المؤلفون: Ling, Xiao Chun, Huang, Pin-Hsuan, Chen, Hung-Chi, Hsueh, Yi-Jen, Lee, Chia-Wen, Lien, Reyin, Lee, Chien-Chung, Chu, Shih-Ming, Chen, Kuan-Jen, Hwang, Yih-Shiou, Lai, Chi-Chun, Chiang, Ming-Chou, Wu, Wei-Chi

المصدر: Frontiers in Pediatrics ; volume 11 ; ISSN 2296-2360

مصطلحات موضوعية: Pediatrics, Perinatology and Child Health

الوصف: Introduction Retinopathy of prematurity (ROP) is a retinal vascular developmental disease associated with risks factors such as supplementary oxygen use or low birth weight/early gestational age. Multiple studies have reported associations between ROP and systemic inflammation. In this study, we investigated serum cytokines associated with ROP development and severity and assessed their applicability as potential biomarkers of ROP. Methods This prospective study was conducted at an institutional referral center between 2019 and 2021. To measure the serum levels of 40 inflammatory cytokines in eligible premature patients, we collected their serum samples during the enrollment of patients or the intravitreal injection of anti–vascular endothelial growth factor (VEGF) agents and after 2 and 4 weeks. Results Fifty patients were enrolled. In patients with type 1 ROP who received anti-VEGF agents ( n = 22), the levels of serum intercellular adhesion molecule-1 decreased significantly ( p < 0.05) at 4 weeks compared with the baseline level, whereas those of serum granulocyte–macrophage colony-stimulating factor increased significantly ( p < 0.05). In patients with ROP who did not require any treatment ( n = 14), no significant change was noted in the level of any of the 40 inflammatory cytokines. In control infants without ROP ( n = 14), the serum levels of tumor necrosis factor-α, interleukin (IL)-15, and IL-12p40 increased significantly ( p < 0.05) at 4 weeks. The changes in the levels of serum inflammatory cytokines did not vary significantly among the aforementioned three groups. A generalized estimating equation indicated that zone 1 ROP, stage 3 ROP, older postmenstrual age, respiratory distress syndrome, necrotizing enterocolitis, and sepsis were associated with the changes in serum cytokine levels. Conclusions Although significant changes (compared with baseline) were observed in the serum levels of certain inflammatory cytokines in patients with type 1 ROP and infants without ROP, no ...

الإتاحة: https://doi.org/10.3389/fped.2023.1195904Test

المؤلفون: Wu, Wei-Hung, Lee, Chien-Chung, Chen, Yi-Ching, Chiang, Ming-Chou, Chiu, Cheng-Hsun

المصدر: Pediatrics & Neonatology ; ISSN 1875-9572

مصطلحات موضوعية: Pediatrics, Perinatology and Child Health

الإتاحة: https://doi.org/10.1016/j.pedneo.2023.05.013Test
https://api.elsevier.com/content/article/PII:S187595722300205X?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S187595722300205X?httpAccept=text/plainTest

المؤلفون: Lee, Chien-Chung, Chiu, Cheng-Hsun

المساهمون: Chang Gung Memorial Hospital

المصدر: Journal of the Formosan Medical Association ; ISSN 0929-6646

مصطلحات موضوعية: General Medicine

الإتاحة: https://doi.org/10.1016/j.jfma.2023.09.019Test
https://api.elsevier.com/content/article/PII:S0929664623003984?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S0929664623003984?httpAccept=text/plainTest

المؤلفون: Lee, Chien-Chung

المصدر: Pediatrics & Neonatology ; volume 64, issue 3, page 229-230 ; ISSN 1875-9572

مصطلحات موضوعية: Pediatrics, Perinatology and Child Health

الإتاحة: https://doi.org/10.1016/j.pedneo.2023.04.001Test
https://api.elsevier.com/content/article/PII:S1875957223000748?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S1875957223000748?httpAccept=text/plainTest

المؤلفون: Yen, Cha-Shien, Hsiao, Hsuan-Ling, Lee, Chien-Chung, Tsai, Tzu-Cheng, Chen, Hui-Yu, Chen, Chyi-Liang, Chiu, Cheng-Hsun

المصدر: Pediatrics & Neonatology ; volume 64, issue 2, page 168-175 ; ISSN 1875-9572

مصطلحات موضوعية: Pediatrics, Perinatology and Child Health

الإتاحة: https://doi.org/10.1016/j.pedneo.2022.05.016Test
https://api.elsevier.com/content/article/PII:S1875957222002108?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S1875957222002108?httpAccept=text/plainTest

المؤلفون: Lee, Chien-Chung, 李箭仲

مرشدي الرسالة: Jian, Hua, 華 健

الوصف: 103
As the world's industrial development caused environmental security issues, transport process for air pollution, according to the latest study by U.S. researchers published on a global scale, commercial transportation fleet emissions of particulate pollutants into the air almost car emissions 50% of particulate pollutants, especially air pollution comes mainly from the ship to the diesel exhaust of carbon oxides and sulfur oxides, ozone-depleting substances used on board, the ship burned and volatile organic compounds generated cargo, not only affects the Earth's climate, but also harmful to the coastal port cities and people's health. In view of this, this study use the data from Keelung EPA and Taiwan International Ports Logistics Corporation enforce comparison and analysis. With a view to improve the Keelung air pollution from ships, to protect the harbor environment, quality of life for people in the port city of residence. This study focused on the plan in the port area of air pollution monitoring and environmental pollution monitoring data related to the seasonal variations and weather conditions (such as precipitation, temperature, wind speed, wind direction) cum pollutants diffusion relationship, plotted to assess Radar analysis of consistency, understanding as the future of the port area to improve air quality and pollution control in accordance with the scope and impact of the environment.

وصف الملف: 100

الإتاحة: http://ndltd.ncl.edu.tw/handle/646s5kTest

المؤلفون: Lee, Chien-Chung, Chiu, Cheng-Hsun

المصدر: Journal of the Formosan Medical Association; Jun2024, Vol. 123 Issue 6, p638-646, 9p

مستخلص: In neonates, the gastrointestinal tract is rapidly colonized by bacteria after birth. Gut microbiota development is critical during the first few years of life. However, disruption of gut microbiota development in neonates can lead to gut dysbiosis, characterized by overcolonization by pathogenic bacteria and delayed or failed maturation toward increasing microbial diversity and Fermicutes dominance. Gut dysbiosis can predispose infants to sepsis. Pathogenic bacteria can colonize the gut prior to sepsis and cause sepsis through translocation. This review explores gut microbiota development in neonates, the evidence linking gut dysbiosis to neonatal sepsis, and the potential role of probiotics in gut microbiota modulation and sepsis prevention. [ABSTRACT FROM AUTHOR]

: Copyright of Journal of the Formosan Medical Association is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

المؤلفون: Wu, Wei-Hung, Lee, Chien-Chung, Chen, Yi-Ching, Chiang, Ming-Chou, Chiu, Cheng-Hsun

المصدر: Pediatrics & Neonatology; May2024, Vol. 65 Issue 3, p282-287, 6p

مصطلحات موضوعية: LITERATURE reviews, CHILD patients, LACTOBACILLUS, LACTOBACILLUS rhamnosus, MICROBIAL sensitivity tests

مصطلحات جغرافية: TAIWAN

مستخلص: Lactobacilli are common microorganisms in the human body. Some species were used as probiotics supplement for many purposes such as preventing necrotizing enterocolitis, or improving allergic diseases or diarrhea. Previously, Lactobacillus infection was thought of as contamination due to its low pathogenicity. However, there have been reports of invasive Lactobacillus infection in immunocompromised patients or patients with comorbidities. The purpose of this study was to analyze the clinical characteristics, antibiotic treatment and outcomes of pediatric patients with invasive Lactobacillus infection. We retrospectively reviewed pediatric patients diagnosed with invasive Lactobacillus infection between 2004 and 2020. Invasive Lactobacillus infection was diagnosed if sterile sites yielded Lactobacillus spp. Clinical manifestations, chronic diseases, potential predisposing factors, medical treatments, antimicrobial susceptibility tests and outcomes were recorded. Fifteen pediatric patients were diagnosed with invasive Lactobacillus infection, accounting for 2.4% of total invasive Lactobacillus infections during the 16-year period. Eleven infections were bacteremia, two were intra-abdominal infections, and two were biliary tract infections. Fever was the most common symptom. Potential predisposing factors were immunocompromised status, central venous device, prolonged antibiotics use and receiving supplemented probiotics for at least one week. All patients survived with favorable outcomes. Most pathogens were identified as Lactobacillus spp , and two were Lactobacillus rhamnosus , which were related to supplemented probiotics. The antimicrobial susceptibility tests showed that Lactobacilli were all sensitive to ampicillin but resistant to glycopeptides. Invasive Lactobacillus infections in pediatric patients were rare. Despite its low pathogenicity, Lactobacillus could cause invasive infection in those immunocompromised patients. [ABSTRACT FROM AUTHOR]

: Copyright of Pediatrics & Neonatology is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

المؤلفون: Lee, Chien-Chung, Chiang, Ming-Chou, Chu, Shih-Ming, Wu, Wei-Chi, Ho, Margaret Ming-Chih, Lien, Reyin

المصدر: The Journal of Pediatrics ; page 113913 ; ISSN 0022-3476

مصطلحات موضوعية: Pediatrics, Perinatology and Child Health

الإتاحة: https://doi.org/10.1016/j.jpeds.2024.113913Test
https://api.elsevier.com/content/article/PII:S0022347624000167?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S0022347624000167?httpAccept=text/plainTest

المؤلفون: Lee, Chien-Chung, Cheng, Jur-Shan, Chang, Yi-Jung, Chen, Yi-Chia, Hsin, Yi-Chen, Chiu, Cheng-Hsun

المساهمون: Chang Gung Medical Foundation, Chang Gung University

المصدر: Pediatrics & Neonatology ; volume 63, issue 5, page 527-534 ; ISSN 1875-9572

مصطلحات موضوعية: Pediatrics, Perinatology and Child Health

الإتاحة: https://doi.org/10.1016/j.pedneo.2022.03.020Test
https://api.elsevier.com/content/article/PII:S1875957222001437?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S1875957222001437?httpAccept=text/plainTest