المؤلفون: Joana M. Senra, Kaye J. Williams, James P B O'Connor, Duncan Forster, Marie-Claude Asselin, Ester M. Hammond

المصدر: Clinical Oncology; Vol 26
Clinical Oncology

مصطلحات موضوعية: Oncology, medicine.medical_specialty, Pathology, DNA Repair, medicine.medical_treatment, Cancer therapy, Antineoplastic Agents, Imaging modalities, 03 medical and health sciences, 0302 clinical medicine, Neoplasms, Internal medicine, medicine, Animals, Humans, Prodrugs, Radiology, Nuclear Medicine and imaging, Hypoxia, 030304 developmental biology, 0303 health sciences, medicine.diagnostic_test, business.industry, imaging, Magnetic resonance imaging, Oxygenation, Hypoxia (medical), Magnetic Resonance Imaging, Cell Hypoxia, 3. Good health, Radiation therapy, radiation, Therapy response, Drug Resistance, Neoplasm, Positron emission tomography, Radiology Nuclear Medicine and imaging, Positron-Emission Tomography, 030220 oncology & carcinogenesis, Hypoxia-Inducible Factor 1, medicine.symptom, business, oxygen, Signal Transduction, hypoxia-activated prodrugs

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c33a3714588f386db31a5e13eb0f4c21Test

المؤلفون: Gary Cook, Geoff J M Parker, Gordon C Jayson, Judith E. Adams, Andrew J. I. Jones, Edward F. Jackson, Paul S. Tofts, James P B O'Connor, Laurence P. Clarke, Nathalie Lassau, Sandra Collette, Bruno Morgan, Andrew C. Peet, Lalitha K. Shankar, Fiona J. Gilbert, Ricky A. Sharma, Kevin M. Brindle, Ting-Yim Lee, Sarah E. Bohndiek, Hugo J.W.L. Aerts, Ferdia A. Gallagher, John R. Griffiths, Andrew R. Reynolds, Martin O. Leach, Anwar R. Padhani, John Dickson, Steve Halligan, Ross J. Maxwell, Shonit Punwani, Eric O. Aboagye, John C. Waterton, Adrian L. Harris, Simon Walker-Samuel, Prakash Manoharan, Nandita M. deSouza, James Wason, Stuart A. Taylor, David L. Buckley, Caroline Dive, David J. Hawkes, Thomas E. Yankeelov, Brian Hutton, Gillian M. Tozer, Thomas L. Chenevert, Mike Partridge, Sigrid Stroobants, Dow-Mu Koh, Edward Leen, Sally F. Barrington, Erich P. Huang, Lisa M. McShane, Denis Lacombe, Kaye J. Williams, Ambros J. Beer, Corinne Faivre-Finn, Daniel C. Sullivan, Ashley M. Groves, Kenneth A. Miles, Otto S. Hoekstra, Robert J. Gillies, J. Michael Brady, Simon P. Robinson, Gina Brown, Vicky Goh, Tony Ng, Jeffrey L. Evelhoch, Mark F. Lythgoe, Yan Liu, Ronald Boellaard, Alan Jackson, Dmitry Soloviev, Marcel van Herk, Paul Workman, Arvind P. Pathak, Steve Morris, Jason S. Lewis, Philippe Lambin

المساهمون: Medical Research Council (MRC), Cancer Research UK, Engineering & Physical Science Research Council (EPSRC), US Army (US), National Institute for Health Research, Scottish Power Foundation, Pfizer Limited, Commission of the European Communities, Imperial College Healthcare NHS Trust- BRC Funding, GlaxoSmithKline Services Unlimited, Bohndiek, Sarah [0000-0003-0371-8635], Gallagher, Ferdia [0000-0003-4784-5230], Gilbert, Fiona [0000-0002-0124-9962], Griffiths, John [0000-0001-7369-6836], Morris, Stephen [0000-0002-5828-3563], Wason, James [0000-0002-4691-126X], Brindle, Kevin [0000-0003-3883-6287], Apollo - University of Cambridge Repository, Guided Treatment in Optimal Selected Cancer Patients (GUTS), ​Basic and Translational Research and Imaging Methodology Development in Groningen (BRIDGE), Biomedical Engineering and Physics

المصدر: O'Connor, J P B, Aboagye, E O, Adams, J E, Aerts, H J W L, Barrington, S F, Beer, A J, Boellaard, R, Bohndiek, S E, Brady, M, Brown, G, Buckley, D L, Chenevert, T L, Clarke, L P, Collette, S, Cook, G J, deSouza, N M, Dickson, J C, Dive, C, Evelhoch, J L, Faivre-Finn, C, Gallagher, F A, Gilbert, F J, Gillies, R J, Goh, V, Griffiths, J R, Groves, A M, Halligan, S, Harris, A L, Hawkes, D J, Hoekstra, O S, Huang, E P, Hutton, B F, Jackson, E F, Jayson, G C, Jones, A, Koh, D-M, Lacombe, D, Lambin, P, Lassau, N, Leach, M O, Lee, T-Y, Leen, E L, Lewis, J S, Liu, Y, Lythgoe, M F, Manoharan, P, Maxwell, R J, Miles, K A, Morgan, B, Morris, S, Ng, T, Padhani, A R, Parker, G J M, Partridge, M, Pathak, A P, Peet, A C, Punwani, S, Reynolds, A R, Robinson, S P, Shankar, L K, Sharma, R A, Soloviev, D, Stroobants, S, Sullivan, D C, Taylor, S A, Tofts, P S, Tozer, G M, van Herk, M, Walker-Samuel, S, Wason, J, Williams, K J, Workman, P, Yankeelov, T E, Brindle, K M, McShane, L M, Jackson, A & Waterton, J C 2016, ' Imaging biomarker roadmap for cancer studies ', Nature Reviews Clinical Oncology . https://doi.org/10.1038/nrclinonc.2016.162Test
Nature reviews. Clinical oncology
O'Connor, J P B, Aboagye, E O, Adams, J E, Aerts, H J W L, Barrington, S F, Beer, A J, Boellaard, R, Bohndiek, S E, Brady, M, Brown, G, Buckley, D L, Chenevert, T L, Clarke, L P, Collette, S, Cook, G J, deSouza, N M, Dickson, J C, Dive, C, Evelhoch, J L, Faivre-Finn, C, Gallagher, F A, Gilbert, F J, Gillies, R J, Goh, V, Griffiths, J R, Groves, A M, Halligan, S, Harris, A L, Hawkes, D J, Hoekstra, O S, Huang, E P, Hutton, B F, Jackson, E F, Jayson, G C, Jones, A, Koh, D-M, Lacombe, D, Lambin, P, Lassau, N, Leach, M O, Lee, T-Y, Leen, E L, Lewis, J S, Liu, Y, Lythgoe, M F, Manoharan, P, Maxwell, R J, Miles, K A, Morgan, B, Morris, S, Ng, T, Padhani, A R, Parker, G J M, Partridge, M, Pathak, A P, Peet, A C, Punwani, S, Reynolds, A R, Robinson, S P, Shankar, L K, Sharma, R A, Soloviev, D, Stroobants, S, Sullivan, D C, Taylor, S A, Tofts, P S, Tozer, G M, van Herk, M, Walker-Samuel, S, Wason, J, Williams, K J, Workman, P, Yankeelov, T E, Brindle, K M, McShane, L M, Jackson, A & Waterton, J C 2017, ' Imaging biomarker roadmap for cancer studies ', Nature Reviews Clinical Oncology, vol. 14, no. 3, pp. 169-186 . https://doi.org/10.1038/nrclinonc.2016.162Test
Nature Reviews Clinical Oncology
Nature Reviews Clinical Oncology, 14(3), 169-186. Nature Publishing Group
O'Connor, J P B, Aboagye, E O, Adams, J E, Aerts, H J W L, Barrington, S F, Beer, A J, Boellaard, R, Bohndiek, S E, Brady, M, Brown, G, Buckley, D L, Chenevert, T L, Clarke, L P, Collette, S, Cook, G J, deSouza, N M, Dickson, J C, Dive, C, Evelhoch, J L, Faivre-Finn, C, Gallagher, F A, Gilbert, F J, Gillies, R J, Goh, V, Griffiths, J R, Groves, A M, Halligan, S, Harris, A L, Hawkes, D J, Hoekstra, O S, Huang, E P, Hutton, B F, Jackson, E F, Jayson, G C, Jones, A, Koh, D M, Lacombe, D, Lambin, P, Lassau, N, Leach, M O, Lee, T Y, Leen, E L, Lewis, J S, Liu, Y, Lythgoe, M F, Manoharan, P, Maxwell, R J, Miles, K A, Morgan, B, Morris, S, Ng, T, Padhani, A R, Parker, G J M, Partridge, M, Pathak, A P, Peet, A C, Punwani, S, Reynolds, A R, Robinson, S P, Shankar, L K, Sharma, R A, Soloviev, D, Stroobants, S, Sullivan, D C, Taylor, S A, Tofts, P S, Tozer, G M, van Herk, M, Walker-Samuel, S, Wason, J, Williams, K, Workman, P, Yankeelov, T E, Brindle, K M, McShane, L M, Jackson, A & Waterton, J C 2017, ' Imaging biomarker roadmap for cancer studies ', Nature Reviews Clinical Oncology, vol. 14, no. 3, pp. 169-186 . https://doi.org/10.1038/nrclinonc.2016.162Test
Nature reviews. Clinical oncology, 14(3), 169-186. Nature Publishing Group

مصطلحات موضوعية: Research design, medicine.medical_specialty, Pathology, Imaging biomarker, Standardization, Cost-Benefit Analysis, CELL LUNG-CANCER, Clinical Decision-Making, MEDLINE, HIGH FAMILIAL RISK, Article, 030218 nuclear medicine & medical imaging, 03 medical and health sciences, CONTRAST-ENHANCED MRI, 0302 clinical medicine, Breast cancer, Folic Acid, POSITRON-EMISSION-TOMOGRAPHY, Fluorodeoxyglucose F18, Neoplasms, Biomarkers, Tumor, Medicine, BREAST-CANCER, Humans, Medical physics, GROUP DEVELOPMENTAL PATHWAY, DRUG DEVELOPMENT, Selection Bias, Accreditation, business.industry, Reproducibility of Results, Organotechnetium Compounds, medicine.disease, Prognosis, 3. Good health, Clinical trial, Oncology, Drug development, Research Design, ADVANCED SOLID TUMORS, 030220 oncology & carcinogenesis, Positron-Emission Tomography, Human medicine, Radiopharmaceuticals, business, SURROGATE END-POINTS, CLINICAL-TRIALS, Biomarkers

وصف الملف: application/pdf; pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5d1104a5358332ffc4b9ef8fbc53000Test
https://kclpure.kcl.ac.uk/ws/files/62043218/nrclinonc.2016.162.pdfTest

المؤلفون: Philippe Lambin, Ludwig Dubois, Ala Yaromina, Natasja G. Lieuwes, R. Biemans, Brian A. Telfer, Guido R.M.M. Haenen, Kaye J. Williams, Raymon Niemans, Simon J. A. van Kuijk, Roben G. Gieling

المساهمون: RS: GROW - R3 - Innovative Cancer Diagnostics & Therapy, Promovendi ODB, Radiotherapie, Ondersteunend personeel ODB, Farmacologie en Toxicologie, RS: CARIM - R3.05 - Vascular remodeling in cardiovascular disease, RS: NUTRIM - R3 - Chronic inflammatory disease and wasting

المصدر: PLOS ONE, 11(8):e0161040. Public Library of Science
PLoS ONE, Vol 11, Iss 8, p e0161040 (2016)
PLoS ONE

مصطلحات موضوعية: 0301 basic medicine, Physiology, Cancer Treatment, lcsh:Medicine, Pharmacology, Toxicology, Pathology and Laboratory Medicine, Biochemistry, Mice, 0302 clinical medicine, Tumor Cells, Cultured, Medicine and Health Sciences, Carbonic Anhydrase Inhibitors, Hypoxia, lcsh:Science, Cell Analysis, Carbonic Anhydrases, Sulfonamides, Multidisciplinary, Antibiotics, Antineoplastic, Chemistry, Cell Hypoxia, 3. Good health, Enzymes, Gene Expression Regulation, Neoplastic, Bioassays and Physiological Analysis, Oncology, Physiological Parameters, 030220 oncology & carcinogenesis, Physical Sciences, Cell lines, Female, Biological cultures, medicine.drug, Research Article, Cell Viability Testing, Combination therapy, Mice, Nude, Breast Neoplasms, 03 medical and health sciences, In vivo, medicine, Animals, Humans, Doxorubicin, Viability assay, Carbonic Anhydrase IX, IC50, HT29 cells, Cell Proliferation, Toxicity, Cell growth, Phenylurea Compounds, Body Weight, lcsh:R, Chemical Compounds, Biology and Life Sciences, Proteins, Cell Biology, Carbon Dioxide, A300, Xenograft Model Antitumor Assays, In vitro, Research and analysis methods, 030104 developmental biology, Cell culture, Enzymology, lcsh:Q

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0015a9f0028d8ab1a88076adbb66f6a8Test

المؤلفون: Corinne Faivre-Finn, Muhammad Babur, Ahmed Salem, James P B O'Connor, Kaye J. Williams, Ross A. Little, C. Behan, Garry Ashton, Alan Jackson, Yvonne Watson, Isabel Peset, Hitesh Mistry, Robert G. Bristow, Julian C. Matthews, G. J. Parker, M-C Asselin, Adam K. Featherstone, Susan Cheung, Victoria Tessyman

المصدر: Journal of Thoracic Oncology. 13:S596

مصطلحات موضوعية: Pulmonary and Respiratory Medicine, Oncology, business.industry, medicine, Cancer research, Hypoxia (medical), medicine.symptom, Oxygen enhanced, business, Lung cancer, medicine.disease

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::fbf342b7f849ce6f1b4608f827d7a2a4Test
https://doi.org/10.1016Test/j.jtho.2018.08.892

المؤلفون: Anne White, Emma Dean, Fiona H Blackhall, M. Babur, Rachel Stovold, Suzanne Meredith, Jennifer L. Bryant, Kaye J. Williams, Caroline Dive

المصدر: British Journal of Cancer

مصطلحات موضوعية: endocrine system, Cancer Research, Pathology, medicine.medical_specialty, Lung Neoplasms, Pro-Opiomelanocortin, Transplantation, Heterologous, Immunocytochemistry, Enolase, Mice, Nude, Enzyme-Linked Immunosorbent Assay, Metastasis, Mice, Cytokeratin, Neuroendocrine Cells, medicine, metastasis, Animals, Humans, Carcinoma, Small Cell, Neoplasm Metastasis, Lung cancer, Molecular Diagnostics, biology, Liver Neoplasms, Chromogranin A, Epithelial Cells, Cadherins, Neoplastic Cells, Circulating, medicine.disease, respiratory tract diseases, Survival Rate, xenografts, Phenotype, nervous system, Oncology, biology.protein, Keratins, Immunohistochemistry, Neural cell adhesion molecule, cytokeratin

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5752b353395bd16758c5f7275482caf5Test
https://doi.org/10.1038/bjc.2013.112Test

المؤلفون: Roben G. Gieling, Kaye J. Williams

المصدر: Bioorganic & Medicinal Chemistry
Bioorganic & Medicinal Chemistry; Vol 21

مصطلحات موضوعية: medicine.drug_class, Clinical Biochemistry, Uterine Cervical Neoplasms, Pharmaceutical Science, CA 15-3, Antineoplastic Agents, Breast Neoplasms, Monoclonal antibody, Biochemistry, Metastasis, Small Molecule Libraries, 03 medical and health sciences, 0302 clinical medicine, Antigen, Antigens, Neoplasm, Drug Discovery, medicine, Animals, Humans, Carbonic Anhydrase IX, Carbonic Anhydrase Inhibitors, Cell adhesion, Molecular Biology, Carbonic Anhydrases, 030304 developmental biology, 0303 health sciences, biology, Chemistry, Organic Chemistry, Antibodies, Monoclonal, Cancer, medicine.disease, Xenograft Model Antitumor Assays, Kidney Neoplasms, 3. Good health, Head and Neck Neoplasms, Lymphatic Metastasis, 030220 oncology & carcinogenesis, Cancer cell, Immunology, Cancer research, biology.protein, Molecular Medicine, Female, Antibody

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f39726575c960a63866529e2b46d1e4fTest
https://doi.org/10.1016Test/j.bmc.2012.09.062

المؤلفون: Lisa A. De Costa, N Robertson, Kaye J. Williams, Adrian L. Harris, Roben G. Gieling, Ian J. Stratford, Catriona Parker

المصدر: Journal of Enzyme Inhibition and Medicinal Chemistry; Vol 28
Journal of Enzyme Inhibition and Medicinal Chemistry

مصطلحات موضوعية: Intracellular pH, Antineoplastic Agents, Pharmacology, 03 medical and health sciences, Structure-Activity Relationship, 0302 clinical medicine, Neoplasms, Drug Discovery, medicine, Extracellular, Tumor Cells, Cultured, Humans, Protein Isoforms, Doxorubicin, Carbonic Anhydrase Inhibitors, Melphalan, 030304 developmental biology, Carbonic Anhydrases, chemistry.chemical_classification, 0303 health sciences, Dose-Response Relationship, Drug, Molecular Structure, General Medicine, HCT116 Cells, In vitro, 3. Good health, Enzyme, chemistry, Biochemistry, 030220 oncology & carcinogenesis, Toxicity, Drug Screening Assays, Antitumor, Acetazolamide, HT29 Cells, Homeostasis, medicine.drug

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25eea0a3bfce34700cb57160e3bf77f0Test

المؤلفون: Adam McMahon, Cassandra L Hodgkinson, Jamil Gregory, Gavin Brown, Ian D. Wilson, Alison Smigova, Marc Radigois, Roben G. Gieling, Christopher J. Morrow, Caroline Dive, Muhammad Babur, Natalie Burrows, Kaye J. Williams, Christopher Cawthorne, Duncan Hiscock, Duncan Forster, Kathryn Simpson

المصدر: Molecular Cancer Therapeutics
University of Manchester-PURE
Molecular Cancer Therapeutics; Vol 12

مصطلحات موضوعية: Cancer Research, Indazoles, Blood pool, Protein subunit, Antineoplastic Agents, Article, 030218 nuclear medicine & medical imaging, 03 medical and health sciences, Mice, Phosphatidylinositol 3-Kinases, 0302 clinical medicine, Text mining, Glioma, Cell Line, Tumor, Neoplasms, medicine, Animals, Humans, Neoplasm Metastasis, neoplasms, Phosphoinositide-3 Kinase Inhibitors, Sulfonamides, medicine.diagnostic_test, business.industry, Kinase inhibition, medicine.disease, HCT116 Cells, Xenograft Model Antitumor Assays, Dideoxynucleosides, 3. Good health, Tumor Burden, Disease Models, Animal, Oncology, Positron emission tomography, Thymidine kinase, 030220 oncology & carcinogenesis, Pharmacodynamics, Positron-Emission Tomography, Immunology, Cancer research, Female, business, Signal Transduction

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e97c36a1371399cc142da8b85e738c9Test

المؤلفون: Brian A. Telfer, Natalie Burrows, Kaye J. Williams, Georg Brabant

المصدر: Radiotherapy and Oncology
Radiotherapy and Oncology; Vol 108

مصطلحات موضوعية: rho GTP-Binding Proteins, medicine.medical_specialty, Indazoles, GDC-0941, PI3K, Metastasis, Thyroid carcinoma, Mice, Phosphatidylinositol 3-Kinases, 03 medical and health sciences, 0302 clinical medicine, Rho-GTPases, Western blot, Cell Movement, In vivo, Cell Line, Tumor, Internal medicine, medicine, Animals, Humans, Radiology, Nuclear Medicine and imaging, Thyroid Neoplasms, Neoplasm Metastasis, PI3K/AKT/mTOR pathway, Phosphoinositide-3 Kinase Inhibitors, 030304 developmental biology, Sulfonamides, 0303 health sciences, Radiotherapy, medicine.diagnostic_test, Chemistry, HIF-1, Hematology, medicine.disease, In vitro, 3. Good health, Endocrinology, Oncology, Radiology Nuclear Medicine and imaging, 030220 oncology & carcinogenesis, Cancer research, Female, Hypoxia-Inducible Factor 1, Ex vivo, Signal Transduction, Proto-oncogene tyrosine-protein kinase Src

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9761307e9f43a779911b31a016f94dc1Test

المؤلفون: Lucy Ly, John R. Griffiths, Helen Troy, Manuel Mayr, Marion Stubbs, Meg Perumal, Paul M.J. McSheehy, Kaye J. Williams, David Perrett, Monika Golinska, John R. Latigo, Adrian L. Harris, Yuen-Li Chung, Rachel Airley, Eric O. Aboagye, Xiaoke Yin

المصدر: BMC Cancer
BMC Cancer, Vol 11, Iss 1, p 198 (2011)

مصطلحات موضوعية: Proteomics, Cancer Research, medicine.medical_specialty, Carcinoma, Hepatocellular, Glucose uptake, Allosteric regulation, Adaptation, Biological, Glucose Transport Proteins, Facilitative, Mice, Nude, HIF-1β, PFK activation, Biology, Carbohydrate metabolism, lcsh:RC254-282, RC0254, Mice, Enzyme activator, Adenosine Triphosphate, Allosteric Regulation, Downregulation and upregulation, Hepa-1 tumours, Internal medicine, Genetics, medicine, Animals, Glycolysis, Cell Proliferation, Cell growth, Adenylate Kinase, Liver Neoplasms, deficiency, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, Adenosine Monophosphate, glucose uptake, Up-Regulation, Enzyme Activation, Glucose, Endocrinology, Phosphofructokinases, Oncology, Hypoxia-Inducible Factor 1, glycolytic enzymes, AMP/ATP ratio, Research Article, Phosphofructokinase

وصف الملف: application/pdf

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https://ora.ox.ac.uk/objects/uuid:26b7ef33-0a0c-4870-a363-ea1361e183a2Test