المؤلفون: Gale, Chris, Sharkey, Don, Fitzpatrick, Kathryn E, Mactier, Helen, Morelli, Alessandra, Nakahara, Mariko, Hurd, Madeleine, Placzek, Anna, Knight, Marian, Ladhani, Shamez N, Draper, Elizabeth S, Doherty, Cora, Quigley, Maria A, Kurinczuk, Jennifer J, Neonatal complications of COVID-19 Collaborative Group

مصطلحات موضوعية: Original research

الوصف: Objective Neonatal infection with wildtype SARS-CoV-2 is rare and good outcomes predominate. We investigated neonatal outcomes using national population-level data to describe the impact of different SARS-CoV-2 variants. Design Prospective population-based cohort study. Setting Neonatal, paediatric and paediatric intensive care inpatient care settings in the UK. Patients Neonates (first 28 days after birth) with confirmed SARS-CoV-2 infection who received inpatient care, March 2020 to April 2022. Neonates were identified through active national surveillance with linkage to national SARS-CoV-2 testing data, routinely recorded neonatal data, paediatric intensive care data and obstetric and perinatal mortality surveillance data. Outcomes Presenting signs, clinical course, severe disease requiring respiratory support are presented by the dominant SARS-CoV-2 variant in circulation at the time. Results 344 neonates with SARS-CoV-2 infection received inpatient care; breakdown by dominant variant: 146 wildtype, 123 alpha, 57 delta and 18 omicron. Overall, 44.7% (153/342) neonates required respiratory support; short-term outcomes were good with 93.6% (322/344) of neonates discharged home. Eleven neonates died: seven unrelated to SARS-CoV-2 infection, four were attributed to neonatal SARS-CoV-2 infection (case fatality 4/344, 1.2% 95% CI 0.3% to 3.0%) of which three were born preterm due to maternal COVID-19. More neonates were born very preterm (23/54) and required invasive ventilation (27/57) when delta variant was predominant, and all four SARS-CoV-2-related deaths occurred in this period. Conclusions Inpatient care for neonates with SARS-CoV-2 was uncommon. Although rare, severe neonatal illness was more common during the delta variant period, potentially reflecting more severe maternal disease and associated preterm birth. Trial registration number ISRCTN60033461 .

وصف الملف: text/html

العلاقة: http://fn.bmj.com/cgi/content/short/109/3/279Test; http://dx.doi.org/10.1136/archdischild-2023-326167Test

الإتاحة: https://doi.org/10.1136/archdischild-2023-326167Test
http://fn.bmj.com/cgi/content/short/109/3/279Test

المؤلفون: Broughan, Jennifer M, Martin, Danielle, Higgins, Thomas, Swan, Gillian, Cullum, Adrienne, Kurinczuk, Jennifer J, Draper, Elizabeth S, Luyt, Karen, Wellesley, Diana G, Stevens, Sarah, Tedstone, Alison, Rankin, Judith

مصطلحات موضوعية: Original research

الوصف: Objectives To determine the baseline trends in the total birth prevalence of neural tube defects (NTDs) in England (2000–2019) to enable the impact of folic acid fortification of non-wholemeal wheat flour to be monitored. Design Population-based, observational study using congenital anomaly (CA) registration data for England curated by the National Congenital Anomaly and Rare Disease Registration Service (NCARDRS). Setting Regions of England with active registration in the time period. Participants Babies that were liveborn or stillborn and pregnancies that resulted in a termination of pregnancy or a late miscarriage (20–23 weeks’ gestation) with an NTD. Main outcome measures Total birth prevalence of anencephaly, spina bifida and all NTDs in England. Poisson regression analysis was used to evaluate time trends with regional register as a random effect. The progress of national registration across England was assessed. Results There were 4541 NTD pregnancies out of 3 637 842 births in England; 1982 anencephaly and 2127 spina bifida. NTD prevalence was 12.5 (95% CI 12.1 to 12.9) per 10 000 total births. NTD prevalence per 10 000 total births was significantly higher in 2015–2019 (13.6, 95% CI 12.9 to 14.4) compared with 2010–2014 (12.1, 95% CI 11.7 to 12.5). An increasing trend in NTDs overall was detected (incidence rate ratio (IRR) 1.01, 1.00 to 1.02), although further analysis determined this effect was confined to 2015–2019 (compared against 2000–2004, IRR 1.14, 1.04 to 1.24). The birth prevalence of anencephaly reflected this pattern. The prevalence of spina bifida remained relatively stable over time. Conclusions Baseline NTD prevalence for England has been established. National and standardised CA registration is in place, facilitating the systematic and consistent monitoring of pre-fortification and post-fortification NTD trends and evaluating the impact of fortification on NTD prevalence.

وصف الملف: text/html

العلاقة: http://adc.bmj.com/cgi/content/short/109/2/106Test; http://dx.doi.org/10.1136/archdischild-2023-325856Test

الإتاحة: https://doi.org/10.1136/archdischild-2023-325856Test
http://adc.bmj.com/cgi/content/short/109/2/106Test

المؤلفون: Boo, Yebeen Ysabelle, Bora, Amrit K., Chhabra, Shakuntala, Choudhury, Saswati S., Deka, Gitanjali, Kakoty, Swapna, Kumar, Pramod, Mahanta, Pranabika, Minz, Bina, Rani, Anjali, Rao, Sereesha, Roy, Indrani, Solomi V., Carolin, Verma, Ashok, Zahir, Farzana, Deka, Rupanjali, Kurinczuk, Jennifer J., Nair, Manisha

المساهمون: Kellogg College, University of Oxford

المصدر: International Journal of Gynecology & Obstetrics ; volume 165, issue 2, page 462-473 ; ISSN 0020-7292 1879-3479

الوصف: Objective This study aimed to investigate the incidence of and risk factors for stillbirth in an Indian population. Methods We conducted a secondary data analysis of a hospital‐based cohort from the Maternal and Perinatal Health Research collaboration, India (MaatHRI), including pregnant women who gave birth between October 2018–September 2023. Data from 9823 singleton pregnancies recruited from 13 hospitals across six Indian states were included. Univariable and multivariable Poisson regression analysis were performed to examine the relationship between stillbirth and potential risk factors. Model prediction was assessed using the area under the receiver‐operating characteristic (AUROC) curve. Results There were 216 stillbirths (48 antepartum and 168 intrapartum) in the study population, representing an overall stillbirth rate of 22.0 per 1000 total births (95% confidence interval [CI]: 19.2–25.1). Modifiable risk factors for stillbirth were: receiving less than four antenatal check‐ups (adjusted relative risk [aRR]: 1.75, 95% CI: 1.25–2.47), not taking any iron and folic acid supplementation during pregnancy (aRR: 7.23, 95% CI: 2.12–45.33) and having severe anemia in the third trimester (aRR: 3.37, 95% CI: 1.97–6.11). Having pregnancy/fetal complications such as hypertensive disorders of pregnancy (aRR: 1.59, 95% CI: 1.03–2.36), preterm birth (aRR: 4.41, 95% CI: 3.21–6.08) and birth weight below the 10th percentile for gestational age (aRR: 1.35, 95% CI: 1.02–1.79) were also associated with an increased risk of stillbirth. Identified risk factors explained 78.2% (95% CI: 75.0%–81.4%) of the risk of stillbirth in the population. Conclusion Addressing potentially modifiable antenatal factors could reduce the risk of stillbirths in India.

الإتاحة: https://doi.org/10.1002/ijgo.15367Test

المؤلفون: Jackson, Rebecca, Cornish, Rosie P, Daskalopoulou, Zoe, Gale, Christopher, Hurd, Madeleine, Johnson, Samantha, Knight, Marian, Kurinczuk, Jennifer J., Woodward, Kathryn M, Chakkarapani, Elavazhagan

المصدر: Jackson , R , Cornish , R P , Daskalopoulou , Z , Gale , C , Hurd , M , Johnson , S , Knight , M , Kurinczuk , J J , Woodward , K M & Chakkarapani , E 2024 , ' Association of antenatal or neonatal SARS-CoV-2 exposure with developmental and respiratory outcomes, and healthcare usage in early childhood : a national prospective cohort study ' , EClinicalMedicine , vol. 72 , 102628 . https://doi.org/10.1016Test/j.eclinm.2024.102628

الوصف: Background Perinatal exposure to SARS-CoV-2 may affect neurodevelopment before 12 months of age, but longer-term outcomes remain unknown. We examined whether antenatal or neonatal SARS-CoV-2 exposure compared with non-exposure is associated with neurodevelopment, respiratory symptoms, and health care usage in early childhood. Methods This prospective national population-based cohort study was conducted in England and Wales, United Kingdom. We enrolled term-born children (≥37 weeks' gestation) with and without antenatal or neonatal exposure to SARS-CoV-2 infection by approaching parents of eligible children who were cared for in 87 NHS hospitals. Potential participants were identified through the national active surveillance studies of pregnant women and newborn infants hospitalised with confirmed SARS-CoV-2 infection conducted through the UK Obstetric Surveillance System and the British Paediatric Surveillance Unit. We defined antenatal and neonatal SARS-CoV-2 exposure as infants born to mothers hospitalised with confirmed SARS-CoV-2 infection between 14 + 0 and 36 + 6 weeks gestation and infants admitted to hospital with confirmed SARS-CoV-2 infection within the first 28 days after birth. Children born preterm or with major congenital anomaly or who were not residing in the UK were excluded. We assessed children's development (Ages and Stages Questionnaire 3rd Edition (ASQ-3); Ages and Stages Questionnaire Social-Emotional 2nd Edition (ASQ:SE-2)), respiratory symptoms (Liverpool Respiratory Symptom Questionnaire (LRSQ)) and health care usage (parent-completed questionnaire) at 21–32 months of age. Primary outcome: total ASQ-3 score, converted to z-scores. Secondary outcomes: ASQ:SE-2 z-scores; risk of delay in ASQ-3 domains; total LRSQ scores, converted to z-scores. Analyses were adjusted for children's age, sex, maternal ethnicity, parental education, and index of multiple deprivation. Findings Between October 20, 2021 and January 27, 2023, we approached 668 and 1877 families out of 712 and 1917 potentially ...

العلاقة: https://research-information.bris.ac.uk/en/publications/918129a5-e4c7-4b33-942b-a6f338cb70d5Test

الإتاحة: https://doi.org/10.1016Test/j.eclinm.2024.102628
https://hdl.handle.net/1983/918129a5-e4c7-4b33-942b-a6f338cb70d5Test
https://research-information.bris.ac.uk/en/publications/918129a5-e4c7-4b33-942b-a6f338cb70d5Test

المؤلفون: Vousden, Nicola, Bunch, Kathryn, Kenyon, Sara, Kurinczuk, Jennifer J., Knight, Marian

المصدر: The Lancet Regional Health - Europe ; volume 40, page 100893 ; ISSN 2666-7762

مصطلحات موضوعية: Health Policy, Oncology, Internal Medicine

الإتاحة: https://doi.org/10.1016Test/j.lanepe.2024.100893
https://api.elsevier.com/content/article/PII:S2666776224000590?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S2666776224000590?httpAccept=text/plainTest

المؤلفون: Gwacham-Anisiobi, Uchenna, Boo, Yebeen Ysabelle, Oladimeji, Adetola, Kurinczuk, Jennifer J., Roberts, Nia, Opondo, Charles, Nair, Manisha

المصدر: eClinicalMedicine ; volume 67, page 102386 ; ISSN 2589-5370

مصطلحات موضوعية: General Medicine

الإتاحة: https://doi.org/10.1016Test/j.eclinm.2023.102386
https://api.elsevier.com/content/article/PII:S2589537023005631?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S2589537023005631?httpAccept=text/plainTest

المؤلفون: Goulding, Anna, McQuaid, Fiona, Lindsay, Laura, Agrawal, Utkarsh, Auyeung, Bonnie, Calvert, Clara, Carruthers, Jake, Denny, Cheryl, Donaghy, Jack, Hillman, Sam, Hopcroft, Lisa, Hopkins, Leanne, McCowan, Colin, McLaughlin, Terry, Moore, Emily, Ritchie, Lewis, Simpson, Colin R, Taylor, Bob, Fenton, Lynda, Pollock, Louisa, Gale, Christopher, Kurinczuk, Jennifer J, Robertson, Chris, Sheikh, Aziz, Stock, Sarah, Wood, Rachael

المصدر: Goulding , A , McQuaid , F , Lindsay , L , Agrawal , U , Auyeung , B , Calvert , C , Carruthers , J , Denny , C , Donaghy , J , Hillman , S , Hopcroft , L , Hopkins , L , McCowan , C , McLaughlin , T , Moore , E , Ritchie , L , Simpson , C R , Taylor , B , Fenton , L , Pollock , L , Gale , C , Kurinczuk , J J , Robertson , C , Sheikh , A , Stock ....

مصطلحات موضوعية: COVID-19, Neonatology, Epidemiology

الوصف: Objectives : To examine neonates in Scotland aged 0–27 days with SARS-CoV-2 infection confirmed by viral testing; the risk of confirmed neonatal infection by maternal and infant characteristics; and hospital admissions associated with confirmed neonatal infections. Design : Population-based cohort study. Setting and population : All live births in Scotland, 1 March 2020–31 January 2022. Results : There were 141 neonates with confirmed SARS-CoV-2 infection over the study period, giving an overall infection rate of 153 per 100 000 live births (141/92 009, 0.15%). Among infants born to women with confirmed infection around the time of birth, the confirmed neonatal infection rate was 1812 per 100 000 live births (15/828, 1.8%). Two-thirds (92/141, 65.2%) of neonates with confirmed infection had an associated admission to neonatal or (more commonly) paediatric care. Six of these babies (6/92, 6.5%) were admitted to neonatal and/or paediatric intensive care; however, none of these six had COVID-19 recorded as their main diagnosis. There were no neonatal deaths among babies with confirmed infection. Implications and relevance : Confirmed neonatal SARS-CoV-2 infection was uncommon over the first 23 months of the pandemic in Scotland. Secular trends in the neonatal confirmed infection rate broadly followed those seen in the general population, although at a lower level. Maternal confirmed infection at birth was associated with an increased risk of neonatal confirmed infection. Two-thirds of neonates with confirmed infection had an associated admission to hospital, with resulting implications for the baby, family and services, although their outcomes were generally good. Ascertainment of confirmed infection depends on the extent of testing, and this is likely to have varied over time and between groups: the extent of unconfirmed infection is inevitably unknown.

وصف الملف: application/pdf

العلاقة: https://research-portal.st-andrews.ac.uk/en/researchoutput/confirmed-sarscov2-infection-in-scottish-neonates-20202022Test(feed70e6-5830-4366-b2f9-34e448163e39).html

الإتاحة: https://doi.org/10.1136/archdischild-2022-324713Test
https://research-portal.st-andrews.ac.uk/en/researchoutput/confirmed-sarscov2-infection-in-scottish-neonates-20202022Test(feed70e6-5830-4366-b2f9-34e448163e39).html
https://research-repository.st-andrews.ac.uk/bitstream/10023/26753/1/Goulding_2023_ADiC_Confirmed_SARS_CoV2_neonates_CC.pdfTest

المؤلفون: Coi, Alessio, Barisic, Ingeborg, Garne, Ester, Pierini, Anna, Addor, Marie‐claude, Aizpurua Atxega, Amaia, Ballardini, Elisa, Braz, Paula, Broughan, Jennifer, M, Cavero‐carbonell, Clara, de Walle, Hermien, E K, Draper, Elizabeth, S, Gatt, Miriam, Häusler, Martin, Kinsner‐ovaskainen, Agnieszka, Kurinczuk, Jennifer, J, Lelong, Nathalie, Luyt, Karen, Mezzasalma, Lorena, Mullaney, Carmel, Nelen, Vera, Odak, Ljubica, O'Mahony, Mary, T, Perthus, Isabelle, Randrianaivo, Hanitra, Rankin, Judith, Rissmann, Anke, Rouget, Florence, Schaub, Bruno, Tucker, David, Wellesley, Diana, Wiśniewska, Katarzyna, Yevtushok, Lyubov, Santoro, Michele

المساهمون: Istituti di Ricovero e Cura a Carattere Scientifico (IRCCS), University of Zagreb, Obstetrical, Perinatal and Pediatric Epidemiology, Centre for Research in Epidemiology and Statistics, Conservatoire National des Arts et Métiers CNAM (CNAM), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Conservatoire National des Arts et Métiers CNAM (CNAM), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), CEMC-Auvergne, Institut de Veille Sanitaire (INVS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Agence Régionale de Santé d'Auvergne, Centre Hospitalier Universitaire de La Réunion (CHU La Réunion), Institut de recherche en santé, environnement et travail (Irset), Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique EHESP (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Centre Hospitalier Universitaire de Rennes CHU Rennes = Rennes University Hospital Ponchaillou, Centre Hospitalier Universitaire de Martinique Fort-de-France, Martinique, University Hospital Southampton NHS Foundation Trust, Poznan University of Medical Sciences Poland (PUMS)

المصدر: ISSN: 0926-9959.

مصطلحات موضوعية: aplasia cutis congenita, congenital anomaly, EUROCAT, population-based study, [SDV.MHEP.DERM]Life Sciences [q-bio]/Human health and pathology/Dermatology

الوصف: International audience ; Background: Aplasia cutis congenita (ACC) is a rare congenital anomaly characterized by localized or widespread absence of skin at birth, mainly affecting the scalp. Most information about ACC exists as individual case reports and medium-sized studies.Objectives: This study aimed to investigate the epidemiology of ACC, using data from a large European network of population-based registries for congenital anomalies (EUROCAT).Methods: Twenty-eight EUROCAT population-based registries in 16 European countries were involved. Poisson regression models were exploited to estimate the overall and live birth prevalence, to test time trends in prevalence between four 5-year periods and to evaluate the impact of the change of coding for ACC from the unspecific ICD9-BPA code to the specific ICD10 code. Proportions of ACC cases associated with other anomalies were reported.Results: Five hundred cases were identified in the period 1998-2017 (prevalence: 5.10 per 100,000 births). Prevalence across 5-year periods did not differ significantly and no significant differences were evident due to the change from ICD9 to ICD10 in ACC coding. Heterogeneity in prevalence was observed across registries. The scalp was the most common site for ACC (96.4%) and associated congenital anomalies were present in 33.8% of cases. Patau and Adams-Oliver syndromes were the most frequent among the associated chromosomal anomalies (88.3%) and the associated genetic syndromes (57.7%), respectively. 16% of cases were associated with limb anomalies and 15.4% with congenital heart defects. A family history of ACC was found in 2% of cases.Conclusion: To our knowledge, this is the only population-based study on ACC. The EUROCAT methodologies provide reliable prevalence estimates and proportions of associated anomalies.

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/36300660; hal-03955554; https://univ-rennes.hal.science/hal-03955554Test; https://univ-rennes.hal.science/hal-03955554/documentTest; https://univ-rennes.hal.science/hal-03955554/file/Coi%20et%20al.%20-%202022%20-%20Epidemiology%20of%20aplasia%20cutis%20congenita%20a%20populat.pdfTest; PUBMED: 36300660; WOS: 000881755300001

الإتاحة: https://doi.org/10.1111/jdv.18690Test
https://univ-rennes.hal.science/hal-03955554Test
https://univ-rennes.hal.science/hal-03955554/documentTest
https://univ-rennes.hal.science/hal-03955554/file/Coi%20et%20al.%20-%202022%20-%20Epidemiology%20of%20aplasia%20cutis%20congenita%20a%20populat.pdfTest

المؤلفون: Bergman, Jorieke E H, Barišić, Ingeborg, Addor, Marie-Claude, Braz, Paula, Cavero-Carbonell, Clara, Draper, Elizabeth S, Echevarría-González-de-Garibay, Luis J, Gatt, Miriam, Haeusler, Martin, Khoshnood, Babak, Klungsøyr, Kari, Kurinczuk, Jennifer J, Latos-Bielenska, Anna, Luyt, Karen, Martin, Danielle, Mullaney, Carmel, Nelen, Vera, Neville, Amanda J, O'Mahony, Mary T, Perthus, Isabelle, Pierini, Anna, Randrianaivo, Hanitra, Rankin, Judith, Rissmann, Anke, Rouget, Florence, Sayers, Gerardine, Schaub, Bruno, Stevens, Sarah, Tucker, David, Verellen-Dumoulin, Christine, Wiesel, Awi, Gerkes, Erica H, Perraud, Annie, Loane, Maria A, Wellesley, Diana, de Walle, Hermien E K

المصدر: Bergman , J E H , Barišić , I , Addor , M-C , Braz , P , Cavero-Carbonell , C , Draper , E S , Echevarría-González-de-Garibay , L J , Gatt , M , Haeusler , M , Khoshnood , B , Klungsøyr , K , Kurinczuk , J J , Latos-Bielenska , A , Luyt , K , Martin , D , Mullaney , C , Nelen , V , Neville , A J , O'Mahony , M T , Perthus , I , Pierini , A , Randrianaivo , H , Rankin , J , ....

الوصف: Amniotic band syndrome (ABS) and limb body wall complex (LBWC) have an overlapping phenotype of multiple congenital anomalies and their etiology is unknown. We aimed to determine the prevalence of ABS and LBWC in Europe from 1980 to 2019 and to describe the spectrum of congenital anomalies. In addition, we investigated maternal age and multiple birth as possible risk factors for the occurrence of ABS and LBWC. We used data from the European surveillance of congenital anomalies (EUROCAT) network including data from 30 registries over 1980-2019. We included all pregnancy outcomes, including live births, stillbirths, and terminations of pregnancy for fetal anomalies. ABS and LBWC cases were extracted from the central EUROCAT database using coding information responses from the registries. In total, 866 ABS cases and 451 LBWC cases were included in this study. The mean prevalence was 0.53/10,000 births for ABS and 0.34/10,000 births for LBWC during the 40 years. Prevalence of both ABS and LBWC was lower in the 1980s and higher in the United Kingdom. Limb anomalies and neural tube defects were commonly seen in ABS, whereas in LBWC abdominal and thoracic wall defects and limb anomalies were most prevalent. Twinning was confirmed as a risk factor for both ABS and LBWC. This study includes the largest cohort of ABS and LBWC cases ever reported over a large time period using standardized EUROCAT data. Prevalence, clinical characteristics, and the phenotypic spectrum are described, and twinning is confirmed as a risk factor.

وصف الملف: application/pdf

العلاقة: https://research.rug.nl/en/publications/30c0abcb-b606-4458-befd-b154a8a28359Test

الإتاحة: https://doi.org/10.1002/ajmg.a.63107Test
https://hdl.handle.net/11370/30c0abcb-b606-4458-befd-b154a8a28359Test
https://research.rug.nl/en/publications/30c0abcb-b606-4458-befd-b154a8a28359Test
https://pure.rug.nl/ws/files/556305786/Amniotic_band_syndrome_and_limb_body_wall_complex_in_Europe_1980_2019.pdfTest

المؤلفون: Goulding, Anna, McQuaid, Fiona, Lindsay, Laura, Agrawal, Utkarsh, Auyeung, Bonnie, Calvert, Clara, Carruthers, Jade, Denny, Cheryl, Donaghy, Jack, Hillman, Sam, Hopcroft, Lisa, Hopkins, Leanne, McCowan, Colin, McLaughlin, Terry, Moore, Emily, Ritchie, Lewis, Simpson, Colin R., Taylor, Bob, Fenton, Lynda, Pollock, Louisa, Gale, Chris, Kurinczuk, Jennifer J., Robertson, Chris, Sheikh, Aziz, Stock, Sarah, Wood, Rachael

الوصف: Objectives: To examine neonates in Scotland aged 0–27 days with SARS-CoV-2 infection confirmed by viral testing; the risk of confirmed neonatal infection by maternal and infant characteristics; and hospital admissions associated with confirmed neonatal infections. Design: Population-based cohort study. Setting and population: All live births in Scotland, 1 March 2020–31 January 2022. Results: There were 141 neonates with confirmed SARS-CoV-2 infection over the study period, giving an overall infection rate of 153 per 100 000 live births (141/92 009, 0.15%). Among infants born to women with confirmed infection around the time of birth, the confirmed neonatal infection rate was 1812 per 100 000 live births (15/828, 1.8%). Two-thirds (92/141, 65.2%) of neonates with confirmed infection had an associated admission to neonatal or (more commonly) paediatric care. Six of these babies (6/92, 6.5%) were admitted to neonatal and/or paediatric intensive care; however, none of these six had COVID-19 recorded as their main diagnosis. There were no neonatal deaths among babies with confirmed infection. Implications and relevance: Confirmed neonatal SARS-CoV-2 infection was uncommon over the first 23 months of the pandemic in Scotland. Secular trends in the neonatal confirmed infection rate broadly followed those seen in the general population, although at a lower level. Maternal confirmed infection at birth was associated with an increased risk of neonatal confirmed infection. Two-thirds of neonates with confirmed infection had an associated admission to hospital, with resulting implications for the baby, family and services, although their outcomes were generally good. Ascertainment of confirmed infection depends on the extent of testing, and this is likely to have varied over time and between groups: the extent of unconfirmed infection is inevitably unknown.

وصف الملف: text

العلاقة: https://eprints.gla.ac.uk/289344/2/289344.pdfTest; Goulding, A. et al. (2023) Confirmed SARS-CoV-2 infection in Scottish neonates 2020–2022: a national, population-based cohort study. Archives of Disease in Childhood , 108(4), pp. 367-372. (doi:10.1136/archdischild-2022-324713 ) (PMID:36609412) (PMCID:PMC10313998)

الإتاحة: https://doi.org/10.1136/archdischild-2022-324713Test
https://eprints.gla.ac.uk/289344Test/
https://eprints.gla.ac.uk/289344/2/289344.pdfTest