المؤلفون: de Cheveigne, A, Wong, DDE, Di Liberto, GM, Hjortkjaer, J, Slaney, M, Lalor, E

المصدر: Neuroimage , 172 pp. 206-216. (2018)

مصطلحات موضوعية: EEG, MEG, LFP, CCA, Canonical correlation, PCA, ICA, TRF, Reverse correlation, Speech, Modulation filter

الوصف: The relation between a stimulus and the evoked brain response can shed light on perceptual processes within the brain. Signals derived from this relation can also be harnessed to control external devices for Brain Computer Interface (BCI) applications. While the classic event-related potential (ERP) is appropriate for isolated stimuli, more sophisticated “decoding” strategies are needed to address continuous stimuli such as speech, music or environmental sounds. Here we describe an approach based on Canonical Correlation Analysis (CCA) that finds the optimal transform to apply to both the stimulus and the response to reveal correlations between the two. Compared to prior methods based on forward or backward models for stimulus-response mapping, CCA finds significantly higher correlation scores, thus providing increased sensitivity to relatively small effects, and supports classifier schemes that yield higher classification scores. CCA strips the brain response of variance unrelated to the stimulus, and the stimulus representation of variance that does not affect the response, and thus improves observations of the relation between stimulus and response.

وصف الملف: text

العلاقة: https://discovery.ucl.ac.uk/id/eprint/10067228/1/2018_Neuroimage_CCA.pdfTest; https://discovery.ucl.ac.uk/id/eprint/10067228Test/

الإتاحة: https://discovery.ucl.ac.uk/id/eprint/10067228/1/2018_Neuroimage_CCA.pdfTest
https://discovery.ucl.ac.uk/id/eprint/10067228Test/

المؤلفون: Cadilhac, DA, Kilkenny, MF, Andrew, NE, Ritchie, E, Hill, K, Lalor, E

الوصف: BACKGROUND: Establishing a stroke unit (SU) in every hospital may be infeasible because of limited resources. In Australia, it is recommended that hospitals that admit ≥100 strokes per year should have a SU. We aimed to describe differences in processes of care and outcomes among hospitals with and without SUs admitting at least 100 patients/year. METHODS: National stroke audit data of 40 consecutive patients per hospital admitted between 1/7/2010-31/12/2010 and organizational survey for annual admissions were used. Descriptive analyses and multilevel regression were used to compare patient outcomes. Sensitivity analysis including only hospitals meeting all of the Australian SU criteria (e.g., co-location of beds; inter-professional team; weekly meetings; regular training) was performed. RESULTS: Two thousand eight hundred ninety-eight patients from 72/108 eligible hospitals completing the audit (SU = 60; patients: 2,481 [mean age 76 years; 55% male] and non-SU patients: 417 [mean age 77; 53% male]). Hospitals with SUs had greater adherence to recommended care processes than non-SU hospitals. Patients treated in a SU hospital had fewer new strokes while in hospital (OR: 0.20; 95% CI 0.06, 0.61) and there was a borderline reduction in the odds of dying in hospital compared to patients in non-SU hospitals (OR 0.57 95%CI 0.33, 1.00). Among SU hospitals meeting all SU criteria (n = 59; 91%) the adjusted odds of having a poor outcome was further reduced compared with patients attending non-SU hospitals. CONCLUSION: Hospitals annually admitting ≥100 patients with acute stroke should be prioritized for establishment of a SU that meet all recommended criteria to ensure better outcomes.

العلاقة: pii: 10.1186/s12913-017-2150-2; Cadilhac, D. A., Kilkenny, M. F., Andrew, N. E., Ritchie, E., Hill, K. & Lalor, E. (2017). Hospitals admitting at least 100 patients with stroke a year should have a stroke unit: a case study from Australia. BMC HEALTH SERVICES RESEARCH, 17 (1), https://doi.org/10.1186/s12913-017-2150-2Test.; http://hdl.handle.net/11343/258349Test

الإتاحة: https://doi.org/10.1186/s12913-017-2150-2Test
http://hdl.handle.net/11343/258349Test

المؤلفون: Bernhardt, J, Lindley, RI, Lalor, E, Ellery, F, Chamberlain, J, Van Holsteyn, J, Collier, JM, Dewey, HM, Parsons, B, Moodie, M, Lennon, S, Donnan, GA, Thrift, AG, Churilov, L, Langhorne, P

الوصف: OBJECTIVE: To report the number of participants needed to recruit per baby born to trial staff during AVERT, a large international trial on acute stroke, and to describe trial management consequences. DESIGN: Retrospective observational analysis. SETTING: 56 acute stroke hospitals in eight countries. PARTICIPANTS: 1074 trial physiotherapists, nurses, and other clinicians. OUTCOME MEASURES: Number of babies born during trial recruitment per trial participant recruited. RESULTS: With 198 site recruitment years and 2104 patients recruited during AVERT, 120 babies were born to trial staff. Births led to an estimated 10% loss in time to achieve recruitment. Parental leave was linked to six trial site closures. The number of participants needed to recruit per baby born was 17.5 (95% confidence interval 14.7 to 21.0); additional trial costs associated with each birth were estimated at 5736 Australian dollars on average. CONCLUSION: The staff absences registered in AVERT owing to parental leave led to delayed trial recruitment and increased costs, and should be considered by trial investigators when planning research and estimating budgets. However, the celebration of new life became a highlight of the annual AVERT collaborators' meetings and helped maintain a cohesive collaborative group. TRIAL REGISTRATION: Australian New Zealand Clinical Trials Registry no 12606000185561. DISCLAIMER: Participation in a rehabilitation trial does not guarantee successful reproductive activity.

العلاقة: NHMRC/1041401; http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000366470100003&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=d4d813f4571fa7d6246bdc0dfeca3a1cTest; ARTN h6432; Bernhardt, J., Lindley, R. I., Lalor, E., Ellery, F., Chamberlain, J., Van Holsteyn, J., Collier, J. M., Dewey, H. M., Parsons, B., Moodie, M., Lennon, S., Donnan, G. A., Thrift, A. G., Churilov, L. & Langhorne, P. (2015). CHRISTMAS 2015: PROFESSIONAL CONSIDERATIONS AVERT(2) (a very early rehabilitation trial, a very effective reproductive trigger): retrospective observational analysis of the number of babies born to trial staff. BMJ-BRITISH MEDICAL JOURNAL, 351, https://doi.org/10.1136/bmj.h6432Test.; http://hdl.handle.net/11343/58799Test

الإتاحة: https://doi.org/10.1136/bmj.h6432Test
http://hdl.handle.net/11343/58799Test
http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000366470100003&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=d4d813f4571fa7d6246bdc0dfeca3a1cTest

المؤلفون: Paul, CL, Levi, CR, D'Este, CA, Parsons, MW, Bladin, CF, Lindley, RI, Attia, JR, Henskens, F, Lalor, E, Longworth, M, Middleton, S, Ryan, A, Kerr, E, Sanson-Fisher, RW, Anderson, C, Bruce, I, Buchan, H, Burdusel, C, Butler, E, Cadigan, G, Campbell, Z, Coles, T, Corbett, A, Day, S, Denisenko, S, Dennett, J, Dewey, H, Donnan, G, Doughty, M, Evans, M, Gearon, F, Geraghty, R, Gerraty, R, Gounden, S, Grady, A, Grimley, R, Grimshaw, J, Hankey, GJ, Hill, K, Hoffman, K, Huckson, S, Hughes, J, Jayakody, A, Jenkins, B, Jude, M, Kanard, M, Kinchington, M, Krause, M, Kuhle, S, Laird, P, Lee, A, Levy, S, Longworth, K, Macdonald, B, Mackey, E, Mandaleson, K, Mohr, K, Moore, S, Morris, K, O'Brien, E, Paddock, B, Parrey, K, Peake, R, Pollack, M, Price, C, Rose, S, Rupasinghe, J, Ryan, F, Searles, A, Smits, R, Stevenson, M, Taneja, S, Terpening, Z, Teasdale, N, Watson, J, Wilson, A, Weiner, Y, Wijeratne, T, Wolfe, N

المصدر: urn:ISSN:1748-5908 ; Implementation Science, 9, 1, 38

مصطلحات موضوعية: Hematology, Brain Disorders, Stroke, Clinical Research, Clinical Trials and Supportive Activities, Comparative Effectiveness Research, Aspirin, Australia, Cooperative Behavior, Diffusion of Innovation, Emergency Medical Services, Evidence-Based Medicine, Fibrinolytic Agents, Guideline Adherence, Humans, Patient Care Team, Practice Guidelines as Topic, Quality of Health Care, Research Design, Thrombolytic Therapy, Tissue Plasminogen Activator, Triage, Thrombolysis ImPlementation in Stroke (TIPS) Study Group, anzsrc-for: 08 Information and Computing Sciences, anzsrc-for: 11 Medical and Health Sciences

الوصف: Background: Stroke is a leading cause of death and disability internationally. One of the three effective interventions in the acute phase of stroke care is thrombolytic therapy with tissue plasminogen activator (tPA), if given within 4.5 hours of onset to appropriate cases of ischaemic stroke.Objectives: To test the effectiveness of a multi-component multidisciplinary collaborative approach compared to usual care as a strategy for increasing thrombolysis rates for all stroke patients at intervention hospitals, while maintaining accepted benchmarks for low rates of intracranial haemorrhage and high rates of functional outcomes for both groups at three months.Methods and design: A cluster randomised controlled trial of 20 hospitals across 3 Australian states with 2 groups: multi- component multidisciplinary collaborative intervention as the experimental group and usual care as the control group. The intervention is based on behavioural theory and analysis of the steps, roles and barriers relating to rapid assessment for thrombolysis eligibility; it involves a comprehensive range of strategies addressing individual-level and system-level change at each site. The primary outcome is the difference in tPA rates between the two groups post-intervention. The secondary outcome is the proportion of tPA treated patients in both groups with good functional outcomes (modified Rankin Score (mRS <2) and the proportion with intracranial haemorrhage (mRS ≥2), compared to international benchmarks.Discussion: TIPS will trial a comprehensive, multi-component and multidisciplinary collaborative approach to improving thrombolysis rates at multiple sites. The trial has the potential to identify methods for optimal care which can be implemented for stroke patients during the acute phase. Study findings will include barriers and solutions to effective thrombolysis implementation and trial outcomes will be published whether significant or not.Trial registration: Australian New Zealand Clinical Trials Registry: ACTRN12613000939796. © ...

وصف الملف: application/pdf

العلاقة: http://hdl.handle.net/1959.4/unsworks_77700Test; https://unsworks.unsw.edu.au/bitstreams/1cd92253-bcf7-4a94-a1f1-dddd17791301/downloadTest; https://doi.org/10.1186/1748-5908-9-38Test

الإتاحة: https://doi.org/10.1186/1748-5908-9-38Test
http://hdl.handle.net/1959.4/unsworks_77700Test
https://unsworks.unsw.edu.au/bitstreams/1cd92253-bcf7-4a94-a1f1-dddd17791301/downloadTest

المؤلفون: Power, A. J., Lalor, E. C., Reilly, R. B.

المصدر: Cerebral Cortex ; volume 21, issue 6, page 1223-1230 ; ISSN 1047-3211 1460-2199

مصطلحات موضوعية: Cellular and Molecular Neuroscience, Cognitive Neuroscience

الإتاحة: https://doi.org/10.1093/cercor/bhq233Test
http://academic.oup.com/cercor/article-pdf/21/6/1223/1000212/bhq233.pdfTest

المؤلفون: Hill, K M, Lalor, E E

مصطلحات موضوعية: Original research

الوصف: Background: The success of guidelines is determined by their use in the real world. The GuideLine Implementability Appraisal (GLIA) tool was developed as a quality-improvement tool to assist guideline developers and guideline users identify potential problems in implementing recommendations. The objective of this study was to assess the feasibility of using the electronic version of GLIA (eGLIA) by implementers of a clinical guideline for acute stroke management in Australia. Methods: Health professionals who had no previous experience with the eGLIA tool but who are involved in implementing guidelines volunteered for the study. These health professionals were provided background information about the tool and were provided a short training session (<30 min). The participants were asked to consider at least two recommendations from the guideline document. Time spent, numbers of recommendations reviewed and subjective feedback of the process were used for evaluation. Results: 40 participants completed the study, representing nursing and allied health professions from different geographical regions of Australia. The median number of recommendations per participant completed was 2 (range 2–10), taking an average of 47 min (range 15–120 min) to complete or about 22 min per recommendation. Ninety-four per cent of participants agreed or strongly agreed that eGLIA was useful, while 77% indicated they would use the tool again. eGLIA helped participants think systematically about implementation, although only 72% agreed that the tool allowed them to clearly identify potential barriers to implementation. Conclusion: This study suggests that eGLIA may be a useful tool which is relatively easy to use for implementers of guidelines. eGLIA enables a detailed, systematic evaluation of guidelines. Further refinement of the tool is recommended to better assist implementers to clearly identify barriers to implementation and therefore facilitate greater implementation. Further work is also warranted to determine the effect of ...

وصف الملف: text/html

العلاقة: http://qualitysafety.bmj.com/cgi/content/short/18/2/157Test; http://dx.doi.org/10.1136/qshc.2007.025635Test

الإتاحة: https://doi.org/10.1136/qshc.2007.025635Test
http://qualitysafety.bmj.com/cgi/content/short/18/2/157Test

المؤلفون: Burke R, Finucane C, Lalor E, Kelly SP, Smith R, Reilly RB, McDarby G

المصدر: EURASIP Journal on Advances in Signal Processing, Vol 2005, Iss 19, p 706906 (2005)

مصطلحات موضوعية: EEG, BCI, SSVEP, online classification, overt attention, Telecommunication, TK5101-6720, Electronics, TK7800-8360

الوصف: This paper presents the application of an effective EEG-based brain-computer interface design for binary control in a visually elaborate immersive 3D game. The BCI uses the steady-state visual evoked potential (SSVEP) generated in response to phase-reversing checkerboard patterns. Two power-spectrum estimation methods were employed for feature extraction in a series of offline classification tests. Both methods were also implemented during real-time game play. The performance of the BCI was found to be robust to distracting visual stimulation in the game and relatively consistent across six subjects, with 41 of 48 games successfully completed. For the best performing feature extraction method, the average real-time control accuracy across subjects was 89%. The feasibility of obtaining reliable control in such a visually rich environment using SSVEPs is thus demonstrated and the impact of this result is discussed.

العلاقة: http://dx.doi.org/10.1155/ASP.2005.3156Test; https://doaj.org/toc/1687-6172Test; https://doaj.org/toc/1687-6180Test; https://doaj.org/article/0c0d4fff499141d7983714717351d448Test

الإتاحة: https://doi.org/10.1155/ASP.2005.3156Test
https://doaj.org/article/0c0d4fff499141d7983714717351d448Test

المؤلفون: Lalor, E, Kelly, SP, Finucane, C, Burke, R, Smith, R, Reilly, RB, McDarby, G

مصطلحات موضوعية: EEG, BCI, SSVEP, online classification, overt attention

الوصف: This paper presents the application of an effective EEG-based brain-computer interface design for binary control in a visually elaborate immersive 3D game. The BCI uses the steady-state visual evoked potential (SSVEP) generated in response to phase-reversing checkerboard patterns. Two power-spectrum estimation methods were employed for feature extraction in a series of offline classification tests. Both methods were also implemented during real-time game play. The performance of the BCI was found to be robust to distracting visual stimulation in the game and relatively consistent across six subjects, with 41 of 48 games successfully completed. For the best performing feature extraction method, the average real-time control accuracy across subjects was 89%. The feasibility of obtaining reliable control in such a visually rich environment using SSVEPs is thus demonstrated and the impact of this result is discussed.

العلاقة: http://asp.eurasipjournals.com/content/2005/19/706906Test

الإتاحة: http://asp.eurasipjournals.com/content/2005/19/706906Test

المؤلفون: Lalor, E. C., Kelly, S. P., Finucane, C., Burke, R., Smith, R., Reilly, R. B., McDarby, G.

المصدر: EURASIP Journal on Advances in Signal Processing ; volume 2005, issue 19 ; ISSN 1687-6180

الإتاحة: https://doi.org/10.1155/asp.2005.3156Test

المؤلفون: Breslin, N P, Thomson, A B R, Bailey, R J, Blustein, P K, Meddings, J, Lalor, E, VanRosendaal, G M A, Verhoef, M J, Sutherland, L R

مصطلحات موضوعية: CANCER

وصف الملف: text/html

العلاقة: http://gut.bmj.com/cgi/content/short/46/1/93Test; http://dx.doi.org/10.1136/gut.46.1.93Test

الإتاحة: https://doi.org/10.1136/gut.46.1.93Test
http://gut.bmj.com/cgi/content/short/46/1/93Test