نتائج البحث - "Koivisto, V. A."

1

دورية أكاديمية

Impact of COVID-19 pandemic on the incidence of sexually transmitted infections in Northern Finland in 2019 to 2022

المؤلفون: Mäki-Koivisto, V. (Vesa), Sinikumpu, S.-P. (Suvi-Päivikki), Jokelainen, J. (Jari), Aho-Laukkanen, E. (Elina), Junttila, I. S. (Ilkka S.), Huilaja, L. (Laura)

الوصف: The coronavirus SARS-CoV-2 (COVID-19) pandemic led to major restrictions in daily life and social contacts in Finland in March 2020. The effect of these restrictions on sexually transmitted infections (STIs) is unclear. The aim of this study was to analyse the incidence and positive rates of sexually transmitted infections in Northern Finland between 2020 and 2021 and compare these with the years prior to the pandemic. Numbers of positive Chlamydia trachomatis, HIV and hepatitis C samples were lower in 2020 to 2021 than in previous years, whereas more gonorrhoea and syphilis was found during pandemic than in previous years. The number of new cases of C. trachomatis reported each month decreased in the first months of the pandemic, but exceeded the prior pandemic-level in autumn 2020. When the mean positive sample rates were compared with the years 2015 to 2019, there was a significant decrease in positive C. trachomatis (p < 0.001) and hepatitis C (p < 0.001) sample rates in both 2020 and 2021. The positive rates for Treponema pallidum in 2020 did not differ significantly (p = 0.38) from previous years. In conclusion, these results show that sexually transmitted infections occurred despite recommendations for social distancing during the COVID-19 pandemic. Thus, easy access to STI testing should always be available, even during exceptional circumstances.

وصف الملف: application/pdf

الإتاحة: http://urn.fi/urn:nbn:fi-fe2023060552512Test

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2

Konjugaatti

المؤلفون: Koivisto, V. (Veikka)

مصطلحات موضوعية: Matematiikka

الوصف: Tiivistelmä. Tutkielmassa perehdytään konjugaattiin joka on eräänlainen operaatio abstraktissa algebrassa. Konjugaattia ja sen ominaisuuksia tutkitaan sekä yleisellä tasolla, että erinlaisissa ominaisuuksiltaan eroavissa ryhmissä. Tutkielmassa käydään läpi konjugaatin määritelmän lisäksi siihen liittyviä määritelmiä, kuten konjugaattiluokka, normaali aliryhmä, ryhmän keskus ja tekijäryhmä.

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=od______2423::517295cd603e006600b093d6f3aa7bd7Test
http://jultika.oulu.fi/Record/nbnfioulu-202306012070Test

3

دورية أكاديمية

Plasma levels of matrix metalloproteinase-2, -3, -10, and tissue inhibitor of metalloproteinase-1 are associated with vascular complications in patients with type 1 diabetes: The EURODIAB Prospective Complications Study

المؤلفون: Peeters S. A., Engelen L., Buijs J., Chaturvedi N., Fuller J. H., Schalkwijk C. G., Stehouwer C. D., Karamanos B., Kofinis A., Petrou K., Giorgino F., Picca G., Angarano A., de Pergola. G., Laviola L., Giorgino R., Ionescu-Tirgoviste C., Coszma A., Guja C., Songini M., Casu A., Pedron M., Pintus S., Fossarello M., Ferriss J. B., Grealy G., O'Keefe D., Toeller M., Arden C., Rottiers R., Tuyttens C., Priem H., Ebeling P., Kylliainen M., Koivisto V. A., Idzior-Walus B., Sieradzki J., Cyganek K., Solnica B., Lemkes H. H. P. J., Lemkes-Stuffken J. C., Nunes-Correa J., Rogado M. C., Gardete-Correia L., Cardoso M. C., Silva A., Boavida J., Machado Sa Marques M., Michel G., Wirion R., Cardillo S., Pozza G., Mangili R., Asnaghi V., Standl E., Schaffler B., Brand H., Harms A., Ben Soussan M., Verier-Mine O., Fallas P., Fallas M. C., Holloway J., Asbury L., Betteridge D. J., Cathelineau G., Bouallouche A., Villatte Cathelineau B., Santeusanio F., Rosi G., D'Alessandro V., Cagini C., Bottini P., Reboldi G. P., Navalesi R., Penno G., Bandinelli S., Miccoli R., Nannipieri M., Ghirlanda G., Saponara C., Cotroneo P., Manto A., Minnella A., Ward J. D., Tesfaye S., Eaton S., Mody C., Borra M., Cavallo Perin P., Giunti S., Grassi G., Pagano G. F., Porta M., Sivieri R., Vitelli F., Veglio M., Papazoglou N., Manes G., Muggeo M., Iagulli M., Cacciatori V., Cattedra di Malattie del Metabolismo V., Irsigler K., Abrahamian H., Walford S., Sinclair J., Hughes S., McLelland V., Ward J., Roglic G., Metelko Z., Pepeonik Z. R.

المساهمون: Peeters, S. A., Engelen, L., Buijs, J., Chaturvedi, N., Fuller, J. H., Schalkwijk, C. G., Stehouwer, C. D., Karamanos, B., Kofinis, A., Petrou, K., Giorgino, F., Picca, G., Angarano, A., Pergola. G., De, Laviola, L., Giorgino, R., Ionescu-Tirgoviste, C., Coszma, A., Guja, C., Songini, M., Casu, A., Pedron, M., Pintus, S., Fossarello, M., Ferriss, J. B., Grealy, G., O'Keefe, D., Toeller, M., Arden, C., Rottiers, R., Tuyttens, C., Priem, H., Ebeling, P., Kylliainen, M., Koivisto, V. A., Idzior-Walus, B., Sieradzki, J., Cyganek, K., Solnica, B., Lemkes, H. H. P. J., Lemkes-Stuffken, J. C., Nunes-Correa, J., Rogado, M. C., Gardete-Correia, L., Cardoso, M. C., Silva, A., Boavida, J., Machado Sa Marques, M., Michel, G., Wirion, R., Cardillo, S., Pozza, G., Mangili, R., Asnaghi, V., Standl, E., Schaffler, B., Brand, H., Harms, A., Ben Soussan, M., Verier-Mine, O., Fallas, P., Fallas, M. C., Holloway, J., Asbury, L., Betteridge, D. J., Cathelineau, G., Bouallouche, A., Villatte Cathelineau, B., Santeusanio, F., Rosi, G., D'Alessandro, V., Cagini, C., Bottini, P., Reboldi, G. P., Navalesi, R., Penno, G., Bandinelli, S., Miccoli, R., Nannipieri, M., Ghirlanda, G., Saponara, C., Cotroneo, P., Manto, A., Minnella, A., Ward, J. D., Tesfaye, S., Eaton, S., Mody, C., Borra, M., Cavallo Perin, P., Giunti, S., Grassi, G., Pagano, G. F., Porta, M., Sivieri, R., Vitelli, F., Veglio, M., Papazoglou, N., Manes, G.

الوصف: Impaired regulation of extracellular matrix remodeling by matrix metalloproteinases (MMPs) and tissue inhibitor of metalloproteinase (TIMP) may contribute to vascular complications in patients with type 1 diabetes. We investigated associations between plasma MMP-1, -2, -3, -9, -10 and TIMP-1, and cardiovascular disease (CVD) or microvascular complications in type 1 diabetic patients. We also evaluated to which extent these associations could be explained by low-grade inflammation (LGI) or endothelial dysfunction (ED). Methods: 493 type 1 diabetes patients (39.5 ± 9.9 years old, 51% men) from the EURODIAB Prospective Complications Study were included. Linear regression analysis was applied to investigate differences in plasma levels of MMP-1, -2, -3, -9, -10, and TIMP-1 between patients with and without CVD, albuminuria or retinopathy. All analyses were adjusted for age, sex, duration of diabetes, Hba1c and additionally for other cardiovascular risk factors including LGI and ED. Results: Patients with CVD (n = 118) showed significantly higher levels of TIMP-1 [β = 0.32 SD (95%CI: 0.12; 0.52)], but not of MMPs, than patients without CVD (n = 375). Higher plasma levels of MMP-2, MMP-3, MMP-10 and TIMP-1 were associated with higher levels of albuminuria (p-trends were 0.028, 0.004, 0.005 and 0.001, respectively). Severity of retinopathy was significantly associated with higher levels of MMP-2 (p-trend = 0.017). These associations remained significant after further adjustment for markers of LGI and ED. Conclusions: These data support the hypothesis that impaired regulation of matrix remodeling by actions of MMP-2, -3 and-10 and TIMP-1 contributes to the pathogenesis of vascular complications in type 1 diabetes.

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/25848912; info:eu-repo/semantics/altIdentifier/wos/WOS:000350726000001; volume:14; issue:1; firstpage:31; journal:CARDIOVASCULAR DIABETOLOGY; http://hdl.handle.net/11586/353539Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-84925234995

الإتاحة: https://doi.org/10.1186/s12933-015-0195-2Test
http://hdl.handle.net/11586/353539Test

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4

دورية أكاديمية

Discovery of biomarkers for glycaemic deterioration before and after the onset of type 2 diabetes: rationale and design of the epidemiological studies within the IMI DIRECT Consortium

المؤلفون: Koivula, R, Franks, P, Heggie, A, Walker, M, Barnett, A, Pearson, E, Cederberg, H, Siloaho, M, Laakso, M, Hansen, T, Vestergaard, H, Pedersen, O, Koopman, A, Rutters, F, Heymans, M, Dekker, J, Rauh, S, Ridderstråle, M, Gupta, R, Herrgård, S, Brunak, S, Perry, M, McDonald, T, Teare, H, Thorand, B, Bell, J, Frost, G, Jablonka, B, Ruetten, H, Mari, A, Hattersley, A, Koivisto, V

مصطلحات موضوعية: Epidemiology, Diabetes

الوصف: Aims/hypothesis The DIRECT (Diabetes Research on Patient Stratification) Study is part of a European Union Framework 7 Innovative Medicines Initiative project, a joint undertaking between four industry and 21 academic partners throughout Europe. The Consortium aims to discover and validate biomarkers that: (1) predict the rate of glycaemic deterioration before and after type 2 diabetes onset; (2) predict the response to diabetes therapies; and (3) help stratify type 2 diabetes into clearly definable disease subclasses that can be treated more effectively than without stratification. This paper describes two new prospective cohort studies conducted as part of DIRECT. Methods Prediabetic participants (target sample size 2,200-2,700) and patients with newly diagnosed type 2 diabetes (target sample size ~1,000) are undergoing detailed metabolic phenotyping at baseline and 18 months and 36 months later. Abdominal, pancreatic and liver fat is assessed using MRI. Insulin secretion and action are assessed using frequently sampled OGTTs in non-diabetic participants, and frequently sampled mixed-meal tolerance tests in patients with type 2 diabetes. Biosamples include venous blood, faeces, urine and nail clippings, which, among other biochemical analyses, will be characterised at genetic, transcriptomic, metabolomic, proteomic and metagenomic levels. Lifestyle is assessed using high-resolution triaxial accelerometry, 24 h diet record, and food habit questionnaires. Conclusions/interpretation DIRECT will yield an unprecedented array of biomaterials and data. This resource, available through managed access to scientists within and outside the Consortium, will facilitate the development of new treatments and therapeutic strategies for the prevention and management of type 2 diabetes. © 2014 The Author(s).

العلاقة: https://ora.ox.ac.uk/objects/uuid:a3a6afa3-d4af-4528-bfc2-6baee3c01668Test; https://doi.org/10.1007/s00125-014-3216-xTest

الإتاحة: https://doi.org/10.1007/s00125-014-3216-xTest
https://ora.ox.ac.uk/objects/uuid:a3a6afa3-d4af-4528-bfc2-6baee3c01668Test

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5

دورية أكاديمية

Discovery of biomarkers for glycaemic deterioration before and after the onset of type 2 diabetes: rationale and design of the epidemiological studies within the IMI DIRECT Consortium

المصدر: Koivula , R W , Heggie , A , Barnett , A , Cederberg , H , Hansen , T H , Koopman , A D , Ridderstrale , M , Rutters , F , Vestergaard , H , Gupta , R , Herrgard , S , Heymans , M W , Perry , M H , Rauh , S , Siloaho , M , Teare , H J A , Thorand , B , Bell , J , Brunak , S , Frost , G , Jablonka , B , Mari , A , McDonald , T J ....

مصطلحات موضوعية: /dk/atira/pure/sustainabledevelopmentgoals/partnerships, name=SDG 17 - Partnerships for the Goals

الوصف: Aims/hypothesis: The DIRECT (Diabetes Research on Patient Stratification) Study is part of a European Union Framework 7 Innovative Medicines Initiative project, a joint undertaking between four industry and 21 academic partners throughout Europe. The Consortium aims to discover and validate biomarkers that: (1) predict the rate of glycaemic deterioration before and after type 2 diabetes onset; (2) predict the response to diabetes therapies; and (3) help stratify type 2 diabetes into clearly definable disease subclasses that can be treated more effectively than without stratification. This paper describes two new prospective cohort studies conducted as part of DIRECT. Methods: Prediabetic participants (target sample size 2,200-2,700) and patients with newly diagnosed type 2 diabetes (target sample size ~1,000) are undergoing detailed metabolic phenotyping at baseline and 18 months and 36 months later. Abdominal, pancreatic and liver fat is assessed using MRI. Insulin secretion and action are assessed using frequently sampled OGTTs in non-diabetic participants, and frequently sampled mixed-meal tolerance tests in patients with type 2 diabetes. Biosamples include venous blood, faeces, urine and nail clippings, which, among other biochemical analyses, will be characterised at genetic, transcriptomic, metabolomic, proteomic and metagenomic levels. Lifestyle is assessed using high-resolution triaxial accelerometry, 24 h diet record, and food habit questionnaires. Conclusions/interpretation: DIRECT will yield an unprecedented array of biomaterials and data. This resource, available through managed access to scientists within and outside the Consortium, will facilitate the development of new treatments and therapeutic strategies for the prevention and management of type 2 diabetes. © 2014 The Author(s).

العلاقة: https://research.vu.nl/en/publications/0accdd64-9569-4aba-a083-2a10abccb8abTest

الإتاحة: https://doi.org/10.1007/s00125-014-3216-xTest
https://research.vu.nl/en/publications/0accdd64-9569-4aba-a083-2a10abccb8abTest
https://hdl.handle.net/1871.1/0accdd64-9569-4aba-a083-2a10abccb8abTest

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