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المؤلفون: Ulrike Bacher, Laura Flückiger, Thomas Pabst, Carolyn Graber, Katja Seipel
المصدر: International Journal of Molecular Sciences, Vol 22, Iss 8092, p 8092 (2021)
International Journal of Molecular Sciences
Volume 22
Issue 15
Seipel, Katja; Graber, Carolyn; Flückiger, Laura; Bacher, Vera; Pabst, Thomas (2021). Rationale for a Combination Therapy with the STAT5 Inhibitor AC-4-130 and the MCL1 Inhibitor S63845 in the Treatment of FLT3-Mutated or TET2-Mutated Acute Myeloid Leukemia. International journal of molecular sciences, 22(15) MDPI 10.3390/ijms22158092 <http://dx.doi.org/10.3390/ijms22158092Test>مصطلحات موضوعية: 0301 basic medicine, chemistry.chemical_compound, 0302 clinical medicine, fluids and secretions, hemic and lymphatic diseases, Antineoplastic Combined Chemotherapy Protocols, STAT5 Transcription Factor, Medicine, MCL1, Midostaurin, Biology (General), Spectroscopy, Trametinib, Kinase, ten-eleven translocation-2 (TET2), Myeloid leukemia, hemic and immune systems, General Medicine, 3. Good health, Computer Science Applications, DNA-Binding Proteins, Leukemia, Myeloid, Acute, Chemistry, myeloid leukemia cell differentiation protein (MCL1), 030220 oncology & carcinogenesis, embryonic structures, FLT3 Inhibitor, Combination therapy, QH301-705.5, tumor suppressor p53 (TP53), 610 Medicine & health, Thiophenes, Article, Catalysis, Dioxygenases, Inorganic Chemistry, 03 medical and health sciences, signal transducer and activator of transcription 5 (STAT5), acute myeloid leukemia (AML), Cell Line, Tumor, Proto-Oncogene Proteins, Humans, hematological malignancies, Physical and Theoretical Chemistry, Molecular Biology, QD1-999, FMS-like tyrosine kinase 3 (FLT3), business.industry, Venetoclax, Tumor Suppressor Proteins, Organic Chemistry, Pyrimidines, 030104 developmental biology, fms-Like Tyrosine Kinase 3, chemistry, Cancer research, business
وصف الملف: application/pdf
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a86caaa2cbf92ffdc34d64b704e8471Test
https://www.mdpi.com/1422-0067/22/15/8092Test -
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المؤلفون: Katja Seipel, Alexandre Theocharides, Bruktawit Maru, Thomas Pabst, Maureen McKeague, Peter J. M. Valk, Nathan W. Luedtke, Alessandra Messikommer
مصطلحات موضوعية: Chemotherapy, Anthracycline, business.industry, medicine.medical_treatment, Cancer, Myeloid leukemia, medicine.disease, Olaparib, chemistry.chemical_compound, chemistry, Cancer cell, medicine, Cytarabine, Cancer research, Idarubicin, business, medicine.drug
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::b9e18174171c7986b9deb29ab5cb243eTest
https://doi.org/10.1101/2021.05.24.445484Test -
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المؤلفون: Ulrike Bacher, Basil Kopp, Thomas Pabst, Katja Seipel
المصدر: Cancers, Vol 13, Iss 581, p 581 (2021)
Cancers
Volume 13
Issue 3
Seipel, Katja; Kopp, Basil; Bacher, Ulrike; Pabst, Thomas (2021). BMI1-Inhibitor PTC596 in Combination with MCL1 Inhibitor S63845 or MEK Inhibitor Trametinib in the Treatment of Acute Leukemia. Cancers, 13(3) MDPI AG 10.3390/cancers13030581 <http://dx.doi.org/10.3390/cancers13030581Test>مصطلحات موضوعية: 0301 basic medicine, Cancer Research, NPM1, CD34, 610 Medicine & health, BMI1 Inhibitor PTC596, myeloid cell leukemia 1 (MCL1), lcsh:RC254-282, Article, 03 medical and health sciences, meningioma 1 (MN1), 0302 clinical medicine, acute myeloid leukemia (AML), hemic and lymphatic diseases, Medicine, MCL1, neoplasms, Trametinib, Acute leukemia, business.industry, MEK inhibitor, Myeloid leukemia, myelodysplastic syndrome (MDS), lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, 3. Good health, B-cell-specific Moloney murine leukemia virus integration site 1 (BMI1), 030104 developmental biology, Oncology, 030220 oncology & carcinogenesis, tumor suppressor protein 53 (TP53), Cancer research, business, hematopoietic progenitor cell antigen cluster of differentiation 34 (CD34)
وصف الملف: application/pdf
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53ba1f36042ffd3cdb925c7e8e62782eTest
https://www.mdpi.com/2072-6694/13/3/581Test -
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المؤلفون: Ulrike Bacher, Urban Novak, Beatrice U. Mueller, Thomas Pabst, Behrouz Mansouri Taleghani, Laura C. Alva, Katja Seipel
المصدر: Transfusion. 58:2365-2373
مصطلحات موضوعية: medicine.medical_specialty, Myeloid, Blood transfusion, business.industry, medicine.medical_treatment, Immunology, Myeloid leukemia, Hematology, Hematopoietic stem cell transplantation, medicine.disease, Gastroenterology, Transplantation, 03 medical and health sciences, Leukemia, 0302 clinical medicine, Autologous stem-cell transplantation, medicine.anatomical_structure, 030220 oncology & carcinogenesis, Internal medicine, medicine, Immunology and Allergy, business, Hematopoietic Stem Cell Mobilization, 030215 immunology
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::90e093564c9159bba96f20bf2f7bbe0aTest
https://doi.org/10.1111/trf.14895Test -
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المؤلفون: Nathan W. Luedtke, Stephen Byrne, Peter J. M. Valk, Alessandra Messikommer, Thomas Pabst, Katja Seipel
المساهمون: Hematology
المصدر: ACS Pharmacol Transl Sci
ACS Pharmacology and Translational Science, 3(6), 1225-1232. American Chemical Societyمصطلحات موضوعية: Pharmacology, DNA synthesis, biology, Chemistry, RNA, Myeloid leukemia, Molecular biology, chemistry.chemical_compound, Cytarabine, medicine, biology.protein, DNA Polymerase Inhibitor, Pharmacology (medical), RNase H, 610 Medicine & health, Nucleoside, DNA, medicine.drug
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51757f25b68c6b0b9b1a62bd546f0198Test
https://pubmed.ncbi.nlm.nih.gov/33344899Test -
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المصدر: Haematologica
مصطلحات موضوعية: Acute Myeloid Leukemia, Male, 0301 basic medicine, NPM1, Myeloid, HL-60 Cells, Article, 03 medical and health sciences, chemistry.chemical_compound, fluids and secretions, 0302 clinical medicine, hemic and lymphatic diseases, Antineoplastic Combined Chemotherapy Protocols, medicine, Humans, Cytotoxic T cell, Midostaurin, Enzyme Inhibitors, biology, business.industry, Wild type, Myeloid leukemia, Proto-Oncogene Proteins c-mdm2, hemic and immune systems, Hematology, Staurosporine, medicine.disease, Leukemia, Myeloid, Acute, Leukemia, 030104 developmental biology, medicine.anatomical_structure, fms-Like Tyrosine Kinase 3, chemistry, 030220 oncology & carcinogenesis, embryonic structures, biology.protein, Cancer research, Mdm2, Female, business, Nucleophosmin
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d87a3f46f05337d04f986dc39c79468Test
https://doi.org/10.3324/haematol.2018.191650Test -
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المؤلفون: Gertrud Wiedemann, Ulrike Bacher, Katja Seipel, Thomas Pabst, Christian Messerli
المصدر: Leukemia research. 89
مصطلحات موضوعية: Adult, Male, Cancer Research, Myeloid, CD34, Peripheral blood mononuclear cell, Models, Biological, Transplantation, Autologous, 03 medical and health sciences, Young Adult, 0302 clinical medicine, Autologous stem-cell transplantation, hemic and lymphatic diseases, Antineoplastic Combined Chemotherapy Protocols, Biomarkers, Tumor, Medicine, Humans, 610 Medicine & health, Aged, Retrospective Studies, business.industry, Tumor Suppressor Proteins, Hematopoietic Stem Cell Transplantation, Induction chemotherapy, Myeloid leukemia, Forkhead Transcription Factors, Hematology, Induction Chemotherapy, Middle Aged, Prognosis, Gene Expression Regulation, Neoplastic, Repressor Proteins, Haematopoiesis, Leukemia, Myeloid, Acute, MicroRNAs, medicine.anatomical_structure, Treatment Outcome, Oncology, 030220 oncology & carcinogenesis, Mutation, Cancer research, Trans-Activators, Female, Stem cell, business, Nucleophosmin, 030215 immunology
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3df4593d94f150a7e9189cf98b99f336Test
https://pubmed.ncbi.nlm.nih.gov/31927137Test -
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المؤلفون: S Farese, Urban Novak, J-M Luethi, Gabriela M. Baerlocher, Thomas Pabst, Martin Bigler, Beatrice U. Mueller, B Mansouri Taleghani, Katja Seipel, Axel Ruefer, Barbara Jeker, Daniel Betticher
المصدر: Bone Marrow Transplantation. 53:175-179
مصطلحات موضوعية: Adult, Male, medicine.medical_specialty, medicine.medical_treatment, Urology, CD34, Pharmacology, Meloxicam, Vinorelbine, 03 medical and health sciences, 0302 clinical medicine, medicine, Humans, 610 Medicine & health, Multiple myeloma, Aged, Peripheral Blood Stem Cell Transplantation, Transplantation, Chemotherapy, business.industry, Plerixafor, Anti-Inflammatory Agents, Non-Steroidal, Hematology, Middle Aged, medicine.disease, Hematopoietic Stem Cell Mobilization, Gemcitabine, 030220 oncology & carcinogenesis, Female, Multiple Myeloma, business, 030215 immunology, medicine.drug
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43d39d870a9a5dfeef02ee51221e0967Test
https://doi.org/10.1038/bmt.2017.234Test