المؤلفون: Lacour, Jean-Philippe, Khemis, Abdallah, Giordano-Labadie, Francoise, Martin, Ludovic, Staumont, delphine, Hacard, Florence, Tian, Haijun, Mcbride, Doreen, Hollis, Kelly, Hunter, Shannon, Martin, Laurent, Lamirand, Audrey, Le Guen, Sophie, Balp, Maria-Magdalena, Berard, Frederic

المساهمون: Université Côte d'Azur UniCA, Centre Hospitalier Universitaire de Toulouse CHU Toulouse, Centre Hospitalier Universitaire d'Angers CHU Angers, Récepteurs nucléaires, Maladies Cardiovasculaires et Diabète (EGID) - U1011, Université Claude Bernard Lyon 1 UCBL

مصطلحات موضوعية: chronic idiopathic urticaria, chronic spontaneous urticaria, observational study, health economics, health-related quality of life, angioedema

الوصف: Data on the clinical burden of chronic spontaneous urticaria (CSU) and economic consequences are lacking in France. To characterize the clinical and economic burden of CSU in symptomatic patients despite treatment by analysing data of French patients from the ASSURE-CSU study. ASSURE-CSU was an international observational study that included CSU patients with symptoms that lasted for 12 months or more despite treatment. Disease characteristics and healthcare resource use were obtained from medical records. Data on disease history, health-related quality of life (HR-QoL), and work productivity were collected from a patient survey. A total of 101 patients were analysed (76.2% female; mean age: 48.9 years) with moderate to severe disease (UAS7 score ≥16) in 43.4% and angioedema in 72.3%. The mean (S.D.) total scores of Chronic Urticaria Quality of Life (CU-Q2 ; 28

العلاقة: European Journal of Dermatology; Eur J Dermatol; http://hdl.handle.net/20.500.12210/104916Test

الإتاحة: https://doi.org/20.500.12210/104916Test
https://hdl.handle.net/20.500.12210/104916Test

المؤلفون: Bernstein, Jonathan A., Maurer, Marcus, Giménez-Arnau, Ana, Soong, Weily, Sitz, Karl, Hua, Eva, Barbier, Nathalie, Barve, Avantika, Severin, Thomas, Reinhold, Janocha, Lamirand, Audrey

المصدر: Annales de Dermatologie et de Vénéréologie - FMC ; volume 1, issue 8, page A356-A357 ; ISSN 2667-0623

مصطلحات موضوعية: Ocean Engineering, Safety, Risk, Reliability and Quality

الإتاحة: https://doi.org/10.1016/j.fander.2021.09.431Test
https://api.elsevier.com/content/article/PII:S266706232100708X?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S266706232100708X?httpAccept=text/plainTest

المؤلفون: Bernstein, Jonathan A., Maurer, Marcus, Giménez-Arnau, Ana, Soong, Weily, Metz, Martin, Barbier, Nathalie, Barve, Avantika, Severin, Thomas, Balp, Maria-Magdalena, Reinhold, Janocha, Lamirand, Audrey

المصدر: Annales de Dermatologie et de Vénéréologie - FMC ; volume 1, issue 8, page A357-A358 ; ISSN 2667-0623

مصطلحات موضوعية: Ocean Engineering, Safety, Risk, Reliability and Quality

الإتاحة: https://doi.org/10.1016/j.fander.2021.09.433Test
https://api.elsevier.com/content/article/PII:S2667062321007108?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S2667062321007108?httpAccept=text/plainTest

المؤلفون: Lacour, Jean-Philippe, Khemis, Abdallah, Giordano-Labadie, Françoise, Martin, Ludovic, Staumont-Sallé, Delphine, Hacard, Florence, Tian, Haijun, Mcbride, Doreen, Hollis, Kelly, Hunter, Shannon, Martin, Laurent, Lamirand, Audrey, Le Guen, Sophie, Balp, Maria-Magdalena, Bérard, Frédéric

المساهمون: Centre de Référence des Epidermolyses Bulleuses Héréditaires Nice (CREBHN), Centre Hospitalier Universitaire de Nice (CHU Nice), Department of Dermatology, MitoVasc - Physiopathologie Cardiovasculaire et Mitochondriale (MITOVASC), Université d'Angers (UA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Service de Dermatologie, Centre Hospitalier Régional Universitaire CHU Lille (CHRU Lille), Récepteurs nucléaires, maladies cardiovasculaires et diabète - U 1011 (RNMCD), Institut Pasteur de Lille, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire CHU Lille (CHRU Lille), Centre Hospitalier Lyon Sud CHU - HCL (CHLS), Hospices Civils de Lyon (HCL), Institut NeuroMyoGène (INMG), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Clinical Research Department, Necker–Enfants Malades Hospital, APHP, Paris, France, Immunologie de l'allergie cutanée et vaccination – Immunology of skin allergy and vaccination, Centre International de Recherche en Infectiologie (CIRI), École normale supérieure de Lyon (ENS de Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-École normale supérieure de Lyon (ENS de Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)

المصدر: ISSN: 1167-1122.

مصطلحات موضوعية: [SDV]Life Sciences [q-bio]

الوصف: International audience ; Data on the clinical burden of chronic spontaneous urticaria (CSU) and economic consequences are lacking in France. To characterize the clinical and economic burden of CSU in symptomatic patients despite treatment by analysing data of French patients from the ASSURE-CSU study. ASSURE-CSU was an international observational study that included CSU patients with symptoms that lasted for 12 months or more despite treatment. Disease characteristics and healthcare resource use were obtained from medical records. Data on disease history, health-related quality of life (HR-QoL), and work productivity were collected from a patient survey. A total of 101 patients were analysed (76.2% female; mean age: 48.9 years) with moderate to severe disease (UAS7 score ≥16) in 43.4% and angioedema in 72.3%. The mean (S.D.) total scores of Chronic Urticaria Quality of Life (CU-QoL) and Dermatology Life Quality Index (DLQI) were 37.7 (22.3) and 9.7 (6.9), respectively, thus indicating a significant impact of the disease on HR-QoL. Mean absenteeism and presenteeism were 6.4% and 20.8%, respectively, with a mean loss of work productivity estimated at 20.7%. The mean (S.D.) total direct cost of CSU was €2,397 per patient per year and was mainly driven by therapies (€1,435) and inpatient costs (€859). The indirect costs for four weeks were mainly presenteeism (€421) and loss of work productivity (€420). CSU significantly impairs HR-QoL, which increases with the severity of the disease. The direct and indirect costs for the management of symptomatic CSU are an important economic burden.

العلاقة: hal-02616913; https://univ-angers.hal.science/hal-02616913Test; OKINA: ua18848

الإتاحة: https://doi.org/10.1684/ejd.2018.3446Test
https://univ-angers.hal.science/hal-02616913Test

المؤلفون: GIORDANO-LABADIE, Françoise, BECHEREL, Pierre-André, PRALONG, Pauline, OUTTAS, Omar, RUER-MULARD, Mireille, BERARD, Frédéric, GRECO, Matthieu, LACOUR, Jean-Philippe, DEBONS-PEYROUTET, Michèle, PELVET, Bérengère, LAMIRAND, Audrey, GUILLET, Gérard

المصدر: European Journal of Dermatology; mar/avr2021, Vol. 31 Issue 2, p217-224, 8p

المؤلفون: Courtin, Françoise, Zrouri, Hassan, Lamirand, Audrey, Li, Wu Wen, Mercier, Gilles, Schumacher, Michael, Goascogne, Claude Le, Pierre, Michel

المصدر: Thyroid ; volume 15, issue 8, page 931-942 ; ISSN 1050-7256 1557-9077

الإتاحة: https://doi.org/10.1089/thy.2005.15.931Test

المؤلفون: Grenier, Julien, Trousson, Amalia, Chauchereau, Anne, Amazit, Larbi, Lamirand, Audrey, Leclerc, Philippe, Guiochon-Mantel, Anne, Schumacher, Michael, Massaad, Charbel

المساهمون: Stéroïdes et système nerveux : physiopathologie moléculaire et clinique, Institut National de la Santé et de la Recherche Médicale (INSERM), Faculté de Médecine Paris-Sud, Université Paris-Sud - Paris 11 (UP11), Génétique oncologique (GO - UMR 8125), Université Paris-Sud - Paris 11 (UP11)-Institut Gustave Roussy (IGR)-Centre National de la Recherche Scientifique (CNRS), Récepteurs stéroïdiens : physiopathologie endocrinienne et métabolique, Université Paris-Sud - Paris 11 (UP11)-IFR93-Institut National de la Santé et de la Recherche Médicale (INSERM), IFR de Bicêtre, Université Paris-Sud - Paris 11 (UP11)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM), Service de génétique moléculaire, pharmacogénétique et hormonologie, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Bicêtre AP-HP, Le Kremlin-Bicêtre, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)

المصدر: ISSN: 0888-8809 ; Molecular Endocrinology -Baltimore- ; https://hal.science/hal-01939763Test ; Molecular Endocrinology -Baltimore-, 2004, 18 (12), pp.2866-79. ⟨10.1210/me.2004-0241⟩.

مصطلحات موضوعية: [SDV.CAN]Life Sciences [q-bio]/Cancer, [SDV.BBM.MN]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Molecular Networks [q-bio.MN], [SDV.BBM.BM]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Molecular biology

الوصف: International audience ; In the nervous system, glucocorticoid hormones play a major role during development and throughout life. We studied the mechanisms of action of the glucocorticoid receptor (GR) and its interactions with p160 coactivator family members [steroid receptor coactivator (SRC)-1 (a and e), SRC-2 and SRC-3] in mouse Schwann cells (MSC80). We found that the three p160s were expressed in MSC80 cells. We have shown by functional overexpression and RNA interference experiments that the recruitment of these coactivators by the GR is promoter dependent. A minimal promoter containing two glucocorticoid response elements, (GRE)2-TATA, recruits SRC-1 (a and e) and SRC-3, whereas SRC-2 is excluded. Within the context of the more complex mouse mammary tumor virus promoter, GR recruits SRC-1e and SRC-2, whereas SRC-1a and SRC-3 are not implicated. Furthermore, we have identified cytosolic aspartate aminotransferase as a GR target gene in MSC80 cells by microarray experiments. The GR recruits exclusively SRC-1e in the context of the cytosolic aspartate aminotransferase promoter. Because SRC-1 is the omnipresent coactivator of GR, we further investigated the interactions between GR and this coactivator in Schwann cells by reporter assays and immunocytochemistry experiments with deleted forms of SRC-1. We have shown that SRC-1 unexpectedly interacts with GR via its two nuclear receptor binding domains, thus providing a novel mechanism of GR signaling within the nervous system.

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/15331759; hal-01939763; https://hal.science/hal-01939763Test; PUBMED: 15331759

الإتاحة: https://doi.org/10.1210/me.2004-0241Test
https://hal.science/hal-01939763Test