المؤلفون: Fernández-Rhodes, Lindsay, Graff, Mariaelisa, Buchanan, Victoria L, Justice, Anne E, Highland, Heather M, Guo, Xiuqing, Zhu, Wanying, Chen, Hung-Hsin, Young, Kristin L, Adhikari, Kaustubh, Palmer, Nicholette D, Below, Jennifer E, Bradfield, Jonathan, Pereira, Alexandre C, Glover, LáShauntá, Kim, Daeeun, Lilly, Adam G, Shrestha, Poojan, Thomas, Alvin G, Zhang, Xinruo, Chen, Minhui, Chiang, Charleston WK, Pulit, Sara, Horimoto, Andrea, Krieger, Jose E, Guindo-Martínez, Marta, Preuss, Michael, Schumann, Claudia, Smit, Roelof AJ, Torres-Mejía, Gabriela, Acuña-Alonzo, Victor, Bedoya, Gabriel, Bortolini, Maria-Cátira, Canizales-Quinteros, Samuel, Gallo, Carla, González-José, Rolando, Poletti, Giovanni, Rothhammer, Francisco, Hakonarson, Hakon, Igo, Robert, Adler, Sharon G, Iyengar, Sudha K, Nicholas, Susanne B, Gogarten, Stephanie M, Isasi, Carmen R, Papnicolaou, George, Stilp, Adrienne M, Qi, Qibin, Kho, Minjung, Smith, Jennifer A, Langefeld, Carl D, Wagenknecht, Lynne, Mckean-Cowdin, Roberta, Gao, Xiaoyi Raymond, Nousome, Darryl, Conti, David V, Feng, Ye, Allison, Matthew A, Arzumanyan, Zorayr, Buchanan, Thomas A, Chen, Yii-Der Ida, Genter, Pauline M, Goodarzi, Mark O, Hai, Yang, Hsueh, Willa, Ipp, Eli, Kandeel, Fouad R, Lam, Kelvin, Li, Xiaohui, Nadler, Jerry L, Raffel, Leslie J, Roll, Kathryn, Sandow, Kevin, Tan, Jingyi, Taylor, Kent D, Xiang, Anny H, Yao, Jie, Audirac-Chalifour, Astride, Peralta Romero, Jose de Jesus, Hartwig, Fernando, Horta, Bernando, Blangero, John, Curran, Joanne E, Duggirala, Ravindranath, Lehman, Donna E, Puppala, Sobha, Fejerman, Laura, John, Esther M, Aguilar-Salinas, Carlos, Burtt, Noël P, Florez, Jose C, García-Ortíz, Humberto, González-Villalpando, Clicerio, Mercader, Josep, Orozco, Lorena, Tusié-Luna, Teresa, Blanco, Estela, Gahagan, Sheila, Cox, Nancy J, Hanis, Craig

المصدر: Human Genetics and Genomics Advances. 4(1)

الوصف: [This corrects the article DOI: 10.1016/j.xhgg.2022.100099.].

وصف الملف: application/pdf

الوصول الحر: https://escholarship.org/uc/item/4b44f87vTest

المؤلفون: Fernández-Rhodes, Lindsay, Graff, Mariaelisa, Buchanan, Victoria L, Justice, Anne E, Highland, Heather M, Guo, Xiuqing, Zhu, Wanying, Chen, Hung-Hsin, Young, Kristin L, Adhikari, Kaustubh, Palmer, Nicholette D, Below, Jennifer E, Bradfield, Jonathan, Pereira, Alexandre C, Glover, LáShauntá, Kim, Daeeun, Lilly, Adam G, Shrestha, Poojan, Thomas, Alvin G, Zhang, Xinruo, Chen, Minhui, Chiang, Charleston WK, Pulit, Sara, Horimoto, Andrea, Krieger, Jose E, Guindo-Martínez, Marta, Preuss, Michael, Schumann, Claudia, Smit, Roelof AJ, Torres-Mejía, Gabriela, Acuña-Alonzo, Victor, Bedoya, Gabriel, Bortolini, Maria-Cátira, Canizales-Quinteros, Samuel, Gallo, Carla, González-José, Rolando, Poletti, Giovanni, Rothhammer, Francisco, Hakonarson, Hakon, Igo, Robert, Adler, Sharon G, Iyengar, Sudha K, Nicholas, Susanne B, Gogarten, Stephanie M, Isasi, Carmen R, Papnicolaou, George, Stilp, Adrienne M, Qi, Qibin, Kho, Minjung, Smith, Jennifer A, Langefeld, Carl D, Wagenknecht, Lynne, Mckean-Cowdin, Roberta, Gao, Xiaoyi Raymond, Nousome, Darryl, Conti, David V, Feng, Ye, Allison, Matthew A, Arzumanyan, Zorayr, Buchanan, Thomas A, Chen, Yii-Der Ida, Genter, Pauline M, Goodarzi, Mark O, Hai, Yang, Hsueh, Willa, Ipp, Eli, Kandeel, Fouad R, Lam, Kelvin, Li, Xiaohui, Nadler, Jerry L, Raffel, Leslie J, Roll, Kathryn, Sandow, Kevin, Tan, Jingyi, Taylor, Kent D, Xiang, Anny H, Yao, Jie, Audirac-Chalifour, Astride, de Jesus Peralta Romero, Jose, Hartwig, Fernando, Horta, Bernando, Blangero, John, Curran, Joanne E, Duggirala, Ravindranath, Lehman, Donna E, Puppala, Sobha, Fejerman, Laura, John, Esther M, Aguilar-Salinas, Carlos, Burtt, Noël P, Florez, Jose C, García-Ortíz, Humberto, González-Villalpando, Clicerio, Mercader, Josep, Orozco, Lorena, Tusié-Luna, Teresa, Blanco, Estela, Gahagan, Sheila, Cox, Nancy J, Hanis, Craig

المصدر: Human Genetics and Genomics Advances. 3(2)

مصطلحات موضوعية: Biological Sciences, Genetics, Obesity, Human Genome, Hispanic/Latino, anthropometrics, diversity, fine-mapping, obesity, population stratification, trans-ancestral or trans-ethnic

الوصف: Hispanic/Latinos have been underrepresented in genome-wide association studies (GWAS) for anthropometric traits despite their notable anthropometric variability, ancestry proportions, and high burden of growth stunting and overweight/obesity. To address this knowledge gap, we analyzed densely imputed genetic data in a sample of Hispanic/Latino adults to identify and fine-map genetic variants associated with body mass index (BMI), height, and BMI-adjusted waist-to-hip ratio (WHRadjBMI). We conducted a GWAS of 18 studies/consortia as part of the Hispanic/Latino Anthropometry (HISLA) Consortium (stage 1, n = 59,771) and generalized our findings in 9 additional studies (stage 2, n = 10,538). We conducted a trans-ancestral GWAS with summary statistics from HISLA stage 1 and existing consortia of European and African ancestries. In our HISLA stage 1 + 2 analyses, we discovered one BMI locus, as well as two BMI signals and another height signal each within established anthropometric loci. In our trans-ancestral meta-analysis, we discovered three BMI loci, one height locus, and one WHRadjBMI locus. We also identified 3 secondary signals for BMI, 28 for height, and 2 for WHRadjBMI in established loci. We show that 336 known BMI, 1,177 known height, and 143 known WHRadjBMI (combined) SNPs demonstrated suggestive transferability (nominal significance and effect estimate directional consistency) in Hispanic/Latino adults. Of these, 36 BMI, 124 height, and 11 WHRadjBMI SNPs were significant after trait-specific Bonferroni correction. Trans-ancestral meta-analysis of the three ancestries showed a small-to-moderate impact of uncorrected population stratification on the resulting effect size estimates. Our findings demonstrate that future studies may also benefit from leveraging diverse ancestries and differences in linkage disequilibrium patterns to discover novel loci and additional signals with less residual population stratification.

وصف الملف: application/pdf

الوصول الحر: https://escholarship.org/uc/item/8nr6j68kTest

المؤلفون: Kim, Daeeun, Memili, Aylin, Chen, Hung-Hsin, Highland, Heather M., Polikowsky, Hannah G., Anwar, Mohammad Yaser, Laing, Susan T., Lee, Miryoung, McCormick, Joseph B., Fisher-Hoch, Susan P., Below, Jennifer E., North, Kari E., Gutierrez, Absalon D.

المساهمون: American Heart Association, National Institutes of Health, National Institute of Health

المصدر: Cardiovascular Diabetology ; volume 22, issue 1 ; ISSN 1475-2840

مصطلحات موضوعية: Cardiology and Cardiovascular Medicine, Endocrinology, Diabetes and Metabolism

الوصف: Background Adipokines are hormones secreted from adipose tissue and are associated with cardiometabolic diseases (CMD). Functional differences between adipokines (leptin, adiponectin, and resistin) are known, but inconsistently reported associations with CMD and lack of studies in Hispanic populations are research gaps. We investigated the relationship between subclinical atherosclerosis and multiple adipokine measures. Methods Cross-sectional data from the Cameron County Hispanic Cohort (N = 624; mean age = 50; Female = 70.8%) were utilized to assess associations between adipokines [continuous measures of adiponectin, leptin, resistin, leptin-to-adiponectin ratio (LAR), and adiponectin-resistin index (ARI)] and early atherosclerosis [carotid-intima media thickness (cIMT)]. We adjusted for sex, age, body mass index (BMI), smoking status, cytokines, fasting blood glucose levels, blood pressure, lipid levels, and medication usage in the fully adjusted linear regression model. We conducted sexes-combined and sex-stratified analyses to account for sex-specificity and additionally tested whether stratification of participants by their metabolic status (metabolically elevated risk for CMD as defined by having two or more of the following conditions: hypertension, dyslipidemia, insulin resistance, and inflammation vs. not) influenced the relationship between adipokines and cIMT. Results In the fully adjusted analyses, adiponectin, leptin, and LAR displayed significant interaction by sex (p < 0.1). Male-specific associations were between cIMT and LAR [β(SE) = 0.060 (0.016), p = 2.52 × 10 –4 ], and female-specific associations were between cIMT and adiponectin [β(SE) = 0.010 (0.005), p = 0.043] and ARI [β(SE) = − 0.011 (0.005), p = 0.036]. When stratified by metabolic health status, the male-specific positive association between LAR and cIMT was more evident among the metabolically healthy group [β(SE) = 0.127 (0.015), p = 4.70 × 10 –10 ] (p for interaction by metabolic health < 0.1). However, the ...

الإتاحة: https://doi.org/10.1186/s12933-023-01968-4Test

المؤلفون: Kim, Daeeun, Justice, Anne E., Chittoor, Geetha, Blanco, Estela, Burrows, Raquel, Graff, Mariaelisa, Green Howard, Annie, Wang, Yujie, Rohde, Rebecca, Buchanan, Victoria L., Voruganti, V. Saroja, Almeida, Marcio, Peralta, Juan, Lehman, Donna M., Curran, Joanne E., Comuzzie, Anthony G., Duggirala, Ravindranath, Blangero, John, Albala, Cecilia, Santos Martín, José Luis, Angel, Bárbara, Lozoff, Betsy, Gahagan, Sheila, North, Kari E.

مصطلحات موضوعية: Medicina y salud

الوقت: 610

الوصف: Background: Metabolic regulation plays a significant role in energy homeostasis, and adolescence is a crucial life stage for the development of cardiometabolic disease (CMD). This study aims to investigate the genetic determinants of metabolic biomarkers—adiponectin, leptin, ghrelin, and orexin—and their associations with CMD risk factors. Methods: We characterized the genetic determinants of the biomarkers among Hispanic/Latino adolescents of the Santiago Longitudinal Study (SLS) and identified the cumulative effects of genetic variants on adiponectin and leptin using biomarker polygenic risk scores (PRS). We further investigated the direct and indirect effect of the biomarker PRS on downstream body fat percent (BF%) and glycemic traits using structural equation modeling. Results: We identified putatively novel genetic variants associated with the metabolic biomarkers. A substantial amount of biomarker variance was explained by SLS-specific PRS, and the prediction was improved by including the putatively novel loci. Fasting blood insulin and insulin resistance were associated with PRS for adiponectin, leptin, and ghrelin, and BF% was associated with PRS for adiponectin and leptin. We found evidence of substantial mediation of these associations by the biomarker levels. Conclusions: The genetic underpinnings of metabolic biomarkers can affect the early development of CMD, partly mediated by the biomarkers.

العلاقة: https://doi.org/10.1038/s41390-021-01729-7Test; https://www.nature.com/articles/s41390-021-01729-7Test; https://repositorio.uc.cl/handle/11534/80700Test

الإتاحة: https://doi.org/10.1038/s41390-021-01729-7Test
https://repositorio.uc.cl/handle/11534/80700Test
https://www.nature.com/articles/s41390-021-01729-7Test

المؤلفون: Kim, Daeeun, Justice, Anne E., Chittoor, Geetha, Blanco, Estela, Almeida, Marcio, Peralta, Juan M, Lehman, Donna M, Curran, Joanne E, Comuzzie, Anthony G., Duggirala, Ravi, Blangero, John

المصدر: School of Medicine Publications and Presentations

مصطلحات موضوعية: Medicine and Health Sciences

الوصف: Background: Metabolic regulation plays a significant role in energy homeostasis, and adolescence is a crucial life stage for the development of cardiometabolic disease (CMD). This study aims to investigate the genetic determinants of metabolic biomarkers-adiponectin, leptin, ghrelin, and orexin-and their associations with CMD risk factors. Methods: We characterized the genetic determinants of the biomarkers among Hispanic/Latino adolescents of the Santiago Longitudinal Study (SLS) and identified the cumulative effects of genetic variants on adiponectin and leptin using biomarker polygenic risk scores (PRS). We further investigated the direct and indirect effect of the biomarker PRS on downstream body fat percent (BF%) and glycemic traits using structural equation modeling. Results: We identified putatively novel genetic variants associated with the metabolic biomarkers. A substantial amount of biomarker variance was explained by SLS-specific PRS, and the prediction was improved by including the putatively novel loci. Fasting blood insulin and insulin resistance were associated with PRS for adiponectin, leptin, and ghrelin, and BF% was associated with PRS for adiponectin and leptin. We found evidence of substantial mediation of these associations by the biomarker levels. Conclusions: The genetic underpinnings of metabolic biomarkers can affect the early development of CMD, partly mediated by the biomarkers. Impact: This study characterized the genetic underpinnings of four metabolic hormones and investigated their potential influence on adiposity and insulin biology among Hispanic/Latino adolescents. Fasting blood insulin and insulin resistance were associated with polygenic risk score (PRS) for adiponectin, leptin, and ghrelin, with evidence of some degree of mediation by the biomarker levels. Body fat percent (BF%) was also associated with PRS for adiponectin and leptin. This provides important insight on biological mechanisms underlying early metabolic dysfunction and reveals candidates for prevention efforts. ...

وصف الملف: application/pdf

العلاقة: https://scholarworks.utrgv.edu/som_pub/561Test; https://scholarworks.utrgv.edu/context/som_pub/article/1562/viewcontent/nihms_1736148.pdfTest

الإتاحة: https://doi.org/10.1038/s41390-021-01729-7Test
https://scholarworks.utrgv.edu/som_pub/561Test
https://scholarworks.utrgv.edu/context/som_pub/article/1562/viewcontent/nihms_1736148.pdfTest

المؤلفون: Chae, Jihwan, Kim, Kunil, Kim, Yuri, Lim, Gahyun, Kim, Daeeun, Kim, Hackjin

المصدر: Scientific Reports ; volume 12, issue 1 ; ISSN 2045-2322

مصطلحات موضوعية: Multidisciplinary

الوصف: Ingroup favoritism and fairness are two potentially competing motives guiding intergroup behaviors in human. Here, we investigate if and how limited resources can modulate the way these two motives affect individuals’ decisions in intergroup situation. In the present study, participants ( N = 58) were asked to accept or reject three types of resource allocation proposals generated by a computer: the ingroup advantageous condition, outgroup advantageous condition, and neutral condition. In general, participants were more willing to accept the proposals in the ingroup advantageous condition than the outgroup advantageous or the neutral conditions, and also in the moderate inequality than the extreme inequality condition. This may indicate that people sought a careful balance between ingroup favoritism and fairness, although we also found marked individual differences in their preferences for ingroup favoritism or fairness. Importantly, as predicted, participants were more likely to show ingroup favoritism only when limited resources affect the well-being of ingroup members. The present study provides novel insights into the situational and personality factors affecting human intergroup behaviors, shedding light on motives underlying intergroup conflicts prevalent in human societies.

الإتاحة: https://doi.org/10.1038/s41598-022-08460-1Test
https://www.nature.com/articles/s41598-022-08460-1.pdfTest
https://www.nature.com/articles/s41598-022-08460-1Test

المؤلفون: Kim, Daeeun, Howard, Annie Green, Blanco, Estela, Burrows, Raquel, Correa-Burrows, Paulina, Memili, Aylin, Albala, Cecilia, Santos, José L., Angel, Bárbara, Lozoff, Betsy, Justice, Anne E., Gordon-Larsen, Penny, Gahagan, Sheila, North, Kari E.

المساهمون: NIDDK, American Heart Association Inc, University of North Carolina at Chapel Hill, NICHD, NHLBI

المصدر: Nutrition, Metabolism and Cardiovascular Diseases ; volume 32, issue 4, page 1055-1063 ; ISSN 0939-4753

مصطلحات موضوعية: Cardiology and Cardiovascular Medicine, Nutrition and Dietetics, Endocrinology, Diabetes and Metabolism, Medicine (miscellaneous)

الإتاحة: https://doi.org/10.1016/j.numecd.2022.01.001Test
https://api.elsevier.com/content/article/PII:S0939475322000011?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S0939475322000011?httpAccept=text/plainTest

المؤلفون: Jang, Hyoeun, Kim, Sanghee, Kim, DaeEun, Park, Mehee, Rhue, Sunemee, Lee, Changmin, Kim, Seulgee, Kang, Byungmun, Lee, Haeri

المصدر: Asia-Pacific Journal of Oncology Nursing ; volume 9, issue 8, page 100072 ; ISSN 2347-5625

مصطلحات موضوعية: Oncology (nursing), Oncology

الإتاحة: https://doi.org/10.1016/j.apjon.2022.04.011Test
https://api.elsevier.com/content/article/PII:S2347562522001305?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S2347562522001305?httpAccept=text/plainTest

المؤلفون: Kim, DaeEun

مصطلحات موضوعية: 006.3

الوصف: When building controllers for autonomous agents, such as real or simulated robots, there is very little theoretical guidance on how complex the controller must be in terms of internal state to be able to achieve good performance in a particular task. The underlying problem is that it is hard to quantify the amount of internal state — memory — the controller should have based on knowledge of the task to be tackled. This problem manifests itself in two related questions: how complex is a given task in terms of the amount of memory a controller needs to enable a particular agent to complete it? and how does this complexity vary depending on the sensorimotor abilities of the agent? In this thesis I address these questions empirically using evolutionary computation techniques, by attempting to evolve controllers with good performance for a task while simultaneously minimizing the amount of internal memory used. Boolean logic networks with memory elements (registers) allow a natural progression from purely reactive (memoryless) controllers while being straightforward to use with evolutionary computations. Controllers are evolved using three kinds of representational structure — finite state machines, rule-based state machines and tree state machines — equivalent to Boolean logic networks with memory, for which the internal state can easily be quantified. Various evolutionary computational techniques are adapted to support analysis of memory, including evolutionary multiobjective optimisation, a sample selection method, the design of suitable genetic operators and an elitism strategy. Performance evaluation and evolutionary algorithm issues for noisy environments are also considered. The evolutionary computational approaches are applied to a variety of standard grid world and simple robotic tasks to quantify the memory needed for adequate performance. The results demonstrate, as expected, that internal state plays a significant role in improving performance of agent behaviours when sensors or motor actions are restricted, and is related to the amount of perceptual aliasing present in the interaction between agent and environment. New results concerning the "difficulty" of the standard problems are obtained. The investigation of these problems also demonstrates the utility of the tools developed for quantifying and analysing memory use.

الإتاحة: http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.649067Test

المؤلفون: Son, Choonghyun, Lee, Anna, Lee, Junkyung, Kim, DaeEun, Kim, Seung-Jong, Chun, Min Ho, Choi, Junho

المساهمون: Korea Institute of Science and Technology, Asan Institute for Life Sciences, Asan Medical Center, National Research Foundation of Korea

المصدر: Journal of NeuroEngineering and Rehabilitation ; volume 18, issue 1 ; ISSN 1743-0003

مصطلحات موضوعية: Health Informatics, Rehabilitation

الوصف: Background Aging societies lead to higher demand for gait rehabilitation as age-related neurological disorders such as stroke and spinal cord injury increase. Since conventional methods for gait rehabilitation are physically and economically burdensome, robotic gait training systems have been studied and commercialized, many of which provided movements confined in the sagittal plane. For better outcomes of gait rehabilitation with more natural gait patterns, however, it is desirable to provide pelvic movements in the transverse plane. In this study, a robotic gait training system capable of pelvic motions in the transverse plane was used to evaluate the effect of the pelvic motions on stroke patients. Method Healbot T, which is a robotic gait training system and capable of providing pelvic movements in the transverse plane as well as flexion/extension of the hip and knee joints and adduction/abduction of the hip joints, is introduced and used to evaluate the effect of the pelvic movement on gait training of stroke patients. Gait trainings in Healbot T with and without pelvic movements are carried out with stroke patients having hemiparesis. Experiment Twenty-four stroke patients with hemiparesis were randomly assigned into two groups and 23 of them successfully completed the experiment except one subject who had dropped out due to personal reasons. Pelvis-on group was provided with pelvic motions whereas no pelvic movement was allowed for pelvis-off group during 10 sessions of gait trainings in Healbot T. Electromyography (EMG) signals and interaction forces as well as the joint angles of the robot were measured. Gait parameters such as stride length, cadence, and walking speed were measured while walking on the ground without assistance of Healbot T after gait training on 1st, 5th, and 10th day. Result Stride length significantly increased in both groups. Furthermore, cadence and walking speed of the pelvis-on group were increased by 10.6% and 11.8%. Although interaction forces of both groups except ...

الإتاحة: https://doi.org/10.1186/s12984-021-00964-7Test