المؤلفون: Harvey, Nick, Ward, K A, Agnusdei, D, Binkley, N, Biver, E, Campusano, C, Cavalier, Etienne, Clark, P, Diaz-Curiel, M, Fuleihan, G E-H, Khashayar, P, Lane, N E, Messina, O D, Mithal, A, Rizzoli, René, Sempos, C, Dawson-Hughes, B

المصدر: Osteoporosis International (2024-06-05)

مصطلحات موضوعية: Cholecalciferol, Deficiency, Ergocalciferol, Population, Supplementation, Vitamin D, Human health sciences, Endocrinology, metabolism & nutrition, Sciences de la santé humaine, Endocrinologie, métabolisme & nutrition

الوصف: Vitamin D is important for musculoskeletal health. Concentrations of 25-hydroxyvitamin D, the most commonly measured metabolite, vary markedly around the world and are influenced by many factors including sun exposure, skin pigmentation, covering, season and supplement use. Whilst overt vitamin D deficiency with biochemical consequences presents an increased risk of severe sequelae such as rickets, osteomalacia or cardiomyopathy and usually warrants prompt replacement treatment, the role of vitamin D supplementation in the population presents a different set of considerations. Here the issue is to keep, on average, the population at a level whereby the risk of adverse health outcomes in the population is minimised. This position paper, which complements recently published work from the European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases, addresses key considerations regarding vitamin D assessment and intervention from the population perspective. This position paper, on behalf of the International Osteoporosis Foundation Vitamin D Working Group, summarises the burden and possible amelioration of vitamin D deficiency in global populations. It addresses key issues including screening, supplementation and food fortification.

العلاقة: https://link.springer.com/content/pdf/10.1007/s00198-024-07127-z.pdfTest; urn:issn:0937-941X; urn:issn:1433-2965

الوصول الحر: https://orbi.uliege.be/handle/2268/319515Test

المؤلفون: Van Dyke, T. E., Hatch, N. E., Joshipura, K., Lane, N. E., Murshed, M., Nociti, F., Olsen, B., Somerman, M. J.

المصدر: Frontiers in Dental Medicine ; volume 4 ; ISSN 2673-4915

مصطلحات موضوعية: Geriatrics and Gerontology

الإتاحة: https://doi.org/10.3389/fdmed.2023.1244033Test

المؤلفون: Westbury, L. D., Beaudart, C., Bruyere, O., Cauley, J. A., Cawthon, P., Cruz-Jentoft, A. J., Curtis, E. M., Ensrud, K., Fielding, R. A., Johansson, Helena, 1981, Kanis, J. A., Karlsson, M. K., Lane, N. E., Lengele, L., Lorentzon, M., McCloskey, E., Mellström, Dan, 1945, Newman, A. B., Ohlsson, Claes, 1965, Orwoll, E., Reginster, J. Y., Ribom, E., Rosengren, B. E., Schousboe, J. T., Shiroma, E. J., Harvey, N. C., Dennison, E. M., Cooper, C., Int Musculoskeletal Ageing, Network

المصدر: Journal of Cachexia Sarcopenia and Muscle. 14(1):565-575

مصطلحات موضوعية: Public Health, Global Health, Social Medicine and Epidemiology, Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi, Epidemiology, Sarcopenia, Ageing, Mortality, Prevalence, quality-of-life, gait speed, older, epidemiology, determinants, performance, fractures, mros, Geriatrics & Gerontology, General & Internal Medicine

الوصف: BackgroundThe 2019 European Working Group on Sarcopenia in Older People (EWGSOP2) and the Sarcopenia Definitions and Outcomes Consortium (SDOC) have recently proposed sarcopenia definitions. However, comparisons of the performance of these approaches in terms of thresholds employed, concordance in individuals and prediction of important health-related outcomes such as death are limited. We addressed this in a large multinational assembly of cohort studies that included information on lean mass, muscle strength, physical performance and health outcomes. MethodsWhite men from the Health Aging and Body Composition (Health ABC) Study, Osteoporotic Fractures in Men (MrOS) Study cohorts (Sweden, USA), the Hertfordshire Cohort Study (HCS) and the Sarcopenia and Physical impairment with advancing Age (SarcoPhAge) Study were analysed. Appendicular lean mass (ALM) was ascertained using DXA; muscle strength by grip dynamometry; and usual gait speed over courses of 2.4-6 m. Deaths were recorded and verified. Definitions of sarcopenia were as follows: EWGSOP2 (grip strength <27 kg and ALM index <7.0 kg/m(2)), SDOC (grip strength <35.5 kg and gait speed <0.8 m/s) and Modified SDOC (grip strength <35.5 kg and gait speed <1.0 m/s). Cohen's kappa statistic was used to assess agreement between original definitions (EWGSOP2 and SDOC). Presence versus absence of sarcopenia according to each definition in relation to mortality risk was examined using Cox regression with adjustment for age and weight; estimates were combined across cohorts using random-effects meta-analysis. ResultsMean (SD) age of participants (n = 9170) was 74.3 (4.9) years; 5929 participants died during a mean (SD) follow-up of 12.1 (5.5) years. The proportion with sarcopenia according to each definition was EWGSOP2 (1.1%), SDOC (1.7%) and Modified SDOC (5.3%). Agreement was weak between EWGSOP2 and SDOC (kappa = 0.17). Pooled hazard ratios (95% CI) for mortality for presence versus absence of each definition were EWGSOP2 [1.76 (1.42, 2.18), I-2: 0.0%]; SDOC [2.75 (2.28, 3.31), I-2: 0.0%]; and Modified SDOC [1.93 (1.54, 2.41), I-2: 58.3%]. ConclusionsThere was low prevalence and poor agreement among recent sarcopenia definitions in community-dwelling cohorts of older white men. All indices of sarcopenia were associated with mortality. The strong relationship between sarcopenia and mortality, regardless of the definition, illustrates that identification of appropriate management and lifecourse intervention strategies for this condition is of paramount importance.

الوصول الحر: https://gup.ub.gu.se/publication/324441Test

المؤلفون: Harvey, N. C., Ward, K. A., Agnusdei, D., Binkley, N., Biver, E., Campusano, C., Cavalier, E., Clark, P., Diaz-Curiel, M., Fuleihan, G. E. H., Khashayar, Patricia, Lane, N. E., Messina, O. D., Mithal, A., Rizzoli, R., Sempos, C., Dawson-Hughes, B.

المصدر: OSTEOPOROSIS INTERNATIONAL ; ISSN: 0937-941X ; ISSN: 1433-2965

مصطلحات موضوعية: Cholecalciferol, Deficiency, Ergocalciferol, Population, Supplementation, Vitamin D, D FOOD FORTIFICATION, 25-HYDROXYVITAMIN D, D SUPPLEMENTATION, D DEFICIENCY, CALCIUM SUPPLEMENTATION, COST-EFFECTIVENESS, HIP FRACTURE, PREVENTION, ADULTS, WOMEN

الوصف: Vitamin D is important for musculoskeletal health. Concentrations of 25-hydroxyvitamin D, the most commonly measured metabolite, vary markedly around the world and are influenced by many factors including sun exposure, skin pigmentation, covering, season and supplement use. Whilst overt vitamin D deficiency with biochemical consequences presents an increased risk of severe sequelae such as rickets, osteomalacia or cardiomyopathy and usually warrants prompt replacement treatment, the role of vitamin D supplementation in the population presents a different set of considerations. Here the issue is to keep, on average, the population at a level whereby the risk of adverse health outcomes in the population is minimised. This position paper, which complements recently published work from the European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases, addresses key considerations regarding vitamin D assessment and intervention from the population perspective. This position paper, on behalf of the International Osteoporosis Foundation Vitamin D Working Group, summarises the burden and possible amelioration of vitamin D deficiency in global populations. It addresses key issues including screening, supplementation and food fortification.

وصف الملف: application/pdf

العلاقة: https://biblio.ugent.be/publication/01J0KNKTNTQ6Q83DTM1KF0WD6STest; http://hdl.handle.net/1854/LU-01J0KNKTNTQ6Q83DTM1KF0WD6STest; http://doi.org/10.1007/s00198-024-07127-zTest; https://biblio.ugent.be/publication/01J0KNKTNTQ6Q83DTM1KF0WD6S/file/01J0KNN9HC6Q7NHJMY0TXA3Y5FTest

الإتاحة: https://doi.org/10.1007/s00198-024-07127-zTest
https://biblio.ugent.be/publication/01J0KNKTNTQ6Q83DTM1KF0WD6STest
http://hdl.handle.net/1854/LU-01J0KNKTNTQ6Q83DTM1KF0WD6STest
https://biblio.ugent.be/publication/01J0KNKTNTQ6Q83DTM1KF0WD6S/file/01J0KNN9HC6Q7NHJMY0TXA3Y5FTest

المؤلفون: Pinto, D., Alshahrani, M., Chapurlat, R., Chevalley, T., Dennison, E., Camargos, B. M., Papaioannou, A., Silverman, S., Kaux, Jean-François, Lane, N. E., Morales Torres, J., Paccou, J., Rizzoli, R., Bruyère, Olivier

المصدر: Osteoporosis International, 33 (3), 527-540 (2022-03)

مصطلحات موضوعية: Education, Fracture, Exercise, Rehabilitation, Nutrition, Osteoporosis, Human health sciences, Orthopedics, rehabilitation & sports medicine, Sciences de la santé humaine, Orthopédie, rééducation & médecine sportive

الوصف: PURPOSE: To conduct a review of the current state of the evidence for rehabilitation strategies post-fragility fracture. METHODS: Narrative review conducted by the Rehabilitation Working Group of the International Osteoporosis Foundation Committee of Scientific Advisors characterizing the range of rehabilitation modalities instrumental for the management of fragility fractures. RESULTS: Multi-modal exercise post-fragility fracture to the spine and hip is strongly recommended to reduce pain, improve physical function, and improve quality of life. Outpatient physiotherapy post-hip fracture has a stronger evidence base than outpatient physiotherapy post-vertebral fracture. Appropriate nutritional care after fragility fracture provides a large range of improvement in morbidity and mortality. Education increases understanding of osteoporosis which in turn increases utilization of other rehabilitation services. Education may improve other health outcomes such as pain and increase a patient's ability for self-advocacy. CONCLUSION: Rehabilitation interventions are inter-reliant, and research investigating the interaction of exercise, nutrition, and other multi-modal therapies may increase the relevance of rehabilitation research to clinical care.

العلاقة: urn:issn:0937-941X; urn:issn:1433-2965

الوصول الحر: https://orbi.uliege.be/handle/2268/267427Test

المؤلفون: Pinto, D., Alshahrani, M., Chapurlat, R., Chevalley, Thierry, Dennison, E., Camargos, B. M., Papaioannou, A., Silverman, S., Kaux, J.-F., Lane, N. E., Morales Torres, J., Paccou, J., Rizzoli, René, Bruyere, O., Rehabilitation Working Group of IOF Committee of Scientific Advisors

المصدر: ISSN: 0937-941X ; Osteoporosis international, vol. 33, no. 3 (2022) p. 527-540.

مصطلحات موضوعية: info:eu-repo/classification/ddc/616, Education, Exercise, Fracture, Nutrition, Osteoporosis, Rehabilitation

الوصف: Purpose: To conduct a review of the current state of the evidence for rehabilitation strategies post-fragility fracture. Methods: Narrative review conducted by the Rehabilitation Working Group of the International Osteoporosis Foundation Committee of Scientific Advisors characterizing the range of rehabilitation modalities instrumental for the management of fragility fractures. Results: Multi-modal exercise post-fragility fracture to the spine and hip is strongly recommended to reduce pain, improve physical function, and improve quality of life. Outpatient physiotherapy post-hip fracture has a stronger evidence base than outpatient physiotherapy post-vertebral fracture. Appropriate nutritional care after fragility fracture provides a large range of improvement in morbidity and mortality. Education increases understanding of osteoporosis which in turn increases utilization of other rehabilitation services. Education may improve other health outcomes such as pain and increase a patient's ability for self-advocacy. Conclusion: Rehabilitation interventions are inter-reliant, and research investigating the interaction of exercise, nutrition, and other multi-modal therapies may increase the relevance of rehabilitation research to clinical care.

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/35048200; https://archive-ouverte.unige.ch/unige:161397Test; unige:161397

الإتاحة: https://doi.org/10.1007/s00198-021-06240-7Test
https://archive-ouverte.unige.ch/unige:161397Test

المؤلفون: van Buuren, M. M.A., Arden, N. K., Bierma-Zeinstra, S. M.A., Bramer, W. M., Casartelli, N. C., Felson, D. T., Jones, G., Lane, N. E., Lindner, C., Maffiuletti, N. A., van Meurs, J. B.J., Nelson, A. E., Nevitt, M. C., Valenzuela, P. L., Verhaar, J. A.N., Weinans, H., Agricola, R.

المصدر: van Buuren , M M A , Arden , N K , Bierma-Zeinstra , S M A , Bramer , W M , Casartelli , N C , Felson , D T , Jones , G , Lane , N E , Lindner , C , Maffiuletti , N A , van Meurs , J B J , Nelson , A E , Nevitt , M C , Valenzuela , P L , Verhaar , J A N , Weinans , H & Agricola , R 2021 , ' Statistical shape modeling of the hip and the association with ....

الوصف: Objective: To summarize available evidence on the association between hip shape as quantified by statistical shape modeling (SSM) and the incidence or progression of hip osteoarthritis. Design: We conducted a systematic search of five electronic databases, based on a registered protocol (available: PROSPERO CRD42020145411). Articles presenting original data on the longitudinal relationship between radiographic hip shape (quantified by SSM) and hip OA were eligible. Quantitative meta-analysis was precluded because of the use of different SSM models across studies. We used the Newcastle–Ottawa Scale (NOS) for risk of bias assessment. Results: Nine studies (6,483 hips analyzed with SSM) were included in this review. The SSM models used to describe hip shape ranged from 16 points on the femoral head to 85 points on the proximal femur and hemipelvis. Multiple hip shape features and combinations thereof were associated with incident or progressive hip OA. Shape variants that seemed to be consistently associated with hip OA across studies were acetabular dysplasia, cam morphology, and deviations in acetabular version (either excessive anteversion or retroversion). Conclusions: Various radiographic, SSM-defined hip shape features are associated with hip OA. Some hip shape features only seem to increase the risk for hip OA when combined together. The heterogeneity of the used SSM models across studies precludes the estimation of pooled effect sizes. Further studies using the same SSM model and definition of hip OA are needed to allow for the comparison of outcomes across studies, and to validate the found associations.

وصف الملف: application/pdf

الإتاحة: https://doi.org/10.1016/j.joca.2020.12.003Test
https://pure.eur.nl/en/publications/f60bbea9-c99a-46a6-ac2d-7f33a5b25bfaTest
https://pure.eur.nl/ws/files/53153071/Statistical_shape_modeling_of_the_hip_and_the_association_with_hip_osteoarthritis_a_systematic_review.pdfTest
http://www.scopus.com/inward/record.url?scp=85099264385&partnerID=8YFLogxKTest

المؤلفون: Lane, N. E., Saag, K., O’Neill, T. J., Manion, M., Shah, R., Klause, U., Eastell, R.

المصدر: Osteoporosis International ; volume 32, issue 3, page 609-609 ; ISSN 0937-941X 1433-2965

مصطلحات موضوعية: Endocrinology, Diabetes and Metabolism

الإتاحة: https://doi.org/10.1007/s00198-021-05828-3Test

المؤلفون: Lane, N. E., Saag, K., O’Neill, T. J., Manion, M., Shah, R., Klause, U., Eastell, R.

المساهمون: Roche Diagnostics International Ltd and Roche Diagnostics Information Solutions

المصدر: Osteoporosis International ; volume 32, issue 5, page 831-840 ; ISSN 0937-941X 1433-2965

مصطلحات موضوعية: Endocrinology, Diabetes and Metabolism

الإتاحة: https://doi.org/10.1007/s00198-020-05734-0Test

المؤلفون: Kerkhof, H. J. M., Meulenbelt, I., Akune, T., Arden, N. K., Aromaa, A., Bierma-Zeinstra, S. M. A., Carr, A., Cooper, C., Dai, J., Doherty, M., Doherty, S. A., Felson, D., Gonzalez, A., Gordon, A., Harilainen, A., Hart, D. J., Hauksson, V. B., Heliovaara, M., Hofman, A., Ikegawa, S., Ingvarsson, T., Jiang, Q., Jonsson, H, Jonsdottir, I., Kawaguchi, H., Kloppenburg, M., Kujala, U. M., Lane, N. E., Leino-Arjas, P., Lohmander, Stefan, Luyten, F. P., Malizos, K. N., Nakajima, M., Nevitt, M. C., Pols, H. A. P., Rivadeneira, F., Shi, D., Slagboom, E., Spector, T. D., Stefansson, K., Sudo, A., Tamm, A., Tamm, A. E., Tsezou, A., Uchida, A., Uitterlinden, A. G., Wilkinson, J. M., Yoshimura, N., Valdes, A. M., van Meurs, J. B. J.

المصدر: Osteoarthritis and Cartilage EpiHealth: Epidemiology for Health. 19(3):254-264

مصطلحات موضوعية: Genetics, Osteoarthritis, Phenotype, Definition, TREATOA, Medicin och hälsovetenskap, Klinisk medicin, Reumatologi och inflammation, Medical and Health Sciences, Clinical Medicine, Rheumatology and Autoimmunity

الوصف: Objective: To address the need for standardization of osteoarthritis (OA) phenotypes by examining the effect of heterogeneity among symptomatic (SOA) and radiographic osteoarthritis (ROA) phenotypes. Methods: Descriptions of OA phenotypes of the 28 studies involved in the TREAT-OA consortium were collected. We investigated whether different OA definitions result in different association results by creating various hip OA definitions in one large population based cohort (the Rotterdam Study I (RSI)) and testing those for association with gender, age and body mass index using one-way ANOVA. For ROA, we standardized the hip-, knee- and hand ROA definitions and calculated prevalence's of ROA before and after standardization in nine cohort studies. This procedure could only be performed in cohort studies and standardization of SOA definitions was not feasible at this moment. Results: In this consortium, all studies with SOA phenotypes (knee, hip and hand) used a different definition and/or assessment of OA status. For knee-, hip- and hand ROA five, four and seven different definitions were used, respectively. Different hip ROA definitions do lead to different association results. For example, we showed in the RSI that hip OA defined as "at least definite joint space narrowing (JSN) and one definite osteophyte" was not associated with gender (P=0.22), but defined as "at least one definite osteophyte" was significantly associated with gender (P=3 x 10(-9)). Therefore, a standardization process was undertaken for ROA definitions. Before standardization a wide range of ROA prevalence's was observed in the nine cohorts studied. After standardization the range in prevalence of knee- and hip ROA was small. Conclusion: Phenotype definitions influence the prevalence of OA and association with clinical variables. ROA phenotypes within the TREAT-OA consortium were standardized to reduce heterogeneity and improve power in future genetics studies. (C) 2010 Osteoarthritis Research Society International. Published by Elsevier Ltd. All rights reserved.

وصف الملف: electronic

الوصول الحر: https://lup.lub.lu.se/record/1936099Test
https://portal.research.lu.se/files/1608973/2149997.pdfTest
http://dx.doi.org/10.1016/j.joca.2010.10.027Test