المؤلفون: Lunn, Andrew J., Winder, Isabelle C., Shaw, Vivien

المصدر: Microscopy Techniques for Biomedical Education and Healthcare Practice ; Biomedical Visualization ; page 55-88 ; ISSN 2731-6130 2731-6149 ; ISBN 9783031368493 9783031368509

الإتاحة: https://doi.org/10.1007/978-3-031-36850-9_4Test

المؤلفون: Lunn, Andrew, Urmston, Ann, Seymour, Steven, Manfrin, Andrea

مصطلحات موضوعية: B200 - Pharmacology, toxicology & pharmacy

الوصف: Purpose: This study aimed to evaluate the impact of Patient As Teacher (PAT) sessions on the knowledge, communication skills, and participation of pharmacy students in the United Kingdom. Methods: During the academic year 2019-2020, year 1 and 2 pharmacy students at the University of Central Lancashire were invited to complete a questionnaire following PAT sessions. Data were analyzed by means of descriptive statistics, including mean and standard deviation (SD) for: continuous variables and reliability analysis. Pearson’s Chi-Square or Fisher Exact Test, odds ratio, and Phi were used for analyzing dichotomous variables. Thematic analysis was used for free text comments. Results: Sixty eight of 228 students participated, (response rate of 29.8%). No statistical difference was found between gender (p=0.090); a statistically significant difference was found between year (p=0.008). Cronbach's alpha (0.809) confirmed a good internal consistency. 97.0% of the students learned a lot, and 85.3% appreciated and valued the PAT sessions; 89.7% wanted more sessions. 92.7% perceived the sessions to contextualize their learning. Five questions were dichotomized by grouping the responses into negative and positive; 90.3% of responses were positive and did not show statistically significant differences in gender and year of study. Overall students’ free text comments were positive, but active listening and consultation appeared in the positive and negative domains, highlighting the need for more student engagement. Conclusions: PAT sessions had a positive impact on students’ knowledge, communication skills, and participation, and contextualized learning. They provide a valuable contribution to the pharmcy students’ experience in the United Kingdom.

وصف الملف: application/pdf

العلاقة: https://clok.uclan.ac.uk/33363/1/proof%20aproval%20text.pdfTest; https://clok.uclan.ac.uk/33363/9/33363%20jeehp-17-15.pdfTest; Lunn, Andrew orcid iconorcid:0000-0003-2884-2755 , Urmston, Ann, Seymour, Steven and Manfrin, Andrea orcid iconorcid:0000-0003-3457-9981 (2020) Patient as teacher sessions contextualize learning, enhancing knowledge, communication, and participation of pharmacy students in the United Kingdom. Journal of education evaluation for health professionals, 17 (15).

الإتاحة: https://doi.org/10.3352/jeehp.2020.17.15Test
https://clok.uclan.ac.uk/33363Test/
https://clok.uclan.ac.uk/33363/1/proof%20aproval%20text.pdfTest
https://clok.uclan.ac.uk/33363/9/33363%20jeehp-17-15.pdfTest

المؤلفون: Tanaka, Joji, Song, Ji-Inn, Lunn, Andrew, Hand, Rachel, Hakkinen, Satu, Schiller, Tara, Perrier, Sebastien, Davis, Tom, Wilson, Paul

مصطلحات موضوعية: B230 - Pharmacy

الوصف: Here arsenohydrogels are introduced for the first time as functional, tuneable and responsive hydrogels. The distinctive redox reactivity of arsenic has been exploited to crosslink high molecular weight (Mw > 300 kDa) polymeric arsenical scaffolds (PDMAmx-co-AsAmy) via reductive coupling of As(V) to As(I) which proceeds with the formation of As–As in the form of As(I)n homocycles. Soft arsenohydrogels (G′ ∼ 400–1700 Pa) that failed in compression tests at low compression and loading are formed when the polymer weight fraction is 2.5 wt%. When the polymer weight fraction is increased to 10 wt% the mechanical properties (stiffness and relaxation) of the arsenohydrogels are significantly improved and correlate with the mole fraction of arsenic (AsAm, y) present in the copolymer scaffolds. Furthermore, increasing the mole fraction of AsAm, reduces the degree of swelling and increases the stability of the gels against hydrolysis and oxidation of the As–As crosslinks. The functionality of the polymeric arsenical scaffolds has also been exploited to load arsenohydrogels with a model organic arsenical drug. The rate and degree of release of the loaded organic arsenical under simulated oxidative stress (H2O2) is inversely proportional to the mole fraction of arsenic in the original polymer scaffold. Finally, the polymeric arsenical scaffolds and the resulting arsenohydrogels have been shown to be non-toxic to NIH/3T3 (mouse fibroblast) and PC3 (human prostate cancer) cell lines. The properties and versitility of the arsenohydrogels alludes to their potential as a functional platform for biomaterials.

وصف الملف: application/pdf

العلاقة: https://clok.uclan.ac.uk/28417/1/28417%20Revised%20Manuscript_2.pdfTest; Tanaka, Joji, Song, Ji-Inn, Lunn, Andrew orcid iconorcid:0000-0003-2884-2755 , Hand, Rachel, Hakkinen, Satu, Schiller, Tara, Perrier, Sebastien, Davis, Tom and Wilson, Paul (2019) Polymeric arsenicals as scaffolds for functional and responsive hydrogels. Journal of Materials Chemistry B, 7 . pp. 4263-4271. ISSN 2050-750X

الإتاحة: https://doi.org/10.1039/C8TB02569JTest
https://clok.uclan.ac.uk/28417Test/
https://clok.uclan.ac.uk/28417/1/28417%20Revised%20Manuscript_2.pdfTest

المؤلفون: Lunn, Andrew J., Shaw, Vivien, Winder, Isabelle C.

المساهمون: Shapiro, Leonard, Rea, Paul M.

مصطلحات موضوعية: Animal Cognition, Statistical and Graphical Visualisations, Science Communication, Accessible Science, Large Complex Datasets, Visualisation Alternatives

الوصف: Visual representations of complex data are a cornerstone of how scientific information is shared. By taking large quantities of data and creating accessible visualisations that show relationships, patterns, outliers, and conclusions, important research can be communicated effectively to any audience. The nature of animal cognition is heavily debated with no consensus on what constitutes animal intelligence. Over the last half-century, the methods used to define intelligence have evolved to incorporate larger datasets and more complex theories—moving from relatively simple comparisons of brain mass and body mass to explorations of brain composition and how neuron count changes between specific groups of animals. The primary aim of this chapter is therefore to explore how visualisation choice influences the accessibility of complex scientific information, using animal cognition as a case study. As the datasets concerned with animal intelligence have increased in both size and complexity, have the visualisations that accompany them evolved as well? We first investigate how the basic presentation of visualisations (figure legends, inclusion of statistics, use of colour, etc.) has changed, before discussing alternative approaches that might improve communication with both scientific and general audiences. By building upon the types of visualisation techniques that everyone is taught at school (bar charts, XY scatter plots, pie charts, etc.), we show how small changes can improve our communication with both scientific and general audiences. We suggest that there is no single right way to visualise data, but careful consideration of the audience and the specific message can help, even where communications are constrained by time, technology, or medium.

العلاقة: https://hull-repository.worktribe.com/output/4448733Test; Pagination 51-84; https://hull-repository.worktribe.com/file/4448733/1/ChapterTest

الإتاحة: https://doi.org/10.1007/978-3-031-10889-1_3Test
https://hull-repository.worktribe.com/file/4448733/1/ChapterTest
https://hull-repository.worktribe.com/output/4448733Test

المؤلفون: Lunn, Andrew, Perrier, Sebastien

مصطلحات موضوعية: Chemistry, Applied chemistry, Materials science

الوصف: The facile synthesis of sub-100 nm glyco nanoparticles is presented via a one-step, free radical, and surfactant free emulsion polymerization. It is shown that by using sterically large, hydrophilic glycomonomers such as a lactose acrylamide with the charged azo initiator 4,4′-azobis(4-cyanovaleric acid), growing particles are stabilized enough to reproducibly produce well defined (PDi ≤ 0.1) glycoparticles with diameters below 100 nm

وصف الملف: application/pdf

العلاقة: https://clok.uclan.ac.uk/28419/1/28419%20WRAP-synthesis-Sub-100-glycosylated-nanoparticles-emulsion-polymerisation.pdfTest; https://clok.uclan.ac.uk/28419/8/28418%2028419%2028420.pdfTest; Lunn, Andrew orcid iconorcid:0000-0003-2884-2755 and Perrier, Sebastien (2018) Synthesis of Sub-100 nm Glycosylated Nanoparticles via a One Step, Free Radical, and Surfactant Free Emulsion Polymerization. Macromolecular Rapid Communications, 39 (19). ISSN 1022-1336

الإتاحة: https://doi.org/10.1002/marc.201800122Test
https://clok.uclan.ac.uk/28419Test/
https://clok.uclan.ac.uk/28419/1/28419%20WRAP-synthesis-Sub-100-glycosylated-nanoparticles-emulsion-polymerisation.pdfTest
https://clok.uclan.ac.uk/28419/8/28418%2028419%2028420.pdfTest

المؤلفون: Shaikh, Huda, Lunn, Andrew, peltier, Raoul, Perrier, Sebastien, macdougall, Laura, Gurnani, Pratik, Yang, Jie, Huband, Steve, Mansfield, Ed

مصطلحات موضوعية: B230 - Pharmacy

الوصف: Breaking away from the linear structure of previously reported peptide-based gelators, this study reports the first example of gel formation based on the use of cyclic peptides made of alternating d- and l-amino acids, known to self-assemble in solution to form long nanotubes. Herein, a library of cyclic peptides was systemically studied for their gelation properties in various solvents, uncovering key parameters driving both organogel and hydrogel formation. The hierarchical nature of the self-assembly process in water was characterised by a combination of electron microscopy imaging and small-angle X-ray scattering, revealing a porous network of entangled nanofibres composed by the aggregation of several cyclic peptide nanotubes. Rheology measurements then confirmed the formation of soft hydrogels

وصف الملف: application/pdf

العلاقة: https://clok.uclan.ac.uk/28418/1/28418%2028419%2028420.pdfTest; https://clok.uclan.ac.uk/28418/8/28418%20lunn_send_2.pdfTest; Shaikh, Huda, Lunn, Andrew orcid iconorcid:0000-0003-2884-2755 , peltier, Raoul, Perrier, Sebastien, macdougall, Laura, Gurnani, Pratik, Yang, Jie, Huband, Steve and Mansfield, Ed (2018) Hydrogel and Organogel Formation by Hierarchical Self-Assembly of Cyclic Peptides Nanotubes. Chemistry - A European Journal, 24 (71). pp. 19066-19074. ISSN 0947-6539

الإتاحة: https://doi.org/10.1002/chem.201804576Test
https://clok.uclan.ac.uk/28418Test/
https://clok.uclan.ac.uk/28418/1/28418%2028419%2028420.pdfTest
https://clok.uclan.ac.uk/28418/8/28418%20lunn_send_2.pdfTest

المؤلفون: Lunn, Andrew, Winder, Isabelle C., Shaw, Vivien

الوصف: Human brains require the most energy per unit of mass of any animal and also have the largest cortical neuron count, which is afforded by having the largest primate brain and abiding by economic scaling rules. Cortical neuron count is one of the most useful biological indicators of intelligence but providing neurons with enough energy requires a high blood supply (achieved through internal carotid and vertebral arteries). Vertebral arteries pass through cervical vertebrae transverse foramina before joining to form the basilar artery, which, with several connecting arteries and the internal carotids, forms the circle of Willis. The circle of Willis, although highly variable in humans, exhibits a less well-developed connection in animals considered ‘less intelligent’, such as Artiodactyls. We hypothesised that if viable neuron count has a relationship with total cerebral circulation, then a relationship may exist between vertebral blood flow and animal cognition. We conducted geometric morphometrics on 40 Mammalia and 26 Aves, measuring cervical vertebrae transverse foramen area, as a proxy to vessel size and an accurate representation of arterial blood flow to the brain. Foramen area was subsequently calculated as a proportion of the vertebral canal, to adjust for organism size across the dataset. We then compared the foramen area with a measure of ‘cognitive complexity’, obtained by counting how many of 12 indicators of complex cognition (broadly encompassing theory of mind, social/emotional intelligence, tool use and mental time travel) each species demonstrated within the literature. Linear regressions showed a positive significant relationship within Mammalia but not when assessed within taxonomic order. Aves also showed a positive relationship between foramen area and cognition, but this should be interpreted with caution due to the low sample size. AIC models and regressions assessed this study’s indicators of cognition against established literature-sourced indicators and showed our ranking system was an ...

العلاقة: https://hull-repository.worktribe.com/output/3858420Test

الإتاحة: https://doi.org/10.1111/joa.13592Test
https://hull-repository.worktribe.com/output/3858420Test

المؤلفون: Carter, Sean, Dixit, Abhijit, Lunn, Andrew, Deorukhkar, Anjum, Christian, Martin

المصدر: Pediatric Nephrology ; volume 31, issue 12, page 2257-2257 ; ISSN 0931-041X 1432-198X

مصطلحات موضوعية: Nephrology, Pediatrics, Perinatology and Child Health

الإتاحة: https://doi.org/10.1007/s00467-016-3331-7Test

المؤلفون: Lunn, Andrew, Jeffs, Katherine, Hay, Peter

المصدر: Nephrology Dialysis Transplantation ; volume 30, issue suppl_3, page iii143-iii143 ; ISSN 1460-2385 0931-0509

مصطلحات موضوعية: Transplantation, Nephrology

الإتاحة: https://doi.org/10.1093/ndt/gfv173.10Test
http://academic.oup.com/ndt/article-pdf/30/suppl_3/iii143/8122028/gfv173.10.pdfTest

المؤلفون: Harrington, Lydia Kathryn, Bautista-Rodriguez, Carles, Gomez, Anna, Lunn, Andrew, Beardsall, Kathy

المصدر: Archives of Disease in Childhood - Fetal and Neonatal Edition ; volume 107, issue 3, page 335-335 ; ISSN 1359-2998 1468-2052

مصطلحات موضوعية: Obstetrics and Gynecology, General Medicine, Pediatrics, Perinatology and Child Health

الإتاحة: https://doi.org/10.1136/archdischild-2020-321302Test