المؤلفون: M. Guftar Shaikh, Angela K. Lucas-Herald, Antonia Dastamani, Maria Salomon Estebanez, Senthil Senniappan, Noina Abid, Sumera Ahmad, Sophie Alexander, Bindu Avatapalle, Neelam Awan, Hester Blair, Roisin Boyle, Alexander Chesover, Barbara Cochrane, Ross Craigie, Annaruby Cunjamalay, Sarah Dearman, Paolo De Coppi, Karen Erlandson-Parry, Sarah E. Flanagan, Clare Gilbert, Niamh Gilligan, Caroline Hall, Jayne Houghton, Ritika Kapoor, Helen McDevitt, Zainab Mohamed, Kate Morgan, Jacqueline Nicholson, Ana Nikiforovski, Elaine O'Shea, Pratik Shah, Kirsty Wilson, Chris Worth, Sarah Worthington, Indraneel Banerjee

المصدر: Frontiers in Endocrinology, Vol 14 (2023)

مصطلحات موضوعية: congenital hyperinsulinism, glucose, hypoglycaemia, consensus, patient organisation, standardised practice, Diseases of the endocrine glands. Clinical endocrinology, RC648-665

الوصف: Congenital hyperinsulinism (CHI) is a condition characterised by severe and recurrent hypoglycaemia in infants and young children caused by inappropriate insulin over-secretion. CHI is of heterogeneous aetiology with a significant genetic component and is often unresponsive to standard medical therapy options. The treatment of CHI can be multifaceted and complex, requiring multidisciplinary input. It is important to manage hypoglycaemia in CHI promptly as the risk of long-term neurodisability arising from neuroglycopaenia is high. The UK CHI consensus on the practice and management of CHI was developed to optimise and harmonise clinical management of patients in centres specialising in CHI as well as in non-specialist centres engaged in collaborative, networked models of care. Using current best practice and a consensus approach, it provides guidance and practical advice in the domains of diagnosis, clinical assessment and treatment to mitigate hypoglycaemia risk and improve long term outcomes for health and well-being.

وصف الملف: electronic resource

العلاقة: https://www.frontiersin.org/articles/10.3389/fendo.2023.1231043/fullTest; https://doaj.org/toc/1664-2392Test

الوصول الحر: https://doaj.org/article/6ae549a70f2e4683982d8ee5ac0a6878Test

المؤلفون: Madhini Sivasubramanian, Parizad Avari, Clare Gilbert, Louise Doodson, Kate Morgan, Nick Oliver, Pratik Shah

المصدر: Frontiers in Endocrinology, Vol 14 (2023)

مصطلحات موضوعية: hyperinsulinism, continuous glucose monitoring, hypoglycaemia, neurodevelopment, time below range, Diseases of the endocrine glands. Clinical endocrinology, RC648-665

الوصف: ObjectiveContinuous glucose monitoring (CGM) is the standard of care for glucose monitoring in children with diabetes, however there are limited data reporting their use in hyperinsulinaemic hypoglycaemia (HH). Here, we evaluate CGM accuracy and its impact on quality of life in children with HH.MethodsReal-time CGM (Dexcom G5 and G6) was used in children with HH aged 0-16years. Data from self-monitoring capillary blood glucose (CBG) and CGM were collected over a period of up to 28days and analysed. Quality of life was assessed by the PedsQL4.0 general module and PedsQL2.0 family impact module, completed by children and their parents/carers before and after CGM insertion. Analysis of accuracy metrics included mean absolute relative difference (MARD) and proportion of CGM values within 15, 20, and 30% or 15, 20, and 30 mg/dL of reference glucose values >100 mg/dL or ≤100 mg/dL, respectively (% 15/15, % 20/20, % 30/30). Clinical reliability was assessed with Clarke error grid (CEG) analyses.ResultsProspective longitudinal study with data analysed from 40 children. The overall MARD between reference glucose and paired CGM values (n=4,928) was 13.0% (Dexcom G5 12.8%, Dexcom G6 13.1%). The proportion of readings meeting %15/15 and %20/20 were 77.3% and 86.4%, respectively, with CEG analysis demonstrating 97.4% of all values in zones A and B. Within the hypoglycaemia range (

وصف الملف: electronic resource

العلاقة: https://www.frontiersin.org/articles/10.3389/fendo.2023.1265076/fullTest; https://doaj.org/toc/1664-2392Test

الوصول الحر: https://doaj.org/article/f6eac0ce3b144f5ea5cdae65b04d4eadTest

المؤلفون: Valeria Magarotto, Julien Thevenon, Kate Morgan, Silene Ten Seldam, Wafae Iraqi, Xavier Guillaume, Dahbia Horchi, Bleuenn Rault, Traugott Ludwig Gruppe

المصدر: HemaSphere, Vol 7, p e8967582 (2023)

مصطلحات موضوعية: Diseases of the blood and blood-forming organs, RC633-647.5

وصف الملف: electronic resource

العلاقة: http://journals.lww.com/10.1097/01.HS9.0000977392.89675.82Test; https://doaj.org/toc/2572-9241Test

الوصول الحر: https://doaj.org/article/ba784431125e45e583b148652f00206fTest

المؤلفون: Helen L. MacLaughlin, Erynn McAuley, Jessica Fry, Elissa Pacheco, Natalie Moran, Kate Morgan, Lisa McGuire, Marguerite Conley, David W. Johnson, Sharad K. Ratanjee, Belinda Mason

المصدر: Nutrients, Vol 16, Iss 1, p 3 (2023)

مصطلحات موضوعية: chronic kidney disease, potassium, hyperkalaemia, potassium additives, dietary potassium restriction, Nutrition. Foods and food supply, TX341-641

الوصف: Potassium dysregulation can be life-threatening. Dietary potassium modification is a management strategy for hyperkalaemia. However, a 2017 review for clinical guidelines found no trials evaluating dietary restriction for managing hyperkalaemia in chronic kidney disease (CKD). Evidence regarding dietary hyperkalaemia management was reviewed and practice recommendations disseminated. A literature search using terms for potassium, hyperkalaemia, and CKD was undertaken from 2018 to October 2022. Researchers extracted data, discussed findings, and formulated practice recommendations. A consumer resource, a clinician education webinar, and workplace education sessions were developed. Eighteen studies were included. Observational studies found no association between dietary and serum potassium in CKD populations. In two studies, 40–60 mmol increases in dietary/supplemental potassium increased serum potassium by 0.2–0.4 mmol/L. No studies examined lowering dietary potassium as a therapeutic treatment for hyperkalaemia. Healthy dietary patterns were associated with improved outcomes and may predict lower serum potassium, as dietary co-factors may support potassium shifts intracellularly, and increase excretion through the bowel. The resource recommended limiting potassium additives, large servings of meat and milk, and including high-fibre foods: wholegrains, fruits, and vegetables. In seven months, the resource received > 3300 views and the webinar > 290 views. This review highlights the need for prompt review of consumer resources, hospital diets, and health professionals’ knowledge.

وصف الملف: electronic resource

العلاقة: https://www.mdpi.com/2072-6643/16/1/3Test; https://doaj.org/toc/2072-6643Test

الوصول الحر: https://doaj.org/article/18b06f78f5164d2384bbb5e95e0c69bcTest

المؤلفون: Rosanne Janssens, Tamika Lang, Ana Vallejo, Jayne Galinsky, Kate Morgan, Ananda Plate, Chris De Ronne, Margaux Verschueren, Elise Schoefs, Anneleen Vanhellemont, Michel Delforge, Fredrik Schjesvold, Elena Cabezudo, Martina Vandebroek, Hilde Stevens, Steven Simoens, Isabelle Huys

المصدر: Frontiers in Oncology, Vol 12 (2022)

مصطلحات موضوعية: multiple myeloma, patients’ preferences, discrete choice experiment, swing weighting, quality of life, preference heterogeneity, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

الوصف: IntroductionGiven the rapid increase in novel treatments for patients with multiple myeloma (MM), this patient preference study aimed to establish which treatment attributes matter most to MM patients and evaluate discrete choice experiment (DCE) and swing weighting (SW) as two elicitation methods for quantifying patients’ preferences.MethodsA survey incorporating DCE and SW was disseminated among European MM patients. The survey included attributes and levels informed by a previous qualitative study with 24 MM patients. Latent class and mixed logit models were used to estimate the DCE attribute weights and descriptive analyses were performed to derive SW weights. MM patients and patient organisations provided extensive feedback during survey development.Results393 MM patients across 21 countries completed the survey (Myears since diagnosis=6; Mprevious therapies=3). Significant differences (p

وصف الملف: electronic resource

العلاقة: https://www.frontiersin.org/articles/10.3389/fonc.2022.1027353/fullTest; https://doaj.org/toc/2234-943XTest

الوصول الحر: https://doaj.org/article/3adfee30c6ce4269ac1b2d69f4c3ba46Test

المؤلفون: Amanda J. Wagg PhD, RGN, SCPHN-HV, IBCLC, QN, Kate Morgan BSc, PGdip, RGN SCPHN-SN

المصدر: SAGE Open Nursing, Vol 8 (2022)

مصطلحات موضوعية: Nursing, RT1-120

الوصف: Introduction A need to increase student placements, in a culture that is under unprecedented demand, means that practice providers and partner higher education institutions need to find new and innovative ways to ensure quality learning experiences for students. Virtual placements are just one way of providing student placements, and this study presents a case for this. Objective This research aims to explore the student’s experience of virtual blended placements and to consider future sustainability. Method This is a qualitative, exploratory study observing the attitudes, thoughts, and feelings of student nurse experiences of online virtual nursing placements. Key cases were identified, and two participants were asked to reflect upon their experiences of the blended virtual learning placement. Student evaluations, and virtual placement day plans, form part of the data collection, and results are presented in a theory building and comparative approach, adopting pattern matching. Results Three themes emerged from the narratives, supported by student evaluations and day plans. Students reviewed the placement positively in that they were able to achieve their required practice proficiencies. Second, they discussed the way in which the virtual days were facilitated and that building relationships with professionals and peers while on placement was of high importance. Conclusion This case study presents a novel and unique student experience within a 0–19 community nursing service, which through 3 days of practice placement supported by two virtually taught days, students were able to reach their practice proficiencies. This virtual placement model offers a unique way to reduce the pressures on frontline staff and enriches the students’ experiences.

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/2377-9608Test

الوصول الحر: https://doaj.org/article/6a3633da273e4c02a4e93f4f67c4f1e6Test

المؤلفون: Eloisa Colin-Ramirez, BSc, PhD, JoAnne Arcand, RD, PhD, Elizabeth Woo, RD, Margaret Brum, RD, CDE, Kate Morgan, BAS, MDietSt, Winnie Christopher, RD, MSc, CDE, Lubia Velázquez, BSc, PhD, Amirhossein Sharifzad, HBSc, Sinead Feeney, RD, MSc, Justin A. Ezekowitz, MBBCh MSc

المصدر: CJC Open, Vol 2, Iss 1, Pp 8-14 (2020)

مصطلحات موضوعية: Diseases of the circulatory (Cardiovascular) system, RC666-701

الوصف: Background: Restricting dietary sodium consumption has been considered a major component of self-care management in heart failure (HF); however, the evidence supporting this recommendation has not been conclusive. The Study of Dietary Intervention Under 100 MMOL in Heart Failure (SODIUM-HF) trial aims to assess the effects of dietary sodium reduction on clinical outcomes in a HF population using a pragmatic design to provide empirical evidence to guide dietary sodium intake recommendations in patients with chronic HF. Methods: SODIUM-HF is a multicentre, open-label, blinded adjudicated endpoint, randomized controlled trial in ambulatory patients with chronic HF. This trial involves participants recruited from sites in Canada, Australia, New Zealand, Mexico, Colombia, and Chile, who are followed up to 24 months. Rationale and methods of the SODIUM-HF trial were published elsewhere. As an international pragmatic dietary trial, SODIUM-HF was designed to address several challenges, such as defining the most suitable intervention to account for country-specific variations in food intake and availability. In SODIUM-HF, we implemented the Nutrition-Care Model to provide a comprehensive intervention delivered directly to patients, focusing on modifying the nutrient composition of the diet (sodium restriction), using a personalized counselling and close follow-up. Results: Available upon completion of the trial. Conclusions: This long-term dietary trial is one of the first in its type in the HF field. This article describes in detail the rationale and methods for the dietary intervention employed and the region-specific adaptation of the SODIUM-HF intervention, so that the learning and processes taken in this trial can be applied to future multicountry dietary clinical trials. Résumé: Contexte: La restriction de l’apport en sodium alimentaire est considérée comme étant un élément important de l’auto-prise en charge de l’insuffisance cardiaque (IC); or, les données à l’appui de cette recommandation ne sont pas concluantes. L’étude SODIUM-HF (Study of Dietary Intervention Under 100 MMOL in Heart Failure) vise à évaluer en contexte réel les effets de la réduction de l’apport en sodium alimentaire sur les résultats cliniques au sein d’une population de patients atteints d’IC, afin d’obtenir des données empiriques qui serviront à orienter les recommandations en matière d’apport en sodium alimentaire chez les patients atteints d’IC chronique. Méthodologie: L’étude SODIUM-HF est un essai multicentrique contrôlé avec répartition aléatoire et mené en mode ouvert auprès de patients ambulatoires atteints d’IC chronique, dont les paramètres sont évalués à l’insu. Les participants sont recrutés dans des centres situés au Canada, en Australie, en Nouvelle-Zélande, au Mexique, en Colombie et au Chili, et font l’objet d’un suivi pendant 24 mois. La raison d’être et la méthodologie de l’étude SODIUM-HF sont présentées ailleurs. Comme il s’agit d’une étude internationale sur l’alimentation menée en contexte réel, l’étude SODIUM-HF a été conçue de manière à résoudre plusieurs difficultés, dont la façon la plus appropriée de tenir compte des variations entre pays en matière d’apport alimentaire et de disponibilité des aliments. L’étude met en œuvre le processus de soins en nutrition, afin d’assurer directement auprès des patients une intervention exhaustive axée sur la modification de la composition en nutriments de l’alimentation (restriction de l’apport en sodium) et faisant appel à des conseils personnalisés et à un suivi étroit. Résultats: Les résultats seront publiés à la fin de l’étude. Conclusions: Cette étude de longue durée sur l’alimentation est l’une des premières en son genre dans le domaine de l’IC. Les auteurs décrivent en détail la raison d’être et la méthodologie des mesures d’intervention alimentaire employées ainsi que les adaptations propres à chaque région mises en œuvre dans le cadre de l’étude SODIUM-HF, afin que les apprentissages et les processus issus de l’étude puissent être utilisés dans d’autres études cliniques multinationales sur l’alimentation.

وصف الملف: electronic resource

العلاقة: http://www.sciencedirect.com/science/article/pii/S2589790X19300745Test; https://doaj.org/toc/2589-790XTest

الوصول الحر: https://doaj.org/article/91e87dce29464ecaa232e5aa65fad548Test

المؤلفون: Hermann Einsele, Javier Briones, Fabio Ciceri, Irene García Cadenas, Fred Falkenburg, Natacha Bolaños, H.M. Mirjam Heemskerk, Roch Houot, Michael Hudecek, Franco Locatelli, Kate Morgan, Emma C. Morris, Michael O’Dwyer, Jordi Gil Sierra, Marcel van den Brink, Arjan A. van de Loosdrecht

المصدر: HemaSphere, Vol 5, Iss 10, p e642 (2021)

مصطلحات موضوعية: Diseases of the blood and blood-forming organs, RC633-647.5

وصف الملف: electronic resource

العلاقة: http://journals.lww.com/10.1097/HS9.0000000000000642Test; https://doaj.org/toc/2572-9241Test

الوصول الحر: https://doaj.org/article/f7bde4df68684867baf82fb55cc1d6b8Test

المؤلفون: Rosanne Janssens, Tamika Lang, Ana Vallejo, Jayne Galinsky, Ananda Plate, Kate Morgan, Elena Cabezudo, Raija Silvennoinen, Daniel Coriu, Sorina Badelita, Ruxandra Irimia, Minna Anttonen, Riikka-Leena Manninen, Elise Schoefs, Martina Vandebroek, Anneleen Vanhellemont, Michel Delforge, Hilde Stevens, Steven Simoens, Isabelle Huys

المصدر: Frontiers in Medicine, Vol 8 (2021)

مصطلحات موضوعية: multiple myeloma, patient preferences, nominal group technique, qualitative research, attributes, drug development, Medicine (General), R5-920

الوصف: Background: Investigational and marketed drugs for the treatment of multiple myeloma (MM) are associated with a range of characteristics and uncertainties regarding long term side-effects and efficacy. This raises questions about what matters most to patients living with this disease. This study aimed to understand which characteristics MM patients find most important, and hence should be included as attributes and levels in a subsequent quantitative preference survey among MM patients.Methods: This qualitative study involved: (i) a scoping literature review, (ii) discussions with MM patients (n = 24) in Belgium, Finland, Romania, and Spain using Nominal Group Technique, (iii) a qualitative thematic analysis including multi-stakeholder discussions.Results: MM patients voiced significant expectations and hopes that treatments would extend their lives and reduce their cancer signs and symptoms. Participants however raised concerns about life-threatening side-effects that could cause permanent organ damage. Bone fractures and debilitating neuropathic effects (such as chronic tingling sensations) were highlighted as major issues reducing patients' independence and mobility. Patients discussed the negative impact of the following symptoms and side-effects on their daily activities: thinking problems, increased susceptibility to infections, reduced energy, pain, emotional problems, and vision problems. MM patients were concerned with uncertainties regarding the durability of positive treatment outcomes, and the cause, severity, and duration of their symptoms and side-effects. Patients feared short-term positive treatment responses complicated by permanent, severe side-effects and symptoms.Conclusions: This study gained an in-depth understanding of the treatment and disease-related characteristics and types of attribute levels (severity, duration) that are most important to MM patients. Results from this study argue in favor of MM drug development and individual treatment decision-making that focuses not only on extending patients' lives but also on addressing those symptoms and side-effects that significantly impact MM patients' quality of life. This study underscores a need for transparent communication toward MM patients about MM treatment outcomes and uncertainties regarding their long-term efficacy and safety. Finally, this study may help drug developers and decision-makers understand which treatment outcomes and uncertainties are most important to MM patients and therefore should be incorporated in MM drug development, evaluation, and clinical practice.

وصف الملف: electronic resource

العلاقة: https://www.frontiersin.org/articles/10.3389/fmed.2021.686165/fullTest; https://doaj.org/toc/2296-858XTest

الوصول الحر: https://doaj.org/article/2f7a9f0125f74320923fd8baca99dce4Test

المؤلفون: Kate Morgan

المصدر: HemaSphere, Vol 6, Pp 1-1 (2022)

مصطلحات موضوعية: Diseases of the blood and blood-forming organs, RC633-647.5

وصف الملف: electronic resource

العلاقة: http://journals.lww.com/10.1097/01.HS9.0000829484.22331.6cTest; https://doaj.org/toc/2572-9241Test

الوصول الحر: https://doaj.org/article/d5c8b18b82124e7a82e6f242fbf7bc44Test