المؤلفون: Kinsley, Sarah E., Williams, Emma E., Lenhard, Nora K., Shah, Sejal B., Edwards, Robert R., Katz, Jeffrey N., Talbot, Simon G.

المصدر: The Journal of Hand Surgery ; volume 47, issue 4, page 387.e1-387.e19 ; ISSN 0363-5023

مصطلحات موضوعية: Orthopedics and Sports Medicine, Surgery

الإتاحة: https://doi.org/10.1016/j.jhsa.2021.05.005Test
https://api.elsevier.com/content/article/PII:S036350232100280X?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S036350232100280X?httpAccept=text/plainTest

المؤلفون: Mobasheri, Ali, Im, Gun il, Katz, Jeffrey N., Loughlin, John, Kraus, Virginia B., Sandell, Linda J., Berenbaum, Francis, Abramson, Steve, Lotz, Martin, Hochberg, Marc, Pelletier, Jean Pierre, Madry, Henning, Block, Joel A., Lohmander, L. Stefan, Altman, Roy D.

المصدر: Osteoarthritis and Cartilage Open EpiHealth: Epidemiology for Health. 3(2)

مصطلحات موضوعية: COVID-19, History, Mission, OARSI, Osteoarthritis (OA), Strategic objectives, Treatment guidelines, Vision, Medicin och hälsovetenskap, Klinisk medicin, Ortopedi, Medical and Health Sciences, Clinical Medicine, Orthopedics

الوصف: We provide a detailed account of the origin and establishment of the Osteoarthritis Research Society International (OARSI) and celebrate its history from inception to the current day. We discuss the mission, vision and strategic objectives of OARSI and how these have developed and evolved over the last 3 decades. We celebrate the achievements of the society as we approach its 30th birthday, honor the entire presidential line and respectfully pay tribute to the past presidents who are no longer with us. We reflect on the strong foundations of our society, OARSI's efforts to disseminate understanding of the health, disability and economic burdens of osteoarthritis (OA) to policymakers, and the exciting initiatives to make the society inclusive and international. We thank our corporate and industrial sponsors, who have supported us over many years, without whom our annual congresses would not have been possible. We celebrate our longstanding strategic partnership with our publisher, Elsevier, and the successful launch of our new journal Osteoarthritis and Cartilage Open, the most significant new development in our dissemination toolbox. For the first time in the history of the organization, our annual congress was cancelled in April 2020 and the 2021 meeting will be virtual. Despite the numerous challenges posed by the ongoing COVID-19 pandemic and the need to adapt quickly to a rapidly changing landscape, we must remain optimistic about the future. We will take advantage of new exciting opportunities to advance our mission and vision to enhance the quality of life of persons with OA.

الوصول الحر: https://lup.lub.lu.se/record/ca9a6938-a063-483c-b128-a1586c751e95Test
http://dx.doi.org/10.1016/j.ocarto.2021.100146Test

المؤلفون: Losina, Elena, Paltiel, A David, Weinstein, Alexander M, Yelin, Edward, Hunter, David J, Chen, Stephanie P, Klara, Kristina, Suter, Lisa G, Solomon, Daniel H, Burbine, Sara A, Walensky, Rochelle P, Katz, Jeffrey N

المصدر: Arthritis Care & Research. 67(2)

مصطلحات موضوعية: Osteoarthritis, Chronic Pain, Health Services, Pain Research, Arthritis, Aging, Clinical Research, 6.1 Pharmaceuticals, Evaluation of treatments and therapeutic interventions, Musculoskeletal, Good Health and Well Being, Adult, Aged, Arthroplasty, Replacement, Knee, Female, Health Care Costs, Health Services Needs and Demand, Humans, Male, Middle Aged, Models, Economic, Osteoarthritis, Knee, United States, Clinical Sciences, Public Health and Health Services, Psychology

الوصف: ObjectiveThe impact of increasing utilization of total knee arthroplasty (TKA) on lifetime costs in persons with knee osteoarthritis (OA) is understudied.MethodsWe used the Osteoarthritis Policy Model to estimate total lifetime costs and TKA utilization under a range of TKA eligibility criteria among US persons with symptomatic knee OA. Current TKA utilization was estimated from the Multicenter Osteoarthritis Study and calibrated to Health Care Cost and Utilization Project data. OA treatment efficacy and toxicity were drawn from published literature. Costs in 2013 dollars were derived from Medicare reimbursement schedules and Red Book Online. Time costs were derived from published literature and the US Bureau of Labor Statistics.ResultsEstimated average discounted (3% per year) lifetime costs for persons diagnosed with knee OA were $140,300. Direct medical costs were $129,600, with $12,400 (10%) attributable to knee OA over 28 years. OA patients spent a mean ± SD of 13 ± 10 years waiting for TKA after failing nonsurgical regimens. Under current TKA eligibility criteria, 54% of knee OA patients underwent TKA over their lifetimes. Estimated OA-related discounted lifetime direct medical costs ranged from $12,400 (54% TKA uptake) when TKA eligibility was limited to Kellgren/Lawrence grades 3 or 4 to $16,000 (70% TKA uptake) when eligibility was expanded to include symptomatic OA with a lesser degree of structural damage.ConclusionBecause of low efficacy of nonsurgical regimens, knee OA treatment-attributable costs are low, representing a small portion of all costs for OA patients. Expanding TKA eligibility increases OA-related costs substantially for the population, underscoring the need for more effective nonoperative therapies.

وصف الملف: application/pdf

الوصول الحر: https://escholarship.org/uc/item/49w7j4fmTest

المؤلفون: Solomon, Daniel H, Tonner, Chris, Lu, Bing, Kim, Seoyoung C, Ayanian, John Z, Brookhart, M Alan, Katz, Jeffrey N, Yelin, Ed

المصدر: Arthritis Care & Research. 66(8)

مصطلحات موضوعية: Arthritis, Autoimmune Disease, Clinical Research, Inflammatory and immune system, Adult, Age Factors, Antirheumatic Agents, Arthritis, Rheumatoid, Female, Hispanic or Latino, Humans, Male, Medication Adherence, Middle Aged, Socioeconomic Factors, Surveys and Questionnaires, Treatment Outcome, White People, Withholding Treatment, Clinical Sciences, Public Health and Health Services, Psychology

الوصف: ObjectiveDisease-modifying antirheumatic drugs (DMARDs) are the standard of care for rheumatoid arthritis (RA); however, studies have found that many patients do not receive them. We examined predictors of starting and stopping DMARDs among a longitudinal cohort of patients with RA.MethodsStudy participants came from a cohort of RA patients recruited from a random sample of rheumatologists' practices in Northern California. We examined patterns and predictors of stopping and starting nonbiologic and biologic DMARDs during 1982-2009 based on annual questionnaires. Stopping was defined as stopping all DMARDs and starting was defined as transitioning from no DMARDs to any DMARDs across 2 consecutive years.ResultsThe analysis of starting DMARDs included 471 subjects with 1,974 pairs of years with no DMARD use in the first of 2 consecutive years. From this population, subjects started DMARD use by year 2 in 313 (15.9%) of the pairs. The analysis of stopping DMARDs included 1,026 subjects with 7,595 pairs of years with DMARD use in the first of 2 consecutive years; in 423 pairs (5.6%), subjects stopped DMARD use by year 2. In models that adjusted for RA-related factors, sociodemographics, and comorbidities, significant predictors of starting DMARDs included younger age, Hispanic ethnicity, shorter disease duration, and the use of oral glucocorticoids. In separate adjusted models, predictors of stopping DMARDs included Hispanic ethnicity and low income, while younger age was associated with a reduced risk of stopping.ConclusionEfforts to improve DMARD use should focus on patient age, ethnicity, and income and RA-related factors.

وصف الملف: application/pdf

الوصول الحر: https://escholarship.org/uc/item/1qj887fmTest

المؤلفون: Messier, Stephen P., Gill, Malia E., Mihalko, Shannon L., Beavers, Daniel P., Queen, Kate, Miller, Gary D., Losina, Elena, Katz, Jeffrey N., Loeser, Richard F., DeVita, Paul, Hunter, David J., Quandt, Sara A., Lyles, Mary F., Hudson, David, Callahan, Leigh F.

المصدر: Arthritis Care and Research; April 2024, Vol. 76 Issue: 4 p503-510, 8p

مستخلص: The purpose of this study was to determine whether clinical, health‐related quality of life (HRQL), and gait characteristics in adults with knee osteoarthritis (OA) differed by obesity category. This cross‐sectional analysis of 823 older adults (mean age 64.6 years, SD 7.8 years) with knee OA and overweight or obesity compared clinical, HRQL, and gait outcomes among obesity classifications (overweight or class I, body mass index [BMI] 27.0–34.9; class II, BMI 35.0–39.9; class III BMI ≥40.0). Patients with class III obesity had worse Western Ontario McMasters Universities Arthritis Index knee pain (0–20) than the overweight or class I (mean 8.6 vs 7.0; difference 1.5; 95% confidence interval [CI] 1.0–2.1; P< 0.0001) and class II (mean 8.6 vs 7.4; difference 1.1; 95% CI 0.6–1.7; P= 0.0002) obesity groups. The Short Form 36 physical HRQL measure was lower in the class III obesity group compared to the overweight or class I (mean 31.0 vs 37.3; difference −6.2; 95% CI −7.8 to −4.7; P< 0.0001) and class II (mean 31.0 vs 35.0; difference −3.9; 95% CI −5.6 to −2.2; P< 0.0001) obesity groups. The class III obesity group had a base of support (cm) during gait that was wider than that for the overweight or class I (mean 14.0 vs 11.6; difference 3.3; 95% CI 2.6–4.0; P< 0.0001) and class II (mean 14.0 vs 11.6; difference 2.4; 95% CI 1.6–3.2; P< 0.0001) obesity groups. Among adults with knee OA, those with class III obesity had significantly higher pain levels and worse physical HRQL and gait characteristics compared to adults with overweight or class I or class II obesity.

المؤلفون: Yelin, Edward, Tonner, Chris, Kim, Seoyoung C, Katz, Jeffrey N, Ayanian, John Z, Brookhart, M Alan, Solomon, Daniel H

المصدر: Arthritis Care & Research. 66(7)

مصطلحات موضوعية: Aging, Clinical Research, Arthritis, Behavioral and Social Science, Autoimmune Disease, Inflammatory and immune system, Adult, Aged, Antirheumatic Agents, Arthritis, Rheumatoid, Biological Factors, Delivery of Health Care, Female, Humans, Longitudinal Studies, Male, Middle Aged, Socioeconomic Factors, Clinical Sciences, Public Health and Health Services, Psychology

الوصف: ObjectiveTo analyze the effect of sociodemographic, disease, and health system characteristics and contextual features about the community of residence on the subsequent initiation of treatment with biologic agents for rheumatoid arthritis (RA).MethodsWe analyzed data from the University of California, San Francisco Rheumatoid Arthritis Panel Study for the years 1999-2011. Principal data collection was by a structured annual phone survey. We estimated Kaplan-Meier curves of the time until initiation of biologic agents, stratified by age and income. We also used Cox regression to estimate the effect of individual-level sociodemographic and medical factors, contextual-level socioeconomic status measures, and density of health providers in the local community on the probability of initiating therapy with biologic agents for RA.ResultsIn total, 527 persons were included in the panel in 1999, and 229 persons (44%) had initiated therapy with biologic agents by 2011. In multivariable Cox regression models, age

وصف الملف: application/pdf

الوصول الحر: https://escholarship.org/uc/item/3wr1c681Test

المؤلفون: Roy, Adam E., Carrier, Charles S., Schwab, Pierre-Emmanuel, Thornhill, Thomas S., Losina, Elena, Chen, Antonia F., Katz, Jeffrey N., Lange, Jeffrey K.

المصدر: Journal of Arthroplasty; Dec2023, Vol. 38 Issue 12, p2630-2633, 4p

مستخلص: Spino-pelvic orientation may affect dislocation risk following total hip arthroplasty (THA). It can be measured on lateral lumbo-pelvic radiographs. The sacro-femoro-pubic (SFP) angle, measured on an antero-posterior (AP) pelvis radiograph, is a reliable proxy for pelvic tilt, a measurement of spino-pelvic orientation measured on a lateral lumbo-pelvic radiograph. The purpose of this study was to investigate the relationship between SFP angle and dislocation following THA. An Institutional Review Board-approved retrospective case-control study was conducted at a single academic center. We matched 71 dislocators (cases) to 71 nondislocators (controls) following THA performed by 1 of 10 surgeons between September 2001 and December 2010. Two authors (readers) independently calculated SFP angle from single preoperative AP pelvis radiographs. Readers were blinded to cases and controls. Conditional logistic regressions were used to identify factors differentiating cases and controls. The data did not show a clinically relevant or statistically significant difference in SFP angles after adjusting for gender, American Society of Anesthesiologists classification, prosthetic head size, age at time of THA, measurement laterality, and surgeon. We did not find an association between preoperative SFP angle and dislocation following THA in our cohort. Based on our data, SFP angle as measured on a single AP pelvis radiograph should not be used to assess dislocation risk prior to THA. [ABSTRACT FROM AUTHOR]

: Copyright of Journal of Arthroplasty is the property of Churchill Livingstone, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

المؤلفون: Dykes, Patricia C., Curtin-Bowen, Mica, Franz, Calvin, Syrowatka, Ania, Lipsitz, Stuart, Sainlaire, Michael, Businger, Alexandra, Tien Thai, Chen, Antonia F., Schoenfeld, Andrew J., Lieberman, Jay R., Iorio, Richard, O'Brien, Todd, Blanchfield, Bonnie, Katz, Jeffrey N., Jiranek, William A., Melnic, Christopher, Bates, David W.

المصدر: Journal of Patient Safety; Dec2023, Vol. 19 Issue 8, p539-546, 8p

المؤلفون: Mass, Hanna¹ (AUTHOR), Katz, Jeffrey N.^1,2,3,4 (AUTHOR) jnkatz@bwh.harvard.edu

المصدر: Skeletal Radiology. Nov2023, Vol. 52 Issue 11, p2045-2055. 11p.

مصطلحات موضوعية: *OSTEOARTHRITIS, *KNEE osteoarthritis, *KNEE pain, *MENISCUS injuries, *PATHOLOGY, *OLDER people, *AGE groups

مستخلص: Importance: Knee osteoarthritis (OA) is a common cause of pain and disability in older persons, affecting approximately 14 million individuals in the USA. Meniscal damage is also common in this age group with a prevalence of 35% in a middle-aged and older community sample and 82% in persons with evidence of radiographic knee osteoarthritis. This paper systematically reviews evidence on the association of meniscal pathology and incident radiographic knee OA. Observations: We included 15 articles, published between 2013 and 2021, assessing the relationship between meniscal pathology and OA incidence (Fig. 1). The menisci are crucial load-bearing structures, and the resulting increase in biomechanical stress due to meniscal damage increases the risk for OA development. While some discrepancies are present in the literature, a clinically meaningful association has been generally established between the presence of a meniscal tear or meniscal extrusion and subsequent development of incident OA. Of note, larger radial tears as well as complex and more severe tears exhibit the strongest association with the development of incident OA. The relationship between other features of meniscal morphology—such as meniscal volume and meniscal coverage—and incident OA is less clearly documented. Conclusions and relevance: The early detection of meniscal pathology can be used to trigger preventative and therapeutic strategies designed to avert or delay knee OA in this at-risk population. [ABSTRACT FROM AUTHOR]

المؤلفون: Smith, Lacey M., Yuchiao Chang, Feldman, Candace H., Santacroce, Leah M., Earle, Madison, Katz, Jeffrey N., Novais, Eduardo N.

المصدر: Journal of Bone & Joint Surgery, American Volume; 11/1/2023, Vol. 105 Issue 21, p1655-1662, 8p

مستخلص: Background: Extensive literature documents the adverse sequelae of delayed diagnosis of slipped capital femoral epiphysis (SCFE), including worsening deformity and surgical complications. Less is known about predictors of delayed diagnosis of SCFE, particularly the effects of social determinants of health. The purpose of this study was to evaluate the impact of insurance type, family structure, and neighborhood-level socioeconomic vulnerability on the delay of SCFE diagnosis. Methods: We reviewed medical records of patients who underwent surgical fixation for stable SCFE at a tertiary pediatric hospital from 2002 to 2021. We abstracted data on demographic characteristics, insurance status, family structure, home address, and symptom duration. We measured diagnostic delay in weeks from the date of symptom onset to diagnosis. We then geocoded patient addresses to determine their Census tract-level U.S. Centers for Disease Control and Prevention (CDC) and Agency for Toxic Substances and Disease Registry (ATSDR) Social Vulnerability Index (SVI), using U.S. Census and American Community Survey data. We performed 3 separate logistic regression models to examine the effects of (1) insurance status, (2) family structure, and (3) SVI on a delay of ≥12 weeks (reference, <12 weeks). We adjusted for age, sex, weight status, number of siblings, and calendar year. Results: We identified 351 patients with SCFE; 37% (129) had a diagnostic delay of ≥12 weeks. In multivariable logistic regression models, patients with public insurance were more likely to have a delay of ≥12 weeks than patients with private insurance (adjusted odds ratio [OR], 1.83 [95% confidence interval (CI), 1.12 to 2.97]; p = 0.015) and patients from single-guardian households were more likely to have a delay of ≥12 weeks than patients from multiguardian households (adjusted OR, 1.95 [95% CI, 1.11 to 3.45]; p = 0.021). We did not observe a significant increase in the odds of delay among patients in the highest quartile of overall SVI compared with patients from the lower 3 quartiles, in both the U.S. comparison (adjusted OR, 1.43 [95% CI, 0.79 to 2.58]; p = 0.24) and the Massachusetts comparison (adjusted OR, 1.45 [95% CI, 0.79 to 2.66]; p = 0.23). Conclusions: The delay in diagnosis of SCFE remains a concern, with 37% of patients with SCFE presenting with delay of ≥12 weeks. Public insurance and single-guardian households emerged as independent risk factors for diagnostic delay. Interventions to reduce delay may consider focusing on publicly insured patients and those from single-guardian households. [ABSTRACT FROM AUTHOR]

: Copyright of Journal of Bone & Joint Surgery, American Volume is the property of Lippincott Williams & Wilkins and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)