المؤلفون: Indu Sharma, Veena Dhawan, Lakhbir Kaur Dhaliwal, Nitin Mahajan, Subhash Chand Saha

المصدر: Fertility and Sterility. 94:1639-1646.e1

مصطلحات موضوعية: Lipopolysaccharides, Vascular Endothelial Growth Factor A, Biopsy, medicine.medical_treatment, Atorvastatin, Receptor for Advanced Glycation End Products, Peroxisome proliferator-activated receptor, RAGE (receptor), Endometrium, chemistry.chemical_compound, Gene expression, Receptors, Immunologic, Receptor, Cells, Cultured, Liver X Receptors, Uterine Diseases, chemistry.chemical_classification, S100 Proteins, Obstetrics and Gynecology, Cell Differentiation, Orphan Nuclear Receptors, Vascular endothelial growth factor, Female, lipids (amino acids, peptides, and proteins), medicine.drug, Adult, medicine.medical_specialty, Stromal cell, Adolescent, Cell Survival, Endometriosis, Biology, Andrology, Young Adult, Internal medicine, medicine, Humans, Pyrroles, Cell Proliferation, Dose-Response Relationship, Drug, Growth factor, S100A12 Protein, Insulin-Like Growth Factor Binding Protein 1, PPAR gamma, Endocrinology, Gene Expression Regulation, Reproductive Medicine, chemistry, Cyclooxygenase 2, Heptanoic Acids, Case-Control Studies, Hydroxymethylglutaryl-CoA Reductase Inhibitors, Stromal Cells

الوصف: Objective To investigate the in vitro effects of atorvastatin on lipopolysaccharide (LPS)-induced gene expression in endometrial-endometriotic stromal cells. Design In vitro experimental study using flow cytometry, ELISA, semiquantitative reverse transcriptase polymerase chain reaction, and Western blot. Setting Postgraduate Institute of Medical Education and Research. Patient(s) Twenty-five women undergoing laparoscopy (n = 10) and laparotomy (n = 15). Intervention(s) Endometriotic cyst wall (group I) and endometrial biopsy (group II) collection. Main Outcome Measure(s) The endometrial-endometriotic stromal cells were isolated from ectopic (group I) and eutopic (group II) endometrium by established methods, cultured, and stimulated with LPS (1 μg/mL), followed by atorvastatin treatment in a time- and dose-dependent manner to investigate the effects of LPS on proliferation (Ki-67) and expression of cyclooxygenase-2 (COX-2), vascular endothelial growth factor (VEGF), receptor for advanced glycation end products (RAGE), extracellular newly identified RAGE binding protein (EN-RAGE), peroxisome proliferator activated receptor-γ (PPAR-γ), and liver X receptor-α (LXR-α) genes in endometrial-endometriotic stromal cells and on levels of insulin-like growth factor binding protein-1 (IGFBP-1) and 17β-E 2 in endometrial-endometriotic stromal cell culture supernatant. Result(s) Significant inhibition of Ki-67 and LPS-induced expression of inflammatory and angiogenic genes (COX-2, VEGF, RAGE, and EN-RAGE) was observed in atorvastatin-treated endometrial-endometriotic stromal cells. In contrast, a significant dose- and time-dependent increase in expression of anti-inflammatory genes (PPAR-γ and LXR-α) and levels of IGFBP-1 was observed after atorvastatin treatment in both the groups. However, atorvastatin treatment had no effect on 17β-E 2 levels in endometrial/endometriotic stromal cell culture supernatant. Conclusion(s) The data of the present study provide new insights for the implication of atorvastatin treatment for endometriosis in humans.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa6f8a418f29123e98d6db5b6519510aTest
https://doi.org/10.1016/j.fertnstert.2009.10.003Test

المؤلفون: A. K. Bhalla, Lakhbir Kaur Dhaliwal, G. Sarala

المصدر: The AustralianNew Zealand journal of obstetricsgynaecology. 32(3)

مصطلحات موضوعية: Infertility, Adult, medicine.medical_specialty, Time Factors, medicine.medical_treatment, Abortion, Infant, Newborn, Diseases, Pregnancy, Risk Factors, medicine, Humans, Caesarean section, Cardiotocography, Fetal Death, Gynecology, Labor, Obstetric, Ectopic pregnancy, medicine.diagnostic_test, Antepartum haemorrhage, Obstetrics, business.industry, Cesarean Section, Age Factors, Infant, Newborn, Obstetrics and Gynecology, General Medicine, medicine.disease, Gestational diabetes, Pregnancy Complications, Female, business, Infertility, Female

الوصف: EDITORIAL COMMENT: We accepted this paper for publication because its findings will inform readers that infertile women who conceive have pregnancies that are not only ‘special’ to them, but are also ‘high risk’ - there is an increased incidence of spontaneous abortion, ectopic pregnancy, intrauterine growth retardation and stillbirths. This has been reported from Sweden (1) and Australia (2) and is confirmed in this study. The findings seem to apply to spontaneous conceptions and those occurring as a result of ovulation induction, GIFT or IVF. The overall rate of malformations is not increased in the total infertile group although certain malformations are more common. All pregnancies occurring in infertile women warrant genetic counselling, ultrasonography, appropriate testing for fetal growth retardation and hypoxia in late pregnancy (oestriol assay, cardiotocography, ultrasonography) and the exclusion of gestational diabetes (these women have a higher mean age, the most important indication other than Asian-birth, for glucose tolerance testing in pregnancy). 1. Ghazi HA, Spielberger C, Kailen B. Delivery outcome after infertility-a registry study. Fertil Steril 1991; 55: 726–731. 2. Venn A, Lumley J. Births after a period of infertility in Victorian women, 1982–1989. Abstract. Centre for the study of mothers' and children's health, Carlton, Victoria. Summary: Pregnancies of 112 patients who had conceived after a history of a minimum of 2 years of infertility were compared to an equal number of matching controls without prior infertility to find out any risk of increased pregnancy complications. These patients were at a significantly higher risk of developing first trimester bleeding, antepartum haemorrhage and intrauterine fetal death. Also there were higher rates of preterm delivery and Caesarean section. The patients in the study group had a significantly higher number of stillborn babies. The incidence of other complications such as ectopic pregnancy, multiple pregnancy, and medical complications was also higher in these patients but the difference was not statistically significant.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0e7cb7fe09e6cedb2f1cff914b7f079Test
https://pubmed.ncbi.nlm.nih.gov/1445139Test

المؤلفون: Lakhbir Kaur Dhaliwal, Sarala Gopalan, I. Das

المصدر: International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics. 37(4)

مصطلحات موضوعية: Adult, medicine.medical_specialty, Vaginal Neoplasms, Hysterectomy, Ovarian function, Rare case, medicine, Humans, neoplasms, Gynecology, Leiomyoma, business.industry, Rare entity, Obstetrics and Gynecology, Vaginal Leiomyoma, General Medicine, musculoskeletal system, medicine.disease, female genital diseases and pregnancy complications, Surgery, body regions, surgical procedures, operative, medicine.anatomical_structure, Vagina, Female, Neoplasm Recurrence, Local, business

الوصف: A rare case of huge vaginal leiomyoma recurrence is reported. Vaginal leiomyoma is a rare entity and recurrence after its removal is extremely rare. However, if recurrence occurs with intact ovarian function ovariectomy should also be done.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9dd5e101b63092fee40275dfa04c0802Test
https://pubmed.ncbi.nlm.nih.gov/1350544Test

المؤلفون: Lakhbir Kaur Dhaliwal, M. Thakur, V. Suri

المصدر: Fertility and Sterility. 90:S159

مصطلحات موضوعية: Gynecology, Biophysical profile, medicine.medical_specialty, Pregnancy, Reproductive Medicine, business.industry, Obstetrics, medicine, Obstetrics and Gynecology, business, medicine.disease, Value (mathematics), Unexplained infertility

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::31edfc0ce9a5d0690866306d35115a10Test
https://doi.org/10.1016/j.fertnstert.2008.07.363Test

المؤلفون: Nirja Chawla, Lakhbir Kaur Dhaliwal, Arvind Rajwanshi, Sarala Gopalan

المصدر: Asia-Oceania journal of obstetrics and gynaecology. 16(2)

مصطلحات موضوعية: Female circumcision, Adult, medicine.medical_specialty, Pathology, medicine.medical_treatment, Neoplasms, Multiple Primary, immune system diseases, hemic and lymphatic diseases, Laparotomy, medicine, Humans, Radical surgery, Ovarian Neoplasms, Both ovaries, business.industry, Lymphoma, Non-Hodgkin, Obstetrics and Gynecology, medicine.disease, Combined Modality Therapy, Appendix, Lymphoma, Non-Hodgkin's lymphoma, medicine.anatomical_structure, Appendiceal Neoplasms, Histopathology, Female, Radiology, business

الوصف: Involvement of the female genital tract by non-Hodgkin's lymphoma is extremely rare. Here is the report of a patient who presented as a bilateral malignant ovarian tumour and was diagnosed by laparotomy and subsequent histopathology to have non-Hodgkin's lymphoma of both ovaries and appendix. The patient had radical surgery followed by multiagent chemotherapy and is alive without disease at one year of follow-up.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4e7d95924679cb2fdf1e8a94b777e73Test
https://pubmed.ncbi.nlm.nih.gov/2378590Test

المؤلفون: Raje Nijhawan, Nalini Gupta, Lakhbir Kaur Dhaliwal, Radhika Srinivasan

المصدر: CytoJournal. 2:20

مصطلحات موضوعية: Gynecology, Pathology, medicine.medical_specialty, animal structures, urogenital system, business.industry, General Medicine, medicine.disease, Malignancy, female genital diseases and pregnancy complications, Transitional cell carcinoma, medicine.anatomical_structure, Gynecological malignancy, medicine, Carcinoma, Right Fallopian Tube, Malignant cells, Cervical pap smear, business, Fallopian tube

الوصف: Primary fallopian tubal carcinoma is a rare (0.2- 0.5%) gynecological malignancy. A primary transitional cell carcinoma (TCC) of the fallopian tube accounts for about 10% of primary fallopian tubal carcinomas. Exfoliation of cells of primary fallopian tubal TCC in cervical Pap smear has not been described previously. The present case is of a 52 years old female, who presented with episodic spotting per vaginum. Cervical Pap smear revealed clusters of malignant cells. Total abdominal hysterectomy with bilateral salpingo ophrectomy was performed. A tumor was found in the right fallopian tube occluding its fimbrial end. On microscopy, the tumor was confirmed to be a TCC. Therefore, if cervical Pap smear is positive for malignant cells and the cervical biopsy is negative, the patient should be investigated for a gynecological malignancy higher up in the gynecological tract. Though rare, a possibility of primary fallopian tubal malignancy should be considered in these cases.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::b3b511eb35ff7c1d79905a30bd1d0188Test
https://doi.org/10.1186/1742-6413-2-20Test

المؤلفون: Rakesh Yadav, Nalini Gupta, N. Rajkumari, S. Sethi, Lakhbir Kaur Dhaliwal, S S Banga, M. Sharma

المصدر: International Journal of Infectious Diseases. :e270

مصطلحات موضوعية: Microbiology (medical), Infertility, Gynecology, medicine.medical_specialty, biology, business.industry, General Medicine, medicine.disease, biology.organism_classification, Non pregnant, Infectious Diseases, Obstetric history, Medicine, business, Mycoplasma genitalium

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9373968c376f8572176d046079c275eaTest