المؤلفون: Arlotti M., Colombo M., Bonfanti A., Mandat T., Lanotte M. M., Pirola E., Borellini L., Rampini P., Eleopra R., Rinaldo S., Romito L., Janssen M. L. F., Priori A., Marceglia S.

المساهمون: Arlotti, M., Colombo, M., Bonfanti, A., Mandat, T., Lanotte, M. M., Pirola, E., Borellini, L., Rampini, P., Eleopra, R., Rinaldo, S., Romito, L., Janssen, M. L. F., Priori, A., Marceglia, S.

مصطلحات موضوعية: closed-loop, deep brain stimulation, implantable device, local field potential (LFP), neural interface, neuromodulation, Parkinson’s disease

الوصف: Deep brain stimulation (DBS) is used for the treatment of movement disorders, including Parkinson’s disease, dystonia, and essential tremor, and has shown clinical benefits in other brain disorders. A natural path for the improvement of this technique is to continuously observe the stimulation effects on patient symptoms and neurophysiological markers. This requires the evolution of conventional deep brain stimulators to bidirectional interfaces, able to record, process, store, and wirelessly communicate neural signals in a robust and reliable fashion. Here, we present the architecture, design, and first use of an implantable stimulation and sensing interface (AlphaDBSR System) characterized by artifact-free recording and distributed data management protocols. Its application in three patients with Parkinson’s disease (clinical trial n. NCT04681534) is shown as a proof of functioning of a clinically viable implanted brain-computer interface (BCI) for adaptive DBS. Reliable artifact free-recordings, and chronic long-term data and neural signal management are in place.

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/34949982; info:eu-repo/semantics/altIdentifier/wos/WOS:000743039600001; volume:15; firstpage:"-"; lastpage:"-"; numberofpages:12; journal:FRONTIERS IN NEUROSCIENCE; http://hdl.handle.net/11368/3015269Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85121628196; https://www.frontiersin.org/articles/10.3389/fnins.2021.763235/fullTest

الإتاحة: https://doi.org/10.3389/fnins.2021.763235Test
http://hdl.handle.net/11368/3015269Test

المؤلفون: Cofano F., Pesce A., Vercelli G., Mammi M., Massara A., Minardi M., Palmieri M., D'Andrea G., Fronda C., Lanotte M. M., Tartara F., Zenga F., Frati A., Garbossa D.

المساهمون: Cofano, F., Pesce, A., Vercelli, G., Mammi, M., Massara, A., Minardi, M., Palmieri, M., D'Andrea, G., Fronda, C., Lanotte, M. M., Tartara, F., Zenga, F., Frati, A., Garbossa, D.

مصطلحات موضوعية: chronic subdural hematoma, corticosteroid, craniostomy, drain, recurrence

الوصف: Background: Chronic Subdural Hematoma (CSDH) is a common condition in the elderly population. Recurrence rates after surgical evacuation range from 5 to 30%. Factors predicting recurrence remain debated and unclear. Objective: To identify factors associated with increased risk of recurrence. Methods: Cases of CSDHs that underwent surgical treatment between 2005 and 2018 in the Neurosurgery Units of two major Italian hospitals were reviewed. Data extracted from a prospectively maintained database included demographics, laterality, antithrombotic therapy, history of trauma, corticosteroid therapy, preoperative and postoperative symptoms, type of surgical intervention, use of surgical drain, and clinical outcomes. Results: A total of 1313 patients was analyzed. The overall recurrence rate was 10.1%. The risk of recurrence was not significantly different between patients with unilateral or bilateral CSDH (10.4 vs. 8.8%, p = 0.39). The risk of recurrence was higher in patients that underwent surgical procedure without postoperative drainage (16.1 vs. 5.4%, p < 0.01). No relationship was found between recurrence rates and therapy with antithrombotic drugs (p = 0.97). The risk of recurrence was increasingly higher considering craniostomy, craniectomy, and craniotomy (9.3, 11.3, and 18.9%, respectively, p = 0.013). Lower recurrence rates following Dexamethasone therapy were recorded (p = 0.013). Conclusion: No association was found between the risk of recurrence of CSDH after surgical evacuation and age, use of antithrombotic medication, or laterality. Burr-hole craniostomy was found to be associated with lower recurrence rates, when compared to other surgical procedures. Placement of surgical drain and Dexamethasone therapy were significantly associated with reduced risk of recurrence of CSDHs.

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/33329304; info:eu-repo/semantics/altIdentifier/wos/WOS:000596261600001; volume:11; firstpage:560269; journal:FRONTIERS IN NEUROLOGY; http://hdl.handle.net/11573/1469998Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85097413254

الإتاحة: https://doi.org/10.3389/fneur.2020.560269Test
http://hdl.handle.net/11573/1469998Test

المؤلفون: Specchia F. M. C., Monticelli M., Zeppa P., Bianconi A., Zenga F., Altieri R., Pugliese B., Di Perna G., Cofano F., Tartara F., Bertero L., Cassoni P., Melcarne A., Lanotte M. M., Garbossa D.

المساهمون: Specchia F.M.C., Monticelli M., Zeppa P., Bianconi A., Zenga F., Altieri R., Pugliese B., Di Perna G., Cofano F., Tartara F., Bertero L., Cassoni P., Melcarne A., Lanotte M.M., Garbossa D.

مصطلحات موضوعية: 5-ALA, Extent of resection, Fluorescence, Glioblastoma, IDH1, MGMT, Molecular pathways

الوصف: Background: Despite the aggressiveness of multimodal treatment, glioblastoma (GBM) is still a challenge for neurosurgeons, neurooncologists, and radiotherapists. A surgical approach is still a cornerstone in GBM therapeutic management, as the extent of resection is strongly related both to overall survival and progression-free survival. From this perspective, the use of photodynamic molecules could represent an interesting tool to achieve maximal and safe resection. Being able to trace the lesion’s edges, indeed, could allow to improve the extent of resection and to minimize resid-ual tumor while sparing normal tissue. The use of 5-aminolevulinic acid (5-ALA) as a photodynamic tracer is well established due to its strict correlation both with cellularity and metabolic activity of the GBM cell clones. Objective: Our study aims to define whether a different molecular asset of GBM (especially investigating IDH 1/2 mutation, proliferation index, and MGMT promoter methylation) results in different fluorescence expression, possibly because of differences in metabolic pathways due to different genotypes. Methods: Patients undergoing surgery for GBM removal at our Institute (Dep. Of Neurosurgery, Ospedale Città della Salute e della Scienza, University of Turin, Italy) were retrospectively reviewed. Patients with histological diagnosis confirmation and to whom 5-ALA was given before surgery were included. The whole surgical procedure was recorded and then analyzed by three different people (a medical student, a resident, and a senior surgeon with an interest in neurooncology and experience in using 5-ALA) and a score was assigned to the different degrees of intraoperative fluorescence. The degree of fluorescence was then matched with the genotype. Results: A trend of grade 2 fluorescence (i.e., ”strong”) was observed in the IDH 1/2 wild-type (WT) genotype, suggesting a more intense metabolic activity in this particular subgroup, while, no or weak fluorescence was observed more often in the IDH 1/2 mutated tumors, ...

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/34208653; info:eu-repo/semantics/altIdentifier/wos/WOS:000665501700001; volume:11; issue:6; firstpage:1; lastpage:9; numberofpages:9; journal:BRAIN SCIENCES; http://hdl.handle.net/2318/1793889Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85108875167

الإتاحة: https://doi.org/10.3390/brainsci11060795Test
http://hdl.handle.net/2318/1793889Test

المؤلفون: Penner, F., Grottoli, S., Lanotte, M. M. R., Garbossa, D., Zenga, F.

المصدر: Journal of Endocrinological Investigation ; volume 44, issue 3, page 635-636 ; ISSN 1720-8386

مصطلحات موضوعية: Endocrinology, Endocrinology, Diabetes and Metabolism

الإتاحة: https://doi.org/10.1007/s40618-020-01354-xTest

المؤلفون: Zeppa P., De Marco R., Monticelli M., Massara A., Bianconi A., Di Perna G., Crasto S. G., Cofano F., Melcarne A., Lanotte M. M., Garbossa D.

المساهمون: Zeppa, P., De Marco, R., Monticelli, M., Massara, A., Bianconi, A., Di Perna, G., Crasto, S. G., Cofano, F., Melcarne, A., Lanotte, M. M., Garbossa, D.

مصطلحات موضوعية: 5-ALA, fluorescence-guided surgery, glioblastoma, high-grade glioma, sodium fluorescein

الوصف: Background: Glioblastoma (GBM) is the most common primary brain tumor. The extent of resection (EOR) has been claimed as one of the most important prognostic factors. Fluorescent dyes aid surgeons in detecting a tumor’s borders. 5-aminolevulinic acid (5-ALA) and sodium fluorescein (SF) are the most used. Only a few studies have directly compared these two fluorophores. Methods: A single center retrospective analysis of patients treated for GBM in the period between January 2018 and January 2021 was built to find any differences in terms of EOR, Karnofsky Performance Status (KPS), and overall survival (OS) on the use of 5-ALA, SF, or both. Results: Overall, 99 patients affected by isocitrate dehydrogenase (IDH) wild-type Glioblastoma were included. 5-ALA was administered to 40 patients, SF to 44, and both to 15. No statistically significant associations were identified between the fluorophore and EOR (p = 0.783) or postoperative KPS (p = 0.270). Survival analyses did not show a selective advantage for the use of a given fluorophore (p = 0.184), although there appears to be an advantageous trend associated with the concomitant use of both dyes, particularly after stratification by MGMT (p = 0.071). Conclusions: 5-Ala and SF are equally useful in achieving gross total resection of the enhancing tumor volume. The combination of both fluorophores could lead to an OS advantage.

وصف الملف: STAMPA

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/35624942; info:eu-repo/semantics/altIdentifier/wos/WOS:000804311700001; volume:12; issue:5; firstpage:.; lastpage:.; journal:BRAIN SCIENCES; https://hdl.handle.net/11392/2530891Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85129868444

الإتاحة: https://doi.org/10.3390/brainsci12050555Test
https://hdl.handle.net/11392/2530891Test

المؤلفون: de Cuba C. M. K. E., Albanese A., Antonini A., Cossu G., Deuschl G., Eleopra R., Galati A., Hoffmann C. F. E., Knudsen K., Landi A., Lanotte M. M. R., Marcante A., Mosch A., Pilleri M., Reich M. M., Ricchi V., Rinaldo S., Romito L. M., Saba F. S., Sacristan H. E., Schuurman P. R., Trezza A., van den Munckhof P., Volkmann J., Zibetti M., Contarino M. F.

المساهمون: de Cuba, C. M. K. E., Albanese, A., Antonini, A., Cossu, G., Deuschl, G., Eleopra, R., Galati, A., Hoffmann, C. F. E., Knudsen, K., Landi, A., Lanotte, M. M. R., Marcante, A., Mosch, A., Pilleri, M., Reich, M. M., Ricchi, V., Rinaldo, S., Romito, L. M., Saba, F. S., Sacristan, H. E., Schuurman, P. R., Trezza, A., van den Munckhof, P., Volkmann, J., Zibetti, M., Contarino, M. F.

مصطلحات موضوعية: Complication, Deep brain stimulation, Delayed onset, Edema

العلاقة: info:eu-repo/semantics/altIdentifier/wos/WOS:000388777000017; volume:32; firstpage:108; lastpage:115; numberofpages:8; journal:PARKINSONISM & RELATED DISORDERS; http://hdl.handle.net/11577/3313586Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-84992723817; www.elsevier.com/locate/parkreldis

الإتاحة: https://doi.org/10.1016/j.parkreldis.2016.09.007Test
http://hdl.handle.net/11577/3313586Test

المؤلفون: Altieri R., Melcarne A., Soffietti R., Ruda R., Franchino F., Pellerino A., La Rocca G., Sabatino G., Olivi A., Ducati A., Zeppa P., Tardivo V., Mantovani C., Chiovatero I., Martini S., Dolce P., Savastano R., Lanotte M. M., Zenga F., Garbossa D.

المساهمون: Altieri, R., Melcarne, A., Soffietti, R., Ruda, R., Franchino, F., Pellerino, A., La Rocca, G., Sabatino, G., Olivi, A., Ducati, A., Zeppa, P., Tardivo, V., Mantovani, C., Chiovatero, I., Martini, S., Dolce, P., Savastano, R., Lanotte, M. M., Zenga, F., Garbossa, D.

الوصف: BACKGROUND: A relationship between the extent of resection (EOR) and survival has been demonstrated in patients with glioblastomas (GBMs). However, despite gross total resection (GTR) of the enhancing nodule (EN), GBMs usually relapse, generally near the surgical cavity. OBJECTIVE: The aim of this study was to determine the prognostic role of FLAIR resection of GBMs by analyzing pre- and post-operative MRIs to estimate the EOR of EN, FLAIR-hyperintense regions and total tumor volume (TTV). METHODS: Radiologic and clinical outcomes were analyzed retrospectively. Pre- and post-operative EN volume, pre- and postoperative FLAIR volume (POFV), and pre- and postoperative TTV were analyzed. EOR was then calculated for each component. Time-dependent ROC curves and cut-off values for pre- and post-operative volumes and EOR were calculated. A Kaplan-Meier analysis with the log-rank test and Cox regression analysis were then used to analyze progression-free survival (PFS) and overall survival (OS). RESULTS: We did not find any correlation between EOR of FLAIR-altered regions and patient survival. On the other hand, there were statistically significant relationships between the prognosis and both a preoperative EN volume less than 31.35 cm3 (p=0.032) and a postoperative EN volume less than 0.57 cm3 (p=0.015). Moreover, an EOR of EN greater than 96% was significantly associated with the prognosis (p=0.0051 for OS and p=0.022 for PFS). CONCLUSION: Our retrospective, multi-center study suggests that survival in patients with GBM is not affected by the extent of resection of FLAIR-hyperintense areas.

العلاقة: info:eu-repo/semantics/altIdentifier/wos/WOS:000567363300022; volume:35; firstpage:432; lastpage:440; numberofpages:9; journal:SURGICAL TECHNOLOGY INTERNATIONAL; http://hdl.handle.net/11588/788957Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85087876884

الإتاحة: http://hdl.handle.net/11588/788957Test

المؤلفون: Lanotte, M M, Rizzone, M, Bergamasco, B, Faccani, G, Melcarne, A, Lopiano, L

مصطلحات موضوعية: Papers

الوصف: Objectives: Bilateral chronic high frequency stimulation of the subthalamic nucleus (STN), through the stereotactical placement of stimulating electrodes, effectively improves the motor symptoms of severe Parkinson's disease. Intraoperative neurophysiological and clinical monitoring techniques (neuronal electrical activity recording and intraoperative stimulation) may improve and refine the localisation of the nucleus. The objective of this work was to compare the preoperative CT and MRI localisation with the intraoperative neurophysiological identification of STN. The relation between the localisation of the STN and the position of the most effective contact of the permanent quadripolar electrode at a 3 month and 1 year follow up was also studied. Methods: Fourteen consecutive parkinsonian patients were submitted to bilateral implant for STN stimulation. All the patients underwent a standard MRI and stereotactic CT to obtain, by image fusion and localisation software, the stereotactical coordinates of STN. The STN extension and boundaries were identified by a semimicrorecording of the neuronal electrical activity. The definitive quadripolar electrode was positioned to locate at least two contacts within the STN recording area. Intraoperative macrostimulation was performed to confirm the correct position of the electrode. Postoperative clinical evaluation of the effects of stimulation was checked for each contact of the quadripolar electrode testing the improvement on contralateral rigidity to select the best contact. This evaluation was repeated at 3 months and 1 year after surgery. Results: In 35.7% of the procedures it was necessary to perform more than one track to get a recording of neuronal activity consistent with STN. The mean position of the central point of all the 28 STN recording areas in respect of the AC-PC line midpoint was 2.7 mm posterior (SD 0.7), 3.8 mm inferior (SD 1.1), and 11.6 mm lateral (SD 0.9), and the mean distance between the anatomical target and the central point of the STN as ...

وصف الملف: text/html

العلاقة: http://jnnp.bmj.com/cgi/content/short/72/1/53Test; http://dx.doi.org/10.1136/jnnp.72.1.53Test

الإتاحة: https://doi.org/10.1136/jnnp.72.1.53Test
http://jnnp.bmj.com/cgi/content/short/72/1/53Test

المؤلفون: Penner, F., Grottoli, S., Lanotte, M. M. R., Garbossa, D., Zenga, F.

المصدر: Journal of Endocrinological Investigation; Mar2021, Vol. 44 Issue 3, p635-636, 2p

المؤلفون: Lanotte, M. M., Rizzone, M., Bergamasco, B., Faccani, G., Melcarne, A., Lopiano, L.

المصدر: Journal of Neurology, Neurosurgery & Psychiatry; Jan2002, p53-58, 6p, 3 Charts, 1 Graph