المؤلفون: Liu,Jianhua, Guo,Liantao, Rao,Yan, Zheng,Weijie, Gao,Dongcheng, Zhang,Jing, Luo,Lan, Kuang,Xinwen, Sukumar,Saraswati, Tu,Yi, Chen,Chuang, Sun,Shengrong

مصطلحات موضوعية: International Journal of Nanomedicine

الوصف: Liu J, Guo L, Rao Y, et al. Int J Nanomedicine. 2022;17:2661–2678. The Editor and Publisher of International Journal of Nanomedicine wish to retract the published article. Concerns were raised regarding the duplication of mice images in Figure 4A and H&E images in Figure 9A. Specifically, The images for Figure 4A, MNs-PEG/IR780-DOX+MF, 6h and 24h appear to be duplicates of each other. The images for Figure 4A, MNs-PEG/IR780-DOX, 1h and 3h appear to be duplicates of each other. The images for Figure 9A, Liver, 1 (PBS) and 5 (MNs-PEG/IR780-DOX+L) appear to have overlapping regions. The images for Figure 9A, Spleen, 1 (PBS), 3 (MNs-PEG/IR780-DOX) and 6 (MNs-PEG/IR780-DOX+MF+L) appear to have overlapping regions. The authors were cooperative and provided some of the original data that was requested. However, the authors explained that the 6h data shown in Figure 4 did not exist and asked to remove it. The Editor questioned how non-existent data came to be used and was concerned that this issue was only being raised post-publication. The authors explanation regarding this did not clearly explain how the error was made. Overall, in combination with the alleged image duplication and addition of non-existent data, the Editor expressed their overall concerns relating to the integrity and reliability of the findings and requested for the article to be retracted. The authors were notified and agreed with this decision. We have been informed in our decision-making by our policy on publishing ethics and integrity and the COPE guidelines on retractions. The retracted article will remain online to maintain the scholarly record, but it will be digitally watermarked on each page as “Retracted”.

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العلاقة: https://www.dovepress.com/retraction-in-situ-injection-of-ph--and-temperature-sensitive-nanomate-peer-reviewed-fulltext-article-IJNTest

الإتاحة: https://doi.org/10.2147/IJN.S411463Test
https://www.dovepress.com/retraction-in-situ-injection-of-ph--and-temperature-sensitive-nanomate-peer-reviewed-fulltext-article-IJNTest

المؤلفون: Liu, Jianhua, Guo, Liantao, Rao, Yan, Zheng, Weijie, Gao, Dongcheng, Zhang, Jing, Luo, Lan, Kuang, Xinwen, Sukumar, Saraswati, Tu, Yi, Chen, Chuang, Sun, Shengrong

المصدر: International Journal of Nanomedicine ; volume Volume 18, page 1193-1194 ; ISSN 1178-2013

الإتاحة: https://doi.org/10.2147/ijn.s411463Test
https://www.dovepress.com/getfile.php?fileID=88005Test

المؤلفون: Xia, Yijun, Wang, Youbin, Hao, Yan, Shan, Mengjie, Liu, Hao, Liang, Zhengyun, Kuang, Xinwen

المساهمون: National Natural Science Foundation of China, Beijing Municipal Science and Technology Commission

المصدر: Frontiers in Immunology ; volume 14 ; ISSN 1664-3224

مصطلحات موضوعية: Immunology, Immunology and Allergy

الوصف: Objectives Keloid is a highly aggressive fibrotic disease resulting from excessive extracellular matrix deposition after dermal injury. Intra-lesional injection of triamcinolone acetonide (TAC) in combination with 5-fluorouracil (5-FU) is a commonly used pharmacological regimen and long-term repeated injections can achieve sustained inhibition of keloid proliferation. However, the molecular mechanisms underlying the inhibitory effect on keloids remain insufficiently investigated. Methods and materials This study performed single-cell RNA sequencing analysis of keloids treated with TAC+5-FU injections, keloids, and skins to explore patterns of gene expression regulation and cellular reprogramming. Results The results revealed that TAC+5-FU interrupted the differentiation trajectory of fibroblasts toward pro-fibrotic subtypes and induced keloid atrophy possibly by inhibiting the FGF signaling pathway in intercellular communication. It also stimulated partial fibroblasts to develop the potential for self-replication and multidirectional differentiation, which may be a possible cellular source of keloid recurrence. T cell dynamics demonstrated elevated expression of secretory globulin family members, which may be possible immunotherapeutic targets. Schwann cell populations achieved functional changes by increasing the proportion of apoptotic or senescence-associated cell populations and reducing cell clusters that promote epidermal development and fibroblast proliferation. Conclusions Our findings elucidated the molecular and cellular reprogramming of keloids by intra-lesional injection of TAC+5-FU, which will provide new insights to understand the mechanism of action and therapeutic targets.

الإتاحة: https://doi.org/10.3389/fimmu.2023.1106289Test

المؤلفون: Liu,Jianhua, Guo,Liantao, Rao,Yan, Zheng,Weijie, Gao,Dongcheng, Zhang,Jing, Luo,Lan, Kuang,Xinwen, Sukumar,Saraswati, Tu,Yi, Chen,Chuang, Sun,Shengrong

مصطلحات موضوعية: International Journal of Nanomedicine

الوصف: Jianhua Liu,1,* Liantao Guo,1,* Yan Rao,2 Weijie Zheng,1 Dongcheng Gao,1 Jing Zhang,2 Lan Luo,1 Xinwen Kuang,1 Saraswati Sukumar,3 Yi Tu,1 Chuang Chen,1 Shengrong Sun1 1Department of Breast and Thyroid Surgery, Renmin Hospital of Wuhan University, Wuhan, People’s Republic of China; 2Animal Biosafety Level III Laboratory at the Center for Animal Experiment, Wuhan University School of Medicine, Wuhan, People’s Republic of China; 3Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD, USA*These authors contributed equally to this workCorrespondence: Shengrong Sun; Chuang Chen, Tel +86-13707198696 ; +86-1476064785, Email sun137@sina.com; chenc2469@163.comPurpose: Triple-negative breast cancer (TNBC) is challenging to treat with traditional “standard of care†therapy due to the lack of targetable biomarkers and rapid progression to distant metastasis.Methods: We synthesized a novel combination regimen that included chemotherapy and photothermal therapy (PTT) to address this problem. Here, we tested a magnetic nanosystem (MNs-PEG/IR780-DOX micelles) loaded with the near-infrared (NIR) photothermal agent IR780 and doxorubicin (DOX) to achieve chemo-photothermal and boost antitumor immunity. Intraductal (i.duc) administration of MNs-PEG/IR780-DOX could increase the concentration of the drug in the tumor while reducing systemic side effects.Results: We showed more uptake of MNs-PEG/IR780-DOX by 4T1-luc cells and higher penetration in the tumor. MNs-PEG/IR780-DOX exhibited excellent photothermal conversion in vivo and in vitro. The release of DOX from MNs-PEG/IR780-DOX is pH- and temperature-sensitive. Facilitated by i.duc administration, MNs-PEG/IR780-DOX displayed antitumor effects and prevented distant organs metastasis under NIR laser (L) irradiation and magnetic field (MF)while avoiding DOX-induced toxicity. More importantly, MNs-PEG/IR780-DOX alleviated tumor immunosuppressive microenvironment by increasing tumor CD8+ T cells infiltration and reducing the proportion of ...

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العلاقة: https://www.dovepress.com/in-situ-injection-of-ph--and-temperature-sensitive-nanomaterials-incre-peer-reviewed-fulltext-article-IJNTest

الإتاحة: https://doi.org/10.2147/IJN.S367121Test
https://www.dovepress.com/in-situ-injection-of-ph--and-temperature-sensitive-nanomaterials-incre-peer-reviewed-fulltext-article-IJNTest

المؤلفون: Liu, Jianhua, Guo, Liantao, Rao, Yan, Zheng, Weijie, Gao, Dongcheng, Zhang, Jing, Luo, Lan, Kuang, Xinwen, Sukumar, Saraswati, Tu, Yi, Chen, Chuang, Sun, Shengrong

المصدر: International Journal of Nanomedicine ; volume Volume 17, page 2661-2678 ; ISSN 1178-2013

الإتاحة: https://doi.org/10.2147/ijn.s367121Test
https://www.dovepress.com/getfile.php?fileID=81532Test

المؤلفون: Chen, Guang, Li, Jiqiang, Kuang, Xinwen, Wu, Yaofeng, Wu, Fengshun

المصدر: Soldering & Surface Mount Technology, 2019, Vol. 31, Issue 4, pp. 261-270.

الوصول الحر: http://www.emeraldinsight.com/doi/10.1108/SSMT-11-2018-0043Test

المؤلفون: Zhang, Feng, Liu, Zheng, Wang, Yue, Mao, Pingli, Kuang, Xinwen, Zhang, Zhenglai, Ju, Yingdong, Xu, Xiaozhong

المساهمون: State Natural Science Fund

المصدر: Journal of Magnesium and Alloys ; volume 8, issue 1, page 172-183 ; ISSN 2213-9567

مصطلحات موضوعية: Metals and Alloys, Mechanics of Materials

الإتاحة: https://doi.org/10.1016/j.jma.2019.05.013Test
https://api.elsevier.com/content/article/PII:S2213956719300866?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S2213956719300866?httpAccept=text/plainTest

المؤلفون: Kuang, Xinwen, Luo, Zixuan, Sun, Zhihong, Hu, Jiawei, Liu, Jianhua, Kong, Deguang, Wang, Guannan, Guo, Liantao, Luo, Lan, Zheng, Weijie, Sun, Shengrong, Rao, Yan, Chen, Chuang

المصدر: International Journal of Cancer; Sep2023, Vol. 153 Issue 5, p1067-1079, 13p

مصطلحات موضوعية: TRIPLE-negative breast cancer, CARCINOMA in situ, ESTROGEN, DUCTAL carcinoma, NANOPARTICLES

مستخلص: Given that the transition from ductal carcinoma in situ (DCIS) to invasive breast cancer (BC) is crucial during the BC progression, the mechanism involved in the invasion transition behind triple‐negative breast cancer (TNBC) and estrogen receptor‐positive (ER‐positive) subtype has remained elusive. This article detected distinct invasion patterns of BC cells between the ER‐positive and TNBC using intraductal murine models with intraductal administration of carbon nanoparticles (CNPs). First, the feasibility of the utility of CNPs as a tracer was proved. The area ratio of CNPs and tumor cells invading the stroma at the late stage was found significantly higher than that in the early stage in MNU‐induced ER‐positive BC. However, opposite results were obtained in the triple‐negative model. Consequently, we proposed that the ER‐positive phenotype cells behave differently between different stages during tumor progression while there is no such difference in the invasion process of TNBC cells. The analysis regarding the duct integrity along with immunohistochemical characteristics further explained the distinct invasion features between the ER‐positive and triple‐negative subtypes. Last, the relationship between the duct thickness and the duct integrity suggested that ER‐positive tumors gradually increased in size within the lumen before the invasion. Overall, this study suggested the different invasion characteristics of ER‐positive BC and TNBC in vivo. [ABSTRACT FROM AUTHOR]

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