المؤلفون: Hiroyuki Kamiya, Kinya Shinoda, Koichiro Kudo, Nobuyuki Kobayashi, Takatomo Morita, Takeshi Fujii, Tomokiyo Nomura

المصدر: Internal Medicine. 2006, 45(5):275

المؤلفون: Akihiko Gemma, Datong Zou, Kinya Shinoda, Kiyoshi Takenaka, Kuniko Matsuda, Masahiko Shibuya, Shoji Kudoh, Suguru Hibino, 工藤 翔二, 弦間 昭彦, 日比野 俊, 松田 久仁子, 渋谷 昌彦, 竹中 圭, 篠田 欣也, 鄒 大同

المصدر: Journal of Nippon Medical School. 2004, 71(3):181

المؤلفون: Akihiko Gemma, Hiroshi Ono, Kinya Shinoda, Shoji Kudoh, Tetsu Sakamoto, Yasuyuki Taniguchi

المصدر: Journal of Nippon Medical School. 2009, 76(2):67

المؤلفون: Hisanobu Niitan, Jiro Usuki, Kazutsugu Uematsu, Kinya Shinoda, Kouzoh Yoshimori, Masahiro Seike, Shoji Kudoh, Tatsuji Enomoto, Yuh Fukuda

المصدر: The Japanese journal of thoracic diseases. 1995, 33(8):894

المؤلفون: Shoji Kudoh, Akihiko Gemma, Tetsu Sakamoto, Hiroshi Ono, Yasuyuki Taniguchi, Kinya Shinoda

المصدر: Journal of Nippon Medical School = Nippon Ika Daigaku zasshi. 76(2)

مصطلحات موضوعية: Adult, Male, medicine.medical_specialty, Pathology, Severity of Illness Index, Pulmonary function testing, Correlation, Internal medicine, medicine, Humans, Respiratory sounds, Aged, Respiratory Sounds, Lung, medicine.diagnostic_test, Receiver operating characteristic, business.industry, General Medicine, Auscultation, Middle Aged, Respiratory Function Tests, medicine.anatomical_structure, Quartile, Cardiology, Crackles, medicine.symptom, business, Lung Diseases, Interstitial

الوصف: Purpose: We investigated whether spectral analysis with fast Fourier transform (FFT) of inspiratory lung sounds is useful in the diagnosis and evaluation of the severity of interstitial pneumonia (IP). Subjects and Methods: The study population included 10 healthy volunteers (healthy group) and 21 patients with IP (IP group). We generated inspiratory averaged linear intensities using FFT and determined frequency at maximum sound intensity (Fmax), and quartile frequencies (f25, f50, and f75), compared these values between the groups, generated receiver operating characteristic curves to compare the detectability of IP between the indices and auscultation in all cases, and tested for the correlation of these indices with pulmonary function tests and the fibrosis scores from high-resolution computed tomography images assessed by 3 observers. Results: Both f50 and f75 were significantly higher in the IP group, but their ability to detect IP was inferior to that of auscultation. They had negative correlations with percent vital capacity and had positive correlations with the fibrosis scores calculated by the 3 different observers. Discussion: These results were considered to reflect the presence of fine crackles and alterations in pulmonary sound-conduction characteristics caused by IP and indicate that spectral analysis of lung sounds is useful in the diagnosis and evaluation of the severity of IP, although future study is necessary to improve its utility.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa6732aa6b5a43ab61c692db6d0060b2Test
https://pubmed.ncbi.nlm.nih.gov/19443991Test

المؤلفون: Kinya Shinoda, Hiroyuki Kamiya, Takatomo Morita, Nobuyuki Kobayashi, Tomokiyo Nomura, Koichiro Kudo, Takeshi Fujii

المصدر: Internal medicine (Tokyo, Japan). 45(5)

مصطلحات موضوعية: Cortical tubers, Adult, medicine.medical_specialty, Pathology, Tuberous sclerosis, Tuberous Sclerosis, Internal Medicine, medicine, Humans, Atypical adenomatous hyperplasia, Lung, Hyperplasia, medicine.diagnostic_test, business.industry, Thoracic Surgery, Video-Assisted, Calcinosis, Magnetic resonance imaging, General Medicine, medicine.disease, Multifocal micronodular pneumocyte hyperplasia, Adenocarcinoma, Female, Radiology, Fibroma, business, Tomography, X-Ray Computed, Calcification

الوصف: A 41-year-old woman with a history of epilepsy was referred for multiple nodular ground-glass opacities on a chest computed tomography (CT) scan. They were initially suspected of representing atypical adenomatous hyperplasia or well-differentiated adenocarcinoma. However, the subsequent brain CT and magnetic resonance imaging (MRI) scans revealed a coarse nodular calcification and cortical tubers. A subungual fibroma was also noted. Histological examination of a video-assisted thoracoscopic lung biopsy specimen disclosed multiple nodules of type II pneumocyte hyperplasia with septal thickening. Based on all of these findings taken together, a diagnosis of tuberous sclerosis complex with multifocal micronodular pneumocyte hyperplasia (MMPH) was made.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a582033e955078462d1ac673253c4fb3Test
https://pubmed.ncbi.nlm.nih.gov/16595993Test

المؤلفون: Kinya Shinoda, Masahiko Shibuya, Datong Zou, Kuniko Matsuda, Shoji Kudoh, Kiyoshi Takenaka, Suguru Hibino, Akihiko Gemma

المصدر: Journal of Nippon Medical School = Nippon Ika Daigaku zasshi. 71(3)

مصطلحات موضوعية: Oncology, Male, Vascular Endothelial Growth Factor A, medicine.medical_specialty, Lung Neoplasms, Angiogenesis, Gene Expression, Mice, Nude, Matrix (biology), Adenocarcinoma, Metastasis, chemistry.chemical_compound, Mice, In vivo, Internal medicine, Gene expression, medicine, Animals, Humans, Neoplasm Metastasis, Cells, Cultured, Oligonucleotide Array Sequence Analysis, Mice, Inbred BALB C, Mice, Inbred ICR, Neovascularization, Pathologic, General Medicine, medicine.disease, Molecular biology, Blot, Vascular endothelial growth factor, chemistry, Cell culture, Matrix Metalloproteinase 2, Female, Neoplasm Transplantation

الوصف: We investigated the ability of angiogenesis in PC9/F9 cells (from a highly metastatic human lung adenocarcinoma cell line) as compared with PC9 cells (from a low metastatic human lung adenocarcinoma cell line). In vivo tumor growth assay using BALB/c nude mice (7 mice/group), showed that the tumor volume of PC9/F9 cells on day 35 (230.7+/-31.3 mm(3)) was significantly larger than that of PC9 cells (90.9+/-24.7 mm(3)) (p

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60d65bd63ba7b4b31e89e9779913d180Test
https://pubmed.ncbi.nlm.nih.gov/15226609Test

المؤلفون: Shoji Kudoh, Yasushi Ono, Kuniko Matsuda, Suguru Hibino, Kinya Shinoda, Datong Zou, Akira Takemura, Akiko Takechi, Yutaka Kokubo, Masahiko Shibuya

المصدر: International journal of oncology. 22(2)

مصطلحات موضوعية: Cancer Research, Pathology, medicine.medical_specialty, Lung Neoplasms, Matrix metalloproteinase inhibitor, Angiogenesis, Fibrosarcoma, Injections, Subcutaneous, Mice, Nude, Angiogenesis Inhibitors, Antineoplastic Agents, Matrix metalloproteinase, Biology, Matrix Metalloproteinase Inhibitors, Hydroxamic Acids, Guanidines, Metastasis, Mice, medicine, Tumor Cells, Cultured, Animals, Humans, MTT assay, Protease Inhibitors, Mice, Inbred BALB C, Mice, Inbred ICR, Molecular Structure, Cell growth, medicine.disease, Xenograft Model Antitumor Assays, Neoplasm Proteins, Oncology, Cancer research, Female, Marimastat, medicine.drug

الوصف: The matrix metalloproteinases (MMPs) are likely to contribute to tumor cell invasion, metastasis and angiogenesis. Several MMP inhibitors have been developed, recently and their anti-tumor efficacy is being evaluated in clinical trials. FYK-1388 is a novel broad MMP inhibitor which blocks the activity of MMP-1, -2, -3, -7, -9, -13 and -14 (MT-MMP-1). It is especially effective against MMP-2 and -9 more so than other MMP inhibitors such as Marimastat, Ro 32-3555 and D-2163. Here, we investigated the anti-tumor efficacy of FYK-1388 using the human fibrosarcoma cell line HT-1080. These cells produced MMP-2 and -9, which FYK-1388 inhibited at a dose of 10(-8) M. FYK-1388 at 0.2 mg/mouse/day significantly suppressed tumor growth when given by s.c. injection for 22 days, experimental lung metastasis after 5 days s.c. injection and also suppressed tumor-induced angiogenesis in the dorsal air sac assay after 7 days s.c. injection. In the MTT assay, FYK-1388 had no effect on the in vitro growth of HT-1080 cells. These results suggest that FYK-1388 possesses anti-tumor efficacy as a result of inhibiting angiogenesis through the suppression of MMP-2 and -9 activity.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::066a13b8894590478e948bcd337db225Test
https://pubmed.ncbi.nlm.nih.gov/12527923Test