المؤلفون: Yoko Omi, Kento Haniu, Hidenori Kamio, Mikiko Fujimoto, Yusaku Yoshida, Kiyomi Horiuchi, Takahiro Okamoto

المصدر: World Journal of Surgical Oncology, Vol 20, Iss 1, Pp 1-7 (2022)

مصطلحات موضوعية: Papillary thyroid carcinoma, Multifocal, Surgery, RD1-811, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

الوصف: Abstract Introduction Non-total thyroidectomy (non-TTx) is a widely accepted operative procedure for low-risk papillary thyroid carcinoma (PTC). PTC patients preoperatively diagnosed with unifocal disease are often revealed as having multifocal foci by microscopy. The present study determined whether or not patients with clinically unifocal, but pathologically multifocal non-high-risk PTC treated with non-TTx have an increased risk of a poor prognosis compared to those with pathologically unifocal PTC. Materials and methods PTC patients diagnosed as unifocal preoperatively who underwent non-TTx were multifocal in 61 and unifocal in 266 patients microscopically. Oncologic event rates were compared between pathologically multifocal and unifocal PTC patients. Results Pathological multifocality was associated with positive clinical lymph node metastasis (cN1) (odds ratio [OR] 4.01, 95% confidence interval [CI]: 1.91–8.04) and positive pathological lymph node metastasis (pN1) in > 5 nodes (OR 3.68, 95% CI: 1.60–8.49). No patients died from PTC. There was no significant difference in the disease-free survival rate, remnant thyroid disease-free survival rate, lymph node disease-free survival rate, or distant disease-free survival rate between the two groups. Recurrence in pathologically multifocal PTC patients was locoregional in all cases and able to be salvaged by reoperation. Cox proportional hazard model analyses showed no significant difference in recurrence rates with regard to pathological multifocality and cN or number of pNs. Conclusion The prognosis of PTC with pathological multifocality treated by non-TTx was not inferior to that of unifocal PTC. Immediate completion thyroidectomy is not necessary when microscopic foci are proven.

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/1477-7819Test

الوصول الحر: https://doaj.org/article/ab9ce594555e4d99a74e5a627aceabacTest

المؤلفون: Akiko SAKAMOTO, Erin NAGAI, Hiroki TOKUMITSU, Kento HANIU, Kiyomi HORIUCHI, Takahiro OKAMOTO, Yoko OMI, Yusaku YOSHIDA, 吉田 有策, 坂本 明子, 堀内 喜代美, 尾身 葉子, 岡本 高宏, 徳光 宏紀, 永井 絵林, 羽二生 賢人

المصدر: 日本臨床外科学会雑誌 / Nihon Rinsho Geka Gakkai Zasshi (Journal of Japan Surgical Association). 2019, 80(6):1035

المؤلفون: Erin Nagai, Kento Haniu, Kiyomi Horiuchi, Momoko Tokura, Osamu Isozaki, Takahiro Okamoto, Yoji Nagashima, Yoko Omi

المصدر: Endocrine Journal. 2018, 65(2):245

المؤلفون: Akiko SAKAMOTO, Erin NAGAI, Hiroki TOKUMITSU, Kenji FUKUSHIMA, Kento HANIU, Kiyomi HORIUCHI, Koichiro ABE, Momoko SAKURAI, Takahiro OKAMOTO, Yoko OMI, Yusaku YOSHIDA, 吉田 有策, 坂本 明子, 堀内 喜代美, 尾身 葉子, 岡本 高宏, 徳光 宏紀, 櫻井 桃子, 永井 絵林, 福島 賢慈, 羽二生 賢人, 阿部 光一郎

المصدر: 日本臨床外科学会雑誌 / Nihon Rinsho Geka Gakkai Zasshi (Journal of Japan Surgical Association). 2016, 77(12):2875

المؤلفون: Yoko Omi, Yusaku Yoshida, Hiroki Tokumitsu, Erin Nagai, Takahiro Okamoto, Akiko Sakamoto, Kento Haniu, Kiyomi Horiuchi

المصدر: Nihon Rinsho Geka Gakkai Zasshi (Journal of Japan Surgical Association). 80:1035-1040

مصطلحات موضوعية: medicine.medical_specialty, Breast cancer, business.industry, General Engineering, medicine, General Earth and Planetary Sciences, medicine.symptom, business, medicine.disease, Postoperative nausea and vomiting, General Environmental Science, Surgery

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::804d43bc4f78dff893e332944e16f361Test
https://doi.org/10.3919/jjsa.80.1035Test

المؤلفون: Erin Nagai, Kiyomi Horiuchi, Kento Haniu, Kenji Fukushima, Yoko Omi, Hiroki Tokumitsu, Takahiro Okamoto, Momoko Sakurai, Yusaku Yoshida, Koichiro Abe, Akiko Sakamoto

المصدر: Nihon Rinsho Geka Gakkai Zasshi (Journal of Japan Surgical Association). 77:2875-2880

مصطلحات موضوعية: medicine.medical_specialty, business.industry, Radioiodine ablation, 030209 endocrinology & metabolism, medicine.disease, 03 medical and health sciences, 0302 clinical medicine, medicine, Adjuvant therapy, 030212 general & internal medicine, Radiology, Post operative, business, Thyroid cancer

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::cbea3adf921c30d1beacfb5c8e1eac5aTest
https://doi.org/10.3919/jjsa.77.2875Test

المؤلفون: Osamu Isozaki, Yoji Nagashima, Momoko Tokura, Kento Haniu, Kiyomi Horiuchi, Erin Nagai, Yoko Omi, Takahiro Okamoto

المصدر: Endocrine journal. 65(2)

مصطلحات موضوعية: Adult, Male, endocrine system, Pathology, medicine.medical_specialty, endocrine system diseases, Endocrinology, Diabetes and Metabolism, 030209 endocrinology & metabolism, Thyroid Lobectomy, Choristoma, Paraneoplastic Endocrine Syndromes, Neoplasms, Multiple Primary, Parathyroid Glands, 03 medical and health sciences, 0302 clinical medicine, Endocrinology, Multiple Endocrine Neoplasia Type 1, Medicine, Humans, Thyroid Neoplasms, Hyperparathyroidism, medicine.diagnostic_test, business.industry, Thyroid, Hyperplasia, medicine.disease, Hyperparathyroidism, Primary, Pancreatic Neoplasms, medicine.anatomical_structure, Fine-needle aspiration, Parathyroid Neoplasms, Parathyroid carcinoma, Parathyroid Hormone, 030220 oncology & carcinogenesis, business, hormones, hormone substitutes, and hormone antagonists, Primary hyperparathyroidism, Hormone

الوصف: Primary hyperparathyroidism is the most common hormonal manifestation associated with multiple endocrine neoplasia 1 (MEN1). It is generally caused by parathyroid hyperplasia, and parathyroid carcinoma is rare. Here, we report a case of MEN1 with parathyroid carcinoma in two parathyroid glands causing primary hyperparathyroidism. A 40-year-old man with primary hyperparathyroidism due to MEN1 underwent a total parathyroidectomy. His corrected calcium and intact PTH (i-PTH) serum levels were 10.8 mg/dL and 203 pg/mL, respectively. Although three glands were successfully removed, the left upper parathyroid gland could not be detected. Since the right lower parathyroid lesion had invaded into the thyroid, right lobectomy was performed. A portion of the left lower parathyroid tissue was transplanted into his forearm. The histological findings of the left lower and the right upper parathyroid glands were consistent with hyperplasia while that of the right lower parathyroid gland was parathyroid carcinoma. Since the post-surgical i-PTH levels remained high, the intrathyroidal lesion of the left lobe, which was initally diagnosed as an adenomatous nodule, was suspected to contain parathyroid tumor. A fine needle aspiration of the tumor revealed a high concentration of i-PTH. One week after the first surgery, a left thyroid lobectomy was performed. The pathological diagnosis of the tumor was parathyroid carcinoma. After the surgery, calcium and i-PTH levels were normal. Although it is rare, parathyroid carcinoma should be considered as a cause of hyperparathyroidism in MEN1 patients. Since it is difficult to diagnose parathyroid carcinoma before surgery, intraoperative findings are important for the appropriate treatment.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2cb4a15e3d81b612daa479f3589c7607Test
https://pubmed.ncbi.nlm.nih.gov/29225207Test

المؤلفون: Kiyomi Horiuchi, Kento Haniu, Erin Nagai, Akiko Sakamoto, Yusaku Yoshida, Momoko Sakurai, Takahiro Okamoto, Yoko Omi, Hiroki Tokumitsu

المصدر: World journal of surgery. 42(6)

مصطلحات موضوعية: Parathyroidectomy, Adult, Male, endocrine system, medicine.medical_specialty, medicine.medical_treatment, Urology, 030230 surgery, Subtotal Parathyroidectomy, 03 medical and health sciences, 0302 clinical medicine, Multiple Endocrine Neoplasia Type 1, Medicine, Humans, Multiple endocrine neoplasia, Retrospective Studies, Hyperparathyroidism, business.industry, Retrospective cohort study, Middle Aged, medicine.disease, Hyperparathyroidism, Primary, Cardiothoracic surgery, 030220 oncology & carcinogenesis, Surgery, Female, business, Primary hyperparathyroidism, Abdominal surgery

الوصف: Whether total parathyroidectomy (TPTX) or subtotal parathyroidectomy (SPTX) should be performed for primary hyperparathyroidism (PHPT) in patients with multiple endocrine neoplasia type 1 (MEN1) is controversial. At our institution, the parathyroidectomy strategy is based on the number of enlarged intraoperative parathyroid glands. We retrospectively analyzed our parathyroidectomy procedures. Data of PHPT treatment in patients with MEN1 who underwent parathyroidectomy from 1982 to 2012 at our department were retrospectively collected. The data were grouped according to the surgical procedure: TPTX, SPTX, and less than SPTX (LPTX). TPTX or SPTX was selected based on the preoperative examination findings and number of enlarged intraoperative parathyroid glands. The outcomes were the disease-free survival (DFS) rate and postoperative calcium replacement rate based on Kaplan–Meier analysis for each type of surgical procedure. Forty-five patients were analyzed. The overall 5- and 10-year DFS was 91.7 and 55.8%, respectively. The 5- and 10-year DFS in each subgroup was 100.0 and 85.7% in the TPTX group, 89.4 and 57.3% in the SPTX group, and 91.6 and 57.3% in the LPTX group, respectively. The postoperative calcium replacement rate at 1 and 12 months was 91.7 and 58.3% in the TPTX group, 21.1 and 7.0% in the SPTX group, and 30.0 and 0.0% in the LPTX group, respectively. Although LPTX was not satisfactory as a standard procedure, both SPTX and TPTX are effective treatment methods for PHPT in patients with MEN1. The parathyroidectomy strategy should be based on intraoperative evaluation of the parathyroid glands.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9fef226e6fa9611be9fea8343a6b92efTest
https://pubmed.ncbi.nlm.nih.gov/29138914Test

المؤلفون: Yoko Omi, Kiyomi Horiuchi, Kento Haniu, Momoko Tokura, Erin Nagai, Osamu Isozaki, Yoji Nagashima, Takahiro Okamoto

المصدر: Endocrine Journal; 2018, Vol. 65 Issue 2, p245-252, 8p