المؤلفون: Oh, Min-Ha, Kim, Young-Hwan, Lee, Seung-Min, Hwang, Gyeong-Seok, Kim, Kyung-Sub, Bae, Jae-Young, Kim, Ju-Young, Lee, Ju-Yong, Kim, Yu-Chan, Kim, Sang Yup, Kang, Seung-Kyun

مصطلحات موضوعية: Computer Science - Robotics, Condensed Matter - Materials Science, Condensed Matter - Soft Condensed Matter

الوصف: Developing soft robots that can control their own life-cycle and degrade on-demand while maintaining hyper-elasticity is a significant research challenge. On-demand degradable soft robots, which conserve their original functionality during operation and rapidly degrade under specific external stimulation, present the opportunity to self-direct the disappearance of temporary robots. This study proposes soft robots and materials that exhibit excellent mechanical stretchability and can degrade under ultraviolet (UV) light by mixing a fluoride-generating diphenyliodonium hexafluorophosphate (DPI-HFP) with a silicone resin. Spectroscopic analysis revealed the mechanism of Si-O-Si backbone cleavage using fluoride ion (F-), which was generated from UV exposed DPI-HFP. Furthermore, photo-differential scanning calorimetry (DSC) based thermal analysis indicated increased decomposition kinetics at increased temperatures. Additionally, we demonstrated a robotics application of this composite by fabricating a gaiting robot. The integration of soft electronics, including strain sensors, temperature sensors, and photodetectors, expanded the robotic functionalities. This study provides a simple yet novel strategy for designing lifecycle mimicking soft robotics that can be applied to reduce soft robotics waste, explore hazardous areas where retrieval of robots is impossible, and ensure hardware security with on-demand destructive material platforms.
Comment: 58 pages, 6 figures, 2 Supplementary Text, 15 Supplementary figures, 1 movie

الوصول الحر: http://arxiv.org/abs/2302.14331Test

المؤلفون: Choo, Seryung, Kim, Ju Young, Jung, Se Young, Kim, Sarah, Kim, Jeong Eun, Han, Jong Soo, Kim, Sohye, Kim, Jeong Hyun, Kim, Jeehye, Kim, Yongseok, Kim, Dongouk, Steinhubl, Steve

المصدر: JMIR mHealth and uHealth, Vol 4, Iss 1, p e24 (2016)

مصطلحات موضوعية: Information technology, T58.5-58.64, Public aspects of medicine, RA1-1270

الوصف: BackgroundAlthough complications of obesity are well acknowledged and managed by clinicians, management of obesity itself is often difficult, which leads to its underdiagnosis and undertreatment in hospital settings. However, tools that could improve the management of obesity, including self-monitoring, engagement with a social network, and open channels of communication between the patient and doctor, are limited in a clinic-based setting. ObjectiveThe objective of our study was to evaluate the usability and acceptability of a newly developed mobile app linked with an accelerometer and its early effects on patient-doctor relationships. MethodsFrom September 2013 to February 2014, we developed a mobile app linked with an accelerometer as a supportive tool for a clinic-based weight loss program. The app used information from electronic health records and delivered tailored educational material. Personal goal setting, as well as monitoring of weight changes and physical activity combined with feedback, are key features of the app. We also incorporated an interactive message board for patients and doctors. During the period of March 2014 to May 2014, we tested our mobile app for 1 month in participants in a hospital clinic setting. We assessed the app’s usability and acceptability, as well as the patient-doctor relationship, via questionnaires and analysis of app usage data. ResultsWe recruited 30 individuals (18 male and 12 female) for the study. The median number of log-ins per day was 1.21, with the most frequently requested item being setting goals, followed by track physical activities and view personal health status. Scales of the depth of the patient-doctor relationship decreased from 27.6 (SD 4.8) to 25.1 (SD 4.5) by a Wilcoxon signed rank test (P=.02). ConclusionsA mobile phone app linked with an accelerometer for a clinic-based weight loss program is useful and acceptable for weight management but exhibited less favorable early effects on patient-doctor relationships.

وصف الملف: electronic resource

العلاقة: http://mhealth.jmir.org/2016/1/e24Test/; https://doaj.org/toc/2291-5222Test

الوصول الحر: https://doaj.org/article/b6ac7aa96f5e4006858b29daa58814bcTest

المؤلفون: Kim, Keonkuk, Choo, Seungjun, Lee, Jungsoo, Ju, Hyejin, Jung, Soo‐h., Jo, Seungki, Lee, So‐Hyeon, Baek, Seongheon, Kim, Ju‐Young, Kim, Kyung Tae, Chae, Han Gi, Son, Jae Sung

المساهمون: National Research Foundation of Korea

المصدر: Advanced Science ; ISSN 2198-3844 2198-3844

الوصف: Thermoelectric devices have received significant attention because of their potential for sustainable energy recovery. In these devices, a thermal design that optimizes heat transfer and dissipation is crucial for maximizing the power output. Heat dissipation generally requires external active or passive cooling devices, which often suffer from inevitable heat loss and heavy systems. Herein, the design of heat‐sink integrated thermoelectric legs is proposed to enhance heat dissipation without external cooling devices, realized by finite element model simulation and 3D printing of ternary silver chalcogenide‐based thermoelectric materials. Owing to the self‐induced surface charges of the synthesized AgBiSe 2 (n‐type) and AgSbTe 2 (p‐type) particles, these particle‐based colloidal inks exhibited high viscoelasticity, which enables the creation of complex heat‐dissipation architectures via 3D printing. Power generators made from 3D‐printed heat‐dissipating legs exhibit higher temperature differences and output power than traditional cuboids, offering a new strategy for enhancing thermoelectric power generation.

الإتاحة: https://doi.org/10.1002/advs.202402934Test

المؤلفون: Kim, Eun Sil, Choi, Sujin, Choe, Byung-Ho, Park, Sowon, Lee, Yeoun Joo, Sohn, Sang Jun, Kim, Soon Chul, Kang, Ki Soo, Lee, Kunsong, Shim, Jung Ok, Kim, Yu Bin, Hong, Suk Jin, Lee, Yoo Min, Kim, Hyun Jin, Choi, So Yoon, Kim, Ju Young, Lee, Yoon, Park, Ji-Sook, Kim, Jae Young, Yi, Dae Yong, Lee, Ji Hyuk, Choi, Kwang-Hae, Jang, Hyo-Jeong, Jeong, In Sook, Kang, Ben

المساهمون: National Research Foundation of Korea

المصدر: Frontiers in Immunology ; volume 15 ; ISSN 1664-3224

مصطلحات موضوعية: Immunology, Immunology and Allergy

الوصف: Background and aims Favourable clinical data were published on the efficacy of CT-P13, the first biosimilar of infliximab (IFX), in pediatric inflammatory bowel disease (IBD); however, few studies have compared the effect on endoscopic healing (EH) and drug retention rate between the IFX originator and CT-P13. Therefore, we aimed to compare EH and the drug retention rate between the IFX originator and CT-P13. Methods Children with Crohn’s disease (CD) and ulcerative colitis (UC)/IBD-unclassified (IBD-U) at 22 medical centers were enrolled, with a retrospective review conducted at 1-year and last follow-up. Clinical remission, EH and drug retention rate were evaluated. Results We studied 416 pediatric patients with IBD: 77.4% had CD and 22.6% had UC/IBD-U. Among them, 255 (61.3%) received the IFX originator and 161 (38.7%) received CT-P13. No statistically significant differences were found between the IFX originator and CT-P13 in terms of corticosteroid-free remission and adverse events. At 1-year follow-up, EH rates were comparable between them (CD: P =0.902, UC: P =0.860). The estimated cumulative cessation rates were not significantly different between the two groups. In patients with CD, the drug retention rates were 66.1% in the IFX originator and 71.6% in the CT-P13 group at the maximum follow-up period ( P > 0.05). In patients with UC, the drug retention rates were 49.8% in the IFX originator and 56.3% in the CT-P13 group at the maximum follow-up period ( P > 0.05). Conclusions The IFX originator and CT-P13 demonstrated comparable therapeutic response including EH, clinical remission, drug retention rate and safety in pediatric IBD.

الإتاحة: https://doi.org/10.3389/fimmu.2024.1284181Test

المؤلفون: Kang, Jisong, Kim, Ju Young, Sung, Suhyeon, Lee, Yerin, Gu, Sangseo, Choi, Jae-Wook, Yoo, Chun-Jae, Suh, Dong Jin, Choi, Jungkyu, Ha, Jeong-Myeong

المساهمون: Ministry of Environment, Korea Environmental Industry and Technology Institute, Ministry of Trade, Industry and Energy

المصدر: Environmental Pollution ; volume 342, page 123074 ; ISSN 0269-7491

مصطلحات موضوعية: Health, Toxicology and Mutagenesis, Pollution, Toxicology, General Medicine

الإتاحة: https://doi.org/10.1016/j.envpol.2023.123074Test
https://api.elsevier.com/content/article/PII:S0269749123020766?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S0269749123020766?httpAccept=text/plainTest

المؤلفون: Son, Youngkyun, Kim, Min-Ji, Kim, Ju-Young, Rollett, Anthony D., Lee, Sukbin

المساهمون: Office of Naval Research, Ministry of Science, ICT and Future Planning, National Research Foundation of Korea

المصدر: Acta Materialia ; volume 265, page 119613 ; ISSN 1359-6454

مصطلحات موضوعية: Metals and Alloys, Polymers and Plastics, Ceramics and Composites, Electronic, Optical and Magnetic Materials

الإتاحة: https://doi.org/10.1016/j.actamat.2023.119613Test
https://api.elsevier.com/content/article/PII:S1359645423009412?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S1359645423009412?httpAccept=text/plainTest

المؤلفون: Najjar, Yana G, McCurry, Dustin, Lin, Huang, Lin, Yan, Zang, Yan, Davar, Diwakar, Karunamurthy, Arivarasan, Drabick, Joseph J, Neves, Rogerio I, Butterfield, Lisa H, Ernstoff, Marc S, Puzanov, Igor, Skitzki, Joseph J, Bordeaux, Jennifer, Summit, IlaSri B, Bender, Jehovana O, Kim, Ju Young, Chen, Beiru, Sarikonda, Ghanashyam, Pahuja, Anil, Tsau, Jennifer, Alfonso, Zeni, Laing, Christian, Pingpank, James F, Holtzman, Matthew P, Sander, Cindy, Rose, Amy, Zarour, Hassane M, Kirkwood, John M, Tarhini, Ahmad A

المصدر: Clinical Cancer Research. 27(15)

مصطلحات موضوعية: Immunization, Clinical Research, Cancer, Evaluation of treatments and therapeutic interventions, 6.1 Pharmaceuticals, Adult, Aged, Aged, 80 and over, Antibodies, Monoclonal, Humanized, Antineoplastic Agents, Drug Therapy, Combination, Female, Humans, Interferon alpha-2, Male, Melanoma, Middle Aged, Neoadjuvant Therapy, Neoplasm Staging, Skin Neoplasms, Oncology and Carcinogenesis, Oncology & Carcinogenesis

الوصف: PurposeNeoadjuvant immunotherapy may improve the clinical outcome of regionally advanced operable melanoma and allows for rapid clinical and pathologic assessment of response. We examined neoadjuvant pembrolizumab and high-dose IFNα-2b (HDI) therapy in patients with resectable advanced melanoma.Patients and methodsPatients with resectable stage III/IV melanoma were treated with concurrent pembrolizumab 200 mg i.v. every 3 weeks and HDI 20 MU/m2/day i.v., 5 days per week for 4 weeks, then 10 MU/m2/day subcutaneously 3 days per week for 2 weeks. Definitive surgery followed, as did adjuvant combination immunotherapy, completing a year of treatment. Primary endpoint was safety of the combination. Secondary endpoints included overall response rate (ORR), pathologic complete response (pCR), recurrence-free survival (RFS), and overall survival (OS). Blood samples for correlative studies were collected throughout. Tumor tissue was assessed by IHC and flow cytometry at baseline and at surgery.ResultsA total of 31 patients were enrolled, and 30 were evaluable. At data cutoff (October 2, 2019), median follow-up for OS was 37.87 months (range, 33.2-43.47). Median OS and RFS were not reached. Radiographic ORR was 73.3% [95% confidence interval (CI): 55.5-85.8], with a 43% (95% CI: 27.3-60.1) pCR rate. None of the patients with a pCR have had a recurrence. HDI and pembrolizumab were discontinued in 73% and 43% of patients, respectively. Correlative analyses suggested that intratumoral PD-1/PD-L1 interaction and HLA-DR expression are associated with pCR (P = 0.002 and P = 0.008, respectively).ConclusionsNeoadjuvant concurrent HDI and pembrolizumab demonstrated promising clinical activity despite high rates of treatment discontinuation. pCR is a prognostic indicator.See related commentary by Menzies et al., p. 4133.

وصف الملف: application/pdf

الوصول الحر: https://escholarship.org/uc/item/4150p572Test

المؤلفون: Kim, Ju Young

مرشدي الرسالة: Naidoo, Kevin J

مصطلحات موضوعية: Chemistry

الوصف: Bioinformatics is a subfield in computational science that is principally focused on developing methods and performing data analytics in the areas of proteomics and genomics. In this thesis I draw a link between proteomics and genomics by focusing on the regulation patterns of glycosyltransferase (GT) genes in breast cancer cell line following the treatment with a large set of Food and Drug Administration (FDA) approved drugs. This is based on the understanding that aberrant glycosylation in breast cancer tumours stem from altered GT gene expression. A major goal of genomic research is the identification of genes that have been differentially expressed under abnormal conditions. A gene expression profile provides a snapshot of the transcriptional level of a cell. A comparative gene expression profile between a diseased and normal-state can be used to map out the regulatory mechanisms of disease. In this thesis, the results of Microarray experiments on MCF-7 human breast cancer cell-lines are analysed using statistical and computational tools to identify differentially expressed genes. Here a bioinformatics analysis of the regulation of GT gene expressions was performed to identify a set of glycosylation related genes with the aim of making an inference about their biological functions. A set of raw gene expression profiles from MCF-7 human breast cancer cell-line treated with different therapeutic drugs were obtained from the Connectivity Map (CMap) database. Initially 7,000 gene expression profiles were used and these were treated by 1,309 different FDA-approved drugs. The number of genes initially was counted up to 22,000. Using the Bioconductor open source software in R statistical programming environment a statistical differential expression analysis followed by several data filtering and pre-processing steps were performed to identify up and down regulated GT genes using. Using non-parametric rank sum meta-analysis three cancer drugs and two non-cancer drugs were identified as effective agents able to control the transcriptional regulatory state of GT genes. The study concluded by employing co-expression gene module analysis using the Weighted Gene Co-Expression Network Analysis (WGCNA) package on each of the cancer and non-cancer drug treatments. The gene modules discovered from the analysis were used to perform gene ontology enrichment analysis to identify the biological functions where they were significantly enriched in. The co-expression modules where GT genes have been down regulated by the drugs, were involved in processes such as Wnt signalling and cell surface pattern recognition receptor signalling important for cancer development. Immune response and apoptotic processes in the cell were identified from co-expression modules where GT genes were up regulated. This key finding that the GT gene expressions are markers for treatment analysis points to their use in drug development studies. The second more direct finding is that non-breast cancer specific FDA-approved drugs may have a role in treating breast cancer and may be the subject of future drug repurposing strategies.

وصف الملف: application/pdf

الإتاحة: http://hdl.handle.net/11427/29866Test

المؤلفون: Johnson, Douglas B, Bordeaux, Jennifer, Kim, Ju Young, Vaupel, Christine, Rimm, David L, Ho, Thai H, Joseph, Richard W, Daud, Adil I, Conry, Robert M, Gaughan, Elizabeth M, Hernandez-Aya, Leonel F, Dimou, Anastasios, Funchain, Pauline, Smithy, James, Witte, John S, McKee, Svetlana B, Ko, Jennifer, Wrangle, John M, Dabbas, Bashar, Tangri, Shabnam, Lameh, Jelveh, Hall, Jeffrey, Markowitz, Joseph, Balko, Justin M, Dakappagari, Naveen

المصدر: Clinical cancer research : an official journal of the American Association for Cancer Research. 24(21)

مصطلحات موضوعية: Cell Line, Tumor, Humans, Melanoma, Neoplasm Metastasis, HLA-DR Antigens, Biopsy, Neoplasm Staging, Prognosis, Treatment Outcome, Retreatment, Immunohistochemistry, Protein Binding, Models, Biological, Adult, Aged, Middle Aged, Female, Male, Indoleamine-Pyrrole 2, 3, -Dioxygenase, Programmed Cell Death 1 Receptor, Biomarkers, Tumor, Antineoplastic Agents, Immunological, B7-H1 Antigen, Cancer, Prevention, Clinical Research, 2.1 Biological and endogenous factors, Aetiology, 4.2 Evaluation of markers and technologies, Detection, screening and diagnosis, Oncology and Carcinogenesis, Oncology & Carcinogenesis

الوصف: Purpose: PD-1/L1 axis-directed therapies produce clinical responses in a subset of patients; therefore, biomarkers of response are needed. We hypothesized that quantifying key immunosuppression mechanisms within the tumor microenvironment by multiparameter algorithms would identify strong predictors of anti-PD-1 response.Experimental Design: Pretreatment tumor biopsies from 166 patients treated with anti-PD-1 across 10 academic cancer centers were fluorescently stained with multiple markers in discovery (n = 24) and validation (n = 142) cohorts. Biomarker-positive cells and their colocalization were spatially profiled in pathologist-selected tumor regions using novel Automated Quantitative Analysis algorithms. Selected biomarker signatures, PD-1/PD-L1 interaction score, and IDO-1/HLA-DR coexpression were evaluated for anti-PD-1 treatment outcomes.Results: In the discovery cohort, PD-1/PD-L1 interaction score and/or IDO-1/HLA-DR coexpression was strongly associated with anti-PD-1 response (P = 0.0005). In contrast, individual biomarkers (PD-1, PD-L1, IDO-1, HLA-DR) were not associated with response or survival. This finding was replicated in an independent validation cohort: patients with high PD-1/PD-L1 and/or IDO-1/HLA-DR were more likely to respond (P = 0.0096). These patients also experienced significantly improved progression-free survival (HR = 0.36; P = 0.0004) and overall survival (HR = 0.39; P = 0.0011). In the combined cohort, 80% of patients exhibiting higher levels of PD-1/PD-L1 interaction scores and IDO-1/HLA-DR responded to PD-1 blockers (P = 0.000004). In contrast, PD-L1 expression was not predictive of survival.Conclusions: Quantitative spatial profiling of key tumor-immune suppression pathways by novel digital pathology algorithms could help more reliably select melanoma patients for PD-1 monotherapy. Clin Cancer Res; 24(21); 5250-60. ©2018 AACR.

وصف الملف: application/pdf

الوصول الحر: https://escholarship.org/uc/item/92k1g956Test

المؤلفون: Yang, Han-Mo, Lee, Joo-Eun, Kim, Ju-Young, You, Jihye, Kim, Joonoh, Lee, Hak S., Yoo, Hee M., Kong, Min Gyu, Han, Jung-Kyu, Cho, Hyun-Jai, Park, Kyung Woo, Kang, Hyun-Jae, Koo, Bon-Kwon, Park, Young-Bae, Kim, Hyo-Soo

مصطلحات موضوعية: oronary artery spasm, Vasospastic angina, Calcium, Ex vivo diagnosis

الوصف: Background Although vasospastic angina (VSA) is known to be caused by coronary artery spasm, no study has fully elucidated the exact underlying mechanism. Moreover, in order to confirm VSA, patients should undergo invasive coronary angiography with spasm provocation test. Herein, we investigated the pathophysiology of VSA using peripheral blood-derived induced pluripotent stem cells (iPSCs) and developed an ex vivo diagnostic method for VSA. Methods and results With 10 mL of peripheral blood from patients with VSA, we generated iPSCs and differentiated these iPSCs into target cells. As compared with vascular smooth muscle cells (VSMCs) differentiated from iPSCs of normal subjects with negative provocation test, VSA patient-specific iPSCs-derived VSMCs showed very strong contraction in response to stimulants. Moreover, VSA patient-specific VSMCs exhibited a significant increase in stimulation-induced intracellular calcium efflux (Changes in the relative fluorescence unit [ΔF/F]; Control group vs. VSA group, 2.89 ± 0.34 vs. 10.32 ± 0.51, p < 0.01), and exclusively induced a secondary or tertiary peak of calcium efflux, suggesting that those findings could be diagnostic cut-off values for VSA. The observed hyperreactivity of VSA patient-specific VSMCs were caused by the upregulation of sarco/endoplasmic reticulum Ca2+-ATPase 2a (SERCA2a) due to its enhanced small ubiquitin-related modifier (SUMO)ylation. This increased activity of SERCA2a was reversed by treatment with ginkgolic acid, an inhibitor of SUMOylated E1 molecules (pi/µg protein; VSA group vs. VSA + ginkgolic acid, 52.36 ± 0.71 vs. 31.93 ± 1.13, p < 0.01). Conclusions Our findings showed that abnormal calcium handling in sarco/endoplasmic reticulum could be induced by the enhanced SERCA2a activity in patients with VSA, leading to spasm. Such novel mechanisms of coronary artery spasm could be useful for drug development and diagnosis of VSA. ; This study was supported by grants of the Korea Health Technology R&D Project "Korea Research-Driven ...

العلاقة: Biomaterials Research,Vol.27:16; https://hdl.handle.net/10371/194714Test

الإتاحة: https://doi.org/10.1186/s40824-023-00345-2Test
https://hdl.handle.net/10371/194714Test