المؤلفون: Noebauer-Huhmann, Iris-Melanie, Vanhoenacker, Filip M, Vilanova, Joan C, Tagliafico, Alberto S, Weber, Marc-André, Lalam, Radhesh K, Grieser, Thomas, Nikodinovska, Violeta Vasilevska, de Rooy, Jacky W J, Papakonstantinou, Olympia, Mccarthy, Catherine, Sconfienza, Luca Maria, Verstraete, Koenraad, Martel-Villagrán, José, Szomolanyi, Pavol, Lecouvet, Frédéric E, Afonso, Diana, Albtoush, Omar M, Aringhieri, Giacomo, Arkun, Remide, Aström, Gunnar, Bazzocchi, Alberto, Botchu, Rajesh, Breitenseher, Martin, Chaudhary, Snehansh, Dalili, Danoob, Davies, Mark, de Jonge, Milko C, Mete, Berna D, Fritz, Jan, Gielen, Jan L M A, Hide, Geoff, Isaac, Amanda, Ivanoski, Slavcho, Mansour, Ramy M, Muntaner-Gimbernat, Lorenzo, Navas, Ana, O Donnell, Paul, Örgüç, Şebnem, Rennie, Winston, Resano, Santiago, Robinson, Philip, Sanal, Hatice T, Ter Horst, Simone A J, van Langevelde, Kirsten, Wörtler, Klaus, Koelz, Marita, Panotopoulos, Joannis, Windhager, Reinhard, Bloem, Johannes L

المساهمون: MS Radiologie

مصطلحات موضوعية: Connective and soft tissue, Consensus, Diagnostic imaging, Neoplasms, Practice guideline, Radiology Nuclear Medicine and imaging

الوصف: OBJECTIVES: Early, accurate diagnosis is crucial for the prognosis of patients with soft tissue sarcomas. To this end, standardization of imaging algorithms, technical requirements, and reporting is therefore a prerequisite. Since the first European Society of Musculoskeletal Radiology (ESSR) consensus in 2015, technical achievements, further insights into specific entities, and the revised WHO-classification (2020) and AJCC staging system (2017) made an update necessary. The guidelines are intended to support radiologists in their decision-making and contribute to interdisciplinary tumor board discussions. MATERIALS AND METHODS: A validated Delphi method based on peer-reviewed literature was used to derive consensus among a panel of 46 specialized musculoskeletal radiologists from 12 European countries. Statements were scored online by level of agreement (0 to 10) during two iterative rounds. Either "group consensus," "group agreement," or "lack of agreement" was achieved. RESULTS: Eight sections were defined that finally contained 145 statements with comments. Overall, group consensus was reached in 95.9%, and group agreement in 4.1%. This communication contains the first part consisting of the imaging algorithm for suspected soft tissue tumors, methods for local imaging, and the role of tumor centers. CONCLUSION: Ultrasound represents the initial triage imaging modality for accessible and small tumors. MRI is the modality of choice for the characterization and local staging of most soft tissue tumors. CT is indicated in special situations. In suspicious or likely malignant tumors, a specialist tumor center should be contacted for referral or teleradiologic second opinion. This should be done before performing a biopsy, without exception. CLINICAL RELEVANCE: The updated ESSR soft tissue tumor imaging guidelines aim to provide best practice expert consensus for standardized imaging, to support radiologists in their decision-making, and to improve examination comparability both in individual patients and in ...

وصف الملف: application/pdf

العلاقة: https://dspace.library.uu.nl/handle/1874/453666Test

الإتاحة: https://dspace.library.uu.nl/handle/1874/453666Test

المؤلفون: Schubert, Lorenz, Koelz, Marita, Kussmann, Manuel, Metz-Schimmerl, Sylvia, Tobudic, Selma, Traby, Ludwig, Vossen, Matthias G., Winkler, Stefan

المساهمون: Medical University of Vienna

المصدر: Infection ; ISSN 0300-8126 1439-0973

مصطلحات موضوعية: Infectious Diseases, Microbiology (medical), General Medicine

الوصف: Treatment of tularemia during pregnancy is challenging due to toxicity of standard treatment regimens. Here, we report a 31-year-old woman with glandular tularemia who was successfully treated with intravenous azithromycin. Follow-up examinations over a 6-month period showed a sustained response to treatment. She later gave birth to a healthy child.

الإتاحة: https://doi.org/10.1007/s15010-023-02160-2Test

المؤلفون: Noebauer-Huhmann, Iris-Melanie, Vanhoenacker, Filip M, Vilanova, Joan C, Tagliafico, Alberto S, Weber, Marc-André, Lalam, Radhesh K, Grieser, Thomas, Nikodinovska, Violeta Vasilevska, de Rooy, Jacky W J, Papakonstantinou, Olympia, Mccarthy, Catherine, Sconfienza, Luca Maria, Verstraete, Koenraad, Martel-Villagrán, José, Szomolanyi, Pavol, Lecouvet, Frédéric E, Afonso, Diana, Albtoush, Omar M, Aringhieri, Giacomo, Arkun, Remide, Aström, Gunnar, Bazzocchi, Alberto, Botchu, Rajesh, Breitenseher, Martin, Chaudhary, Snehansh, Dalili, Danoob, Davies, Mark, de Jonge, Milko C, Mete, Berna D, Fritz, Jan, Gielen, Jan L M A, Hide, Geoff, Isaac, Amanda, Ivanoski, Slavcho, Mansour, Ramy M, Muntaner-Gimbernat, Lorenzo, Navas, Ana, O Donnell, Paul, Örgüç, Şebnem, Rennie, Winston, Resano, Santiago, Robinson, Philip, Sanal, Hatice T, Ter Horst, Simone A J, van Langevelde, Kirsten, Wörtler, Klaus, Koelz, Marita, Panotopoulos, Joannis, Windhager, Reinhard, Bloem, Johannes L

المساهمون: I. Noebauer-Huhmann, F.M. Vanhoenacker, J.C. Vilanova, A.S. Tagliafico, M. Weber, R.K. Lalam, T. Grieser, V.V. Nikodinovska, J.W.J. de Rooy, O. Papakonstantinou, C. Mccarthy, L.M. Sconfienza, K. Verstraete, J. Martel-Villagrán, P. Szomolanyi, F.E. Lecouvet, D. Afonso, O.M. Albtoush, G. Aringhieri, R. Arkun, G. Aström, A. Bazzocchi, R. Botchu, M. Breitenseher, S. Chaudhary, D. Dalili, M. Davie, M.C. de Jonge, B.D. Mete, J. Fritz, J.L.M.A. Gielen, G. Hide, A. Isaac, S. Ivanoski, R.M. Mansour, L. Muntaner-Gimbernat, A. Nava, P. O Donnell, Ş. Örgüç, W. Rennie, S. Resano, P. Robinson, H.T. Sanal, S.A.J. Ter Horst, K. van Langevelde, K. Wörtler, M. Koelz, J. Panotopoulo, R. Windhager, J.L. Bloem

مصطلحات موضوعية: Connective and soft tissue, Consensu, Diagnostic imaging, Neoplasm, Practice guideline, Settore MED/36 - Diagnostica per Immagini e Radioterapia

الوصف: Objectives: Early, accurate diagnosis is crucial for the prognosis of patients with soft tissue sarcomas. To this end, standardization of imaging algorithms, technical requirements, and reporting is therefore a prerequisite. Since the first European Society of Musculoskeletal Radiology (ESSR) consensus in 2015, technical achievements, further insights into specific entities, and the revised WHO-classification (2020) and AJCC staging system (2017) made an update necessary. The guidelines are intended to support radiologists in their decision-making and contribute to interdisciplinary tumor board discussions. Materials and methods: A validated Delphi method based on peer-reviewed literature was used to derive consensus among a panel of 46 specialized musculoskeletal radiologists from 12 European countries. Statements were scored online by level of agreement (0 to 10) during two iterative rounds. Either "group consensus," "group agreement," or "lack of agreement" was achieved. Results: Eight sections were defined that finally contained 145 statements with comments. Overall, group consensus was reached in 95.9%, and group agreement in 4.1%. This communication contains the first part consisting of the imaging algorithm for suspected soft tissue tumors, methods for local imaging, and the role of tumor centers. Conclusion: Ultrasound represents the initial triage imaging modality for accessible and small tumors. MRI is the modality of choice for the characterization and local staging of most soft tissue tumors. CT is indicated in special situations. In suspicious or likely malignant tumors, a specialist tumor center should be contacted for referral or teleradiologic second opinion. This should be done before performing a biopsy, without exception. Clinical relevance: The updated ESSR soft tissue tumor imaging guidelines aim to provide best practice expert consensus for standardized imaging, to support radiologists in their decision-making, and to improve examination comparability both in individual patients and in ...

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/38062268; info:eu-repo/semantics/altIdentifier/wos/WOS:001117489500004; firstpage:1; lastpage:11; numberofpages:11; journal:EUROPEAN RADIOLOGY; https://hdl.handle.net/2434/1020338Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85178953898

الإتاحة: https://doi.org/10.1007/s00330-023-10425-5Test
https://hdl.handle.net/2434/1020338Test

المؤلفون: Reitermaier, René, Krausgruber, Thomas, Fortelny, Nikolaus, Ayub, Tanya, Vieyra-Garcia, Pablo Augusto, Kienzl, Philip, Wolf, Peter, Scharrer, Anke, Fiala, Christian, Kölz, Marita, Hiess, Manuela, Vierhapper, Martin, Schuster, Christopher, Spittler, Andreas, Worda, Christof, Weninger, Wolfgang, Bock, Christoph, Eppel, Wolfgang, Elbe-Bürger, Adelheid

المساهمون: Austrian Science Fund, Jubiläumsfonds der Oesterreichischen Nationalbank, Medical Scientific Fund of the Mayor of the City of Vienna, Hochschuljubiläumsstiftung der Stadt Wien, European Molecular Biology Organization, Foundation René Touraine-Celgene, European Academy of Dermatology and Venereology

المصدر: Journal of Experimental Medicine ; volume 218, issue 4 ; ISSN 0022-1007 1540-9538

الوصف: T cells in human skin play an important role in the immune defense against pathogens and tumors. T cells are present already in fetal skin, where little is known about their cellular phenotype and biological function. Using single-cell analyses, we identified a naive T cell population expressing αβ and γδ T cell receptors (TCRs) that was enriched in fetal skin and intestine but not detected in other fetal organs and peripheral blood. TCR sequencing data revealed that double-positive (DP) αβγδ T cells displayed little overlap of CDR3 sequences with single-positive αβ T cells. Gene signatures, cytokine profiles and in silico receptor–ligand interaction studies indicate their contribution to early skin development. DP αβγδ T cells were phosphoantigen responsive, suggesting their participation in the protection of the fetus against pathogens in intrauterine infections. Together, our analyses unveil a unique cutaneous T cell type within the native skin microenvironment and point to fundamental differences in the immune surveillance between fetal and adult human skin.

الإتاحة: https://doi.org/10.1084/jem.20201189Test

المؤلفون: Lenglinger, Johannes, Eisler, Margit, Mehrain, Sheida, Koelz, Marita, Riegler, Martin, Zacherl, Johannes, Prager, Gerhard

المصدر: Gastroenterology ; volume 138, issue 5, page S-727 ; ISSN 0016-5085

مصطلحات موضوعية: Gastroenterology, Hepatology

الإتاحة: https://doi.org/10.1016/s0016-5085Test(10)63345-8
https://api.elsevier.com/content/article/PII:S0016508510633458?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S0016508510633458?httpAccept=text/plainTest