون: Sancar, A, Kim, JB, Xu, A, Birnbaum, MJ, Titchenell, P, Cheng, KY, Lee, JH, Jeon, YG, Lee, G, Selby, CP, Lee, GY, Jang, H

الوصف: published_or_final_version

العلاقة: Nature Communications; Nature Communications, 2016, v. 7, p. 12180:1-14; 14; 726505493; 267178; PMC4947181; 12180:1; http://hdl.handle.net/10722/232082Test

الإتاحة: https://doi.org/10.1038/ncomms12180Test
http://hdl.handle.net/10722/232082Test