المؤلفون: de Jong, Audrey, Bignon, Anne, Stephan, François, Godet, Thomas, Constantin, Jean-Michel, Asehnoune, Karim, Sylvestre, Aude, Sautillet, Juliette, Blondonnet, Raiko, Ferrandière, Martine, Seguin, Philippe, Lasocki, Sigismond, Rollé, Amélie, Fayolle, Pierre-Marie, Muller, Laurent, Pardo, Emmanuel, Terzi, Nicolas, Ramin, Séverin, Jung, Boris, Abback, Paer-Selim, Guerci, Philippe, Sarton, Benjamine, Rozé, Hadrien, Dupuis, Claire, Cousson, Joel, Faucher, Marion, Lemiale, Virginie, Cholley, Bernard, Chanques, Gerald, Belafia, Fouad, Huguet, Helena, Futier, Emmanuel, Azoulay, Elie, Molinari, Nicolas, Jaber, Samir, Calypso, Roman, Bouteau-Durand, Astrid, Carles, Michel, Mehdaoui, Hossen, Souweine, Bertrand, Calvet, Laure, Jabaudon, Matthieu, Rieu, Benjamin, Candille, Clara, Sigaud, Florian, Riu, Beatrice, Papazian, Laurent, Valera, Sabine, Mokart, Djamel, Chow Chine, Laurent, Bisbal, Magali, Pouliquen, Camille, de Guibert, Jean-Manuel, Tourret, Maxime, Mallet, Damien, Leone, Marc, Zieleskiewicz, Laurent, Cossic, Jeanne, Assefi, Mona, Baron, Elodie, Quemeneur, Cyril, Monsel, Antoine, Biais, Matthieu, Ouattara, Alexandre, Bonnardel, Eline, Monziols, Simon, Mahul, Martin, Lefrant, Jean-Yves, Roger, Claire, Barbar, Saber, Lambiotte, Fabien, Saint-Leger, Piehr, Paugam, Catherine, Pottecher, Julien, Ludes, Pierre-Olivier, Darrivere, Lucie, Garnier, Marc, Kipnis, Eric, Lebuffe, Gilles, Garot, Matthias, Falcone, Jeremy, Chousterman, Benjamin, Collet, Magali, Gayat, Etienne, Dellamonica, Jean, Mfam, Willy-Serge, Ochin, Evelina, Nebli, Mohamed, Tilouche, Nejla, Madeux, Benjamin, Bougon, David, Aarab, Yassir, Garnier, Fanny

المساهمون: Physiologie & médecine expérimentale du Cœur et des Muscles U 1046 (PhyMedExp), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM), Centre Hospitalier Régional Universitaire Montpellier (CHRU Montpellier), Centre Hospitalier Régional Universitaire CHU Lille (CHRU Lille), Hypertension pulmonaire : physiopathologie et innovation thérapeutique (HPPIT), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay, Centre d'études et de recherche sur les services de santé et la qualité de vie (CEReSS), Aix Marseille Université (AMU), Nutrition, Métabolismes et Cancer (NuMeCan), Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Centre Hospitalier Universitaire de Rennes CHU Rennes = Rennes University Hospital Ponchaillou, Biologie des maladies cardiovasculaires = Biology of Cardiovascular Diseases, Université de Bordeaux (UB)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Hôpital universitaire Robert Debré Reims (CHU Reims), Centre Hospitalier Régional Universitaire de Montpellier, PHRCN-18–0078 Finess 340780477, Ministère des Affaires Sociales et de la Santé

المصدر: ISSN: 2213-2600.

مصطلحات موضوعية: [SDV]Life Sciences [q-bio]

الوصف: International audience

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/36693403; hal-03955429; https://hal.science/hal-03955429Test; https://hal.science/hal-03955429/documentTest; https://hal.science/hal-03955429/file/2023%20De%20jong%20et%20al.,%20Effect%20of%20non.pdfTest; PUBMED: 36693403

الإتاحة: https://doi.org/10.1016/S2213-2600Test(22)00529-X
https://hal.science/hal-03955429Test
https://hal.science/hal-03955429/documentTest
https://hal.science/hal-03955429/file/2023%20De%20jong%20et%20al.,%20Effect%20of%20non.pdfTest

المؤلفون: Solis, Morgane, Gallais, Floriane, Garnier-Kepka, Sabrina, Lefebvre, Nicolas, Benotmane, Ilies, Ludes, Pierre-Olivier, Castelain, Vincent, Meziani, Ferhat, Caillard, Sophie, Collange, Olivier, Fafi-Kremer, Samira

المصدر: Journal of Clinical Virology ; volume 148, page 105120 ; ISSN 1386-6532

مصطلحات موضوعية: Infectious Diseases, Virology

الإتاحة: https://doi.org/10.1016/j.jcv.2022.105120Test
https://api.elsevier.com/content/article/PII:S1386653222000567?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S1386653222000567?httpAccept=text/plainTest

المؤلفون: Noll, Eric, Soler, Luc, Ohana, Mickaël, Ludes, Pierre-Olivier, Pottecher, Julien, Bennett-Guerrero, Elliott, Veillon, Francis, Goichot, Bernard, Schneider, Francis, Meyer, Nicolas, Diemunsch, Pierre

المساهمون: Hôpital de Hautepierre Strasbourg, Centre Hospitalier Universitaire Strasbourg (CHU Strasbourg), Les Hôpitaux Universitaires de Strasbourg (HUS), Nouvel Hôpital Civil de Strasbourg, Mitochondrie, Stress oxydant et Protection musculaire (MSP), Université de Strasbourg (UNISTRA), L'Institut hospitalo-universitaire de Strasbourg (IHU Strasbourg), Les Hôpitaux Universitaires de Strasbourg (HUS)-Institut National de Recherche en Informatique et en Automatique (Inria)-l'Institut de Recherche contre les Cancers de l'Appareil Digestif (IRCAD)-La Fédération des Crédits Mutuels Centre Est (FCMCE)-L'Association pour la Recherche contre le Cancer (ARC)-La société Karl STORZ

المصدر: ISSN: 2352-5568 ; Anaesthesia Critical Care & Pain Medicine ; https://hal.science/hal-03522161Test ; Anaesthesia Critical Care & Pain Medicine, 2021, 40 (1), pp.100780. ⟨10.1016/j.accpm.2020.10.014⟩.

مصطلحات موضوعية: ARDS, COVID-19, CT-scan, Infectious disease, Severity assessment, Triage, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology

الوصف: Objective: Ground-glass opacities are the most frequent radiologic features of COVID-19 patients. We aimed to determine the feasibility of automated lung volume measurements, including ground-glass volumes, on the CT of suspected COVID-19 patients. Our goal was to create an automated and quantitative measure of ground-glass opacities from lung CT images that could be used clinically for diagnosis, triage and research. Design: Single centre, retrospective, observational study. Measurements: Demographic data, respiratory support treatment (synthetised in the maximal respiratory severity score) and CT-images were collected. Volume of abnormal lung parenchyma was measured with conventional semi-automatic software and with a novel automated algorithm based on voxels X-Ray attenuation. We looked for the relationship between the automated and semi-automated evaluations. The association between the ground-glass opacities volume and the maximal respiratory severity score was assessed. Main results: Thirty-seven patients were included in the main outcome analysis. The mean duration of automated and semi-automated volume measurement process were 15 (2) and 93 (41) min, respectively (p=8.05*10-8). The intraclass correlation coefficient between the semi-automated and automated measurement of ground-glass opacities and restricted normally aerated lung were both superior to 0.99. The association between the automated measured lung volume and the maximal clinical severity score was statistically significant for the restricted normally aerated (p=0.0097, effect-size: -385mL) volumes and for the ratio of ground-glass opacities/restricted normally aerated volumes (p=0.027, effect-size: 3.3). Conclusion: The feasibility and preliminary validity of automated impaired lung volume measurements in a high-density COVID-19 cluster was confirmed by our results.

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/33197638; hal-03522161; https://hal.science/hal-03522161Test; https://hal.science/hal-03522161/documentTest; https://hal.science/hal-03522161/file/S2352556820302666.pdfTest; PII: S2352-5568(20)30266-6; PUBMED: 33197638; PUBMEDCENTRAL: PMC7664353

الإتاحة: https://doi.org/10.1016/j.accpm.2020.10.014Test
https://hal.science/hal-03522161Test
https://hal.science/hal-03522161/documentTest
https://hal.science/hal-03522161/file/S2352556820302666.pdfTest

المؤلفون: Danion, François, Duval, Céline, Séverac, François, Bachellier, Philippe, Candolfi, Ermanno, Castelain, Vincent, Clere-Jehl, Raphael, Denis, Julie, Dillenseger, Laurence, Epailly, Eric, Gantzer, Justine, Guffroy, Blandine, Hansmann, Yves, Herbrecht, Jean-Etienne, Letscher-Bru, Valerie, Leyendecker, Pierre, Le van Quyen, Pauline, Ludes, Pierre-Olivier, Morel, Guillaume, Moulin, Bruno, Paillard, Catherine, Renaud-Picard, Benjamin, Roche, Anne-Claude, Sabou, Alina Marcela, Schneider, Francis, Solis, Morgane, Talagrand-Reboul, Émilie, Veillon, Francis, Ledoux, Marie-Pierre, Simand, Célestine, Herbrecht, Raoul

المساهمون: Les Hôpitaux Universitaires de Strasbourg (HUS), Institut de Cancérologie de Strasbourg Europe (ICANS), Laboratoire des sciences de l'ingénieur, de l'informatique et de l'imagerie (ICube), École Nationale du Génie de l'Eau et de l'Environnement de Strasbourg (ENGEES)-Université de Strasbourg (UNISTRA)-Les Hôpitaux Universitaires de Strasbourg (HUS)-Institut National des Sciences Appliquées - Strasbourg (INSA Strasbourg), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Centre National de la Recherche Scientifique (CNRS)-Matériaux et Nanosciences Grand-Est (MNGE), Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Chimie - CNRS Chimie (INC-CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Chimie - CNRS Chimie (INC-CNRS)-Centre National de la Recherche Scientifique (CNRS)-Réseau nanophotonique et optique, Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS), Dynamique des interactions Hôte pathogène, Université de Strasbourg (UNISTRA), Immuno-Rhumatologie Moléculaire (IRM), Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM), Nanomédecine Régénérative (NanoRegMed), Biomatériaux et Bioingénierie (BB), Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Matériaux et Nanosciences Grand-Est (MNGE), Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Chimie - CNRS Chimie (INC-CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Chimie - CNRS Chimie (INC-CNRS)-Centre National de la Recherche Scientifique (CNRS), Virulence bactérienne précoce : fonctions cellulaires et contrôle de l'infection aiguë et subaiguë, Interface de Recherche Fondamentale et Appliquée en Cancérologie (IRFAC - Inserm U1113), Centre Paul Strauss (CRLCC Paul Strauss), UNICANCER-UNICANCER-Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Fédération de Médecine Translationelle de Strasbourg (FMTS)

المصدر: ISSN: 1198-743X.

مصطلحات موضوعية: Coinfections, Fungal, Invasive fungal infections, Leukaemia, Mortality, Risk factors, [SDV.MP]Life Sciences [q-bio]/Microbiology and Parasitology

الوصف: Objectives: To describe the coinfections in invasive aspergillosis (IA), to identify factors associated with coinfections, and to evaluate the impact of coinfection on mortality.Patients and methods: We conducted a monocentric retrospective study of consecutive putative, probable, or proven IA that occurred between 1997 and 2017. All coinfections, with an onset within 7 days before or after the first sign of aspergillosis, were identified. Factors associated with coinfections and mortality were analysed by multivariable analysis.Results: Among the 690 patients with IA included in the study, the median age was 57 years (range 7 days to 90 years). A coinfection was diagnosed in 272/690 patients (39.4%, 95%CI 35.8-43.2). The location of this coinfection was pulmonary only in 131/272 patients (48%), bloodstream only in 66/272 patients (24%) and other/multiple sites in 75/272 patients (28%). Coinfections were bacterial (110/272 patients, 40%), viral (58/272, 21%), fungal (57/272, 21%), parasitic (5/272, 2%) or due to multiple types of pathogens (42/272, 15%). Factors associated with a coinfection in adjusted analysis were: allogeneic haematopoietic stem-cell transplantation (OR 2.3 (1.2-4.4)), other haematological malignancies (OR 2.1 (1.2-3.8)), other underlying diseases (OR 4.3 (1.4-13.6)), lymphopenia (OR 1.7 (1.1-2.5)), C-reactive protein >180 mg/L (OR 1.9 (1.2-3.0)), fever (OR 2.4 (1.5-4.1)), tracheal intubation (OR 2.6 (1.5-4.7)), isolation of two or more different Aspergillus species (OR 2.7 (1.1-6.3)), and the presence of non-nodular lesions on chest computed tomography (OR 2.2 (1.3-3.7) and OR 2.2 (1.2-4.0)). Coinfections were independently associated with a higher mortality at week 12 (adjusted HR 1.5 (1.1-1.9), p < 0.01).Conclusions: Coinfections are frequent in IA patients and are associated with higher mortality.

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/33662543; hal-03473453; https://hal.science/hal-03473453Test; https://hal.science/hal-03473453/documentTest; https://hal.science/hal-03473453/file/S1198743X21001038.pdfTest; PII: S1198-743X(21)00103-8; PUBMED: 33662543

الإتاحة: https://doi.org/10.1016/j.cmi.2021.02.021Test
https://hal.science/hal-03473453Test
https://hal.science/hal-03473453/documentTest
https://hal.science/hal-03473453/file/S1198743X21001038.pdfTest

المؤلفون: Ferreira, David, Ludes, Pierre-Olivier, Diemunsch, Pierre, Noll, Eric, Torp, K. D., Meyer, Nicolas

المساهمون: Laboratoire des sciences de l'ingénieur, de l'informatique et de l'imagerie (ICube), École Nationale du Génie de l'Eau et de l'Environnement de Strasbourg (ENGEES)-Université de Strasbourg (UNISTRA)-Institut National des Sciences Appliquées - Strasbourg (INSA Strasbourg), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Les Hôpitaux Universitaires de Strasbourg (HUS)-Centre National de la Recherche Scientifique (CNRS)-Matériaux et Nanosciences Grand-Est (MNGE), Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Chimie - CNRS Chimie (INC-CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Chimie - CNRS Chimie (INC-CNRS)-Centre National de la Recherche Scientifique (CNRS)-Réseau nanophotonique et optique, Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS), Mitochondrie, stress oxydant et protection musculaire (MSP), Université de Strasbourg (UNISTRA)

المصدر: ISSN: 0007-0912.

مصطلحات موضوعية: [INFO.INFO-TI]Computer Science [cs]/Image Processing [eess.IV]

العلاقة: hal-03797833; https://hal.science/hal-03797833Test; https://hal.science/hal-03797833/documentTest; https://hal.science/hal-03797833/file/S0007091220307960.pdfTest; PII: S0007-0912(20)30796-0

الإتاحة: https://doi.org/10.1016/j.bja.2020.08.062Test
https://hal.science/hal-03797833Test
https://hal.science/hal-03797833/documentTest
https://hal.science/hal-03797833/file/S0007091220307960.pdfTest

المؤلفون: Ludes, Pierre-Olivier, de Roquetaillade, Charles, Chousterman, Benjamin Glenn, Pottecher, Julien, Mebazaa, Alexandre

المصدر: Frontiers in Immunology ; volume 12 ; ISSN 1664-3224

الوصف: Damage-associated molecular patterns (DAMPs) are a group of immunostimulatory molecules, which take part in inflammatory response after tissue injury. Kidney-specific DAMPs include Tamm-Horsfall glycoprotein, crystals, and uromodulin, released by tubular damage for example. Non-kidney-specific DAMPs include intracellular particles such as nucleus [histones, high-mobility group box 1 protein (HMGB1)] and cytosol parts. DAMPs trigger innate immunity by activating the NRLP3 inflammasome, G-protein coupled class receptors or the Toll-like receptor. Tubular necrosis leads to acute kidney injury (AKI) in either septic, ischemic or toxic conditions. Tubular necrosis releases DAMPs such as histones and HMGB1 and increases vascular permeability, which perpetuates shock and hypoperfusion via Toll Like Receptors. In acute tubular necrosis, intracellular abundance of NADPH may explain a chain reaction where necrosis spreads from cell to cell. The nature AKI in intensive care units does not have preclinical models that meet a variation of blood perfusion or a variation of glomerular filtration within hours before catecholamine infusion. However, the dampening of several DAMPs in AKI could provide organ protection. Research should be focused on the numerous pathophysiological pathways to identify the relative contribution to renal dysfunction. The therapeutic perspectives could be strategies to suppress side effect of DAMPs and to promote renal function regeneration.

الإتاحة: https://doi.org/10.3389/fimmu.2021.606622Test

المؤلفون: Ludes, Pierre-Olivier, Diemunsch, Sophie, Dupanloup, Danièle, Noll, Eric, Pottecher, Julien

المصدر: Oxymag ; volume 34, issue 177, page 16-20 ; ISSN 0990-1310

مصطلحات موضوعية: Emergency Nursing, Emergency Medicine

الإتاحة: https://doi.org/10.1016/j.oxy.2021.03.004Test
https://api.elsevier.com/content/article/PII:S0990131021000256?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S0990131021000256?httpAccept=text/plainTest

المؤلفون: Marjanovic, Nicolas, Boisson, Matthieu, Asehnoune, Karim, Foucrier, Arnaud, Lasocki, Sigismond, Ichai, Carole, Leone, Marc, Pottecher, Julien, Lefrant, Jean-Yves, Falcon, Dominique, Veber, Benoit, Chabanne, Russell, Drevet, Claire-Marie, Pili-Floury, Sébastien, Dahyot-Fizelier, Claire, Kerforne, Thomas, Seguin, Sabrina, de Keizer, Joe, Frasca, Denis, Guenezan, Jérémy, Mimoz, Olivier, Besch, Guillaume, Bouhemad, Bélaid, Caumon, Elodie, Chamaraux-Tran, Thien-Nga, Cinotti, Raphael, Gaillard, Thomas, Gergaud, Soizic, Ginet, Marc, Gouin, Philippe, Grimaldi, Florian, Guitard, Pierre-Gildas, Hammad, Emmanuelle, Kelesyan, Lilit, Leduc, Sébastien, Leger, Maxime, Ludes, Pierre-Olivier, Muler, Laurent, Nadji, Abdelouaid, Paugam-Burtz, Catherine, Po, Marie-Héléne, Quintard, Hervé, Roger, Claire, Roquilly, Antoine

المساهمون: Ministère des Affaires Sociales et de la Santé, Ministere de la Sante et des Solidarites

المصدر: Chest ; volume 160, issue 2, page 499-508 ; ISSN 0012-3692

مصطلحات موضوعية: Cardiology and Cardiovascular Medicine, Critical Care and Intensive Care Medicine, Pulmonary and Respiratory Medicine

الإتاحة: https://doi.org/10.1016/j.chest.2021.03.007Test
https://api.elsevier.com/content/article/PII:S0012369221004815?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S0012369221004815?httpAccept=text/plainTest

المؤلفون: Schneider, Francis, Castelain, Vincent, Morel, Guillaume, Dureau, Anne-Florence, Poidevin, Antoine, Ludes, Pierre-Olivier, Fabacher, Thibaut, Senger, Bernard, Meyer, Nicolas, Metz-Boutigue, Marie-Hélène

المساهمون: Biomatériaux et Bioingénierie (BB), Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Matériaux et Nanosciences Grand-Est (MNGE), Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Chimie - CNRS Chimie (INC-CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Chimie - CNRS Chimie (INC-CNRS)-Centre National de la Recherche Scientifique (CNRS), Hôpital de Hautepierre Strasbourg, Fédération de Médecine Translationnelle de Strasbourg (FMTS), Université de Strasbourg (UNISTRA), Centre Hospitalier Emile Muller Mulhouse (CH E.Muller Mulhouse), Groupe Hospitalier de Territoire Haute Alsace (GHTHA), Centre Hospitalier Universitaire Strasbourg (CHU Strasbourg), Les Hôpitaux Universitaires de Strasbourg (HUS), Laboratoire des sciences de l'ingénieur, de l'informatique et de l'imagerie (ICube), École Nationale du Génie de l'Eau et de l'Environnement de Strasbourg (ENGEES)-Université de Strasbourg (UNISTRA)-Les Hôpitaux Universitaires de Strasbourg (HUS)-Institut National des Sciences Appliquées - Strasbourg (INSA Strasbourg), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Centre National de la Recherche Scientifique (CNRS)-Matériaux et Nanosciences Grand-Est (MNGE), Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Chimie - CNRS Chimie (INC-CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Chimie - CNRS Chimie (INC-CNRS)-Centre National de la Recherche Scientifique (CNRS)-Réseau nanophotonique et optique, Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS)

المصدر: ISSN: 2330-4316 ; American Journal of Internal Medicine ; https://hal.science/hal-03711976Test ; American Journal of Internal Medicine, 2020, 8 (3), pp.89-100. ⟨10.11648/j.ajim.20200803.11⟩.

مصطلحات موضوعية: Albumin, Care-related Infection, Outcome, Oxidative Stress, Septic Shock, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology, [SDV.SP.PHARMA]Life Sciences [q-bio]/Pharmaceutical sciences/Pharmacology, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie

الوصف: Whether a specific way of infusing albumin affects outcome in patients with major oxidative stress remains uncertain. To determine whether outcome measurements (survival, organ failure and care-related infections) are different according to different regimens of albumin infusion, we conducted a phase IV, randomized, open-label trial to compare the effects of continuous infusion of 4 percent albumin versus intermittent 20 percent albumin on outcome measurements in three third level-hospital intensive care unit (ICU) patients with septic shock. We randomly assigned 125 consecutive patients with septic shock when serum albumin became <20g/L. Patients received either 4 percent albumin (12.5mL/kg) continuously or 20 percent albumin (100mL over 1h/8h) intermittently (controls) until serum albumin ranged between 25 and 30g/L and norepinephrine could be weaned. The primary outcome measure was death from any cause during the 28-day period after randomization. The other outcome parameters were ICU- and hospital length of stay, serum albumin concentrations, SOFA score and lactate over the 4 days following inclusion, care-related infections and tolerance of albumin over the 28-day period after randomization. Data were analyzed with Bayesian methods. Of the 125 patients who underwent randomization, 63 received 4 percent albumin and 62 received 20 percent albumin; groups had balanced baseline characteristics. There were 19 deaths in the experimental group, as compared with 20 in the control group (Pr=0.40). The proportion of patients with new multiple-organ failure (assessed by daily SOFA) was similar in the groups (RR=0.71 [0.29-1.41], Pr=0.14). There were no differences in the medians [IQR]) numbers of days spent in the ICU (12.0 [7.5; 22.0] versus 13 [8.0; 24.5] days, Pr=0.23), in days spent within hospital (29.0 [10.5; 44.0] versus 24 [14.0; 46.8] days, Pr=0.32). In contrast, there were fewer patients with care-related infection in the study group, (14.3% versus 45.2%, Pr<0.001). Limitations concern lack of double ...

العلاقة: hal-03711976; https://hal.science/hal-03711976Test; https://hal.science/hal-03711976/documentTest; https://hal.science/hal-03711976/file/10.11648.j.ajim.20200803.11.pdfTest

الإتاحة: https://doi.org/10.11648/j.ajim.20200803.11Test
https://hal.science/hal-03711976Test
https://hal.science/hal-03711976/documentTest

المؤلفون: Noll, Eric, Muccioli, Christophe, Ludes, Pierre-Olivier, Pottecher, Julien, Diemunsch, Pierre, Diemunsch, Sophie, Tchentcheli, Anaëlle, Clavert, Philippe, Joshi, Girish P., Liverneaux, Philippe A.

المصدر: Surgical Innovation ; volume 27, issue 6, page 564-569 ; ISSN 1553-3506 1553-3514

مصطلحات موضوعية: Surgery

الوصف: Background. The COVID-19 epidemic has resulted in a massive surge in the need for intensive care unit (ICU) care. To avoid being overwhelmed, hospitals had to adapt and support the ICU teams in structured ICU care including involving surgical teams. This work aims at describing the collaborative efforts between the ICU care team and the Surgical Task Force (STF) during a surge of ICU activity in a University Hospital in a French high-density COVID-19 cluster. Study Design. This retrospective single center study analyzed the STF workflow and the ICU population. The study included 55 patients hospitalized in our ICU, ICU-converted step-down units, and post-anesthesia care units. The primary measure was the global daily STF activity. The secondary measure was the daily activity for each of the 5 tasks accomplished by the STF. Results. The STF attempted 415 phone calls for 55 patients’ families, 237 mobilizations of patients requiring prone positions, follow-up of 20 patients requiring medevac, and contribution to ethical discussion for 2 patients. The mean (SD) daily number of successful phones calls, ethical discussions, mobilizations of patients requiring prone positions and medevac follow-up were 18 (7), .1 (.4), 10 (7), and 2 (3), respectively. No actions for discharge summaries writing were required. The maximum number of daily mobilizations for patients requiring prone positions was 25. The maximum number of daily attempted phone calls and successful phone calls were 37 and 26, respectively. Conclusion. Surgeons’ technical and nontechnical skills represented an effective support for ICU teams during the COVID-19 pandemic.

الإتاحة: https://doi.org/10.1177/1553350620954571Test