المؤلفون: Koskela, Mikael, Virtanen, Helena E., Rodprasert, Wiwat, Jahnukainen, Kirsi, Toppari, Jorma, Koskenniemi, Jaakko J.

المساهمون: Lastentautien Tutkimussäätiö, Turun Yliopistollinen Keskussairaala, Novo Nordisk Fonden, European Commission, Academy of Finland, Sigrid Juséliuksen Säätiö

المصدر: Andrology ; ISSN 2047-2919 2047-2927

الوصف: Background Testicular volume is a marker of male pubertal development. Various clinical conditions and their treatments may influence testicular growth. Objectives To create ruler‐based age‐dependent pubertal testicular volume references that enable calculation of standard deviation (SD) scores. Materials and Methods Study cohort comprised 65 boys who attended clinical examination twice a year from the age of 8.5 years until the attainment of final testicular size. Forty‐nine (75.4%) boys completed the follow‐up and 16 (24.6%) boys dropped out before the attainment of final post‐pubertal testicular size. At each follow‐up visit testicular size was measured with a ruler, orchidometer, and ultrasonography. LMS or LMSP method served as the technique for creating reference growth curves for testicular volumes. Using the novel references for ruler measurements, development of SD scores was assessed in a cohort of boys with unilateral cryptorchidism. Results Reference growth curves were constructed separately for ruler, orchidometer, and ultrasonography measurements. Median orchidometer volume of 4 mL, marker of male pubertal onset, occurred at the age of 11.7 years, whereas +2SD curve surpassed 4 mL at 10.2 years and −2SD curve at 13.7 years. Modeled ages at the attainment of 4 mL testicular volume based on ruler measurements were 9.7 years for +2SD curve, 11.5 years for median curve, and 13.6 years for −2SD curve. Ultrasonography‐based volume of 1.3 mL corresponded with the median modeled orchidometer‐based volume of 4 mL. In boys with unilateral cryptorchidism, ruler‐based SD scores decreased during puberty in undescended testes, but not in descended testes. Discussion and Conclusion The present study provides reference values for pubertal testicular volume measured with a ruler enabling an age‐dependent assessment of testicular size. Comparison with measurements by an orchidometer and ultrasonography is also presented.

الإتاحة: https://doi.org/10.1111/andr.13629Test

المؤلفون: Korhonen, Melanie, Tainio, Juuso, Koskela, Mikael, Madanat-Harjuoja, Laura Maria, Jahnukainen, Kirsi

المساهمون: Children's Hospital, HUS Children and Adolescents

مصطلحات موضوعية: 3122 Cancers, Childhood cancer survivors, Divorce, Follow-up, Male fertility, Marriage, Paternity, Therapeutic exposure

الوصف: Background: Childhood cancer therapy may cause long-term effects. This cross-sectional study evaluated adulthood milestones in male childhood cancer survivors (CCS). Methods: The study population comprised 252 male CCS with 6 to 42 years of survival diagnosed at the Children’s Hospital in Helsinki (1964–2000) at the age of 0 to 17 years. Sex-, age-, and area of residence–matched population controls were randomly selected from the Finnish national registries. Data on moving away from the parental home, marital status, offspring, and adoption in CCS were compared with the population controls. We analyzed the influence of chemotherapy and radiation exposures and testicular dysfunction (ever nontestosterone-substituted serum follicle stimulating hormone >15 IU/L, luteinizing hormone >15 IU/L, testosterone <2 ng/mL (5 nmol/L), need of testosterone replacement therapy, or testicular volume <12 mL at the end of puberty) during pubertal maturation on long-term social outcomes. Results: CCS moved away from their parental home as frequently as population controls (97.8% vs. 98.5%, p =.45). CCS were less likely to marry or live in a registered relationship (46.4% vs. 57.5%, p <.001), especially when diagnosed at a young age (<4 years). Among those married, the probability of divorce was similar between CCS and population controls (27.4% vs. 23.8%, p =.41). Survivors were less likely to sire a child (38.5% vs. 59.1%, p <.001) and more likely to adopt (2% vs. 0.4%, p =.015). Lower probability of paternity was associated with hematopoietic stem cell therapy, testicular radiation dose >6 Gy, pubertal signs of testicular dysfunction (nontestosterone-substituted serum follicle stimulating hormone >15 IU/L, luteinizing hormone >15 IU/L, testosterone <2 ng/mL (5 nmol/L), or need of testosterone replacement therapy during puberty, or testicular volume <12 mL at the end of puberty) or azoospermia after puberty. Conclusions: This study emphasizes the value of pubertal monitoring of testicular ...

وصف الملف: application/pdf

العلاقة: Swedish Childhood Cancer Foundation; ALF Stockholm County and the Karolinska Institute; state research funding of the Helsinki University Hospital; Finnish Cancer Society; Lasten Syoepaesaeaetioe Vaereen; Swedish Research Council; Finnish Pediatric Research Foundation; Korhonen , M , Tainio , J , Koskela , M , Madanat-Harjuoja , L M & Jahnukainen , K 2023 , ' Therapeutic exposures and pubertal testicular dysfunction are associated with adulthood milestones and paternity after childhood cancer ' , Cancer , vol. 129 , no. 22 , pp. 3633-3644 . https://doi.org/10.1002/cncr.34971Test; 85166944493; 79dc14cd-7904-44d7-83ea-151936871a27; http://hdl.handle.net/10138/567813Test; 001043931100001

الإتاحة: http://hdl.handle.net/10138/567813Test

المؤلفون: Barbour, Sean J., Coppo, Rosanna, Er, Lee, Pillebout, Evangeline, Russo, Maria Luisa, Alpers, Charles E., Fogo, Agnes B., Ferrario, Franco, Jennette, J. Charles, Roberts, Ian S. D., Cook, H. Terence, Ding, Jie, Su, Baige, Zhong, Xuhui, Fervenza, Fernando C., Zand, Ladan, Peruzzi, Licia, Lucchetti, Laura, Katafuchi, Ritsuko, Shima, Yuko, Yoshikawa, Norishige, Ichikawa, Daisuke, Suzuki, Yusuke, Murer, Luisa, Wyatt, Robert J., Nelson, Raoul D., Narus, JoAnn H., Wenderfer, Scott, Geetha, Duvuru, Daugas, Eric, Monteiro, Renato C., Nakatani, Shinya, Mastrangelo, Antonio, Nuutinen, Matti, Koskela, Mikael, Weber, Lutz T, Hackl, Agnes, Pohl, Martin, Pecoraro, Carmine, Tsuboi, Nobuo, Yokoo, Takashi, Takafumi, Ito, Fujimoto, Shouichi, Conti, Giovanni, Santoro, Domenico, Materassi, Marco, Zhang, Hong, Shi, Sufang, Liu, Zhi-Hong, Tesar, Vladimir, Maixnerova, Dita, Avila-Casado, Carmen, Bajema, Ingeborg, Barreca, Antonella, Becker, Jan U., Comstock, Jessica M., Cornea, Virgilius, Eldin, Karen, Hernandez, Loren Herrera, Hou, Jean, Joh, Kensuke, Lin, Mercury, Messias, Nidia, Muda, Andrea Onetti, Pagni, Fabio, Diomedi-Camassei, Francesca, Tokola, Heikki, D’Armiento, Maria, Seidl, Maximilian, Rosenberg, Avi, Sannier, Aurélie, Soares, Maria Fernanda, Wang, Suxia, Zeng, Caihong, Haas, Mark

المساهمون: Barbour, S, Coppo, R, Er, L, Pillebout, E, Russo, M, Alpers, C, Fogo, A, Ferrario, F, Jennette, J, Roberts, I, Cook, H, Ding, J, Su, B, Zhong, X, Fervenza, F, Zand, L, Peruzzi, L, Lucchetti, L, Katafuchi, R, Shima, Y, Yoshikawa, N, Ichikawa, D, Suzuki, Y, Murer, L, Wyatt, R, Nelson, R, Narus, J, Wenderfer, S, Geetha, D, Daugas, E, Monteiro, R, Nakatani, S, Mastrangelo, A, Nuutinen, M, Koskela, M, Weber, L, Hackl, A, Pohl, M, Pecoraro, C, Tsuboi, N, Yokoo, T, Takafumi, I, Fujimoto, S, Conti, G, Santoro, D, Materassi, M, Zhang, H, Shi, S, Liu, Z, Tesar, V, Maixnerova, D, Avila-Casado, C, Bajema, I, Barreca, A, Becker, J, Comstock, J, Cornea, V, Eldin, K, Hernandez, L, Hou, J, Joh, K, Lin, M, Messias, N, Muda, A, Pagni, F, Diomedi-Camassei, F, Tokola, H, D’Armiento, M, Seidl, M, Rosenberg, A, Sannier, A, Soares, M, Wang, S, Zeng, C, Haas, M

مصطلحات موضوعية: Renal pathology

الوصف: Background: Nephritis is a common manifestation of IgA vasculitis and is morphologically indistinguishable from IgA nephropathy. While MEST-C scores are predictive of kidney outcomes in IgA nephropathy, their value in IgA vasculitis nephritis has not been investigated in large multiethnic cohorts. Methods: Biopsies from 262 children and 99 adults with IgA vasculitis nephritis (N=361) from 23 centers in North America, Europe and Asia were independently scored by 3 pathologists. MEST-C scores were assessed for correlation with eGFR/proteinuria at biopsy. Because most patients (N=309, 86%) received immunosuppression, risk factors for outcomes were evaluated in this group using Latent Class Mixed Models (LCMM) to identify classes of eGFR trajectories over a median follow-up of 2.7 years (IQR 1.2, 5.1). Clinical and histologic parameters associated with each class were determined using logistic regression. Results: M, E, T and C scores were correlated with either eGFR or proteinuria at biopsy. Two classes were identified by LCMM, one with initial improvement in eGFR followed by a late decline (Class 1, N=91) and another with stable eGFR (Class 2, N=218). Class 1 was associated with a higher risk of an established kidney outcome (time to >30% decline in eGFR or kidney failure, HR 5.84, 95%CI 2.37, 14.4). Among MEST-C scores, only E1 was associated with Class 1 by multivariable analysis. Other factors associated with Class 1 were age <18 years, male sex, lower eGFR at biopsy, and extrarenal non-cutaneous disease. Fibrous crescents without active changes were associated with Class 2. Conclusions: Kidney outcome in patients with biopsied IgA vasculitis nephritis treated with immunosuppression was determined by clinical risk factors, and endocapillary hypercellularity (E1) and fibrous crescents, which are features that are not part of the ISKDC classification.

وصف الملف: STAMPA

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/38261310; info:eu-repo/semantics/altIdentifier/wos/WOS:001184989400001; journal:CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY; https://hdl.handle.net/10281/457404Test

الإتاحة: https://doi.org/10.2215/CJN.0000000000000398Test
https://hdl.handle.net/10281/457404Test

المؤلفون: Rohner, Katharina, Marlais, Matko, Ahn, Yo Han, Ali, Alaa, Alsharief, Abrar, Novak, Anja Blejc, Brambilla, Marta, Cakici, Evrim Kargin, Candan, Cengiz, Canpolat, Nur, Chan, Eugene Yu-hin, Decramer, Stéphane, Didsbury, Madeleine, Durao, Filipa, Durkan, Anne M, Düzova, Ali, Forbes, Thomas, Gracchi, Valentina, Güngör, Tulin, Horinouchi, Tomoko, Kasap Demir, Belde, Kobayashi, Yasuko, Koskela, Mikael, Kurt-Sukur, Eda Didem, La Scola, Claudio, Langan, Dean, Li, Xiaozhong, Malgieri, Gabriele, Mastrangelo, Antonio, Min, Jeesu, Mizerska-Wasiak, Malgorzata, Moussaoui, Nabila, Noyan, Aytul, Nuutinen, Matti, O'Gormon, Jennifer, Okamoto, Takayuki, Oni, Louise, Oosterveld, Michiel, Pańczyk-Tomaszewska, Malgorzata, Parmaksiz, Gonul, Pasini, Andrea, Rianthavorn, Pornpimol, Roelofs, Joris, Shen, Yunyan, Sinha, Rajiv, Topaloglu, Rezan, Torres, Diletta Domenica, Udagawa, Tomohiro, Wennerström, Martin, Yap, Yok Chin

المصدر: Nephrology Dialysis Transplantation ; ISSN 0931-0509 1460-2385

الوصف: Background Immunoglobulin A vasculitis with nephritis (IgAVN) is the most common vasculitis in children. Due to a lack of evidence, treatment recommendations are based on expert opinion, resulting in variation. The aim of this study was to describe the clinical presentation, treatment and outcome of an extremely large cohort of children with biopsy-proven IgAVN in order to identify prognostic risk factors and signals of treatment efficacy. Methods Retrospective data were collected on 1148 children with biopsy-proven IgAVN between 2005 and 2019 from 41 international paediatric nephrology centres across 25 countries and analysed using multivariate analysis. The primary outcome was estimated glomerular filtration rate (eGFR) and persistent proteinuria at last follow-up. Results The median follow-up was 3.7 years (interquartile range 2–6.2). At last follow-up, 29% of patients had an eGFR <90 mL/min/1.73 m2, 36% had proteinuria and 3% had chronic kidney disease stage 4–5. Older age, lower eGFR at onset, hypertension and histological features of tubular atrophy and segmental sclerosis were predictors of poor outcome. There was no evidence to support any specific second-line immunosuppressive regimen being superior to others, even when further analysing subgroups of children with reduced kidney function, nephrotic syndrome or hypoalbuminemia at onset. Delayed start of immunosuppressive treatment was associated with a lower eGFR at last follow-up. Conclusion In this large retrospective cohort, key features associated with disease outcome are highlighted. Importantly, there was no evidence to support that any specific immunosuppressive treatments were superior to others. Further discovery science and well-conducted clinical trials are needed to define accurate treatment and improve outcomes of IgAVN.

الإتاحة: https://doi.org/10.1093/ndt/gfae009Test

المؤلفون: Koskela, Mikael, Nihtilä, Julia, Ylinen, Elisa, Kolho, Kaija-Leena, Nuutinen, Matti, Ritari, Jarmo, Jahnukainen, Timo

المساهمون: Children's Hospital, HUS Children and Adolescents, University of Helsinki, Helsinki University Hospital Area, Clinicum, University Management

مصطلحات موضوعية: Crohn's disease, Inflammatory bowel disease, Children, Genetics, IgA vasculitis, 3123 Gynaecology and paediatrics

الوصف: Background The pathophysiology of Henoch-Schonlein purpura (HSP) is still unclear, but several findings suggest that genetic factors may influence disease susceptibility. We aimed to perform a genome-wide association study (GWAS) in pediatric HSP patients with an emphasis on severe HSP nephritis. Methods The study included 46 HSP patients, 42 of whom had undergone kidney biopsy. Forty-nine pediatric patients with an inflammatory bowel disease (IBD) served as an autoimmune disease control group while Finnish bone marrow and blood donors represented the general reference population (n = 18,757). GWAS was performed for HSP and IBD samples in a case-control manner against the reference population. The analysis also included imputation of human leukocyte antigen (HLA) alleles. Results GWAS analysis in HSP revealed several polymorphisms from the HLA region that surpassed the genome-wide significance level. Three HLA class II alleles were also significantly more frequent in HSP than in the reference population: DQA1*01:01, DQB1*05:01, and DRB1*01:01. Haplotype DQA1*01:01/DQB1*05:01/DRB1*01:01 occurred in 43.5% of HSP patients, whereas its frequency was 8.2% in IBD patients and 15.0% in the reference population. HSP patients with this haplotype showed similar baseline clinical findings and outcome as HSP patients negative for the haplotype. In IBD patients, no polymorphism or HLA allele appeared significant at the genome-wide level. Conclusions Our results suggest that haplotype DQA1*01:01/DQB1*05:01/DRB1*01:01 is associated with susceptibility to HSP, but not with the severity of the kidney involvement. These HLA associations did not occur in IBD patients, suggesting that they are specific to HSP and not related to susceptibility to autoimmune diseases in general. ; Peer reviewed

وصف الملف: application/pdf

العلاقة: This work was supported by a grant to M. K. from the Foundation for Pediatric Research, the Paivikki and Sakari Sohlberg Foundation, and the Alma and K.A. Snellman Foundation, Oulu, Finland. Open Access funding provided byUniversity of Helsinki including Helsinki University Central Hospital.; Koskela , M , Nihtilä , J , Ylinen , E , Kolho , K-L , Nuutinen , M , Ritari , J & Jahnukainen , T 2021 , ' HLA-DQ and HLA-DRB1 alleles associated with Henoch-Schonlein purpura nephritis in Finnish pediatric population : a genome-wide association study ' , Pediatric Nephrology , vol. 36 , no. 8 , pp. 2311-2318 . https://doi.org/10.1007/s00467-021-04955-7Test; ORCID: /0000-0001-9170-8415/work/108071242; ec2ce206-2e44-4e4c-9034-e0fe412af929; http://hdl.handle.net/10138/340177Test; 000618606500001

الإتاحة: http://hdl.handle.net/10138/340177Test

المؤلفون: Koskela, Mikael, Annila, Arto

المصدر: Monthly Notices of the Royal Astronomical Society 2011, 417, 1742-1746

مصطلحات موضوعية: Physics - General Physics

الوصف: The precession of Mercury's perihelion is reinspected by the principle of least action. The anomalous advancement of the apside line that is customarily accounted by the theory of general relativity, is ascribed to the gravitational effect due to the entire Universe. When the least action is written in the Sun's frame of reference, the residual rotation is seen to stem from inertia due to all bodies in the Universe. Since mass corresponds to a bound form of energy, gravity, as any other force, can be described as an energy density difference between a system of bodies and its surrounding energy densities that are dispersed throughout the Universe. According to the principle of least action the Universe is expanding by combustion of mass to radiation in the quest of equilibrating the bound forms of energy with "zero-density surroundings" in least time. Keywords: cosmological principle; energy density; energy dispersal; evolution; gravity; the principle of least action
Comment: 7 pages, 3 figures

الوصول الحر: http://arxiv.org/abs/1009.1571Test

المؤلفون: Koskela, Mikael, Nihtilä, Julia, Ylinen, Elisa, Kolho, Kaija Leena, Nuutinen, Matti, Ritari, Jarmo, Jahnukainen, Timo

المساهمون: Tampere University, Clinical Medicine

مصطلحات موضوعية: 3123 Gynaecology and paediatrics

الوصف: Background: The pathophysiology of Henoch-Schönlein purpura (HSP) is still unclear, but several findings suggest that genetic factors may influence disease susceptibility. We aimed to perform a genome-wide association study (GWAS) in pediatric HSP patients with an emphasis on severe HSP nephritis. Methods: The study included 46 HSP patients, 42 of whom had undergone kidney biopsy. Forty-nine pediatric patients with an inflammatory bowel disease (IBD) served as an autoimmune disease control group while Finnish bone marrow and blood donors represented the general reference population (n = 18,757). GWAS was performed for HSP and IBD samples in a case-control manner against the reference population. The analysis also included imputation of human leukocyte antigen (HLA) alleles. Results: GWAS analysis in HSP revealed several polymorphisms from the HLA region that surpassed the genome-wide significance level. Three HLA class II alleles were also significantly more frequent in HSP than in the reference population: DQA1*01:01, DQB1*05:01, and DRB1*01:01. Haplotype DQA1*01:01/DQB1*05:01/DRB1*01:01 occurred in 43.5% of HSP patients, whereas its frequency was 8.2% in IBD patients and 15.0% in the reference population. HSP patients with this haplotype showed similar baseline clinical findings and outcome as HSP patients negative for the haplotype. In IBD patients, no polymorphism or HLA allele appeared significant at the genome-wide level. Conclusions: Our results suggest that haplotype DQA1*01:01/DQB1*05:01/DRB1*01:01 is associated with susceptibility to HSP, but not with the severity of the kidney involvement. These HLA associations did not occur in IBD patients, suggesting that they are specific to HSP and not related to susceptibility to autoimmune diseases in general. Graphical abstract: [Figure not available: see fulltext.]. ; Peer reviewed

وصف الملف: fulltext

العلاقة: 36; https://trepo.tuni.fi/handle/10024/133412Test; URN:NBN:fi:tuni-202107236330

الإتاحة: https://doi.org/10.1007/s00467-021-04955-7Test
https://trepo.tuni.fi/handle/10024/133412Test

المؤلفون: Koskela, Mikael, Ylinen, Elisa, Autio-Harmainen, Helena, Tokola, Heikki, Heikkilä, Päivi, Lohi, Jouko, Jalanko, Hannu, Nuutinen, Matti, Jahnukainen, Timo

المساهمون: Children's Hospital, HUS Children and Adolescents, University of Helsinki, Clinicum, HUSLAB, Department of Pathology, Medicum, University Management, Lastentautien yksikkö

مصطلحات موضوعية: alpha-SMA, Vimentin, PSGL-1, Semiquantitative, Oxford classification, Immunohistochemistry, IGA NEPHROPATHY, PURPURA NEPHRITIS, FOLLOW-UP, CHILDREN, DISEASE, LESIONS, 3123 Gynaecology and paediatrics, 3126 Surgery, anesthesiology, intensive care, radiology

الوصف: Background In Henoch-Schonlein nephritis (HSN), a risk factor for unfavorable outcome is prolonged proteinuria, but the value of renal biopsies in prognosis assessment is debatable. Methods We evaluated serial renal biopsies from 26 HSN patients. Follow-up biopsy occurred at median 2.1 years after diagnostic biopsy. Patients formed two groups at the follow-up biopsy: patients without proteinuria (group I; n = 11) and with proteinuria (group II; n = 15). Biopsies underwent evaluation according to three classifications: International Study of Kidney Disease in Children (ISKDC), Oxford (MEST-C), and semiquantitative classification (SQC) including an activity and chronicity score. Analysis also included expression of pro-fibrotic (alpha-smooth muscle actin and vimentin) and inflammatory (P-selectin glycoprotein ligand-1) molecules in the diagnostic biopsy specimens. Definition of unfavorable outcome was active renal disease or reduced renal function at last follow-up. Results Between the biopsies, SQC chronicity score increased in 22 (85%) patients, whereas activity score and ISKDC grade decreased in 21 (81%) and 17 (65%), respectively. Of the MEST-C parameters, endocapillary proliferation (from 83 to 13%; p <0.001) and crescents (from 63 to 25%; p = 0.022) showed significant reduction, and segmental glomerulosclerosis (from 38 to 79%; p = 0.006) significant increment. These changes occurred similarly in groups I and II. Expression of the pro-fibrotic and inflammatory molecules showed no clinically significant differences between groups I and II. None in group I and five (33%) patients in group II had unfavorable outcome (p = 0.053). Conclusions Our results suggest that follow-up biopsies provide limited additional information to clinical symptoms in HSN outcome prediction. ; Peer reviewed

وصف الملف: application/pdf

العلاقة: Open access funding provided by University of Helsinki including Helsinki University Central Hospital. The Finnish Kidney Foundation, the Foundation for Pediatric Research, the Orion Research Foundation, and the Alma and K.A. Snellman Foundation, Oulu, Finland supported this study by a grant to M.K.; Koskela , M , Ylinen , E , Autio-Harmainen , H , Tokola , H , Heikkilä , P , Lohi , J , Jalanko , H , Nuutinen , M & Jahnukainen , T 2020 , ' Prediction of renal outcome in Henoch-Schonlein nephritis based on biopsy findings ' , Pediatric Nephrology , vol. 35 , no. 4 , pp. 659-668 . https://doi.org/10.1007/s00467-019-04415-3Test; 696a5044-760b-43e0-a345-c844a2b678d4; http://hdl.handle.net/10138/313150Test; 000500273600002

الإتاحة: http://hdl.handle.net/10138/313150Test

المؤلفون: Koskela, Mikael, Pikas, Ergo

المساهمون: Wartzack, Sandro, Schleich, Benjamin

المصدر: Koskela , M & Pikas , E 2019 , Rhetorical design game for expectation alignment . in S Wartzack & B Schleich (eds) , Proceedings of the Design Society: 22nd International Conference on Engineering Design (ICED19) . Cambridge University Press , Proceedings of the International Conference on Engineering Design , pp. 1593-1602 , 22nd International Conference on Engineering Design (ICED19) , Delft , Netherlands , 05/08/2019 . https://doi.org/10.1017/dsi.2019.165Test

الوصف: While the form of building construction delivery known as Integrated Design-Build (or Integrated Project Delivery) is necessary for handling the complexity of modern projects, it raises up a host of problems due to the amount and variety of stakeholders that are brought together to co-design. Namely, the difficulty in forming a shared mental model of expectations regarding the project can cause disappointment in the results, as well as time and cost overruns. This paper is about creating an intervention to alleviate those issues. Employing knowledge from the field of rhetoric in design, and of mental models, two Integrated Design-Build workshops were analyzed to extract a set of rhetorical topics (topoi) to all such sessions. A design game was formulated around the empirical data by an iterative design process, following established design game theory. The game was found to indeed more than double the alignment of a group’s individual mental models, though more testing is needed to validate this.

وصف الملف: application/pdf

العلاقة: https://orbit.dtu.dk/en/publications/91ee4a19-f8cd-48ab-9cd8-92796230dbc9Test

الإتاحة: https://doi.org/10.1017/dsi.2019.165Test
https://orbit.dtu.dk/en/publications/91ee4a19-f8cd-48ab-9cd8-92796230dbc9Test
https://backend.orbit.dtu.dk/ws/files/195981652/rhetorical_design_game_for_expectation_alignment.pdfTest

المؤلفون: Rohner, Katharina, Marlais, Matko, Ahn, Yo Han, Ali, Alaa, Alsharief, Abrar, Basu, Biswanath, Blejc, Anja, Cakici, Evrim Kargin, Canpolat, Nur, Chan, Eugen Yu-hin, Decramer, Stephane, Durao, Filipa, Durkan, Anne M, Duzova, Ali, Forbes, Thomas, Villegas, Junior Gahona, Goknar, Nilufer, Gracchi, Valentina, Gungor, Tulin, Horinouchi, Tomoko, Demir, Belde Kasap, Kobayashi, Yasuko, Koskela, Mikael, Kurt-Sukur, Eda Didem, La Scola, Claudio, Langan, Dean, Li, Xiaozhong, Malgieri, Gabriele, Mastrangelo, Antonio, Noyan, Aytul, Nuutinen, Matti, Okamoto, Takayuki, Oni, Louise, Oosterveld, Michiel, Panczyk-Tomaszewska, Malgorzata, Parmaksiz, Gonul, Pasini, Andrea, Rianthavorn, Pornpimol, Shen, Yunyan, Sinha, Rajiv, Topaloglu, Rezan, Torres, Diletta Domenica, Udagawa, Tomohiro, Yap, Yok Chin, Tullus, Kjell

العلاقة: Collapse authors list. Rohner, Katharina, Marlais, Matko, Ahn, Yo Han, Ali, Alaa, Alsharief, Abrar, Basu, Biswanath, Blejc, Anja, Cakici, Evrim Kargin, Canpolat, Nur, Chan, Eugen Yu-hin et al (show 35 more authors) , Decramer, Stephane, Durao, Filipa, Durkan, Anne M, Duzova, Ali, Forbes, Thomas, Villegas, Junior Gahona, Goknar, Nilufer, Gracchi, Valentina, Gungor, Tulin, Horinouchi, Tomoko, Demir, Belde Kasap, Kobayashi, Yasuko, Koskela, Mikael, Kurt-Sukur, Eda Didem, La Scola, Claudio, Langan, Dean, Li, Xiaozhong, Malgieri, Gabriele, Mastrangelo, Antonio, Noyan, Aytul, Nuutinen, Matti, Okamoto, Takayuki, Oni, Louise orcid:0000-0002-1532-2390 , Oosterveld, Michiel, Panczyk-Tomaszewska, Malgorzata, Parmaksiz, Gonul, Pasini, Andrea, Rianthavorn, Pornpimol, Shen, Yunyan, Sinha, Rajiv, Topaloglu, Rezan, Torres, Diletta Domenica, Udagawa, Tomohiro, Yap, Yok Chin and Tullus, Kjell (2022) CLINICAL FACTORS AT PRESENTATION INFLUENCING OUTCOME OF BIOPSY PROVEN IGA VASCULITIS NEPHRITIS - A MULTICENTRE STUDY OF 1175 CHILDREN. .

الإتاحة: http://livrepository.liverpool.ac.uk/3165236Test/