يعرض 1 - 10 نتائج من 36 نتيجة بحث عن '"Kassas, S"', وقت الاستعلام: 1.00s تنقيح النتائج
  1. 1
    دورية أكاديمية

    مصطلحات موضوعية: 1117 Public Health and Health Services

    الوصف: Introduction Armed conflict may influence the size and scope of research in Arab countries. We aimed to assess the impact of the 2011 Syrian conflict on health articles about Syria published in indexed journals. Methods We conducted a scoping review on Syrian health-related articles using seven electronic databases. We included clinical, biomedical, public health, or health system topics published between 1991 and 2017. We excluded animal studies and studies conducted on Syrian refugees. We used descriptive and social network analyses to assess the differences in rates, types, topics of articles, and authorship before and after 2011, the start of the Syrian conflict. Results Of 1138 articles, 826 (72.6%) were published after 2011. Articles published after 2011 were less likely to be primary research; had a greater proportion reporting on mental health (4.6% vs. 10.0%), accidents and injuries (2.3% vs. 18.8%), and conflict and health (1.7% vs. 7.8%) (all p < 0.05); and a lower proportion reporting on child and maternal health (8.1 to 3.6%, p = 0.019). The proportion of research articles reporting no funding increased from 1.1 to 14.6% (p < 0.01). While international collaborations increased over time, the number of articles with no authors affiliated to Syrian institutions overtook those with at least one author affiliation to a Syrian institution for the first time in 2015. Conclusion To our knowledge, this is the first study to examine the impact of armed conflict on health scholarship in Syria. The Syrian conflict was associated with a change in the rates, types, and topics of the health-related articles, and authors’ affiliations. Our findings have implications for the prioritization of research funding, development of inclusive research collaborations, and promoting the ethics of conducting research in complex humanitarian settings.

    العلاقة: Conflict and Health; http://hdl.handle.net/10044/1/84553Test

  2. 2
    دورية أكاديمية

    المؤلفون: Robinson, Jg, Farnier, M, Krempf, M, Bergeron, J, Luc, G, Averna, M, Stroes, Es, Langslet, G, Raal, Fj, El Shahawy, M, Koren, Mj, Lepor, Ne, Lorenzato, C, Pordy, R, Chaudhari, U, Kastelein, Jj, Caccavo, A, Codutti, O, Gelersztein, E, Vico, M, Zaidman, C, Majul, C, Balthazar, Y, Capiau, L, Vrolix, M, Vermeersch, P, Gotchev, D, Todorov, G, Tumbev, H, Tzekova, M, Gronkova, N, Dimov, B, Nikolaeva, A, Devedzhiev, T, Mincheva, V, D'Ignazio, G, Dzongowski, P, Elliott, T, Hart, R, Hoag, G, Martinho, V, O'Mahony, M, Tellier, G, Pandey, S, Heaton, K, Constance, C, Phaneuf, Dc, Shu, D, Narvaez, Nc, Cañon, Co, Cardenas, Sp, Loayza, Ms, de Salazar, Dm, Lopez, Rb, Gomez, Ji, Mendoza, Ja, Cure, Cc, Ceska, R, Zidkova, E, Jansky, P, Egstrup, K, Klausen, Ib, Lomholdt, J, Gislason, G, Torp Pedersen, C, Poulsen, S, Kuusela, M, Kekki, S, Nieminen, S, Tuomilehto, J, Boye, A, Bruckert, E, Cadinot, D, Lejay, D, Revol, T, Schaupp, T, Bonnet, J, Paillard, F, Moulin, P, Junggeburth, J, Isermann, B, Zühlke, M, Züchner, D, Theis, E, Stößel, J, König, Hj, Rinke, A, Piechatzek, R, Contzen, C, Lappo, M, Himpel Boenninghoff, Aa, Meissner, G, Maus, O, Degtyareva, E, Schulze, Ed, Horacek, T, Marten, I, Becher, P, Matoltsy, A, Nyirati, G, Paragh, G, Zilahi, Z, Nagy, K, Kanakaridisz, N, Beke, E, Biro, J, Schnabel, R, Elias, M, Gavish, D, Francis, A, Nseir, W, Zimlichman, R, Pozzi, C, Lembo, G, Bucci, M, Mezzetti, A, De Pellegrin, Am, Salvioni, A, De Cesare, N, Briones, Ir, Campos, Pf, Rosas, El, Espinosa, Ev, Salazar, Ma, Ruiz, Ab, Furusho, Lc, Olvera, I, Stroes, E, van den Berg, R, Basart, D, Köse, V, Kentgens, S, Peeters, M, Hoogendijk, J, Voors Pette, C, Agous, I, van Kempen, W, Lingan, Gr, Kooy, A, Troquay, R, Herrman, J, Hoivik, H, Norheim, P, Risberg, K, Høivik, Ho, Elle, S, Derezinski, T, Miekus, P, Ogorek, M, Szymkowiak, K, Cesar, M, Gawron, A, Dabrowska, M, Blach, E, Konieczny, M, Sidor, M, Matias, F, da Silva, Pm, Carvalho, D, Mendonca, I, Andor, M, Andrei, L, Podoleanu, C, Pop, C, Chizhov, P, Chumakova, G, Goloschekin, B, Libov, I, Paltsman, Z, Strutinskiy, A, Koziolova, N, Breedt, J, Ebrahim, I, Ellis, G, Fulat, M, van Rensburg, Dj, Raal, F, van Dyk, C, Vally, T, van der Walt, E, Kotzé, H, Landman, C, Tayob, M, Caixas, A, García, Lr, Fernandez Cruz, A, Gil Extremera, B, Grijalvo, Om, Plana, N, Fuentes, F, Valdivielso, P, Fraile, B, Borgencrantz, B, Larnefeldt, H, Tengmark, Bo, Eriksson, M, Olsson Önerud, Å, Amalyan, W, Dyadyk, O, Koval, O, Kushnir, M, Svintsitskiy, A, Kovalyov, O, Bondarchuk, O, Tashchuk, V, Barna, O, Prokhorov, O, Karpenko, O, Stanciu, D, Pawa, R, Balaji, H, Doig, F, Harvey, P, Ranganath, L, Massalski, W, Hassanin, H, Timmis, H, Pavel Knox, I, Abdulhakim, E, Oyesile, B, Horvathova, V, Donnachie, H, Kondagunta, V, Shaw, H, Thomas, H, Kadr, H, Gunstone, A, Lip, G, Ellery, A, Kerrane, J, Sarker, A, Wong, Yk, Soran, H, Maw, K, Andersen, J, Blair Britt, L, Huffman, C, Kivitz, A, Marple, R, Patron, A, Schear, M, Allegar, N, Awasty, V, Casanova, R, Chaykin, L, Cohen, L, Collins, H, Collins, G, Elkin, G, Reyes, H, Feld, L, Fuller, G, Glover, R, Greenwald, J, Herrod, J, Kaye, W, Kimmel, M, Kolettis, E, Lakin, G, Lorch, D, Palatnik, M, Patel, R, Reichman, A, Rohlf, J, Shockey, G, Shore, K, Radin, D, Alvarado, O, Bellingar, B, Egelhof, R, Mcknight, T, Plevin, S, Pritchard, J, Reddy, R, Velazquez, F, Bolster, E, Broker, R, Butuk, D, Cheung, D, Cohen, K, Golden, G, Murray, A, Naccarato, T, Uusinarkaus, K, Pudi, K, Graff, A, Blumberg, V, Dunn, F, Toth, P, Anspach, R, Chuang, R, Meli, J, Nevins, B, Wayne, J, Schmidt, L, Levinsky, D, Rubino, J, Shealy, N, Torres, D, West, J, Jain, R, Vardi, G, Singh, N, Thew, S, Lo, E, Heitner, J, Gerber, J, Malik, A, Weinstein, D, Prashad, R, Koren, M, Ghitis, A, David, W, Reis, G, Kinzfogl, G, Haught, H, Kantaros, L, O'Dea, D, Weiss, D, Kassas, S, Hunter, J, Mollod, M, Khan, N, Henderson, D, Gatien, L, Schramm, R, Madder, R, Voyce, S, Nadar, V, Stich, M, Kumar, M, Black, R, Treasure, C, Lebeis, M, Mccullough, P, Lepor, N, Moriarty, P, Waxler, A, Talreja, D, Gen, M, Dohad, S, East, C, Conrad, G, Asbill, B, Roberts, J, Robinson, J, Zarich, S, Davis, B, Krolick, M, Sherman, H, Thompson, P., RUBBA, PAOLO OSVALDO FEDERICO

    المساهمون: Robinson, Jg, Farnier, M, Krempf, M, Bergeron, J, Luc, G, Averna, M, Stroes, E, Langslet, G, Raal, Fj, El Shahawy, M, Koren, Mj, Lepor, Ne, Lorenzato, C, Pordy, R, Chaudhari, U, Kastelein, Jj, Caccavo, A, Codutti, O, Gelersztein, E, Vico, M, Zaidman, C, Majul, C, Balthazar, Y, Capiau, L, Vrolix, M, Vermeersch, P, Gotchev, D, Todorov, G, Tumbev, H, Tzekova, M, Gronkova, N, Dimov, B, Nikolaeva, A, Devedzhiev, T, Mincheva, V, D'Ignazio, G, Dzongowski, P, Elliott, T, Hart, R, Hoag, G, Martinho, V, O'Mahony, M, Tellier, G, Pandey, S, Heaton, K, Constance, C, Phaneuf, Dc, Shu, D, Narvaez, Nc, Cañon, Co, Cardenas, Sp, Loayza, M, de Salazar, Dm, Lopez, Rb, Gomez, Ji, Mendoza, Ja, Cure, Cc, Ceska, R, Zidkova, E, Jansky, P, Egstrup, K, Klausen, Ib, Lomholdt, J, Gislason, G, Torp Pedersen, C, Poulsen, S, Kuusela, M, Kekki, S, Nieminen, S, Tuomilehto, J, Boye, A, Bruckert, E, Cadinot, D, Lejay, D, Revol, T, Schaupp, T, Bonnet, J, Paillard, F, Moulin, P, Junggeburth, J, Isermann, B, Zühlke, M, Züchner, D, Theis, E, Stößel, J, König, Hj, Rinke, A, Piechatzek, R, Contzen, C, Lappo, M, Himpel Boenninghoff, Aa, Meissner, G, Maus, O, Degtyareva, E, Schulze, Ed, Horacek, T

    العلاقة: info:eu-repo/semantics/altIdentifier/wos/WOS:000352856500004; volume:372; firstpage:1489; lastpage:1499; numberofpages:11; journal:NEW ENGLAND JOURNAL OF MEDICINE; http://hdl.handle.net/11588/612837Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-84926191670

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    المؤلفون: M. El-hamahmy, El-kassas S., A. El-Beik

    المصدر: Hortscience Journal of Suez Canal University. 6:1-13

    الوصف: The effect of three organic fertilizers; viz, chicken manure (ChM, 20 and 40 m3 fed.-1), pressed olive cake(POC, 20 and 40 m3 fed.-1) and cow manure (CwM, 30 and 60 m3 fed.-1) on growth and productivity of cowpea underwater stress condition was investigated. A field experiment was carried out at The Experimental Farm, Fac. Environ.Agric. Sci., Arish Univ., El-Arish, Egypt in summer seasons of 2013 and 2014 in a sandy soil. Irrigation waterrequirements (IWR) were 50% (1050 m3 fed.-1) and 100% (2100 m3 fed.-1) of the estimated crop evapotranspiration.Results showed that20 m3 fed.-1of both ChM and POC were more effective for most vegetative growth parameters andyield components in well irrigated-cowpea in both seasons. Water stressed-cowpeas fertilized by 60 m3 fed.-1 of CwMshowed the lowest reduction in yield (34.07 and 29.86%) in both seasons, respectively, followed by POC fertilizer at 40m3 fed.-1. Water stressed cowpeas fertilized by 40 m3 fed.-1 of POC gave the highest values of water use efficiency (0.86and 0.87 kg m-3). The lowest total consumed water was recorded with 20 and 40 m3 fed.-1 of ChM–fertilized plantsunder normal and drought conditions. The content of biochemical compounds and macro-elements as well asmeasurements of some important tissues in leaflet of 3rd leaf related to drought and organic fertilizers were also studied.It was concluded that application of 20 m3fed.-1 of ChM gave the highest yield in well irrigated-cowpea. Doubledamount of organic fertilizers reduced the deleterious effect of drought especially POC and CwM by saving irrigationwater.

  4. 4
    مؤتمر

    المساهمون: Baklouti, S., Maritan, Lara, Fouzai, B., Laridhi Ouazaa, N., Casas, L., Joron, J. L., Kassas, S.

    وصف الملف: STAMPA

    العلاقة: ispartofbook:EMAC2013; 12th European Meting of Ancient Ceramics; firstpage:66; lastpage:66; numberofpages:1; http://hdl.handle.net/11577/3042466Test

  5. 5
    مؤتمر

    المساهمون: Fouzai, B., Casas, L., Baklouti, S., Jaron, J. L., Kassas, S., Laridhi Ouazaa, N., Maritan, Lara

    وصف الملف: STAMPA

    العلاقة: ispartofbook:EMAC2013; 12th European Meting of Ancient Ceramics; firstpage:135; lastpage:135; numberofpages:1; http://hdl.handle.net/11577/3042473Test

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    مؤتمر
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    مؤتمر
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    مؤتمر
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    مؤتمر
  10. 10
    دورية أكاديمية

    المؤلفون: Tricoci P, Huang Z, Held C, Moliterno DJ, Armstrong PW, Van de Werf F, White HD, Aylward PE, Wallentin L, Chen E, Lokhnygina Y, Pei J, Leonardi S, Rorick TL, Kilian AM, Jennings LH, Ambrosio G, Bode C, Cequier A, Cornel JH, Diaz R, Erkan A, Huber K, Hudson MP, Jiang L, Jukema JW, Lewis BS, Lincoff AM, Montalescot G, Nicolau JC, Ogawa H, Pfisterer M, Prieto JC, Ruzyllo W, Sinnaeve PR, Storey RF, Valgimigli M, Whellan DJ, Widimsky P, Strony J, Harrington RA, Mahaffey KW, Huo Y, Lixin J, Isaza D, Grande P, Laine M, Wong L, Ofner P, Yamaguchi T, Park SJ, Nordrehaug JE, Providencia L, Cheem TH, Dalby A, Betriu A, Chen MF, Verheugt F, Frye RL, Hochman J, Steg PG, Bailey KR, Easton JD, Lincoff A, Underwood FD, Wrestler J, Larson D, VanDyne B, Kilian A, Harmelin-Kadouri R, Layton L, Lipka L, Petrauskas S, Qidwai M, Sorochuck C, Temple T, Mason D, Sydlowski D, Gallagher B, Villasin A, Beernaert A, Douglas S, Garrett J, Wiering J, Adriaenssens T, Ganame J, Hulselmans M, Katz JN, Kayaert P, La Gerche A, Onsea K, Zalewski J, Johnson A, O'Briant J, Smith M, Akerblom A, Armaganijan L, Bertolami A, Brennan M, da Ponte Nacif SA, de Campos Gonzaga C, deQuadros A, Déry JP, Dev S, Ducrocq G, Eapen ZP, Echenique L, Eggers K, Garcia H, Guimaraes HP, Hagstrom E, Hanet C, James S, Jonelid B, Kolls BJ, Leiria T, Leite R, Lombardi C, Lopes RD, Malagutti P, Mathews R, Mehta RH, Melloni C, Piccini JP, Rodriques Soares P, Roe MT, Shah BR, Stashenko G, Szczech LA, Truffa A, Varenhorst C, Vranckx P, Williams J, Kilaru R, White JA, Binkowitz B, He W, Ramos MS, Hasbani E, Farras HA, Luz del Valle L, Zapata G, Centeno EP, Hominal M, Beloscar J, Panno M, Berli M, Carlevaro O, Wasserman T, Lembo L, Diez F, Bettinotti M, Allall O, Macin S, Hii C, Bett N, Aroney C, Roberts-Thomson P, Arstall M, Horowitz J, Prasan A, Farshid A, Rankin J, Duffy S, Sinhal A, Hendricks R, Waites J, Hill A, French J, Adams M, Soward A, Dick R, Jepson N, Nelson G, Thompson P, Neunteufl T, Pachinger O, Leisch F, Siostrzonek P, Roithinger F, Pieske B, Weber H, Eber B, Zenker G, Sinnaeve P, Roosen J, Vervoort G, Coussement P, Striekwold H, Boland J, Van Dorpe A, Dujardin K, Mertens D, Vanneste L, Celen H, Lesseliers H, Vrolix M, Leone A, De Maeseneire S, Hellemans S, Silva FA, Franken M, Moraes JB Jr, Mora R, Michalaros Y, Perin M, Guimaraes AE, da Silva DG, Mattos MA, Alves AR Jr, Hernandes ME, Golin V, da Silva SA, Ardito W, Dery JP, Mukherjee A, Tanguay JF, Kornder J, Lutchmedial S, DeGrace M, Klinke P, Constance C, Nogareda G, Wong G, MacDonald P, Senaratne M, Rupka D, Halperin F, Ramanathan K, Natarajan M, Lai C, Brossoit R, Tymchak W, Rose B, Dupuis R, Mansour S, Bata I, Zadra R, Turek M, Madan M, Le May M, Leon L, Perez L, Yovaniniz P, Pedemonte O, Campos P, Pincetti C, Sepulveda P, Li W, Zhao R, Li Z, Yang Y, Chen J, Li H, Jiang Y, Li D, Qu P, Sun Y, Zheng Y, Zhou C, Zhang F, Wei M, Wang D, Lemus J, Fernandez RL, Jaramillo C, Ochoa J, Velez S, Cano N, Lutz J, Botero R, Jaramillo M, Saaib J, Sanchez G, Hernandez H, Mendoza F, Rizcala A, Urina M, Polasek R, Motovska Z, Zemanek D, Ostransky J, Kettner J, Spinar J, Groch L, Ramik C, Stumar J, Linhart A, Pleva L, Niedobova E, Macha J, Vojacek J, Stipal R, Galatius S, Eggert S, Mickley H, Egstrup K, Pedersen O, Hvilsted L, Sykulski R, Skagen K, Dodt K, Klarlund K, Husted S, Jensen G, Melchior T, Sjoel A, Steffensen FH, Airaksinen KE, Laukkanen JA, Syvanne MS, Kotila MJ, Mikael K, Naveri HK, Hekkala AM, Mustonen JN, Halkosaari M, Ohlmann P, Khalife K, Dibon O, Hirsch JL, Furber A, Nguyen-Khac JO, Delarche N, Probst V, Lim P, Bayet G, Dauphin R, Levai L, Galinier M, Belhassane A, Wiedemann JY, Fouche R, Coisne D, Henry P, Schiele F, Boueri Z, Vaquette B, Davy JM, Cottin Y, D'Houdain F, Danchin N, Cassat C, Messner P, Elbaz M, Coste P, Zemour G, Maupas E, Feldman L, Soto FX, Ferrari E, Haltern G, Heuer H, Genth-Zotz S, Loges C, Stellbrink C, Terres W, Ferrar M, Zeymer U, Brachmann J, Mudra H, Vohringer HF, vom Dah J, Kreuzer J, Hill S, Kleinertz K, Kadel C, Appel KF, Nienabe C, Behrens S, Frantz S, Mehrhof F, Krings P, Hengstenberg C, Lueders S, Hanefel C, Krulls-Munch J, Dorse T, Leschke M, Nogai K, Butter C, Darius H, Fichtlscherer HP, Schmitt C, Kasisk HP, Dorr M, Fran N, Jereczek M, Wiemer M, Nickenig G, Boudriot E, Werner G, Altila T, Strasser R, Baldus S, Desaga M, Buerke M, Land S, Schunkert H, Schulze HO, Holmer S, Sohn HY, Burkhardt W, Lauer B, Schwimmbeck P, Schoeller R, Lapp H, Gross M, Kindermann I, Schuster P, Yu CM, Lee S, Merkely B, Apro D, Lupkovics G, Edes I, Ungi I, Piroth Z, Csapo K, Dezsi CA, Herczeg B, Sereg M, Butnaru A, Lewis B, Rosenschein U, Mosseri M, Turgeman Y, Pollak A, Shotan A, Hammerman H, Rozenman Y, Gottlieb S, Atar S, Weiss A, Marmor A, Iakobishvili Z, Mascia F, De Cesare N, Piovaccari G, Ceravolo R, Fiscella A, Salvioni A, Silvestri O, Moretti L, Severi S, Carmina MG, De Caterina R, Fattore L, Terrosu P, Trimarco B, Ardissino D, Uguccioni L, Auguadro C, Gregorio G, De Ferrari G, Testa R, Evola R, De Servi S, Sganzerla P, Vassanelli C, Brunelli C, Scherillo M, Tamburino C, Limido A, Luzza F, Percoco GF, Sinagra G, Volpe M, Crea F, Fedele F, Rasetti G, Cinelli F, Merlini P, Sisto F, Biancoli S, Fresco C, Corrada E, Casolo G, Santini M, D'Alessandro B, Antoniucci D, Tuccillo B, Assennato P, Puccioni E, Pasquetto G, Perna GP, Morgagni G, Takizawa K, Kato K, Oshima S, Yagi M, Asai T, Kamiya H, Hirokami M, Sakota S, Sueyoshi A, Shimomura H, Hashimoto T, Miyahara M, Matsumura T, Nakao K, Kakuta T, Nakamura S, Nishi Y, Kawajiri K, Nagai Y, Takahashi A, Ikari Y, Hara K, Koga T, Fujii K, Tobaru T, Tsunoda R, Uchiyama T, Hirayama H, Fujimoto K, Sakurai S, Tanigawa T, Ohno M, Yamamoto E, Ikuta S, Kato A, Kikuta K, Takami A, Chong WP, Ong TK, Yusof A, Maskon O, Kahar A, Breedveld RW, Bendermacher PE, Hamer BJ, Oude Ophuis AJ, Nierop PR, Westendorp IC, Beijerbacht HP, Herrman JP, van 't Hof AW, Troquay RP, van der Meer P, Peters RH, van Rossum P, Liem A, Pieterse MG, van Eck JW, van der Zwaan C, Pasupati S, Elliott J, Tisch J, Hart H, Luke R, Scott D, Ternouth I, White H, Hamer A, Harding S, Wilkins G, O'Meeghan T, Harrison N, Nilsen D, Thalamus J, Aaberge L, Brunvand H, Lutterbey G, Omland TM, Eritsland J, Wiseth R, Aase O, Campos C, Horna M, Toce L, Salazar M, Przewlocki T, Ponikowski P, Kasprzak J, Kopaczewski J, Musial W, Mazurek W, Kawecka-Jaszcz K, Pluta W, Dobrzycki S, Loboz-Grudzien K, Lewczuk J, Karwowski D, Grajek S, Dudek D, Trusz-Gluza M, Kornacewicz-Jach Z, Gil R, Ferreira J, Gavina C, Ferreira R, Martins D, Garcia-Rinaldi R, Ufret R, Vazquez-Tanus J, Banchs H, Wong A, Tan HC, Guerra M, Ebrahim I, Roux J, Blomerus P, Saaiman A, Corbett C, Pillay T, Freeman V, Horak A, Zambakides C, Burgess L, Yoon JH, Ahn TH, Gwon HC, Seong IW, Kim HS, Jeong MH, Kim YD, Chae SC, Hernandez JM, Pique M, Fernandez Portales J, Paz MA, Lopez Palop R, Iniguez A, Diaz Fernandez J, Alvarez P, Sanz E, Heras M, Sala J, Goicolea J, Cruz Fernandez J, 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    المساهمون: Tricoci, P, Huang, Z, Held, C, Moliterno, Dj, Armstrong, Pw, Van de Werf, F, White, Hd, Aylward, Pe, Wallentin, L, Chen, E, Lokhnygina, Y, Pei, J, Leonardi, S, Rorick, Tl, Kilian, Am, Jennings, Lh, Ambrosio, G, Bode, C, Cequier, A, Cornel, Jh, Diaz, R, Erkan, A, Huber, K, Hudson, Mp, Jiang, L, Jukema, Jw, Lewis, B, Lincoff, Am, Montalescot, G, Nicolau, Jc, Ogawa, H, Pfisterer, M, Prieto, Jc, Ruzyllo, W, Sinnaeve, Pr, Storey, Rf, Valgimigli, M, Whellan, Dj, Widimsky, P, Strony, J, Harrington, Ra, Mahaffey, Kw, Huo, Y, Lixin, J, Isaza, D, Grande, P, Laine, M, Wong, L, Ofner, P, Yamaguchi, T, Park, Sj, Nordrehaug, Je, Providencia, L, Cheem, Th, Dalby, A, Betriu, A, Chen, Mf, Verheugt, F

    الوصف: BACKGROUND Vorapaxar is a new oral protease-activated–receptor 1 (PAR-1) antagonist that inhibits thrombin-induced platelet activation. METHODS In this multinational, double-blind, randomized trial, we compared vorapaxar with placebo in 12,944 patients who had acute coronary syndromes without ST-segment elevation. The primary end point was a composite of death from cardiovascular causes, myocardial infarction, stroke, recurrent ischemia with rehospitalization, or urgent coronary revascularization. RESULTS Follow-up in the trial was terminated early after a safety review. After a median follow-up of 502 days (interquartile range, 349 to 667), the primary end point occurred in 1031 of 6473 patients receiving vorapaxar versus 1102 of 6471 patients receiving placebo (Kaplan–Meier 2-year rate, 18.5% vs. 19.9%; hazard ratio, 0.92; 95% confidence interval [CI], 0.85 to 1.01; P = 0.07). A composite of death from cardiovascular causes, myocardial infarction, or stroke occurred in 822 patients in the vorapaxar group versus 910 in the placebo group (14.7% and 16.4%, respectively; hazard ratio, 0.89; 95% CI, 0.81 to 0.98; P = 0.02). Rates of moderate and severe bleeding were 7.2% in the vorapaxar group and 5.2% in the placebo group (hazard ratio, 1.35; 95% CI, 1.16 to 1.58; P<0.001). Intracranial hemorrhage rates were 1.1% and 0.2%, respectively (hazard ratio, 3.39; 95% CI, 1.78 to 6.45; P<0.001). Rates of nonhemorrhagic adverse events were similar in the two groups. CONCLUSIONS In patients with acute coronary syndromes, the addition of vorapaxar to standard therapy did not significantly reduce the primary composite end point but significantly increased the risk of major bleeding, including intracranial hemorrhage.

    وصف الملف: STAMPA

    العلاقة: info:eu-repo/semantics/altIdentifier/wos/WOS:000299968800004; volume:366; issue:1; firstpage:20; lastpage:33; numberofpages:14; journal:NEW ENGLAND JOURNAL OF MEDICINE; http://hdl.handle.net/11568/929791Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-83655177669