المؤلفون: Larissa Carolina Garcia Franco da Rosa, Marcus V. Pinto, Joana Rodrigues Dantas, Gil F. Salles, Melanie Rodacki, Débora Lopes Souto, Lenita Zajdenverg

المصدر: Journal of Diabetes and its Complications. 33:610-615

مصطلحات موضوعية: Adult, Blood Glucose, Male, medicine.medical_specialty, endocrine system diseases, Endocrinology, Diabetes and Metabolism, Renal function, 030209 endocrinology & metabolism, 030204 cardiovascular system & hematology, Logistic regression, Cohort Studies, Excretion, 03 medical and health sciences, 0302 clinical medicine, Endocrinology, Internal medicine, Diabetes mellitus, Internal Medicine, medicine, Humans, Retrospective Studies, Glycemic, Glycated Hemoglobin, Type 1 diabetes, Diabetic Retinopathy, business.industry, Cardiac autonomic neuropathy, Diabetic retinopathy, medicine.disease, Diabetes Mellitus, Type 1, Female, business, Brazil, Glomerular Filtration Rate

الوصف: Aim To evaluate the associations between HbA1c variability and long-term glycemic control with microvascular complications in type 1 diabetes (T1D) patients and multiethnic background. Methods T1D adults with ≥ 10 years of follow-up and ≥ 2 HbA1c measurements were included. Glycemic variability was evaluated by the standard deviation (HbA1c-SD), and coefficient of variation (HbA1c-CV), and glycemic control by mean HbA1c over 10 years. Diabetic retinopathy (DR), increased urinary albumin excretion rate (UAER) and reduced glomerular filtration rate (eGFR) were diagnosed. Cardiac autonomic neuropathy (CAN) was diagnosed by cardiac reflex tests. Associations between glycemic parameters with complications were assessed by multivariate logistic regressions. Results 220 patients were included. Simultaneously adjusted for each other, mean HbA1c was independently associated with DR (OR: 2.82; 95%CI: 1.45-5.50), increased UAER (OR: 1.97; 95%CI: 1.14-3.09) and CAN (OR: 4.42; 95%CI: 1.45-13.51); whereas HbA1c-CV was independently associated with DR (OR: 8.93; 95%CI: 1.86-42.87) and reduced eGFR (OR: 7.02; 95%CI: 1.47-35.55). Conclusions Long-term glycemic control was associated with DR, increased UAER and CAN, while glycemic variability was additionally associated with DR and impaired renal function; suggesting that both good and stable glycemic status might be important to prevent microvascular complications in T1D patients and multiethnic background.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c836ddd66b7b272da626105684203a9Test
https://doi.org/10.1016/j.jdiacomp.2019.05.022Test

المؤلفون: Larissa Carolina Garcia Franco da Rosa, Gil F. Salles, Marcus V. Pinto, Marco Antônio Salles Dantas de Lima, Lenita Zajdenverg, Joana Rodrigues Dantas, Melanie Rodacki, Luiz Felipe Pinto

المصدر: Diabetology & Metabolic Syndrome
Diabetology & Metabolic Syndrome, Vol 12, Iss 1, Pp 1-4 (2020)

مصطلحات موضوعية: medicine.medical_specialty, endocrine system diseases, Endocrinology, Diabetes and Metabolism, Coefficient of variation, Short Report, 030209 endocrinology & metabolism, Neurological examination, 030204 cardiovascular system & hematology, Gastroenterology, 03 medical and health sciences, 0302 clinical medicine, Diabetes mellitus, Internal medicine, Internal Medicine, medicine, lcsh:RC620-627, Long-term glycemic control, Glycemic, Type 1 diabetes, medicine.diagnostic_test, business.industry, Type 2 Diabetes Mellitus, nutritional and metabolic diseases, medicine.disease, Diabetic peripheral neuropathy, lcsh:Nutritional diseases. Deficiency diseases, Peripheral neuropathy, business, Retinopathy

الوصف: Background HbA1c variability has been linked to retinopathy, renal disease and autonomic neuropathy in patients with type 1 diabetes mellitus (T1D) and type 2 diabetes mellitus (T2D). Although the same relationship has been demonstrated for diabetic peripheral neuropathy (DPN) in patients with T2D, data for T1D are still lacking. Methods Patients older than 17 years of age with ≥ 10 years of T1D duration and follow-up were included. All patients underwent nerve conduction studies and neurological examination. Laboratorial data was retrospectively extracted from chart review. Mean HbA1c (mHbA1c) over 10 years was calculated, as well as HbA1c variability estimated by standard deviation (HbA1c-SD) and coefficient of variation (HbA1c-CV). Results Fifty patients with T1D were included (30 females and 21 non-caucasians), with mean age and T1D duration of 25.6 ± 5.0 and 17.9 ± 6.1 years, respectively. The frequency of DPN was 24%. Higher mHbA1c (10.4 ± % vs 8.1 ± %; p Conclusions Not only long-term glycemic control, but also its variability is associated with DPN in patients with T1D. Larger studies are required to confirm this finding.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fd9ff8567addebc1251bbbe5795b1adTest
http://europepmc.org/articles/PMC7539505Test

المؤلفون: Melanie Rodacki, Marcus Miranda, João Batista Jornada Ben, Joana Rodrigues Dantas, Larissa Carolina Garcia Franco da Rosa, Lenita Zajdenverg, Leticia Maria Alcantara Margallo

المصدر: Diabetology & Metabolic Syndrome

مصطلحات موضوعية: medicine.medical_specialty, business.industry, Endocrinology, Diabetes and Metabolism, medicine.disease, Excretion, Endocrinology, Text mining, Diabetes mellitus, Internal medicine, Meeting Abstract, Internal Medicine, medicine, Euthyroid, business, Increased albumin, Retinopathy

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::939fb8a172b10d00708cd63e37c75048Test
http://europepmc.org/articles/PMC4653424Test

المؤلفون: Larissa Carolina Garcia Franco da Rosa, Leticia Maria Alcantara Margallo, Marcus V. Pinto, Melanie Rodacki, Debora Baptista Araújo, Lenita Zajdenverg, Joana Rodrigues Dantas, Marcus Miranda, João Batista Jornada Ben

المصدر: Diabetology & Metabolic Syndrome

مصطلحات موضوعية: medicine.medical_specialty, Type 1 diabetes, endocrine system diseases, business.industry, Endocrinology, Diabetes and Metabolism, nutritional and metabolic diseases, Disease, Bioinformatics, medicine.disease, Peripheral neuropathy, Internal medicine, Diabetes mellitus, Meeting Abstract, medicine, Internal Medicine, In patient, business, Glycated haemoglobin

الوصف: Objectives To assess if there is an association between the development of chronic complications (retinopathy-DR, nephropathy-DN, peripheral neuropathy– PN and cardiac autonomic neuropathy-CAN) in patients with T1D and 1) the mean glycated Haemoglobin during their followup since diabetes onset (mHbA1c); 2) the standard deviation (SD) of HbA1c over this period, 3) the HbA1c in the first 3 yrs. of disease (1st 3 yr.) and 4) the current HbA1c.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51eceb05c7cc7a19c5217499b675d1fdTest