المؤلفون: Volonnino G., La Russa R., Di Fazio N., Ottaviani M., Zamponi M. V., Spadazzi F., Umani-Ronchi F.

المساهمون: Volonnino, G., La Russa, R., Di Fazio, N., Ottaviani, M., Zamponi, M. V., Spadazzi, F., Umani-Ronchi, F.

مصطلحات موضوعية: forensic toxicology, drugs facilitated crime, z-drug, sedative-hypnotic

الوصف: Background: Z-Drugs are a category of non-benzodiazepine sedative-hypnotic drugs that include Zolpidem, Zopiclone and Zaleplon. They are all rapidly adsorbed and have a very short half- life, features that make them first-line treatment of insomnia and, in the meantime, first-choice drugs in cases of poisoning for criminal purposes. Z-drugs are frequently use in Drug Facilitated Crime cases (DFC) and Drug Facilitated Sexual Assault (DFSA), namely crimes, robberies, extortion and sexual violence committed after administration of incapacitating substances able to induce sedative-hypnotic effects. In these circumstances, the psychoactive substance is considered as a weapon and constitutes an aggravating circumstance in the criminal act: accordingly, judicial authority legitimates the analytical determination of these substances. Currently, few tests able to detect such drugs are available in daily clinical practice. Aim: The aim of this work is to evaluate the effective utilization of Z-Drugs. Methods: We have analyzed the literature, focusing on cases in which the criminal use of such incapacitating substances has been demonstrated. Relevant scientific articles were identified from PubMed, Cochrane Central, Scopus, Web of Science, Science Direct, EMBASE up to December 2022 using the following keywords: "z-drugs", "drug facilitated crime", "forensic toxicology". The resulting references were screened to exclude duplicates. In addition, non-English papers were excluded. This evaluation left 10 articles (8 case reports and 2 original studies) divided as follows: 1 case report of a DFC (robbery), 6 cases of confirmed DFSA, 3 cases of suspected DFSA, 2 original studies about DFC. Results: The totality of the selected cases showed positive toxicological tests for a single intake of z-drugs. Conclusions: This work has shown the limitations of screening tests currently in use in the emergency rooms. Forensic toxicology tests should be introduced in daily clinical practice.

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/37750379; volume:174; issue:5; firstpage:451; lastpage:468; numberofpages:18; journal:LA CLINICA TERAPEUTICA; https://hdl.handle.net/11573/1697692Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85172174997

الإتاحة: https://doi.org/10.7417/CT.2023.2465Test
https://hdl.handle.net/11573/1697692Test

المؤلفون: Mezzetti, E., Maiese, A., Spina, F., Del Duca, F., De Matteis, A., Di Paolo, M., La Russa, R., Turillazzi, E., Fineschi, V.

المساهمون: Mezzetti, E., Maiese, A., Spina, F., Del Duca, F., De Matteis, A., Di Paolo, M., La Russa, R., Turillazzi, E., Fineschi, V.

مصطلحات موضوعية: saphenous vein graft, rupture, bypass

الوصف: first_pagesettingsOrder Article Reprints Open AccessReview Early Saphenous Vein Graft Aneurysm Rupture: A Not So-Late Complication. Case Report and Comprehensive Literature Review by Eleonora Mezzetti 1,Aniello Maiese 1,*,Federica Spina 1ORCID,Fabio Del Duca 2ORCID,Alessandra De Matteis 2,Marco Di Paolo 1,Raffaele La Russa 3ORCID,Emanuela Turillazzi 1 andVittorio Fineschi 2ORCID 1 Department of Surgical, Medical and Molecular Pathology and Critical Care Medicine, Section of Legal Medicine, University of Pisa, 56126 Pisa, Italy 2 Department of Anatomical, Histological, Forensic and Orthopedical Sciences, Sapienza University of Rome, Viale Regina Elena 336, 00161 Rome, Italy 3 Department of Clinical and Experimental Medicine, University of Foggia, 71122 Foggia, Italy * Author to whom correspondence should be addressed. Biomedicines 2023, 11(1), 220; https://doi.org/10.3390/biomedicines11010220Test Received: 1 December 2022 / Revised: 9 January 2023 / Accepted: 13 January 2023 / Published: 14 January 2023 (This article belongs to the Section Molecular and Translational Medicine) Download Browse Figures Review Reports Versions Notes Abstract Background and Objectives: Saphenous vein graft (SVG) is a cardiac surgical practice used to create a cardiac bypass in cases of coronary artery obstruction. It consists of a surgical procedure that involves the creation of an aorto-coronary communication by a venous conduit (saphenous vein) to bypass coronary stenosis and allow cardiac revascularization. This practice can be affected by early and late complications. The most feared complication is graft aneurysm or pseudoaneurysm degeneration and rupture which are considered late complications. This paper presents a rare case of SVG aneurysmal rupture that occurred 24 h after surgery and a review of the literature to provide a general look at the state of knowledge. Materials and Methods: The systematic review was carried out using the guidelines according to the PRISMA method. Results: Cases of aneurysmal rupture have never been ...

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/36672728; info:eu-repo/semantics/altIdentifier/wos/WOS:000914470900001; volume:11; issue:1; firstpage:1; lastpage:18; numberofpages:18; journal:BIOMEDICINES; https://hdl.handle.net/11573/1670030Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85146720379

الإتاحة: https://doi.org/10.3390/biomedicines11010220Test
https://hdl.handle.net/11573/1670030Test

المؤلفون: Maiese, A., Spina, F., Visi, G., Del Duca, F., De Matteis, A., La Russa, R., Di Paolo, M., Frati, P., Fineschi, V.

المساهمون: Maiese, A., Spina, F., Visi, G., Del Duca, F., De Matteis, A., La Russa, R., Di Paolo, M., Frati, P., Fineschi, V.

مصطلحات موضوعية: traumatic brain injury, foxo3a, immunohistochemical

الوصف: Traumatic brain injury (TBI) is one of the most well-known causes of neurological impairment and disability in the world. The Forkhead Box class O (FOXO) 3a is a transcription factor that is involved in different molecular processes, such as cell apoptosis regulation, neuroinflammation and the response to oxidative stress. This study is the first to evaluate the post-mortem immunohistochemical (IHC) positivity of FOXO3a expression in human cases of TBI deaths. The autopsy databases of the Legal Medicine and Forensic Institutes of the “Sapienza” University of Roma and the University of Pisa were retrospectively reviewed. After analyzing autopsy reports, 15 cases of TBI deaths were selected as the study group, while the other 15 cases were chosen among non-traumatic brain deaths as the control group. Decomposed bodies and those with initial signs of putrefaction were excluded. Routine histopathological studies were performed using hematoxylin–eosin (H&E) staining. Furthermore, an IHC investigation on cerebral samples was performed. To evaluate FOXO3a expression, anti-FOXO3a antibodies (GTX100277) were utilized. Concerning the IHC analysis, all 15 samples of TBI cases showed positivity for FOXO3a in the cerebral parenchyma. All control cerebral specimens showed FOXO3a negativity. In addition, the longer the survival time, the greater the positivity to the reaction with FOXO3a was. This study shows the important role of FOXO3a in neuronal autophagy and apoptosis regulation and suggests FOXO3a as a possible potential pharmacological target.

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/36768906; info:eu-repo/semantics/altIdentifier/wos/WOS:000929622400001; volume:24; issue:3; firstpage:1; lastpage:11; numberofpages:11; journal:INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES; https://hdl.handle.net/11573/1670025Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85147895468

الإتاحة: https://doi.org/10.3390/ijms24032584Test
https://hdl.handle.net/11573/1670025Test

المؤلفون: Piccioni A., Franza L., Rosa F., Candelli M., Covino M., Ferrara M., Volonnino G., Bertozzi G., Vittoria Zamponi M., Maiese A., Savioli G., Franceschi F., La Russa R.

المساهمون: Piccioni, A., Franza, L., Rosa, F., Candelli, M., Covino, M., Ferrara, M., Volonnino, G., Bertozzi, G., Vittoria Zamponi, M., Maiese, A., Savioli, G., Franceschi, F., La Russa, R.

الوصف: Background: COVID-19 caused by SARS-CoV-2 virus is characterized by respiratory compromise and immune system involvement, even leading to serious disorders, such as cytokine storm. Methods: We then conducted a literature review on the topic of sepsis and covid-19, and in parallel conducted an experimental study on the histological finding of patients who died from SARS-Covid 19 infection and a control group. Results: Sepsis associated with covid-19 infection has some similarities and differences from that from other causes. Conclusion: In this paper the complex interplay between the 2 disorders was discussed, focusing on the similarities and on the effect that one could have on the other. A preliminary experimental section that demonstrates the multisystemic involvement in subjects who die from SARS-CoV-2 is also proposed.

العلاقة: volume:2; issue:3; firstpage:202; lastpage:211; numberofpages:10; journal:INFECTIOUS MEDICINE; https://hdl.handle.net/11568/1203990Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85170244233

الإتاحة: https://doi.org/10.1016/j.imj.2023.04.006Test
https://hdl.handle.net/11568/1203990Test

المؤلفون: Micheletta F., Ferrara M., Bertozzi G., Volonnino G., Nasso M., La Russa R.

المساهمون: Micheletta, F., Ferrara, M., Bertozzi, G., Volonnino, G., Nasso, M., La Russa, R.

مصطلحات موضوعية: anticoagulant therapy, elective surgery, failure mode and effect analysis

الوصف: Introduction: Correct perioperative management of anticoagulant therapy is essential to prevent thromboembolic events and reduce the risk of bleeding. The lack of universally accepted guidelines makes perioperative anticoagulant therapy management difficult. The present study aims to identify the perioperative risks of oral anticoagulant therapy and to reduce adverse events through Failure Mode and Effect Analysis (FMEA). Materials and Methods: A multidisciplinary working group was set up, and four main phases of the process were identified. Each of these phases was divided into micro-activities to identify the related possible failure modes and their potential consequences. The Risk Priority Number was calculated for each failure mode. Results and Discussion: Seventeen failure modes were identified in the entire perioperative period; those with a higher priority of intervention concern the incorrect timing between therapy suspension and surgery, and the incorrect assessment of the bleeding risk related to the invasive procedure. Conclusion: The FMEA method can help identify anticoagulant therapy perioperative failures and implement the management and patient safety of surgical procedures.

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/36554313; info:eu-repo/semantics/altIdentifier/wos/WOS:000900845000001; volume:19; issue:24; firstpage:1; lastpage:9; numberofpages:9; journal:INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH; https://hdl.handle.net/11573/1672362Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85144551706

الإتاحة: https://doi.org/10.3390/ijerph192416430Test
https://hdl.handle.net/11573/1672362Test

المؤلفون: De Simone S., Giacani E., Bosco M. A., Vittorio S., Ferrara M., Bertozzi G., Cipolloni L., La Russa R.

المساهمون: De Simone, S., Giacani, E., Bosco, M. A., Vittorio, S., Ferrara, M., Bertozzi, G., Cipolloni, L., La Russa, R.

مصطلحات موضوعية: miRNA, post-mortem investigation, postmortem miRNA, wound-age determination, wound-age estimation

الوصف: Background: The timing of wounds production is a significant issue in forensic pathology. Although various methods have been evaluated, obtaining an accurate dating of lesions is still a challenge. The pathologist uses many parameters to value wound age, such as histological and immunohistochemical. In recent years, there have been many studies regarding the use of miRNAs in wound-age estimation; indeed, miRNAs have multiple potential uses in forensic pathology. Scope: This review aims to verify the efficacy and feasibility of miRNAs as a tool for determining the timing of lesions. Materials and Methods: The authors conducted the systematic review according to the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines. PubMed was used as a search engine to find articles published between January, 1st 2016 and October, 1st 2021, to evaluate the current state of the art regarding wound-age estimation. Results: A total of 256 articles were collected; after screening according to PRISMA guidelines, the systematic review included 8 articles. The studies included in this review were all Original articles evaluating the use of biomarkers for wound-age determination. Discussion and Conclusion: The literature review showed that analysis of miRNA is an innovative field of study with significant potentiality in forensic pathology. There are few studies, and almost all of them are at an early stage. The challenge is to understand how to standardize the samples' selection to obtain reliable experimental data. This observation represents a necessary prerequisite to planning further clinical trials.

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/35096893; info:eu-repo/semantics/altIdentifier/wos/WOS:000758474300001; volume:8; firstpage:1; lastpage:9; numberofpages:9; journal:FRONTIERS IN MEDICINE; http://hdl.handle.net/11573/1649019Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85123940012

الإتاحة: https://doi.org/10.3389/fmed.2021.803067Test
http://hdl.handle.net/11573/1649019Test

المؤلفون: di Fazio, N, Delogu, G, La Russa, R, Fineschi, B, Bertozzi, G, Macrì, P G, Frati, P

المساهمون: di Fazio, N, Delogu, G, La Russa, R, Fineschi, B, Bertozzi, G, Macrì, P G, Frati, P

مصطلحات موضوعية: italy, VIP, abortion, conscientious objection, guideline, law no.194/1978, voluntary interruption of pregnancy

الوصف: Voluntary interruption of pregnancy (VIP) in Italy is regulated by Law no. 194/1978. Its monitoring is carried out by the VIP Epidemio-logical Surveillance System, which periodically analyses the results of questionnaires compiled by the territorial healthcare structures and sent by each Region. The latest report, covering the years 2019 and 2020, highlights the adequacy of preventive and proactive strategies, an improvement in the quality and effectiveness of the service offered. Furthermore, considering the COVID-19 pandemic, the reorganization of the IVG application guidelines showed a considerable adaptation to the emergency context through measures such as the increase in pharmacological procedures compared to surgical procedures. The interpretation of the data shows that in Italy there is one of the lowest VIP rates in Europe, reflecting the effectiveness of campaigns that promote responsible procreation. Further implementations should be extended to the foreign population, which still shows a medium-high VIP rate. The efficiency of the service offered resulted to be high. The latter was assessed considering the waiting period required for the performance of the VIP procedure. Furthermore, the high percentage of conscientious objectors does not harm the healthcare service. The estimates show an adequate territorial coverage by the authorized structures compared to the female population of fertile age. In conclusion, the central action of planning, organization, and monitoring finds a valid ally in the territorial management entrusted to the Regions. The analyzed report reflects even more margins of efficiency and adequacy when considered within the particular historical context of the pandemic by COVID-19.

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/35612338; volume:173; issue:3; firstpage:235; lastpage:242; numberofpages:8; journal:LA CLINICA TERAPEUTICA; https://hdl.handle.net/11573/1677056Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85131107040

الإتاحة: https://doi.org/10.7417/CT.2022.2426Test
https://hdl.handle.net/11573/1677056Test

المؤلفون: Bernetti A., La Russa R., de Sire A., Agostini F., De Simone S., Fari G., Lacasella G. V., Santilli G., De Trane S., Karaboue M., Ruiu P., Mangone M., Leigheb M., Santilli V., Fiore P.

المساهمون: Bernetti, A., La Russa, R., de Sire, A., Agostini, F., De Simone, S., Fari, G., Lacasella, G. V., Santilli, G., De Trane, S., Karaboue, M., Ruiu, P., Mangone, M., Leigheb, M., Santilli, V., Fiore, P.

مصطلحات موضوعية: cervical artery dissection, cervical spine manipulation, forensic medicine, manipulative therapy, rehabilitation, side effect, spine

الوصف: Background: Cervical spine manipulations (CSM) have been performed for centuries and are a widely practiced intervention to manage cervical spine musculoskeletal disorders. We aimed to perform an overview of the literature concerning the effects and the adverse events of CSM in the Physical and Rehabilitation Medicine (PRM) field with a forensic medicine perspective. Methods: A search in the scientific literature (PubMed, Google Scholar, PEDro and Cochrane) was carried out from inception until October 2020. Results: Fourteen articles were included in this narrative summary. The possible development of side effects requires a careful mandatory balance of benefits and risks even when there is an indication for this approach. Moreover, a qualified professional is essential to perform CSM–a non-invasive therapeutic procedure that can be potentially harmful. Conclusions: In conclusion, it is essential to perform the diagnosis, to treat, and to manage complications within the PRM field, both for the reduction of malpractice claims and, most importantly, for the safety of the patient.

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/35626212; info:eu-repo/semantics/altIdentifier/wos/WOS:000803266300001; volume:12; issue:5; firstpage:1; lastpage:10; numberofpages:10; journal:DIAGNOSTICS; https://hdl.handle.net/11573/1662720Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85129606251

الإتاحة: https://doi.org/10.3390/diagnostics12051056Test
https://hdl.handle.net/11573/1662720Test

المؤلفون: Maiese, A., Ciallella, C., dell’Aquila, M., De Matteis, A., Toni, C., Scatena, A., La Russa, R., Mezzetti, E., Di Paolo, M., Turillazzi, E., Frati, P., Fineschi, V.

المساهمون: Maiese, A., Ciallella, C., Dell’Aquila, M., De Matteis, A., Toni, C., Scatena, A., La Russa, R., Mezzetti, E., Di Paolo, M., Turillazzi, E., Frati, P., Fineschi, V.

مصطلحات موضوعية: charred bodie, flame injurie, forensic protocol, forensic medicine, smoke inhalation, carbonized bodies

الوصف: Our study aims to demonstrate the experience of analyzing fully or partially charred corpses to offer a proper implementation protocol for determining the cause of death. In this study, we present a total of 103 cases obtained from the University of Rome La Sapienza and the University of Pisa archives. All cases were classified based on the extent and severity of burns using a visual method. We divided all cases into two groups. The first group included grade I–II burns (21 cases) without the need for identification. The second group (82 cases) included injuries worse than grade burns II, so all cases were analyzed using an analytical method. For each case, we have documented which of the following analyses have been used and the corresponding findings: inspection, autopsy examination, imaging examination, genetic and toxicological examinations, and histological examination. The results describe the main diagnostic findings and show that only the application of all the above systematic analyses can provide greater accuracy and reliability in describing the causes of death or solving problems, such as identification. In conclusion, we propose an available protocol that defines the main steps of a complete diagnostic pathway that pathologists should follow daily in studying charred bodies.

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/36010336; info:eu-repo/semantics/altIdentifier/wos/WOS:000845920500001; volume:12; issue:8; firstpage:1; lastpage:38; numberofpages:38; journal:DIAGNOSTICS; https://hdl.handle.net/11573/1670043Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85137607397

الإتاحة: https://doi.org/10.3390/diagnostics12081986Test
https://hdl.handle.net/11573/1670043Test

المؤلفون: Frati P., Di Fazio N., La Russa R., Santoro P., Delogu G., Fineschi V.

المساهمون: Frati, P., Di Fazio, N., La Russa, R., Santoro, P., Delogu, G., Fineschi, V.

مصطلحات موضوعية: adverse event, availability, consent form, COVID-19 vaccination, ethical issue, information, liability, no-fault compensation

الوصف: Italy, like other European countries, has produced a series of regulations during the COVID-19 pandemic. Compulsory vaccination has been introduced for the Italian population. Meanwhile, the Decree-Law 27 January 2022 n. 4 provided for the compensation mechanism for those who have received damage of the psycho-physical integrity due to the anti-SARS-CoV-2 vaccination recommended by the Italian Health Authority. Law 1992 no. 210 already provided for the indemnity system for persons damaged by irreversible complications due to compulsory vaccinations, transfusions, and the administration of blood products. The legislator intended to attribute the right to an indemnity that is not compensatory in order to repair a wrong connected to some hypothesis of liability, but it rather has a welfare character in the broad sense, being attributable to Constitutional fundamentals. In the Italian panorama, although the vaccination damages have been fully included in the already existing law no. 210/1992, to date, no precise indications have been provided regarding the ascertainment of the causal link and the extent of the compensable damage. In the near future, the interest of the scientific community will focus on the evaluation of applications for access to the benefit.

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/35632391; info:eu-repo/semantics/altIdentifier/wos/WOS:000802553200001; volume:10; issue:5; firstpage:1; lastpage:11; numberofpages:11; journal:VACCINES; http://hdl.handle.net/11573/1644883Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85129166414

الإتاحة: https://doi.org/10.3390/vaccines10050635Test
http://hdl.handle.net/11573/1644883Test