المؤلفون: Dupont, Annabelle, Rauch, Antoine, Staessens, Senna, Moussa, Mouhamed, Rosa, Mickael, Corseaux, Delphine, Jeanpierre, Emmanuelle, GOUTAY, Julien, Caplan, Morgan, Varlet, Pauline, Lefevre, Guillaume, Lassalle, Fanny, Bauters, Anne, Faure, Karine, Lambert, Marc, Duhamel, Alain, Labreuche, Julien, Garrigue, Delphine, De Meyer, Simon F., Staels, Bart, Vincent, Flavien, Rousse, Natacha, Kipnis, Eric, Lenting, Peter, Poissy, Julien, Susen, Sophie

المساهمون: CHU Lille, CNRS, Inserm, Institut Pasteur de Lille, Université de Lille, Récepteurs nucléaires, Maladies Cardiovasculaires et Diabète (RNMCD) - U1011, Récepteurs nucléaires, Maladies Cardiovasculaires et Diabète (EGID) - U1011, Récepteurs nucléaires, maladies cardiovasculaires et diabète - U 1011 RNMCD, Centre Hospitalier Régional Universitaire CHU Lille CHRU Lille, Lille Inflammation Research International Center - U 995 LIRIC, Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286, Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 CIIL, Centre d'Infection et d'Immunité de Lille (CIIL) - U1019 - UMR 9017, Facteurs de Risque et Déterminants Moléculaires des Maladies liées au Vieillissement - U 1167 RID-AGE, Facteurs de risque et déterminants moléculaires des maladies liées au vieillissement (RID-AGE) - U1167, Evaluation des technologies de santé et des pratiques médicales - ULR 2694 METRICS, METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694, Unité de Glycobiologie Structurale et Fonctionnelle (UGSF) - UMR 8576, Unité de Glycobiologie Structurale et Fonctionnelle UMR 8576 UGSF

مصطلحات موضوعية: SARS-CoV-2, endothelium, respiratory failure, renal failure, liver dysfunction, critically ill, death

الوصف: Objective: Whether endotheliopathy only mirrors COVID-19 severity or plays an intrinsic role in microvascular thrombosis and organ failure remains unanswered. We assessed whether markers of endothelial damage and immune dysregulation were associated with organ failure and death. Approach: Markers of endothelial damage (VWF:Ag, PAI-1, syndecan-1, TFPI and soluble thrombomodulin), complement activation (C5a and C5b-9), cytokines (IL-6, TNFα, IL-2R) and NETs (cell-free DNA, nucleosomes, myeloperoxidase-DNA) were measured at intensive care unit admission in 82 COVID-19 patients. We also analyzed the histological composition of thrombi collected in living-patients successfully weaned from extracorporeal membrane oxygenation. Results: Beside respiratory failure and death, VWF:Ag, PAI-1, TFPI and syndecan-1 were independently associated with liver injury and multi-organ failure development (all p<0.01), underlining the direct role of endotheliopathy in organ failure. Moreover, dysregulated immune response including cytokines, complement and NETs was associated with markers of endothelial damage, respiratory failure and liver injury and COVID-19 thrombi contained a large accumulation of neutrophils, VWF and NETs. Conclusion: This study establishes a link in severe COVID-19 patients between dysregulated immune response and respiratory and liver failure due to endothelial and microvascular damage and provide new evidence for a major role of VWF, a binding partner of NETs, as a scaffold for thrombus formation in these patients. ; 41;5

وصف الملف: application/octet-stream

العلاقة: Arteriosclerosis, Thrombosis, and Vascular Biology; Arterioscler Thromb Vasc Biol; http://hdl.handle.net/20.500.12210/40863Test

الإتاحة: https://doi.org/20.500.12210/40863Test
https://hdl.handle.net/20.500.12210/40863Test

المؤلفون: Bouadma, Lila, Bouhemad, Belaid, Brissaud, Olivier, Dauger, Stephane, Gibot, Sebastien, Hraiech, Sami, Jung, Boris, Kipnis, Eric, Launey, Yoann, Luyt, Charles-Edouard, Margetis, Dimitri, Michel, Fabrice, Mokart, Djamel, Montravers, Philippe, Monsel, Antoine, Nseir, Saad, Pugin, Jerome, Roquilly, Antoine, Velly, Lionel, Zahar, Jean-Ralph, Bruyere, Remi, Chanques, Gerald

المساهمون: Inserm, Université de Lille, CHU Lille, Recherche translationnelle : relations hôte-pathogènes - EA 7366, Lille Inflammation Research International Center (LIRIC) - U995, 198056, 452433, 93591

الوصف: BACKGROUND: The French Society of Anaesthesia and Intensive Care Medicine and the French Society of Intensive Care edited guidelines focused on hospital-acquired pneumonia (HAP) in intensive care unit. The goal of 16 French-speaking experts was to produce a framework enabling an easier decision-making process for intensivists. RESULTS: The guidelines were related to 3 specific areas related to HAP (prevention, diagnosis and treatment) in 4 identified patient populations (COPD, neutropenia, post-operative and paediatric). The literature analysis and the formulation of the guidelines were conducted according to the Grade of Recommendation Assessment, Development and Evaluation methodology. An extensive literature research over the last 10 years was conducted based on publications indexed in PubMed and Cochrane databases. CONCLUSIONS: HAP should be prevented by a standardised multimodal approach and the use of selective digestive decontamination in units where multidrug-resistant bacteria prevalence was below 20%. Diagnosis relies on clinical assessment and microbiological findings. Monotherapy, in the absence of risk factors for multidrug-resistant bacteria, non-fermenting Gram-negative bacilli and/or increased mortality (septic shock, organ failure), is strongly recommended. After microbiological documentation, it is recommended to reduce the spectrum and to prefer monotherapy for the antibiotic therapy of HAP, including for non-fermenting Gram-negative bacilli. ; 8

وصف الملف: application/rdf+xml; charset=utf-8; application/pdf

العلاقة: Annals of Intensive Care; Ann. Intensive Care; http://hdl.handle.net/20.500.12210/4487Test

الإتاحة: https://doi.org/20.500.12210/4487Test
https://hdl.handle.net/20.500.12210/4487Test

المؤلفون: Leone, Marc, Bouadma, Lila, Bouhemad, Belaid, Brissaud, Olivier, Dauger, Stephane, Gibot, Sebastien, Hraiech, Sami, Jung, Boris, Kipnis, Eric, Launey, Yoann, Luyt, Charles-Edouard, Margetis, Dimitri, Michel, Fabrice, Mokart, Djamel, Montravers, Philippe, Monsel, Antoine, Nseir, Saad, Pugin, Jerome, Roquilly, Antoine, Velly, Lionel, Bruyere, Remi, Chanques, Gerald

المساهمون: Inserm, Université de Lille, CHU Lille, Recherche translationnelle : relations hôte-pathogènes - EA 7366, Lille Inflammation Research International Center (LIRIC) - U995, Hôpital Nord CHU - APHM, AP-HP - Hôpital Bichat - Claude Bernard Paris, Service d'anesthésie - réanimation chirurgicale CHU de Dijon, CHU de Bordeaux Pellegrin Bordeaux, Maladies neurodéveloppementales et neurovasculaires NeuroDiderot (UMR_S_1141 / U1141), Service de Réanimation Médicale CHRU Nancy, University Hospital of Montpellier, Physiologie & médecine expérimentale du Cœur et des Muscles U 1046 PhyMedExp, Service d'anesthésie réanimation chirurgicale Rennes, CHU Pitié-Salpêtrière AP-HP, CHU Saint-Antoine AP-HP, Hôpital de la Timone CHU - APHM TIMONE, Institut Paoli-Calmettes IPC, Université Pierre et Marie Curie - Paris 6 UPMC, Hôpitaux universitaires de Genève = University Hospitals of Geneva HUG, Centre hospitalier universitaire de Nantes CHU Nantes, Centre Hospitalier de Bourg en Bresse

الوصف: The French Society of Anesthesia and Intensive Care Medicine and the French Society of Intensive Care edited guidelines focused on hospital-acquired pneumonia (HAP) in intensive care unit (ICU). The goal of 16 French-speaking experts was to produce a framework enabling an easier decision-making process for intensivists. The guidelines were related to 3 specific areas related to HAP (prevention, diagnosis and treatment) in 4 identified patient populations (COPD, neutropenia, postoperative and pediatric). The literature analysis and the formulation of the guidelines were conducted according to the Grade of Recommendation Assessment, Development and Evaluation methodology. An extensive literature research over the last 10 years was conducted based on publications indexed in PubMed and Cochrane databases. HAP should be prevented by a standardized multimodal approach and the use of selective digestive decontamination in units where multidrug-resistant bacteria prevalence was below 20%. Diagnosis relies on clinical assessment and microbiological findings. Monotherapy, in the absence of risk factors for multidrug-resistant bacteria, non-fermenting Gram negative bacilli and/or increased mortality (septic shock, organ failure), is strongly recommended. After microbiological documentation, it is recommended to reduce the spectrum and to prefer monotherapy for the antibiotic therapy of HAP, including for non-fermenting Gram-negative bacilli. ; 37

وصف الملف: application/octet-stream

العلاقة: Anaesthesia Critical Care & Pain Medicine; Anaesth. Crit. Care Pain Med.; http://hdl.handle.net/20.500.12210/4654Test

الإتاحة: https://doi.org/20.500.12210/4654Test
https://hdl.handle.net/20.500.12210/4654Test

المؤلفون: de Jong, Audrey, Bignon, Anne, Stephan, François, Godet, Thomas, Constantin, Jean-Michel, Asehnoune, Karim, Sylvestre, Aude, Sautillet, Juliette, Blondonnet, Raiko, Ferrandière, Martine, Seguin, Philippe, Lasocki, Sigismond, Rollé, Amélie, Fayolle, Pierre-Marie, Muller, Laurent, Pardo, Emmanuel, Terzi, Nicolas, Ramin, Séverin, Jung, Boris, Abback, Paer-Selim, Guerci, Philippe, Sarton, Benjamine, Rozé, Hadrien, Dupuis, Claire, Cousson, Joel, Faucher, Marion, Lemiale, Virginie, Cholley, Bernard, Chanques, Gerald, Belafia, Fouad, Huguet, Helena, Futier, Emmanuel, Azoulay, Elie, Molinari, Nicolas, Jaber, Samir, Calypso, Roman, Bouteau-Durand, Astrid, Carles, Michel, Mehdaoui, Hossen, Souweine, Bertrand, Calvet, Laure, Jabaudon, Matthieu, Rieu, Benjamin, Candille, Clara, Sigaud, Florian, Riu, Beatrice, Papazian, Laurent, Valera, Sabine, Mokart, Djamel, Chow Chine, Laurent, Bisbal, Magali, Pouliquen, Camille, de Guibert, Jean-Manuel, Tourret, Maxime, Mallet, Damien, Leone, Marc, Zieleskiewicz, Laurent, Cossic, Jeanne, Assefi, Mona, Baron, Elodie, Quemeneur, Cyril, Monsel, Antoine, Biais, Matthieu, Ouattara, Alexandre, Bonnardel, Eline, Monziols, Simon, Mahul, Martin, Lefrant, Jean-Yves, Roger, Claire, Barbar, Saber, Lambiotte, Fabien, Saint-Leger, Piehr, Paugam, Catherine, Pottecher, Julien, Ludes, Pierre-Olivier, Darrivere, Lucie, Garnier, Marc, Kipnis, Eric, Lebuffe, Gilles, Garot, Matthias, Falcone, Jeremy, Chousterman, Benjamin, Collet, Magali, Gayat, Etienne, Dellamonica, Jean, Mfam, Willy-Serge, Ochin, Evelina, Nebli, Mohamed, Tilouche, Nejla, Madeux, Benjamin, Bougon, David, Aarab, Yassir, Garnier, Fanny

المساهمون: Physiologie & médecine expérimentale du Cœur et des Muscles U 1046 (PhyMedExp), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM), Centre Hospitalier Régional Universitaire Montpellier (CHRU Montpellier), Centre Hospitalier Régional Universitaire CHU Lille (CHRU Lille), Hypertension pulmonaire : physiopathologie et innovation thérapeutique (HPPIT), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay, Centre d'études et de recherche sur les services de santé et la qualité de vie (CEReSS), Aix Marseille Université (AMU), Nutrition, Métabolismes et Cancer (NuMeCan), Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Centre Hospitalier Universitaire de Rennes CHU Rennes = Rennes University Hospital Ponchaillou, Biologie des maladies cardiovasculaires = Biology of Cardiovascular Diseases, Université de Bordeaux (UB)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Hôpital universitaire Robert Debré Reims (CHU Reims), Centre Hospitalier Régional Universitaire de Montpellier, PHRCN-18–0078 Finess 340780477, Ministère des Affaires Sociales et de la Santé

المصدر: ISSN: 2213-2600.

مصطلحات موضوعية: [SDV]Life Sciences [q-bio]

الوصف: International audience

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/36693403; hal-03955429; https://hal.science/hal-03955429Test; https://hal.science/hal-03955429/documentTest; https://hal.science/hal-03955429/file/2023%20De%20jong%20et%20al.,%20Effect%20of%20non.pdfTest; PUBMED: 36693403

الإتاحة: https://doi.org/10.1016/S2213-2600Test(22)00529-X
https://hal.science/hal-03955429Test
https://hal.science/hal-03955429/documentTest
https://hal.science/hal-03955429/file/2023%20De%20jong%20et%20al.,%20Effect%20of%20non.pdfTest

المؤلفون: Tabah, Alexis, Buetti, Niccolò, Staiquly, Quentin, Ruckly, Stéphane, Akova, Murat, Aslan, Abdullah Tarik, Leone, Marc, Conway Morris, Andrew, Bassetti, Matteo, Arvaniti, Kostoula, Lipman, Jeffrey, Ferrer, Ricard, Qiu, Haibo, Paiva, José-Artur, Povoa, Pedro, de Bus, Liesbet, de Waele, Jan, Zand, Farid, Gurjar, Mohan, Alsisi, Adel, Abidi, Khalid, Bracht, Hendrik, Hayashi, Yoshiro, Jeon, Kyeongman, Elhadi, Muhammed, Barbier, François, Timsit, Jean-François, Pollock, Hamish, Margetts, Ben, Young, Meredith, Bhadange, Neeraj, Tyler, Steven, Ledtischke, Anne, Finnis, Mackenzie, Dwivedi, Jyotsna, Saxena, Manoj, Biradar, Vishwanath, Soar, Natalie, Sarode, Vineet, Brewster, David, Regli, Adrian, Weeda, Elizabeth, Ahmed, Samiul, Fourie, Cheryl, Laupland, Kevin, Ramanan, Mahesh, Walsham, James, Meyer, Jason, Litton, Edward, Palermo, Anna Maria, Yap, Timothy, Eroglu, Ege, Attokaran, Antony George, Jaramillo, C’havala, Nafees, Khalid Mahmood Khan, Rashid, Nurhikmahtul Aqilah Haji Abd, Walid, Haji Adi Muhamad Ibnu, Mon, Tomas, Moorthi, P. Dhakshina, Sudhirchandra, Shah, Sridharan, Dhadappa Damodar, Haibo, Qiu, Jianfeng, Xie, Wei-Hua, Lu, Zhen, Wang, Qian, Chuanyun, Luo, Jili, Chen, Xiaomei, Wang, Hao, Zhao, Peng, Zhao, Juan, Wusi, Qiu, Mingmin, Chen, Xu, Lei, Yin, Chengfen, Wang, Ruilan, Wang, Jinfeng, Yin, Yongjie, Zhang, Min, Ye, Jilu, Hu, Chungfang, Zhou, Suming, Huang, Min, Yan, Jing, Wang, Yan, Qin, Bingyu, Ye, Ling, Weifeng, Xie, Peije, Li, Geng, Nan, Karumai, Toshiyuki, Yamasaki, Masaki, Hashimoto, Satoru, Hosokawa, Koji, Makino, Jun, Matsuyoshi, Takeo, Kuriyama, Akira, Shigemitsu, Hidenobu, Mishima, Yuka, Nagashima, Michio, Yoshida, Hideki, Fujitani, Shigeki, Omori, Koichiro, Rinka, Hiroshi, Saito, Hiroki, Atobe, Kaori, Kato, Hideaki, Takaki, Shunsuke, Hasan, M. Shahnaz, Jamaluddin, Muhamad Fadhil Hadi, Pheng, Lee See, Visvalingam, Sheshendrasurian, Liew, Mun Thing, Wong, Siong Ling Danny, Fong, Kean Khang, Rahman, Hamizah Bt Abdul, Noor, Zuraini Md, Tong, Lee Kok, Azman, Abd. Hamid, Mazlan, Mohd Zulfakar, Ali, Saedah, Lee, Sang-Min, Park, Sunghoon, Park, Seung Yong, Lim, Sung Yoon, Goh, Qing Yuan, Ng, Shin Yi, Lie, Sui An, Kwa, Andrea Lay Hoon, Goh, Ken Junyang, Li, Andrew Yunkai, Ong, Caroline Yu Ming, Lim, Jia Yan, Quah, Jessica Lishan, Ng, Kangqi, Ng, Louis Xiang Long, Yeh, Yu Chang, Chou, Nai-Kuan, Cia, Cong-Tat, Hu, Ting-Yu, Kuo, Li-Kuo, Ku, Shih-Chi, Wongsurakiat, Phunsup, Apichatbutr, Yutthana, Chiewroongroj, Supattra, Nadeem, Rashid, Houfi, Ashraf El, Elhadidy, Amr, Barsoum, Mina, Osman, Nermin, Mostafa, Tarek, Elbahnasawy, Mohamed, Saber, Ahmed, Aldhalia, Amer, Elmandouh, Omar, Elsayed, Ahmed, Elbadawy, Merihan, Awad, Ahmed, Hemead, Hanan, Ouhadian, Maryam, Borsi, Seyed Hamid, Mehraban, Zahra, Kashipazha, Davood, Ahmadi, Fatemeh, Savaie, Mohsen, Soltani, Farhad, Rashidi, Mahboobeh, Baghbanian, Reza, Javaherforoosh, Fatemeh, Amiri, Fereshteh, Kiani, Arash, Zargar, Mohammad Amin, Mahmoodpoor, Ata, Aalinezhad, Fatemeh, Dabiri, Gholamreza, Sabetian, Golnar, Sarshad, Hakimeh, Masjedi, Mansoor, Tajvidi, Ramin, Tabatabaei, Seyed Mohammad Nasirodin, Ahmed, Abdullah Khudhur, Singer, Pierre, Kagan, Ilya, Rigler, Merav, Belman, Daniel, Levin, Phillip, Harara, Belal, Diab, Adei, Abilama, Fayez, Ibrahim, Rebecca, Fares, Aya, Buimsaedah, Ahmad, Gamra, Marwa, Aqeelah, Ahmed, Aliali, Almajdoub Mohammed, Homaidan, Ahmed Gaber Sadik, Almiqlash, Bushray, Bilkhayr, Hala, Bouhuwaish, Ahmad, Taher, Ahmed Sa, Abdulwahed, Eman, Abousnina, Fathi, Hdada, Aisha Khaled, Jobran, Rania, Hasan, Hayat Ben, Hasan, Rabab Shaban Ben, Serghini, Issam, Seddiki, Rachid, Boukatta, Brahim, Kanjaa, Nabil, Mouhssine, Doumiri, Wajdi, Maazouzi Ahmed, Dendane, Tarek, Zeggwagh, Amine Ali, Housni, Brahim, Younes, Oujidi, Hachimi, Abdelhamid, Ghannam, A., Belkhadir, Z., Amro, Sarah, Jayyab, Mustafa Abu, Hssain, Ali Ait, Elbuzidi, Abdurahaman, Karic, Edin, Lance, Marcus, Nissar, Shaikh, Sallam, Hend, Elrabi, Omar, Almekhlafi, Ghaleb, Awad, Maher, Aljabbary, Ahmed, Chaaban, Mohammad Karam, Abu-Sayf, Natalia, Al-Jadaan, Mohammad, Bakr, Lubna, Bouaziz, Mounir, Turki, Olfa, Sellami, Walid, Centeno, Pablo, Morvillo, Lic Natalia, Acevedo, José Oscar, Lopez, Patricia Mabel, Fernández, Rubén, Segura, Matías, Aparicio, Dra Marta, Alonzo, Microbiologa Irene, Nuccetelli, Yanina, Montefiore, Pablo, Reyes, Luis Felipe, Ñamendys-Silva, Silvio, Romero-Gonzalez, Juan, Hermosillo, Mariana, Castillo, Roberto Alejandro, Leal, Jesús Nicolás Pantoja, Aguilar, Candy Garcia, Herrera, Mara Ocotlan Gonzalez, Villafuerte, Missael Vladimir Espinoza, Lomeli-Teran, Manuel, Dominguez-Cherit, Jose, Davalos-Alvarez, Adrian, Sánchez-Hurtado, Luis, Tejeda-Huezo, Brigitte, Perez-Nieto, Orlando, Tomas, Ernesto Deloya, Hollevoet, Isabelle, Denys, Wouter, Bourgeois, Marc, Vanderhaeghen, Sofie, Mesland, Jean-Baptiste, Henin, Pierre, Haentjens, Lionel, Biston, Patrick, Noel, Cindérella, Layos, Nathalie, Misset, Benoît, de Schryver, Nicolas, Serck, Nicolas, Wittebole, Xavier, de Waele, Elisabeth, Opdenacker, Godelive, Kovacevic, Pedja, Zlojutro, Biljana, Custovic, Aida, Filipovic-Grcic, Ina, Radonic, Radovan, Brajkovic, Ana Vujaklija, Persec, Jasminka, Sakan, Sanja, Nikolic, Mario, Lasic, Hrvoje, Arbelot, Charlotte, Patrier, Juliette, Zappela, N., Montravers, P., Dulac, Thierry, Castanera, Jérémy, Auchabie, Johann, Le Meur, Anthony, Marchalot, A., Beuzelin, M., Massri, Alexandre, Guesdon, Charlotte, Escudier, Etienne, Mateu, Philippe, Rosman, Jérémy, Leroy, Olivier, Alfandari, Serge, Nica, Alexandru, Souweine, Bertrand, Coupez, Elisabeth, Duburcq, Thibault, Kipnis, Eric, Bortolotti, Perrine, Le Souhaitier, Mathieu, Mira, Jean-Paul, Garcon, Pierre, Duprey, Matthieu, Thyrault, Martial, Paulet, Rémi, Philippart, François, Tran, Marc, Bruel, Cédric, Weiss, Emmanuel, Janny, Sylvie, Foucrier, Arnaud, Perrigault, Pierre-François, Djanikian, Flora, Gainnier, Marc, Bourenne, Jérémy, Louis, Guillaume, Smonig, Roland, Argaud, Laurent, Baudry, Thomas, Dessap, Armand Mekonted, Razazi, Keyvan, Kalfon, Pierre, Badre, Gaëtan, Larcher, Romaric, Lefrant, Jean-Yves, Roger, Claire, Sarton, Benjamine, Silva, Stein, Demeret, Sophie, Le Guennec, Loïc, Siami, Shidasp, Aparicio, Christelle, Voiriot, Guillaume, Fartoukh, Muriel, Dahyot-Fizelier, Claire, Imzi, Nadia, Klouche, Kada, Hoheisen, Sandra, Bloos, Frank, Thomas-Rueddel, Daniel, Petros, Sirak, Pasieka, Bastian, Dubler, Simon, Schmidt, Karsten, Gottschalk, Antje, Wempe, Carola, Lepper, Philippe, Metz, Carlos, Viderman, Dmitriy, Ymbetzhanov, Yerlan, Mugazov, Miras, Bazhykayeva, Yelena, Kaligozhin, Zhannur, Babashev, Baurzhan, Merenkov, Yevgeniy, Temirov, Talgat, Smyrniotis, Dimitrios, Psallida, Vasiliki, Fildisis, Georgios, Soulountsi, Vasiliki, Kaimakamis, Evangelos, Iasonidou, Cristina, Papoti, Sofia, Renta, Foteini, Vasileiou, Maria, Romanou, Vasiliki, Koutsoukou, Vasiliki, Matei, Mariana Kristina, Moldovan, Leora, Karaiskos, Ilias, Paskalis, Harry, Marmanidou, Kyriaki, Papanikolaou, M., Kampolis, C., Oikonomou, Marina, Kogkopoulos, Evangelos, Nikolaou, Charikleia, Sakkalis, Anastasios, Chatzis, Marinos, Georgopoulou, Maria, Efthymiou, Anna, Chantziara, Vasiliki, Sakagianni, Aikaterini, Athanasa, Zoi, Papageorgiou, Eirini, Ali, Fadi, Dimopoulos, Georges, Almiroudi, Mariota Panagiota, Malliotakis, Polychronis, Marouli, Diamantina, Theodorou, Vasiliki, Retselas, Ioannis, Kouroulas, Vasilios, Papathanakos, Georgios, Montrucchio, Giorgia, Sales, Gabriele, de Pascale, Gennaro, Montini, Luca Maria, Carelli, Simone, Vargas, Joel, Di Gravio, Valentina, Giacobbe, Daniele Roberto, Gratarola, Angelo, Porcile, Elisa, Mirabella, Michele, Daroui, Ivan, Lodi, Giovanni, Zuccaro, Francesco, Schlevenin, Maria Grazia, Pelosi, Paolo, Battaglini, Denise, Cortegiani, Andrea, Ippolito, Mariachiara, Bellina, Davide, Di Guardo, Andrea, Pelagalli, Lorella, Covotta, Marco, Rocco, Monica, Fiorelli, Silvia, Cotoia, Antonella, Rizzo, Anna Chiara, Mikstacki, Adam, Tamowicz, Barbara, Komorowska, Irmina Kaptur, Szczesniak, Anna, Bojko, Jozef, Kotkowska, Anna, Walczak-Wieteska, Paulina, Wasowska, Dominika, Nowakowski, Tomasz, Broda, Hanna, Peichota, Mariusz, Pietraszek-Grzywaczewska, Iwona, Martin-Loeches, Ignacio, Bisanti, Alessandra, Cartoze, Nuno, Pereira, Tiago, Guimarães, Nádia, Alves, Madalena, Marques, Ana Josefina Pinheiro, Pinto, Ana Rios, Krystopchuk, Andriy, Teresa, Ana, de Figueiredo, António Manuel Pereira, Botelho, Isabel, Duarte, Tiago, Costa, Vasco, Cunha, Rui Pedro, Molinos, Elena, da Costa, Tito, Ledo, Sara, Queiró, Joana, Pascoalinho, Dulce, Nunes, Cristina, Moura, José Pedro, Pereira, Énio, Mendes, António Carvalho, Valeanu, Liana, Bubenek-Turconi, Serban, Grintescu, Ioana Marina, Cobilinschi, Cristian, Filipescu, Daniela Carmen, Predoi, Cornelia Elena, Tomescu, Dana, Popescu, Mihai, Marcu, Alexandra, Grigoras, Ioana, Lungu, Olguta, Gritsan, Alexey, Anderzhanova, Anastasia, Meleshkina, Yulia, Magomedov, Marat, Zubareva, Nadezhda, Tribulev, Maksim, Gaigolnik, Denis, Eremenko, Aleksandr, Vistovskaya, Natala, Chukina, Maria, Belskiy, Vladislav, Furman, Mikhail, Rocca, Ricard Ferrer, Martinez, Maria, Casares, Vanessa, Vera, Paula, Flores, Matias, Amerigo, Joaquin Amador, Arnillas, Maria Pilar Gracia, Bermudez, Rosana Munoz, Armestar, Fernando, Catalan, Beatriz, Roig, Regina, Raguer, Laura, Quesada, María Dolores, Santos, Emilio Diaz, Gomà, Gemma, Ubeda, Alejandro, Salgado, Dra Maria, Espina, Lorena Forcelledo, Prieto, Emilio Garcia, Asensio, Dra Mj, Rodriguez, Dra, Maseda, Emilio, de la Rica, Alejandro Suarez, Ayestaran, J. Ignacio, Novo, Mariana, Blasco-Navalpotro, Miguel Angel, Gallego, Alberto Orejas, Sjövall, Fredrik, Spahic, Dzana, Svensson, Carl Johan, Haney, Michael, Edin, Alicia, Åkerlund, Joyce, de Geer, Lina, Prazak, Josef, Jakob, Stephan, Pagani, Jl, Abed-Maillard, S., Timuroglu, Arif, Kocagoz, Sesin, Kusoglu, Hulya, Mehtap, Selcuk, Ceyhun, Solakoğlu, Altintas, Neriman Defne, Talan, Leyla, Kayaaslan, Bircan, Kalem, Ayşe Kaya, Kurt, Ibrahim, Telli, Murat, Ozturk, Barcin, Erol, Çiğdem, Demiray, Emine Kubra Dindar, Çolak, Sait, Akbas, Türkay, Gundogan, Kursat, Sari, Ali, Agalar, Canan, Çolak, Onur, Baykam, Nurcan, Akdogan, Ozlem, Yilmaz, Mesut, Tunay, Burcu, Cakmak, Rumeysa, Saltoglu, Nese, Karaali, Ridvan, Koksal, Iftihar, Aksoy, Firdevs, Eroglu, Ahmet, Saracoglu, Kemal Tolga, Bilir, Yeliz, Guzeldag, Seda, Ersoz, Gulden, Evik, Guliz, Sungurtekin, Hulya, Ozgen, Cansu, Erdoğan, Cem, Gürbüz, Yunus, Altin, Nilgün, Bayindir, Yasar, Ersoy, Yasemin, Goksu, Senay, Akyol, Ahmet, Batirel, Ayse, Aktas, Sabahat Cagan, Morris, Andrew Conway, Routledge, Matthew, Ercole, Ari, Antcliffe, David, Rojo, Roceld, Tizard, Kate, Faulkner, Maria, Cowton, Amanda, Kent, Melanie, Raj, Ashok, Zormpa, Artemis, Tinaslanidis, George, Khade, Reena, Torlinski, Tomasz, Mulhi, Randeep, Goyal, Shraddha, Bajaj, Manan, Soltan, Marina, Yonan, Aimee, Dolan, Rachael, Johnson, Aimee, Macfie, Caroline, Lennard, James, Templeton, Maie, Arias, Sonia Sousa, Franke, Uwe, Hugill, Keith, Angell, Hollie, Parcell, Benjamin, Cobb, Katherine, Cole, Stephen, Smith, Tim, Graham, Clive, Cerman, Jaroslav, Keegan, Allison, Ritzema, Jenny, Sanderson, Amanda, Roshdy, Ashraf, Szakmany, Tamas, Baumer, Tom, Longbottom, Rebecca, Hall, Daniel, Tatham, Kate, Loftus, S., Husain, A., Black, E., Jhanji, S., Baikady, R. Rao, Mcguigan, Peter, Mckee, Rachel, Kannan, Santhana, Antrolikar, Supriya, Marsden, Nicholas, Torre, Valentina Della, Banach, Dorota, Zaki, Ahmed, Jackson, Matthew, Chikungwa, Moses, Attwood, Ben, Patel, Jamie, Tilley, Rebecca, Humphreys, Miss Sally K., Renaud, Paul Jean, Sokhan, Anton, Burma, Yaroslava, Sligl, Wendy, Baig, Nadia, Mccoshen, Lorena, Kutsogiannis, Demetrios, Thompson, Patricia, Hewer, Tayne, Rabbani, Raihan, Huq, Shihan Mahmud Redwanul, Hasan, Rajib, Islam, Mohammad Motiul, Baronia, Arvind, Kothari, Nikhil, Sharma, Ankur, Karmakar, Saurabh, Sharma, Priya, Nimbolkar, Janardan, Samdani, Pratit, Vaidyanathan, R., Rubina, Noor Ahmedi, Jain, Nikhilesh, Pahuja, Madhumati, Singh, Ritu, Shekhar, Saurav, Muzaffar, Syed Nabeel, Ozair, Ahmad, Siddiqui, Suhail Sarwar, Bose, Payel, Datta, Avijatri, Rathod, Darshana, Patel, Mayur, Renuka, M., Baby, Sailaja, Dsilva, Carol, Chandran, Jagadish, Ghosh, Pralay, Mukherjee, Sudipta, Sheshala, Kaladhar, Misra, Krushna Chandra, Yakubu, Saidu Yusuf, Ugwu, Euphemia Mgbosoro, Olatosi, John, Desalu, Ibironke, Asiyanbi, Gabriel, Oladimeji, Motunrayo, Idowu, Olusola, Adeola, Fowotade, Mc Cree, Melanie, Karar, Ali Adil Ali, Saidahmed, Elfayadh, Hamid, Hytham

المساهمون: Université de Montpellier (UM), Centre Hospitalier Universitaire de Nîmes (CHU Nîmes)

المصدر: ISSN: 0342-4642.

مصطلحات موضوعية: [SDV]Life Sciences [q-bio]

الوصف: International audience

العلاقة: hal-03988471; https://hal.science/hal-03988471Test; https://hal.science/hal-03988471/documentTest; https://hal.science/hal-03988471/file/2023%20Tabah%20et%20al.,%20Epidemiology%20and%20outcomes.pdfTest

الإتاحة: https://doi.org/10.1007/s00134-022-06944-2Test
https://hal.science/hal-03988471Test
https://hal.science/hal-03988471/documentTest
https://hal.science/hal-03988471/file/2023%20Tabah%20et%20al.,%20Epidemiology%20and%20outcomes.pdfTest

المؤلفون: Trøseid, Marius, Arribas, José, Assoumou, Lambert, Holten, Aleksander Rygh, Poissy, Julien, Terzić, Vida, Mazzaferri, Fulvia, Baño, Jesús Rodríguez, Eustace, Joe, Hites, Maya, Joannidis, Michael, Paiva, José-Artur, Reuter, Jean, Püntmann, Isabel, Patrick-Brown, Thale, Westerheim, Elin, Nezvalova-Henriksen, Katerina, Beniguel, Lydie, Dahl, Tuva Børresdatter, Bouscambert, Maude, Halanova, Monika, Péterfi, Zoltán, Tsiodras, Sotirios, Rezek, Michael, Briel, Matthias, Ünal, Serhat, Schlegel, Martin, Ader, Florence, Lacombe, Karine, Amdal, Cecilie Delphin, Rodrigues, Serge, Tonby, Kristian, Gaudet, Alexandre, Heggelund, Lars, Mootien, Joy, Johannessen, Asgeir, Møller, Jannicke Horjen, Pollan, Beatriz Diaz, Tveita, Anders Aune, Kildal, Anders Benjamin, Richard, Jean-Christophe, Dalgard, Olav, Simensen, Victoria Charlotte, Baldé, Aliou, de Gastines, Lucie, del Álamo, Marta, Aydin, Burç, Lund-Johansen, Fridtjof, Trabaud, Mary-Anne, Diallo, Alpha, Halvorsen, Bente, Røttingen, John-Arne, Tacconelli, Evelina, Yazdanpanah, Yazdan, Olsen, Inge, Costagliola, Dominique, Dyrhol-Riise, Anne Ma, Stiksrud, Birgitte, Jenum, Synne, Macpherson, Magnhild Eide, Aarskog, Nikolai Ravn, Røstad, Kjerstin, Skeie, Linda Gail, Dahl, Åsne, Steen, Jeanette Konstance, Nur, Sarah, Segers, Filip, Korsan, Katrine Andersen, Sethupathy, Ashwini, Sandstå, Ann Jorunn, Paulsen, Gunn-Janne, Ueland, Thor, Michelsen, Annika, Aukrust, Pål, Berdal, Jan Erik, Melkeraaen, Ingunn, Tollefsen, Merete Moen, Andreassen, Jessica, Dokken, Jannicke, Müller, Karl Erik, Woll, Bjørn Martin, Opsand, Hanne, Bogen, Mette, Rød, Linn-Therese, Steinsvik, Trude, Åsheim-Hansen, Bjørn, Bjerkreim, Randi Haukaas, Berg, Åse, Moen, Solfrid, Kvalheim, Stina, Strand, Kristian, Gravrok, Berit, Skogen, Vegard, Lorentzen, Elias Myrvoll, Schive, Simen Walberg, Rossvoll, Lasse, Hoel, Hedda, Engebråten, Simon, Martinsson, Mia Schie, Thallinger, Monica, Ådnanes, Elise, Hannula, Raisa, Bremnes, Nina, Liyanarachi, Kristin, Ehrnström, Birgitta, Kvalshaug, Martin, Berge, Kari, Bygdås, Marte, Gustafsson, Linda, Aballib, Saad, Strand, Marianne, Andersen, Britt, Barratt-Due, Andreas, Henriksen, Katerina Nezvalova, Kåsine, Trine, Favory, Raphaël, Nseir, Saad, Preau, Sebastien, Jourdain, Mercé, Ledoux, Geoffrey, Durand, Arthur, Houard, Marion, Moreau, Anne-Sophie, Rouzé, Anahita, Tortuyaux, Romain, Degouy, Guillaume, Levy, Clémentin, Liu, Vincent, Dognon, Nicolas, Mariller, Laure, Delcourte, Claire, Reguig, Zineb, Cerf, Amélie, Cuvelliez, Marie, Kipnis, Eric, Boyer-Beysserre, Marielle, Bignon, Anne, Parmentier, Laurie, Meddour, Damia, Frade, Sarah, Timsit, Jean-François, Peiffer-Smadja, Nathan, Wicky, Paul-Henri, de Montmollin, Etienne, Bouadma, Lila, Dessajan, Julien, Sonneville, Romain, Patrier, Juliette, Presente, Simona, Sylia, Zmihi, Rioux, Christophe, Thy, Michaël, Collias, Lio, Bouaraba, Yasmine, Dobremel, Nikita, Dureau, Anne-Florence, Oudeville, Pierre, Pointurier, Valentin, Rabouel, Yannick, Stiel, Laure, Alzina, Camille, Ramstein, Camille, Ait-Oufella, Hafid, Hamoudi, Fatima, Urbina, Thomas, Zerbib, Yoann, Maizel, Julien, Wilpotte, Celine, Piroth, Lionel, Blot, Mathieu, Sixt, Thibault, Moretto, Florian, Charles, Carole, Gohier, Sandrine, Roux, Damien, Le Breton, Camille, Gernez, Coralie, Thiry, Ingrid, Baboi, Loredana, Malvy, Denis, Boyer, Alexandre, Perreau, Pauline, Armellini, Maddalena, de Luca, Giulia, Di Pietro, Ospedale, Romanin, Benedetta, Brogi, Michela, Castelli, Francesco, Amadasi, Silvia, Barchiesi, Francesco, Canovari, Benedetta, Coppola, Nicola, Pisaturo, Mariantonietta, Russo, Antonio, Occhiello, Laura, Cataldo, Francesco, Rillo, Marta Mora, Queiruga, Javier, Seco, Enrique, Stewart, Stefan, Borobia, Alberto, Moraga, Paloma, Prieto, Rocío, García, Irene, Rivera, Carlota, Narro, José Luis, Chacón, Natalia, de la Rosa, Sandra, Macías, María, Barrera, Lydia, Serna, Almudena, Palomo, Virginia, Sánchez, Maria Isabel García, Gutiérrez, David, Campos, Ana Silva, Garfia, Miguel Ángel Gómez, Toyos, Elvira Bonilla, Cabrera, Judith Sanabria, Lucena, María Isabel, Lapique, Eva Larranaga, Englert, Pierre, Khalil, Zineb, Jacobs, Frédérique, Malaise, Justine, Mukangenzi, Odette, Smissaert, Cinderella, Hildebrand, Marc, Martiny, Delphine, Vervacke, Audrey, Scarnière, Axelle, Yin, Nicolas, Michel, Charlotte, Seyler, Lucie, Allard, Sabine, van Laethem, Johan, Verschelden, Gil, Meeuwissen, Annelies, de Waele, Alex, van Buggenhout, Virgini, Monteyne, Dora, Noppe, Nils, Belkhir, Leila, Yombi, Jean Cyr, de Greef, Julien, Mesland, Jean Baptiste, de Ghellinck, Léopold, Kin, Valérie, D’aoust, Céline, Bouvier, Anne, Dekeister, Anne- Charlotte, Hawia, Estelle, Gaillet, Adeline, Deshorme, Hélène, Halleux, Severine, Galand, Vanessa, Roncon-Albuquerque, Roberto, Santos, Luís Linhares, Vieira, César Burgi, Magalhaes, Rosana, Ferreira, Sónia, Bernardo, Mariana, Jackson, Arthur, Sadlier, Corinna, O’connell, Sarah, Blair, Matthew, Manning, Edmund, Cusack, Fiona, Kelly, Niamh, Stephenson, Hannah, Keane, Ruben, Murphy, Aisling, Cunnane, Michele, Keane, Fionnuala, O’regan, Mary-Claire, de Barra, Eoghan, Bellone, Aimee Mcgreal, O’regan, Siobhan, Carey, Patrick, Harte, Jeffrey, Coakley, Peter, Heeney, Aoife, Ryan, Dorothy, Curley, Gerard, Mcconkey, Samuel, Sulaiman, Imran, Costello, Richard, Mcnally, Cora, Foley, Claire, Trainor, Sophie, Jacob, Benson, Vengathodi, Suchitra, Kent, Brian, Bergin, Colm, Townsend, Liam, Kerr, Colm, Panti, Nalini, Sanz, Alberto Garcia, Benny, Binny, Dea, Edel, Galvin, Niamh, Burke, Claire, Galvin, Aisling, Aisiyabi, Sara, Lobo, Deepanjali, Laffey, John, Mcnicolas, Bairbre, Cosgrave, David, Sheehan, J., Nita, Ciprian, Hanley, Ciara, Kelly, Claire, Kernan, Maeve, Murray, Jonathan, Staub, Thérèse, Henin, Thomas, Damilot, Gaelle, Bintener, Tania, Colling, Joelle, Ferretti, Christian, Werer, Christophe, Stammet, Pascal, Braquet, Pierre, Arendt, Vic, Calvo, Esther, Michaux, Christian, Mediouni, Chouaib, Znati, Ali, Montanes, Gloria, Garcia, Laetitia, Thomé, Claudius, Breitkopf, Robert, Peer, Andreas, Lehner, Georg, Bellman, Romuald, Ditlbacher, Adelheid, Finkenstedt, Armin, Zotter, Klemens, Hernandez, Christian Preuss, Rajsic, Sasa, Lanthaler, Barbara, Greil, Richard, Tamás, Kiss, Kovácsné-Levang, Szilvia, Sipos, David, Kappéter, Agnes, Halda-Kiss, Bernadett, Madarassi-Papp, Edit, Hajdu, Edit, Bende, Balázs, Konstantinos, Thomas, Moschopoulos, Charalambos, Labrou, Eleni, Tsakona, Maria, Grigoropoulos, Ioannis, Kotanidou, Anastasia, Fragkou, Paraskevi, Theodorakopoulou, Maria, Pantazi, Eugenia, Jahai, Edison, Moukouli, Maria, Siafakas, Dimitrios, Mühlbauer, Bernd, Dembinski, Rolf, Stich, Kathrin, Schneider, Gerhard, Nagy, Andrej, Grodová, Karolína, Kubelová, Michaela, Součková, Lenka, Švábová, Helena Kartáková, Demlová, Regina, Sonderlichová, Simona, Unal, Serhat, Inkaya, A., de Bono, Stephanie, Kartman, Cynthia, Adams, David, Crowe, Brenda, Yazdanapanah, Yazdan, Ødegård, Tone, Bakkehøi, Gine, Autran, Brigitte, Bjørås, Magnar, Lambellerie, Xavier De-, Mezzarri, Fulvia, Guedj, Jeremie, Esperou, Helene, Lumbroso, Julia, Welte, Tobias, Calmy, Alexandra, Pischke, Søren, Treweek, Shaun, Goetghebeur, Els, Doussau, Adelaide, Weiss, Laurence, Hulstaert, Frank, Botgros, Radu, del Alamo, Marta, Chung, Florence, Zeitlinger, Markus, Escalera, Begonya, Csajka, Chantal, Williams, Clare, Amstutz, Alain, Rüegg, Corina Silvia, Burdet, Charles, Massonnaud, Clement, Belhadi, Drifa, Mentré, France, Aroun, Massinissa, Ehrmann, Stephan, Espoerou, Helene, Falk, Ragnhild Sørum, Bjordal, Kristin, Bakkehøi, Gina

المساهمون: Facteurs de Risque et Déterminants Moléculaires des Maladies liées au Vieillissement - U 1167 (RID-AGE), Institut Pasteur de Lille, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire CHU Lille (CHRU Lille)

المصدر: ISSN: 1364-8535.

مصطلحات موضوعية: [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie

الوصف: International audience ; Abstract Background Baricitinib has shown efficacy in hospitalized patients with COVID-19, but no placebo-controlled trials have focused specifically on severe/critical COVID, including vaccinated participants. Methods Bari-SolidAct is a phase-3, multicentre, randomised, double-blind, placebo-controlled trial, enrolling participants from June 3, 2021 to March 7, 2022, stopped prematurely for external evidence. Patients with severe/critical COVID-19 were randomised to Baricitinib 4 mg once daily or placebo, added to standard of care. The primary endpoint was all-cause mortality within 60 days. Participants were remotely followed to day 90 for safety and patient related outcome measures. Results Two hundred ninety-nine patients were screened, 284 randomised, and 275 received study drug or placebo and were included in the modified intent-to-treat analyses (139 receiving baricitinib and 136 placebo). Median age was 60 (IQR 49–69) years, 77% were male and 35% had received at least one dose of SARS-CoV2 vaccine. There were 21 deaths at day 60 in each group, 15.1% in the baricitinib group and 15.4% in the placebo group (adjusted absolute difference and 95% CI − 0.1% [− 8·3 to 8·0]). In sensitivity analysis censoring observations after drug discontinuation or rescue therapy (tocilizumab/increased steroid dose), proportions of death were 5.8% versus 8.8% (− 3.2% [− 9.0 to 2.7]), respectively. There were 148 serious adverse events in 46 participants (33.1%) receiving baricitinib and 155 in 51 participants (37.5%) receiving placebo. In subgroup analyses, there was a potential interaction between vaccination status and treatment allocation on 60-day mortality. In a subsequent post hoc analysis there was a significant interaction between vaccination status and treatment allocation on the occurrence of serious adverse events, with more respiratory complications and severe infections in vaccinated participants treated with baricitinib. Vaccinated participants were on average 11 years older, with more ...

العلاقة: hal-04399266; https://hal.science/hal-04399266Test; https://hal.science/hal-04399266/documentTest; https://hal.science/hal-04399266/file/s13054-022-04205-8.pdfTest

الإتاحة: https://doi.org/10.1186/s13054-022-04205-8Test
https://hal.science/hal-04399266Test
https://hal.science/hal-04399266/documentTest
https://hal.science/hal-04399266/file/s13054-022-04205-8.pdfTest

المؤلفون: Foucrier, Arnaud, Dessalle, Thomas, Tuffet, Sophie, Federici, Laura, Dahyot‑Fizelier, Claire, Barbier, François, Pottecher, Julien, Monsel, Antoine, Hissem, Tarik, Lefrant, Jean‑Yves, Demoule, Alexandre, Constantin, Jean‑Michel, Rousseau, Alexandra, Simon, Tabassome, Leone, Marc, Bouglé, Adrien, Amour, Julien, Zegdi, Florence Bellenfant, Cholley, Bernard, Massot, Julien, Constantin, Jean-Michel, Mayaux, Julien, Dubée, Vincent, Dupont, Hervé, Duranteau, Jacques, Geeraerts, Thomas, Guichon, Céline, Kalfon, Pierre, Kipnis, Éric, Lasocki, Sigismond, Lefrant, Jean-Yves, Legrand, Matthieu, Lescot, Thomas, Lévy, Bruno, Cousson, Joël, Montravers, Philippe, Tanaka, Sébastien, Novy, Emmanuel, Ouattara, Alexandre, Payen, Jean-François, Picard, Walter, Poète, Pascale, Quesnel, Christophe

المصدر: Critical Care ; volume 27, issue 1 ; ISSN 1364-8535

مصطلحات موضوعية: Critical Care and Intensive Care Medicine

الوصف: Background The optimal treatment duration and the nature of regimen of antibiotics (monotherapy or combination therapy) for Pseudomonas aeruginosa ventilator‑associated pneumonia (PA-VAP) remain debated. The aim of this study was to evaluate whether a combination antibiotic therapy is superior to a monotherapy in patients with PA-VAP in terms of reduction in recurrence and death, based on the 186 patients included in the iDIAPASON trial, a multicenter, randomized controlled trial comparing 8 versus 15 days of antibiotic therapy for PA-VAP. Methods Patients with PA-VAP randomized in the iDIAPASON trial (short-duration—8 days vs. long-duration—15 days) and who received appropriate antibiotic therapy were eligible in the present study. The main objective is to compare mortality at day 90 according to the antibiotic therapy received by the patient: monotherapy versus combination therapy. The primary outcome was the mortality rate at day 90. The primary outcome was compared between groups using a Chi-square test. Time from appropriate antibiotic therapy to death in ICU or to censure at day 90 was represented using Kaplan–Meier survival curves and compared between groups using a Log-rank test. Results A total of 169 patients were included in the analysis. The median duration of appropriate antibiotic therapy was 14 days. At day 90, among 37 patients (21.9%) who died, 17 received monotherapy and 20 received a combination therapy ( P = 0.180). Monotherapy and combination antibiotic therapy were similar for the recurrence rate of VAP, the number of extra pulmonary infections, or the acquisition of multidrug-resistant (MDR) bacteria during the ICU stay. Patients in combination therapy were exposed to mechanical ventilation for 28 ± 12 days, as compared with 23 ± 11 days for those receiving monotherapy ( P = 0.0243). Results remain similar after adjustment for randomization arm of iDIAPASON trial and SOFA score at ICU admission. Conclusions Except longer durations of antibiotic therapy and mechanical ventilation, ...

الإتاحة: https://doi.org/10.1186/s13054-023-04457-yTest

المؤلفون: Le Guern, Rémi, Grandjean, Teddy, Stabler, Sarah, Bauduin, Marvin, Gosset, Philippe, Kipnis, Éric, Dessein, Rodrigue

المصدر: Nature Communications ; volume 14, issue 1 ; ISSN 2041-1723

مصطلحات موضوعية: General Physics and Astronomy, General Biochemistry, Genetics and Molecular Biology, General Chemistry, Multidisciplinary

الوصف: Carbapenemase-producing Enterobacterales (CPE) are spreading rapidly in hospital settings. Asymptomatic CPE gut colonisation may be associated with dysbiosis and gut-lung axis alterations, which could impact lung infection outcomes. In this study, in male C57BL/6JRj mice colonised by CPE, we characterise the resulting gut dysbiosis, and analyse the lung immune responses and outcomes of subsequent Pseudomonas aeruginosa lung infection. Asymptomatic gut colonisation by CPE leads to a specific gut dysbiosis and increases the severity of P. aeruginosa lung infection through lower numbers of alveolar macrophages and conventional dendritic cells. CPE-associated dysbiosis is characterised by a near disappearance of the Muribaculaceae family and lower levels of short-chain fatty acids. Faecal microbiota transplantation restores immune responses and outcomes of lung infection outcomes, demonstrating the involvement of CPE colonisation-induced gut dysbiosis in altering the immune gut-lung axis, possibly mediated by microbial metabolites such as short-chain fatty acids.

الإتاحة: https://doi.org/10.1038/s41467-022-35767-4Test
https://www.nature.com/articles/s41467-022-35767-4.pdfTest
https://www.nature.com/articles/s41467-022-35767-4Test

المؤلفون: Goutelle, Sylvain, Wallet, Florent, Thoma, Yann, Peclard, Jean-Rémi, Bourguignon, Laurent, Cohen, Sabine, Kipnis, Eric, Roberts, Jason, Allaouchiche, Bernard, Friggeri, Arnaud

المساهمون: Hospices Civils de Lyon

المصدر: Anaesthesia Critical Care & Pain Medicine ; volume 42, issue 6, page 101286 ; ISSN 2352-5568

مصطلحات موضوعية: Anesthesiology and Pain Medicine, Critical Care and Intensive Care Medicine, General Medicine

الإتاحة: https://doi.org/10.1016/j.accpm.2023.101286Test
https://api.elsevier.com/content/article/PII:S2352556823000942?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S2352556823000942?httpAccept=text/plainTest

المؤلفون: Louis, Melissande, Tahrioui, Ali, Tremlett, Courtney J., Clamens, Thomas, Leprince, Jérôme, Lefranc, Benjamin, Kipnis, Eric, Grandjean, Teddy, Bouffartigues, Emeline, Barreau, Magalie, Defontaine, Florian, Cornelis, Pierre, Feuilloley, Marc G.J., Harmer, Nicholas J., Chevalier, Sylvie, Lesouhaitier, Olivier

المصدر: Biofilm ; volume 5, page 100131 ; ISSN 2590-2075

مصطلحات موضوعية: Cell Biology, Molecular Biology, Applied Microbiology and Biotechnology, Microbiology

الإتاحة: https://doi.org/10.1016/j.bioflm.2023.100131Test
https://api.elsevier.com/content/article/PII:S259020752300028X?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S259020752300028X?httpAccept=text/plainTest