المؤلفون: Juan Luis Sanchez-Sanchez, Kelly V. Giudici, Sophie Guyonnet, Julien Delrieu, Yan Li, Randall J. Bateman, Angelo Parini, Bruno Vellas, Philipe de Souto Barreto, for the MAPT/DSA Group

المصدر: Alzheimer’s Research & Therapy, Vol 14, Iss 1, Pp 1-13 (2022)

مصطلحات موضوعية: MCP-1, Older adults, Alzheimer’s disease, Cognitive function, Episodic memory, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571, Neurology. Diseases of the nervous system, RC346-429

الوصف: Abstract Background Monocyte Chemoattractant Protein-1 (MCP-1), a glial-derived chemokine, mediates neuroinflammation and may regulate memory outcomes among older adults. We aimed to explore the associations of plasma MCP-1 levels (alone and in combination with β-amyloid deposition—Aβ42/40) with overall and domain-specific cognitive evolution among older adults. Methods Secondary analyses including 1097 subjects (mean age = 75.3 years ± 4.4; 63.8% women) from the Multidomain Alzheimer Preventive Trial (MAPT). MCP-1 (higher is worse) and Aβ42/40 (lower is worse) were measured in plasma collected at year 1. MCP-1 in continuous and as a dichotomy (values in the highest quartile (MCP-1+)) were used, as well as a dichotomy of Aβ42/40. Outcomes were measured annually over 4 years and included the following: cognitive composite z-score (CCS), the Mini-Mental State Examination (MMSE), and Clinical Dementia Rating (CDR) sum of boxes (overall cognitive function); composite executive function z-score, composite attention z-score, Free and Cued Selective Reminding Test (FCSRT - memory). Results Plasma MCP-1 as a continuous variable was associated with the worsening of episodic memory over 4 years of follow-up, specifically in measures of free and cued delayed recall. MCP-1+ was associated with worse evolution in the CCS (4-year between-group difference: β = −0.14, 95%CI = −0.26, −0.02) and the CDR sum of boxes (2-year: β = 0.19, 95%CI = 0.06, 0.32). In domain-specific analyses, MCP-1+ was associated with declines in the FCSRT delayed recall sub-domains. In the presence of low Aβ42/40, MCP-1+ was not associated with greater declines in cognitive functions. The interaction with continuous biomarker values Aβ 42/40 × MCP-1 × time was significant in models with CDR sum of boxes and FCSRT DTR as dependent variables. Conclusions Baseline plasma MCP-1 levels were associated with longitudinal declines in overall cognitive and episodic memory performance in older adults over a 4-year follow-up. How plasma MCP-1 interacts with Aβ42/40 to determine cognitive decline at different stages of cognitive decline/dementia should be clarified by further research. The MCP-1 association on cognitive decline was strongest in those with amyloid plaques, as measured by blood plasma Aβ 42/40.

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/1758-9193Test

الوصول الحر: https://doaj.org/article/1cfb3343946a4f849944b70f0209cf92Test

المؤلفون: Kelly V. Giudici, Sophie Guyonnet, Christelle Cantet, Philipe deSouto Barreto, Michael W. Weiner, Duygu Tosun, Corina Boschat, Julie Hudry, Sandrine Andrieu, Bruno Vellas, Jeroen A. J. Schmitt, for the Nolan/DSA group

المصدر: Alzheimer’s & Dementia: Translational Research & Clinical Interventions, Vol 8, Iss 1, Pp n/a-n/a (2022)

مصطلحات موضوعية: clinical trials, cognition, homocysteine, nutrition, older adults, omega‐3, Neurology. Diseases of the nervous system, RC346-429, Geriatrics, RC952-954.6

الوصف: Abstract Introduction This study aimed to test the efficacy of a nutritional blend (NB) in improving nutritional biomarkers and preventing cognitive decline among older adults. Methods A 1‐year randomized, double‐blind, multicenter, placebo‐controlled trial with 362 adults (58.6% female, mean 78.3 years, SD = 4.8) receiving an NB or placebo. Erythrocyte ω‐3 index and homocysteine concentrations were primary outcomes. Other outcomes included Patient‐Reported Outcomes Measurement Information System (PROMIS) Applied Cognition‐Abilities, composite cognitive score (CCS), Cognitive Function Instrument (CFI) self‐assessment and study partner, hippocampal volume (HV), and Alzheimer's disease signature cortical thickness (CT). Results A total of 305 subjects completed the follow‐up. Supplementation increased ω‐3 index and decreased homocysteine, but did not affect CCS, CFI self‐assessment, HV, and CT. Placebo improved and treatment did not change PROMIS at 1 month. Intervention showed a positive effect on CFI study partner. Discussion Although improving nutritional biomarkers, this 1‐year trial with a multi‐nutrient novel approach was not able to show effects on cognitive outcomes among older adults.

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/2352-8737Test

الوصول الحر: https://doaj.org/article/7f1c2f08bbb54f7ea7ba5c374da4206bTest

المؤلفون: Elizabete A. dos Santos, Kelly V. Giudici, Natasha A. G. de França, Barbara S. Emo Peters, Regina Mara Fisberg, Lígia A. Martini

المصدر: Archives of Endocrinology and Metabolism, Vol 64, Iss 4, Pp 436-444 (2020)

مصطلحات موضوعية: Vitamin K intake, phylloquinone, body fat, lipid profile, glucose homeostasis, Medicine, Diseases of the endocrine glands. Clinical endocrinology, RC648-665

الوصف: ABSTRACT Objective Recent research has investigated the possible inverse relationship between vitamin K intake and body fat. In addition, an increasing number of studies are supporting a key role for this vitamin in improving lipid profile and insulin sensitivity and reducing the risk of type 2 diabetes mellitus, but little is known about what mechanisms would be involved. Thus, the objective of this study was to investigate the relationship between vitamin K intake (in the form of phylloquinone – PK), body fat, lipid profile and markers of glucose homeostasis in adults and the elderly. Subjects and methods A cross-sectional study with 298 participants (46% men) in the São Paulo Health Survey 2014-2015. Spearman correlations were performed to evaluate the associations between vitamin K intake and the biochemical and body composition measures. Results Among normal-weight male adults (n = 15), PK intake presented a positive correlation with the quantitative insulin sensitivity check index (QUICKI) (r = 0.525; p = 0.045). Among men with high fat mass index (FMI) (n = 101), PK intake had a negative correlation with homeostasis model assessment estimate for β-cell function (HOMA-β) (r = −0.227; p = 0.022). In women with high FMI (n = 122), PK intake had a negative correlation with HOMA-β (r = −0.199, p = 0.032) and insulin (r = −0.207, p = 0.026). No correlations were found between PK intake and lipid profile. Conclusions Our findings support a potential relationship among PK intake, body fat and markers of glucose homeostasis in adults and the elderly.

وصف الملف: electronic resource

العلاقة: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S2359-39972020000400436&tlng=enTest; https://doaj.org/toc/2359-4292Test

الوصول الحر: https://doaj.org/article/23c1738df66b447ea6b9079b35f42b6aTest

المؤلفون: Juan Luis Sanchez-Sanchez (11920759), Kelly V. Giudici (8683545), Sophie Guyonnet (593532), Julien Delrieu (4557568), Yan Li (23143), Randall J. Bateman (320470), Angelo Parini (150380), Bruno Vellas (133953), Philipe de Souto Barreto (11679592)

مصطلحات موضوعية: Medicine, Neuroscience, Immunology, Mental Health, Infectious Diseases, Virology, Computational Biology, Mathematical Sciences not elsewhere classified, MCP-1, Older adults, Alzheimer’s disease, Cognitive function, Episodic memory

الوصف: Additional file 4. Evolution in overall cognitive outcomes, executive function and attention according to plasma MCP-1 status (excluding ApoE ε4 genotype). Mixed-effect linear regression analysis for variation in overall cognitive outcomes, executive function and attention over time according to plasma MCP-1 status among community-dwelling older adults (excluding ApoE ε4 genotype).

العلاقة: https://figshare.com/articles/journal_contribution/Additional_file_4_of_Plasma_MCP-1_and_changes_on_cognitive_function_in_community-dwelling_older_adults/18070723Test

الإتاحة: https://doi.org/10.6084/m9.figshare.18070723.v1Test

المؤلفون: Juan Luis Sanchez-Sanchez (11920759), Kelly V. Giudici (8683545), Sophie Guyonnet (593532), Julien Delrieu (4557568), Yan Li (23143), Randall J. Bateman (320470), Angelo Parini (150380), Bruno Vellas (133953), Philipe de Souto Barreto (11679592)

مصطلحات موضوعية: Medicine, Neuroscience, Immunology, Mental Health, Infectious Diseases, Virology, Computational Biology, Mathematical Sciences not elsewhere classified, MCP-1, Older adults, Alzheimer’s disease, Cognitive function, Episodic memory

الوصف: Additional file 2. Neuroimaging procedures. Description of neuroimaging techniques used in the present study.

العلاقة: https://figshare.com/articles/journal_contribution/Additional_file_2_of_Plasma_MCP-1_and_changes_on_cognitive_function_in_community-dwelling_older_adults/18070717Test

الإتاحة: https://doi.org/10.6084/m9.figshare.18070717.v1Test

المؤلفون: Juan Luis Sanchez-Sanchez (11920759), Kelly V. Giudici (8683545), Sophie Guyonnet (593532), Julien Delrieu (4557568), Yan Li (23143), Randall J. Bateman (320470), Angelo Parini (150380), Bruno Vellas (133953), Philipe de Souto Barreto (11679592)

مصطلحات موضوعية: Medicine, Neuroscience, Immunology, Mental Health, Infectious Diseases, Virology, Computational Biology, Mathematical Sciences not elsewhere classified, MCP-1, Older adults, Alzheimer’s disease, Cognitive function, Episodic memory

الوصف: Additional file 1. Description of features of ELLA System for plasma MCP-1 determination.

العلاقة: https://figshare.com/articles/journal_contribution/Additional_file_1_of_Plasma_MCP-1_and_changes_on_cognitive_function_in_community-dwelling_older_adults/18070714Test

الإتاحة: https://doi.org/10.6084/m9.figshare.18070714.v1Test

المؤلفون: Juan Luis Sanchez-Sanchez (11920759), Kelly V. Giudici (8683545), Sophie Guyonnet (593532), Julien Delrieu (4557568), Yan Li (23143), Randall J. Bateman (320470), Angelo Parini (150380), Bruno Vellas (133953), Philipe de Souto Barreto (11679592)

مصطلحات موضوعية: Medicine, Neuroscience, Immunology, Mental Health, Infectious Diseases, Virology, Computational Biology, Mathematical Sciences not elsewhere classified, MCP-1, Older adults, Alzheimer’s disease, Cognitive function, Episodic memory

الوصف: Additional file 3. Differences between included and excluded participants. Differences in baseline characteristics between MAPT study participants included and excluded in the present study.

العلاقة: https://figshare.com/articles/journal_contribution/Additional_file_3_of_Plasma_MCP-1_and_changes_on_cognitive_function_in_community-dwelling_older_adults/18070720Test

الإتاحة: https://doi.org/10.6084/m9.figshare.18070720.v1Test

المؤلفون: Juan Luis Sanchez-Sanchez (11920759), Kelly V. Giudici (8683545), Sophie Guyonnet (593532), Julien Delrieu (4557568), Yan Li (23143), Randall J. Bateman (320470), Angelo Parini (150380), Bruno Vellas (133953), Philipe de Souto Barreto (11679592)

مصطلحات موضوعية: Medicine, Neuroscience, Immunology, Mental Health, Infectious Diseases, Virology, Computational Biology, Mathematical Sciences not elsewhere classified, MCP-1, Older adults, Alzheimer’s disease, Cognitive function, Episodic memory

الوصف: Additional file 5. Evolution in overall memory outcomes according to plasma MCP-1 status (excluding ApoE ε4 genotype). Mixed-effect linear regression analysis for variation in memory outcomes over time according to plasma MCP-1 status among community-dwelling older adults (excluding ApoE ε4 genotype).

العلاقة: https://figshare.com/articles/journal_contribution/Additional_file_5_of_Plasma_MCP-1_and_changes_on_cognitive_function_in_community-dwelling_older_adults/18070726Test

الإتاحة: https://doi.org/10.6084/m9.figshare.18070726.v1Test

المؤلفون: Juan Luis Sanchez-Sanchez (11920759), Kelly V. Giudici (8683545), Sophie Guyonnet (593532), Julien Delrieu (4557568), Yan Li (23143), Randall J. Bateman (320470), Angelo Parini (150380), Bruno Vellas (133953), Philipe de Souto Barreto (11679592)

مصطلحات موضوعية: Medicine, Neuroscience, Immunology, Mental Health, Infectious Diseases, Virology, Computational Biology, Mathematical Sciences not elsewhere classified, MCP-1, Older adults, Alzheimer’s disease, Cognitive function, Episodic memory

الوصف: Additional file 9. Within group evolution in memory outcomes, executive function and attention according to plasma MCP-1 status (excluding ApoE ε4 genotype). Mixed-effect linear regression analysis for variation in memory outcomes over time according to combined plasma Aβ42/40+ and MCP-1 status among community-dwelling older adults (excluding ApoE ε4 genotype).

العلاقة: https://figshare.com/articles/journal_contribution/Additional_file_9_of_Plasma_MCP-1_and_changes_on_cognitive_function_in_community-dwelling_older_adults/18070741Test

الإتاحة: https://doi.org/10.6084/m9.figshare.18070741.v1Test

المؤلفون: Juan Luis Sanchez-Sanchez (11920759), Kelly V. Giudici (8683545), Sophie Guyonnet (593532), Julien Delrieu (4557568), Yan Li (23143), Randall J. Bateman (320470), Angelo Parini (150380), Bruno Vellas (133953), Philipe de Souto Barreto (11679592)

مصطلحات موضوعية: Medicine, Neuroscience, Immunology, Mental Health, Infectious Diseases, Virology, Computational Biology, Mathematical Sciences not elsewhere classified, MCP-1, Older adults, Alzheimer’s disease, Cognitive function, Episodic memory

الوصف: Additional file 8. Within group evolution in memory outcomes, executive function and attention according to plasma MCP-1 status (excluding ApoE ε4 genotype). Mixed-effect linear regression analysis for variation in overall cognitive outcomes, executive function and attention over time according to combined plasma Aβ42/40+ and MCP-1 status among community-dwelling older adults (excluding ApoE ε4 genotype).

العلاقة: https://figshare.com/articles/journal_contribution/Additional_file_8_of_Plasma_MCP-1_and_changes_on_cognitive_function_in_community-dwelling_older_adults/18070738Test

الإتاحة: https://doi.org/10.6084/m9.figshare.18070738.v1Test