المؤلفون: Anastasia Van der Auwera, Laura Peeters, Kenn Foubert, Stefano Piazza, Wim Vanden Berghe, Nina Hermans, Luc Pieters

المصدر: Pharmaceutics, Vol 15, Iss 4, p 1291 (2023)

مصطلحات موضوعية: Filipendula ulmaria, Rosaceae, meadowsweet, gastrointestinal biotransformation, anti-inflammatory activity, Pharmacy and materia medica, RS1-441

الوصف: (1) Background: Filipendula ulmaria (L.) Maxim. (Rosaceae) (meadowsweet) is widely used in phytotherapy against inflammatory diseases. However, its active constituents are not exactly known. Moreover, it contains many constituents, such as flavonoid glycosides, which are not absorbed, but metabolized in the colon by gut microbiota, producing potentially active metabolites that can be absorbed. The aim of this study was to characterize the active constituents or metabolites. (2) Methods: A F. ulmaria extract was processed in an in vitro gastrointestinal biotransformation model, and the metabolites were characterized using UHPLC-ESI-QTOF-MS analysis. In vitro anti-inflammatory activity was evaluated by testing the inhibition of NF-κB activation, COX-1 and COX-2 enzyme inhibition. (3) Results: The simulation of gastrointestinal biotransformation showed a decrease in the relative abundance of glycosylated flavonoids such as rutin, spiraeoside and isoquercitrin in the colon compartment, and an increase in aglycons such as quercetin, apigenin, naringenin and kaempferol. The genuine as well as the metabolized extract showed a better inhibition of the COX-1 enzyme as compared to COX-2. A mix of aglycons present after biotransformation showed a significant inhibition of COX-1. (4) Conclusions: The anti-inflammatory activity of F. ulmaria may be explained by an additive or synergistic effect of genuine constituents and metabolites.

وصف الملف: electronic resource

العلاقة: https://www.mdpi.com/1999-4923/15/4/1291Test; https://doaj.org/toc/1999-4923Test

الوصول الحر: https://doaj.org/article/4e372ace3a9946b6a07d8a71dee1c76eTest

المؤلفون: Stergios Verros, Laura Peeters, Arjen Bergsma, Edsko E. G. Hekman, Gijsbertus J. Verkerke, Bart F. J. M. Koopman

المصدر: BMC Biomedical Engineering, Vol 1, Iss 1, Pp 1-7 (2019)

مصطلحات موضوعية: Duchenne muscular dystrophy, Control interface, Trunk support, Biotechnology, TP248.13-248.65, Medical technology, R855-855.5

الوصف: Abstract Background Arm support devices are available to support people with Duchenne muscular dystrophy (DMD), but active trunk support devices are lacking. An active trunk support device can potentially extend the reach of the arm and stabilize the unstable trunk of people with DMD. In a previous study, we showed that healthy people were able to control an active trunk support using four different control interfaces (based on joystick, force on feet, force on sternum and surface electromyography). All four control interfaces had different advantages and disadvantages. The aim of this study was to explore which of the four inputs is detectably used by people with DMD to control an active trunk support. Results The results were subject-dependent in both experiments. In the active experiment, the joystick was the most promising control interface. Regarding the static experiment, surface electromyography and force on feet worked for two out of the three subjects. Conclusions To our knowledge, this is the first time that people with DMD have engaged in a control task using signals other than those related to their arm muscles. According to our findings, the control interfaces have to be customised to every DMD subject.

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/2524-4426Test

الوصول الحر: https://doaj.org/article/20c6d9181b814d098be7719e7cccf1e6Test

المؤلفون: Laura Peeters, Anke Vandenberghe, Bavo Hendriks, Christine Gilles, Kristien Roelens, Ines Keygnaert

المصدر: BMC International Health and Human Rights, Vol 19, Iss 1, Pp 1-12 (2019)

مصطلحات موضوعية: Sexual violence, Rape, Victims, Belgium, Healthcare Centre, Public aspects of medicine, RA1-1270

الوصف: Abstract Background Sexual violence is a global health problem. After ratifying the Convention of Istanbul in 2016, this Belgian study was set up to map the perspective of victims of rape on the current sexual violence care provision in Belgium and to inquire on their need for more specialised and holistic care in future Sexual Assault Care Centres. Methods Sixteen rape victims participated in this sub-study. A mixed-method design (questionnaire, in-depth interview or small focus group) was applied depending on the time elapsed between rape and participation. Descriptive Thematic Framework Analysis was performed in duo. Results The participants thought it of utmost importance that every victim should receive all medical, psychological and forensic care without necessarily having to involve the police first. They stated that the current Belgian sexual violence care provision could be much more patient-centred, specifically the forensic examination and psychological care. Alongside medical and psychological consequences, victims emphasised the high personal financial and relational burden of sexual violence. The holistic care offered in Sexual Assault Care Centres was perceived to enhance the recovery process of victims of sexual violence. Their doors should be open to all victims and their relatives. They should not only provide acute care for the victim, but also improve victims’ reintegration into society while reducing their personal costs significantly. Conclusion All care for victims of sexual violence, especially forensic and psychological care, needs drastic improvement in Belgium. All participants agreed that having specialised, multidisciplinary and longitudinal care in a Sexual Assault Care Centre that would be open 24/7 for everyone, victims and their significant others, would be an improvement to the currently available care all over Belgium. Trial registration This research was registered on April 1st 2016. Registration number B670201628242.

وصف الملف: electronic resource

العلاقة: http://link.springer.com/article/10.1186/s12914-019-0207-5Test; https://doaj.org/toc/1472-698XTest

الوصول الحر: https://doaj.org/article/c1ceb071c7d2428bbb84f7b51948b707Test

المؤلفون: Anke Vandenberghe, Bavo Hendriks, Laura Peeters, Kristien Roelens, Ines Keygnaert

المصدر: BMC Health Services Research, Vol 18, Iss 1, Pp 1-11 (2018)

مصطلحات موضوعية: Sexual assault, Sexual violence, Sexual assault care Centre, Patient-centred care, Holistic care, Primary health care, Public aspects of medicine, RA1-1270

الوصف: Abstract Background Having ratified the Convention of Istanbul, the Belgian federal government commits itself to the foundation of Sexual Assault Care Centres (SACC). In the light of researching the feasibility of these centres, this study aimed to evaluate the care for victims of sexual violence (SV) in Belgian hospitals anno 2016 as well as to formulate recommendations for the intended model. Methods Between April and October 2016, a questionnaire was distributed to 159 key health professionals active in 17 different hospitals attached to an AIDS Referral Centre. The survey covered four parts, i.e. the health professionals’ profile, their knowledge, attitude and practices, an assessment of the hospital’s policy and the caregivers’ opinion on the care for victims of SV and on the intended SACCs. Subsequently, a descriptive analysis using ‘IBM SPSS Statistics 23’ was performed. Results A total of 60 key health professionals representing 15 different hospitals completed the questionnaire resulting in a response rate of 38%. The results showed a lack of knowledge and practical experience of caregivers’ regarding the care for SV victims. Approximately 30% of responders face personal or professional difficulties upon provision of care to victims of SV. Participants evaluate the current care as good, despite the limited psychosocial support, follow-up, insight for the needs of vulnerable groups and support for family, relatives and health professionals. Yet, the majority of health professionals appraise the SACCs as the best approach for both victims and caregivers. Conclusions By introducing a SACC, the Belgian federal government aims to provide holistic and patient-centred care for victims of SV. Essential in patient-centred health care is an extensive and continuous education, training and supervision of health professionals concerning the care for victims, support for family, relatives and caregivers. At the end and as a result of a participatory process with many professional experts as well as victims, a specific Belgian model, adjusted to the health care system anno 2016 was developed for piloting. The main challenges in establishing SACCs are situated at the institutional and policy level. Collaborating with other institutions and further research are herewith required.

وصف الملف: electronic resource

العلاقة: http://link.springer.com/article/10.1186/s12913-018-3608-6Test; https://doaj.org/toc/1472-6963Test

الوصول الحر: https://doaj.org/article/9e105a2d64704c9e9940eb947e30f303Test

المؤلفون: Bavo Hendriks, Anke Marie-Josée Aimé Vandenberghe, Laura Peeters, Kristien Roelens, Ines Keygnaert

المصدر: International Journal for Equity in Health, Vol 17, Iss 1, Pp 1-10 (2018)

مصطلحات موضوعية: Sexual assault, Sexual violence, Rape, Sexual and gender minorities, Gender-sensitive care, Integrated care, Public aspects of medicine, RA1-1270

الوصف: Abstract Background Sexual assault remains a major threat to public health, affecting every gender, gender identity and sexual orientation. Following the Belgian ratification of the Istanbul Convention in 2016, the feasibility of a Belgian sexual assault centre model was investigated, aiming to provide more integrated and patient-centred health and judiciary services to victims of sexual assault. By actively involving health professionals, police and judiciary system representatives, as well as victims themselves, this feasibility study eventually fed into the Belgian Sexual Assault Care Centre model. In this process, this paper assessed current Belgian health services and the degree to which the implementation of this model could contribute to both a more integrated and gender-sensitive care delivery. Findings from this study and the subsequent recommendations aim to contribute to similar reforms in other countries that have already taken or are about to take steps towards an integrated, multi-agency support framework for victims of sexual assault. Methods A qualitative, descriptive analysis of the survey response of 60 key health professionals (N = 60) representing 15 major Belgian hospitals was first conducted. Comparing their approach with the international guidelines and standards, a Strengths Weaknesses Opportunities and Threats analysis of the current sexual assault health services and their potential transition to the Sexual Assault Care Centre model was then executed. Results Despite adequate equipment, the clear fragmentation of health services and limited follow-up hamper an integrated care delivery in most hospitals. Only three hospitals differentiated their sexual assault care protocol based on the victim’s gender, gender identity and sexual orientation. A striking unawareness among health professionals of sexual assault in male victims, as well as in gender and sexual minorities further hampers a gender-sensitive care delivery. Conclusions The Sexual Assault Care Centre model aims to counter most of the current sexual assault health services’ weaknesses and threats hampering an integrated care for victims of sexual assault. Further research and training of health professionals are however required in order to tune this integrated form of care to sexuality and gender-based differences in victims’ already multi-faceted healthcare needs.

وصف الملف: electronic resource

العلاقة: http://link.springer.com/article/10.1186/s12939-018-0864-3Test; https://doaj.org/toc/1475-9276Test

الوصول الحر: https://doaj.org/article/fe6b33c3a92a4351b7a3e4ec2824f229Test

المؤلفون: Marjolein M. J. Caron, Maarten P. F. Janssen, Laura Peeters, Dominik R. Haudenschild, Andy Cremers, Don A. M. Surtel, Lodewijk W. van Rhijn, Pieter J. Emans, Tim J. M. Welting

المصدر: Frontiers in Bioengineering and Biotechnology, Vol 8 (2020)

مصطلحات موضوعية: chondrocyte hypertrophy, endochondral ossification, COMP, aggrecan, periosteum, periosteal chondrogenesis, Biotechnology, TP248.13-248.65

الوصف: The generation of cartilage from progenitor cells for the purpose of cartilage repair is often hampered by hypertrophic differentiation of the engineered cartilaginous tissue caused by endochondral ossification. Since a healthy cartilage matrix contains high amounts of Aggrecan and COMP, we hypothesized that their supplementation in the biogel used in the generation of subperiosteal cartilage mimics the composition of the cartilage extracellular matrix environment, with beneficial properties for the engineered cartilage. Supplementation of COMP or Aggrecan was studied in vitro during chondrogenic differentiation of rabbit periosteum cells and periosteum-derived chondrocytes. Low melting agarose was supplemented with bovine Aggrecan, human recombinant COMP or vehicle and was injected between the bone and periosteum at the upper medial side of the tibia of New Zealand white rabbits. Generated subperiosteal cartilage tissue was analyzed for weight, GAG and DNA content and ALP activity. Key markers of different phases of endochondral ossification were measured by RT-qPCR. For the in vitro experiments, no significant differences in chondrogenic marker expression were detected following COMP or Aggrecan supplementation, while in vivo favorable chondrogenic marker expression was detected. Gene expression levels of hypertrophic markers as well as ALP activity were significantly decreased in the Aggrecan and COMP supplemented conditions compared to controls. The wet weight and GAG content of the in vivo generated subperiosteal cartilage tissue was not significantly different between groups. Data demonstrate the potential of Aggrecan and COMP to favorably influence the subperiosteal microenvironment for the in vivo generation of cartilage for the optimization of cartilage regenerative approaches.

وصف الملف: electronic resource

العلاقة: https://www.frontiersin.org/article/10.3389/fbioe.2020.01036/fullTest; https://doaj.org/toc/2296-4185Test

الوصول الحر: https://doaj.org/article/36dffda142384c068a95fe5f22f5ffe5Test

المؤلفون: Laura Peeters, Anastasia Van der Auwera, Charlie Beirnaert, Sebastiaan Bijttebier, Kris Laukens, Luc Pieters, Nina Hermans, Kenn Foubert

المصدر: Metabolites, Vol 10, Iss 3, p 111 (2020)

مصطلحات موضوعية: herniaria hirsuta, caryophyllaceae, saponins, urolithiasis, machine learning, dynamic metabolomics, Microbiology, QR1-502

الوصف: Herniaria hirsuta L. (Caryophyllaceae) is used for treatment of urinary stones and as a diuretic. Little is known about the active compounds and the mechanism of action. The phytochemical composition of H. hirsuta was comprehensively characterized using UHPLC-UV-HRMS (Ultrahigh-Performance Liquid Chromatography-Ultraviolet-High Resolution Mass Spectrometry) data. An in vitro gastrointestinal model was used to simulate biotransformation, which allowed the monitoring of the relative abundances of individual compounds over time. To analyze the longitudinal multiclass LC−MS data, XCMS, a platform that enables online metabolomics data processing and interpretation, and EDGE, a statistical method for time series data, were used to extract significant differential profiles from the raw data. An interactive Shiny app in R was used to rate the quality of the resulting features. These ratings were used to train a random forest model. The most abundant aglycone after gastrointestinal biotransformation was subjected to hepatic biotransformation using human S9 fractions. A diversity of compounds was detected, mainly saponins and flavonoids. Besides the known saponins, 15 new saponins were tentatively identified as glycosides of medicagenic acid, acetylated medicagenic acid and zanhic acid. It is suggested that metabolites of phytochemicals present in H. hirsuta, most likely saponins, are responsible for the pharmaceutical effects. It was observed that the relative abundance of saponin aglycones increased, indicating loss of sugar moieties during colonic biotransformation, with medicagenic acid as the most abundant aglycone. Hepatic biotransformation of this aglycone resulted in different metabolites formed by phase I and II reactions.

وصف الملف: electronic resource

العلاقة: https://www.mdpi.com/2218-1989/10/3/111Test; https://doaj.org/toc/2218-1989Test

الوصول الحر: https://doaj.org/article/781201b33d59412f8e0f058924f64432Test

المؤلفون: Charlie Beirnaert, Laura Peeters, Pieter Meysman, Wout Bittremieux, Kenn Foubert, Deborah Custers, Anastasia Van der Auwera, Matthias Cuykx, Luc Pieters, Adrian Covaci, Kris Laukens

المصدر: Metabolites, Vol 9, Iss 3, p 54 (2019)

مصطلحات موضوعية: machine learning, dynamic metabolomics, data simulation, Microbiology, QR1-502

الوصف: Data analysis for metabolomics is undergoing rapid progress thanks to the proliferation of novel tools and the standardization of existing workflows. As untargeted metabolomics datasets and experiments continue to increase in size and complexity, standardized workflows are often not sufficiently sophisticated. In addition, the ground truth for untargeted metabolomics experiments is intrinsically unknown and the performance of tools is difficult to evaluate. Here, the problem of dynamic multi-class metabolomics experiments was investigated using a simulated dataset with a known ground truth. This simulated dataset was used to evaluate the performance of tinderesting, a new and intuitive tool based on gathering expert knowledge to be used in machine learning. The results were compared to EDGE, a statistical method for time series data. This paper presents three novel outcomes. The first is a way to simulate dynamic metabolomics data with a known ground truth based on ordinary differential equations. This method is made available through the MetaboLouise R package. Second, the EDGE tool, originally developed for genomics data analysis, is highly performant in analyzing dynamic case vs. control metabolomics data. Third, the tinderesting method is introduced to analyse more complex dynamic metabolomics experiments. This tool consists of a Shiny app for collecting expert knowledge, which in turn is used to train a machine learning model to emulate the decision process of the expert. This approach does not replace traditional data analysis workflows for metabolomics, but can provide additional information, improved performance or easier interpretation of results. The advantage is that the tool is agnostic to the complexity of the experiment, and thus is easier to use in advanced setups. All code for the presented analysis, MetaboLouise and tinderesting are freely available.

وصف الملف: electronic resource

العلاقة: https://www.mdpi.com/2218-1989/9/3/54Test; https://doaj.org/toc/2218-1989Test

الوصول الحر: https://doaj.org/article/58fb1c6ba83041e5b127fec90ffb918eTest

المؤلفون: Mamadou A. Baldé (10263174), Emmy Tuenter (2854967), Mohamed S. Traoré (10263177), Laura Peeters (3511997), An Matheeussen (191135), Paul Cos (233137), Guy Caljon (119879), Tom Vermeyen (10263180), Wouter Herrebout (684290), Aliou M. Balde (10263183), Kenn Foubert (3340578), Luc Pieters (2375017)

مصطلحات موضوعية: Biochemistry, Medicine, Microbiology, Pharmacology, Ecology, Sociology, Immunology, Infectious Diseases, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, triterpenoid aglycones, 2 D NMR spectroscopy, albidic acid C, 15 μ M, IC 50 values, albidiolic acid, antimicrobial activity, antiplasmodial compounds, Terminalia albida Root Bark Phytoch., antiplasmodial activity, 1 D, 10 oleanane triterpenoids, Antiplasmodial Oleanane Triterpenoids, Staphylococcus aureus, Terminalia albida Sc, ESI mass spectrometry

الوصف: Phytochemical investigation of the n -BuOH extract of the roots of Terminalia albida Sc. Elliot (Combretaceae) led to the isolation and identification of 10 oleanane triterpenoids ( 1 – 10 ), among which six new compounds, i.e., albidanoside A ( 2 ), albidic acid A ( 4 ), albidinolic acid ( 5 ), albidienic acid ( 8 ), albidolic acid ( 9 ), and albidiolic acid ( 10 ), and two triterpenoid aglycones, i.e., albidic acid B ( 6 ) and albidic acid C ( 7 ), were isolated here for the first time from a natural source, along with two known compounds. The structures of these constituents were established by means of 1D and 2D NMR spectroscopy and ESI mass spectrometry. The isolated compounds were evaluated for their antiplasmodial and antimicrobial activity against the chloroquine-resistant strain Plasmodium falciparum K1, Candida albicans , and Staphylococcus aureus . Compounds 1 – 4 , 6 , 7 , and 8 showed moderate antiplasmodial activity with IC 50 values between 5 and 15 μM. None of the tested compounds were active against C. albicans or S. aureus . These findings emphasize the potential of T. albida as a source for discovery of new antiplasmodial compounds.

العلاقة: https://figshare.com/articles/journal_contribution/Antiplasmodial_Oleanane_Triterpenoids_from_i_Terminalia_albida_i_Root_Bark/14173197Test

الإتاحة: https://doi.org/10.1021/acs.jnatprod.0c01119.s001Test

المؤلفون: Donker, Erik M, Spitaleri Timpone, Pietro, Brinkman, David J, Richir, Milan C, Papaioannidou, Paraskevi, Likic, Robert, Sanz, Emilio J, Christiaens, Thierry, Costa, João N, De Ponti, Fabrizio, Gatti, Milo, Böttiger, Ylva, Kramers, Cornelis, Pandit, Rahul, van Agtmael, Michiel A, Tichelaar, Jelle, Philippe Jorens, Galya Stavreva, Ivanka Kostadinova, Ivanka Atanasova, Maria Ganeva, Suzana Mimica, Greta Wozniak, Karel Urbánek, Ondřej Slanař, Anti Kalda, Eric Toussirot, Jean-Luc Cracowski, Yves-Marie Pers, Flora Capelle, Joachim Neumann, Rainer Böger, Ingolf Cascorbi, Ralf Regenthal, Markus Schwaninger, Silke Müller, Petra Thürmann, David Kerins, Helen Gallagher, James Curneen, Anne Harnett, Amelia Filippelli, Gianluca Trifirò, Santa Purvina, Baiba Jansone, Janet Mifsud, Ivan Kocić, Bogusław Okopień, Marlena Broncel, Dagmara Mirowska-Guzel, José Alves, Simona Conea, Ioan Magyar, Olga Horvat, Mojca Krzan, Sebastjan Bevc, Francisco de Abajo, Magi Farre, M Isabel Lucena, Ylva Böttiger, Risto Huupponen, Michael Okorie, Martin Hawes, Vikas Kapil, Andrew Hitchings, Yoon Loke, Vesela Georgieva, Darko Simonov, Kameliya Sokolova, Zhivka Tsokeva, Tinde Halgato, Tomi Kovacevic, Ovidiu Ourta, Candelaria Martín González, Madalin Alexandru Hasan, Lorena Paduraru, Masa Rapajic, Andjela Milak, Miroslav Ilić, Dimo Dimov, Peter Dieleman, Ellen Van Leeuwen, Mirko Petrovic, Chipurici Adrian Marius, Mihaela Zdrinca, Aleksandar Rašković, Nebojša Stilinović, Gavrail Poterov, Vanesa Pilicheva, Venka Tsankova, Evgenia Tsolova, Ilia Kostadinov, Delyan Delev, Darinka Dimitrova, Dimiter Terziivanov, Kristian Dominik Rudez, Vladimir Trkulja, Jelena Osmanovc Barilar, Jakša Vukojević, Martin Poruba, Radmila Vojkůvková, Hana Jureckova, Marek Pecha, Martin Mareš, Martin Šíma, Matthieu Bereau, Pierre-Olivier Girodet, Theodora Angoulvant, François Montastruc, Matthieu Roustit, Radjiv Goulabchand, Padern Guillaume, Lucy Meunier, Patrick Karcher, Carole Greuez, Jonathan Tousch, Lucas Niglis, Aurélie Reiter, Marion Fourtage, Guillaume Becker, Alexandra Audemard-Verger, Adrien Lemaignen, Renke Maas, Jan-Hendrik Lenz, Theresa Buuck, Kathrin Kohlen, Chrysanthi Sardeli, Eirini Apostolidou, Barry Corbett, Emanuel Raschi, Elisabetta Poluzzi, Federico Pea, Riccardo Ripamonti, Valeria Conti, Duilio Pagano, Riccardo Scoglio, Giuseppe Ando, Inese Sviestina, Zane Dzirkale, Andrew Aquilina, Maryanne Caruana, Maria Cordina, Christina Wlodek, Jeffrey Bonnici, Antoine Vella, Marianne Klemp, Ingrid Cameron, Piotr Jakubow, Iga Pawłowska, Łukasz Bułdak, Marcin Basiak, Aleksandra Bołdys, Mateusz Staciwa, Joana Caetano, Renata Ribeiro, Miran Brvar, Uroš Maver, Tina Maver, Eva Jakopin, Tadej Petreski, Juan-Ignacio Pérez-Calvo, Ana Avedillo Salas, Miguel Puerro, Amelia García, Miguel Angel Maria-Tablado, Daniel Fuster, Maria Luisa Bernal, Susan Brooks, Anna Wakelin, Catrin Page, Jitka Rychlickova, Laura Peeters, Thomas Sierkstra, Michael Reumerman, Jarik de Geus, Eveline Van Poelgeest, Hiltsje Heemskerk, Reinier van Hest, Eline van Hattum, Floor van Rosse, Emma Kleipool, Rian Bibo, Geert Lefeber, Glenn Dumont, Narin Martens-Akrawi, Yves Liem, Nella Leijten-Wackwitz, Chiel Bakkum, Anne Dittrich, F G A Versteegh, Michiel Warlé, Karen Keijsers, Ben Semmekrot

المساهمون: Erik M, Donker, Pietro, Spitaleri Timpone, David J, Brinkman, Milan C, Richir, Paraskevi, Papaioannidou, Robert, Likic, Emilio J, Sanz, Thierry, Christiaen, João N, Costa, Fabrizio, De Ponti, Milo, Gatti, Ylva, Böttiger, Cornelis, Kramer, Rahul, Pandit, Michiel A, van Agtmael, Jelle, Tichelaar, Jorens, Philippe, Stavreva, Galya, Kostadinova, Ivanka, Atanasova, Ivanka, Ganeva, Maria, Mimica, Suzana, Wozniak, Greta, Urbánek, Karel, Slanař, Ondřej, Kalda, Anti, Toussirot, Eric, Cracowski, Jean-Luc, Pers, Yves-Marie, Capelle, Flora, Neumann, Joachim, Böger, Rainer, Cascorbi, Ingolf, Regenthal, Ralf, Schwaninger, Marku, Müller, Silke, Thürmann, Petra, Kerins, David, Gallagher, Helen, Curneen, Jame, Harnett, Anne, Filippelli, Amelia, Trifirò, Gianluca, Purvina, Santa, Jansone, Baiba, Mifsud, Janet, Kocić, Ivan, Okopień, Bogusław, Broncel, Marlena, Mirowska-Guzel, Dagmara, Alves, José, Conea, Simona, Magyar, Ioan, Horvat, Olga, Krzan, Mojca, Bevc, Sebastjan, de Abajo, Francisco, Farre, Magi, Isabel Lucena, M, Böttiger, Ylva, Huupponen, Risto, Okorie, Michael, Hawes, Martin, Kapil, Vika, Hitchings, Andrew, Loke, Yoon, Georgieva, Vesela, Simonov, Darko, Sokolova, Kameliya, Tsokeva, Zhivka, Halgato, Tinde, Kovacevic, Tomi, Ourta, Ovidiu, Martín González, Candelaria, Alexandru Hasan, Madalin, Paduraru, Lorena, Rapajic, Masa, Milak, Andjela, Ilić, Miroslav, Dimov, Dimo, Dieleman, Peter, Van Leeuwen, Ellen, Petrovic, Mirko, Adrian Marius, Chipurici, Zdrinca, Mihaela, Rašković, Aleksandar, Stilinović, Nebojša, Poterov, Gavrail, Pilicheva, Vanesa, Tsankova, Venka, Tsolova, Evgenia, Kostadinov, Ilia, Delev, Delyan, Dimitrova, Darinka, Terziivanov, Dimiter, Dominik Rudez, Kristian, Trkulja, Vladimir, Osmanovc Barilar, Jelena, Vukojević, Jakša, Poruba, Martin

الوصف: Rational prescribing is essential for the quality of health care. However, many final-year medical students and junior doctors lack prescribing competence to perform this task. The availability of a list of medicines that a junior doctor working in Europe should be able to independently prescribe safely and effectively without supervision could support and harmonize teaching and training in clinical pharmacology and therapeutics (CPT) in Europe. Therefore, our aim was to achieve consensus on such a list of medicines that are widely accessible in Europe. For this, we used a modified Delphi study method consisting of three parts. In part one, we created an initial list based on a literature search. In part two, a group of 64 coordinators in CPT education, selected via the Network of Teachers in Pharmacotherapy of the European Association for Clinical Pharmacology and Therapeutics, evaluated the accessibility of each medicine in his or her country, and provided a diverse group of experts willing to participate in the Delphi part. In part three, 463 experts from 24 European countries were invited to participate in a 2-round Delphi study. In total, 187 experts (40%) from 24 countries completed both rounds and evaluated 416 medicines, 98 of which were included in the final list. The top three Anatomical Therapeutic Chemical code groups were (1) cardiovascular system (n = 23), (2) anti-infective (n = 21), and (3) musculoskeletal system (n = 11). This European List of Key Medicines for Medical Education could be a starting point for country-specific lists and could be used for the training and assessment of CPT.

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/38062784; info:eu-repo/semantics/altIdentifier/wos/WOS:001131503000001; firstpage:1; lastpage:10; numberofpages:10; journal:CLINICAL PHARMACOLOGY & THERAPEUTICS; https://hdl.handle.net/11570/3284048Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85180893617

الإتاحة: https://doi.org/10.1002/cpt.3132Test
https://hdl.handle.net/11570/3284048Test