-
1دورية أكاديمية
المؤلفون: Grasby, KL, Jahanshad, N, Painter, JN, Colodro-Conde, L, Bralten, J, Hibar, DP, Lind, PA, Pizzagalli, F, Ching, CRK, McMahon, MAB, Shatokhina, N, Zsembik, LCP, Thomopoulos, SI, Zhu, AH, Strike, LT, Agartz, I, Alhusaini, S, Almeida, MAA, Alnaes, D, Amlien, IK, Andersson, M, Ard, T, Armstrong, NJ, Ashley-Koch, A, Atkins, JR, Bernard, M, Brouwer, RM, Buimer, EEL, Bulow, R, Burger, C, Cannon, DM, Chakravarty, M, Chen, Q, Cheung, JW, Couvy-Duchesne, B, Dale, AM, Dalvie, S, de Araujo, TK, de Zubicaray, GI, de Zwarte, SMC, den Braber, A, Doan, NT, Dohm, K, Ehrlich, S, Engelbrecht, HR, Erk, S, Fan, CC, Fedko, IO, Foley, SF, Ford, JM, Fukunaga, M, Garrett, ME, Ge, T, Giddaluru, S, Goldman, AL, Green, MJ, Groenewold, NA, Grotegerd, D, Gurholt, TP, Gutman, BA, Hansell, NK, Harris, MA, Harrison, MB, Haswell, CC, Hauser, M, Herms, S, Heslenfeld, DJ, Ho, NF, Hoehn, D, Hoffmann, P, Holleran, L, Hoogman, M, Hottenga, JJ, Ikeda, M, Janowitz, D, Jansen, IE, Jia, T, Jockwitz, C, Kanai, R, Karama, S, Kasperaviciute, D, Kaufmann, T, Kelly, S, Kikuchi, M, Klein, M, Knapp, M, Knodt, AR, Kramer, B, Lam, M, Lancaster, TM, Lee, PH, Lett, TA, Lewis, LB, Lopes-Cendes, I, Luciano, M, Macciardi, F, Marquand, AF, Mathias, SR, Melzer, TR, Milaneschi, Y, Mirza-Schreiber, N, Moreira, JCV, Muhleisen, TW, Muller-Myhsok, B, Najt, P, Nakahara, S, Nho, K, Loohuis, LMO, Orfanos, DP, Pearson, JF, Pitcher, TL, Putz, B, Quide, Y, Ragothaman, A, Rashid, FM, Reay, WR, Redlich, R, Reinbold, CS, Repple, J, Richard, G, Riedel, BC, Risacher, SL, Rocha, CS, Mota, NR, Salminen, L, Saremi, A, Saykin, AJ, Schlag, F, Schmaal, L, Schofield, PR, Secolin, R, Shapland, CY, Shen, L, Shin, J, Shumskaya, E, Sonderby, IE, Sprooten, E, Tansey, KE, Teumer, A, Thalamuthu, A, Tordesillas-Gutierrez, D, Turner, JA, Uhlmann, A, Vallerga, CL, van der Meer, D, van Donkelaar, MMJ, van Eijk, L, van Erp, TGM, van Haren, NEM, van Rooij, D, van Tol, MJ, Veldink, JH, Verhoef, E, Walton, E, Wang, M, Wang, Y, Wardlaw, JM, Wen, W, Westlye, LT, Whelan, CD, Witt, SH, Wittfeld, K, Wolf, C, Wolfers, T, Wu, JQ, Yasuda, CL, Zaremba, D, Zhang, Z, Zwiers, MP, Artiges, E, Assareh, AA, Ayesa-Arriola, R, Belger, A, Brandt, CL, Brown, GG, Cichon, S, Curran, JE, Davies, GE, Degenhardt, F, Dennis, MF, Dietsche, B, Djurovic, S, Doherty, CP, Espiritu, R, Garijo, D, Gil, Y, Gowland, PA, Green, RC, Hausler, AN, Heindel, W, Ho, BC, Hoffmann, WU, Holsboer, F, Homuth, G, Hosten, N, Jack, CR, Jang, M, Jansen, A, Kimbrel, NA, Kolskar, K, Koops, S, Krug, A, Lim, KO, Luykx, JJ, Mathalon, DH, Mather, KA, Mattay, VS, Matthews, S, Van Son, JM, McEwen, SC, Melle, I, Morris, DW, Mueller, BA, Nauck, M, Nordvik, JE, Nothen, MM, O'Leary, DS, Opel, N, Martinot, MLP, Pike, GB, Preda, A, Quinlan, EB, Rasser, PE, Ratnakar, V, Reppermund, S, Steen, VM, Tooney, PA, Torres, FR, Veltman, DJ, Voyvodic, JT, Whelan, R, White, T, Yamamori, H, Adams, HHH, Bis, JC, Debette, S, Decarli, C, Fornage, M, Gudnason, V, Hofer, E, Ikram, MA, Launer, L, Longstreth, WT, Lopez, OL, Mazoyer, B, Mosley, TH, Roshchupkin, GV, Satizabal, CL, Schmidt, R, Seshadri, S, Yang, Q, Alvim, MKM, Ames, D, Anderson, TJ, Andreassen, OA, Arias-Vasquez, A, Bastin, ME, Baune, BT, Beckham, JC, Blangero, J, Boomsma, DI, Brodaty, H, Brunner, HG, Buckner, RL, Buitelaar, JK, Bustillo, JR, Cahn, W, Cairns, MJ, Calhoun, V, Carr, VJ, Caseras, X, Caspers, S, Cavalleri, GL, Cendes, F, Corvin, A, Crespo-Facorro, B, Dalrymple-Alford, JC, Dannlowski, U, de Geus, EJC, Deary, IJ, Delanty, N, Depondt, C, Desrivieres, S, Donohoe, G, Espeseth, T, Fernandez, G, Fisher, SE, Flor, H, Forstner, AJ, Francks, C, Franke, B, Glahn, DC, Gollub, RL, Grabe, HJ, Gruber, O, Haberg, AK, Hariri, AR, Hartman, CA, Hashimoto, R, Heinz, A, Henskens, FA, Hillegers, MHJ, Hoekstra, PJ, Holmes, AJ, Hong, LE, Hopkins, WD, Pol, HEH, Jernigan, TL, Jonsson, EG, Kahn, RS, Kennedy, MA, Kircher, TTJ, Kochunov, P, Kwok, JBJ, Le Hellard, S, Loughland, CM, Martin, NG, Martinot, JL, McDonald, C, McMahon, KL, Meyer-Lindenberg, A, Michie, PT, Morey, RA, Mowry, B, Nyberg, L, Oosterlaan, J, Ophoff, RA, Pantelis, C, Paus, T, Pausova, Z, Penninx, BWJH, Polderman, TJC, Posthuma, D, Rietschel, M, Roffman, JL, Rowland, LM, Sachdev, PS, Samann, PG, Schall, U, Schumann, G, Scott, RJ, Sim, K, Sisodiya, SM, Smoller, JW, Sommer, IE, St Pourcain, B, Stein, DJ, Toga, AW, Trollor, JN, Van der Wee, NJA, van't Ent, D, Volzke, H, Walter, H, Weber, B, Weinberger, DR, Wright, MJ, Zhou, J, Stein, JL, Thompson, PM, Medland, SE
المصدر: Science (New York, N.Y.). 367(6484):1340
مصطلحات موضوعية: Medicin och hälsovetenskap
-
2دورية أكاديمية
المؤلفون: Hofer E, Roshchupkin GV, Adams HHH, Knol MJ, Lin H, Li S, Zare H, Ahmad S, Armstrong NJ, Satizabal CL, Bernard M, Bis JC, Gillespie NA, Luciano M, Mishra A, Scholz M, Teumer A, Xia R, Jian X, Mosley TH, Saba Y, Pirpamer L, Seiler S, Becker JT, Carmichael O, Rotter JI, Psaty BM, Lopez OL, Amin N, van der Lee SJ, Yang Q, Himali JJ, Maillard P, Beiser AS, Decarli C, Karama S, Lewis L, Harris M, Bastin ME, Deary IJ, Witte AV, Beyer F, Loeffler M, Mather KA, Schofield PR, Thalamuthu A, Kwok JB, Wright MJ, Ames D, Trollor J, Jiang J, Brodaty H, Wen W, Vernooij MW, Hofman A, Uitterlinden AG, Niessen WJ, Wittfeld K, Bülow R, Völker U, Pausova Z, Pike GB, Maingault S, Crivello F, Tzourio C, Amouyel P, Mazoyer B, Neale MC, Franz CE, Lyons MJ, Panizzon MS, Andreassen OA, Dale AM, Logue M, Grasby KL, Jahanshad N, Painter JN, Colodro-Conde L, Bralten J, Hibar DP, Lind PA, Pizzagalli F, Stein JL, Thompson PM, Medland SE, Sachdev PS, Kremen WS, Wardlaw JM, Villringer A, van Duijn CM, Grabe HJ, Longstreth WT, Fornage M, Paus T, Debette S, Ikram MA, Schmidt H, Schmidt R, Seshadri S, Ching CRK
مصطلحات موضوعية: ENIGMA consortium, Brain, Chromosome Structures, Humans, Neurodegenerative Diseases, Cognition, Mental Disorders, Genomics, Aging, Phenotype, Polymorphism, Single Nucleotide, Adult, Aged, 80 and over, Middle Aged, Female, Male, Genome-Wide Association Study, Fields of Research::31 - Biological sciences::3105 - Genetics::310511 - Neurogenetics, Fields of Research::32 - Biomedical and clinical sciences::3209 - Neurosciences
الوصف: Cortical thickness, surface area and volumes vary with age and cognitive function, and in neurological and psychiatric diseases. Here we report heritability, genetic correlations and genome-wide associations of these cortical measures across the whole cortex, and in 34 anatomically predefined regions. Our discovery sample comprises 22,824 individuals from 20 cohorts within the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium and the UK Biobank. We identify genetic heterogeneity between cortical measures and brain regions, and 160 genome-wide significant associations pointing to wnt/β-catenin, TGF-β and sonic hedgehog pathways. There is enrichment for genes involved in anthropometric traits, hindbrain development, vascular and neurodegenerative disease and psychiatric conditions. These data are a rich resource for studies of the biological mechanisms behind cortical development and aging.
وصف الملف: application/pdf
العلاقة: Hofer E, Roshchupkin GV, Adams HHH, Knol MJ, Lin H, Li S, Zare H, Ahmad S, Armstrong NJ, Satizabal CL, Bernard M, Bis JC, Gillespie NA, Luciano M, Mishra A, Scholz M, Teumer A, Xia R, Jian X, Mosley TH, Saba Y, Pirpamer L, Seiler S, Becker JT, Carmichael O, Rotter JI, Psaty BM, Lopez OL, Amin N, van der Lee SJ, Yang Q, Himali JJ, Maillard P, Beiser AS, Decarli C, Karama S, Lewis L, Harris M, Bastin ME, Deary IJ, Witte AV, Beyer F, Loeffler M, Mather KA, Schofield PR, Thalamuthu A, Kwok JB, Wright MJ, Ames D, Trollor J, Jiang J, Brodaty H, Wen W, Vernooij MW, Hofman A, Uitterlinden AG, Niessen WJ, Wittfeld K, Bülow R, Völker U, Pausova Z, Pike GB, Maingault S, Crivello F, Tzourio C, Amouyel P, Mazoyer B, Neale MC, Franz CE, Lyons MJ, Panizzon MS, Andreassen OA, Dale AM, Logue M, Grasby KL, Jahanshad N, Painter JN, Colodro-Conde L, Bralten J, Hibar DP, Lind PA, Pizzagalli F, Stein JL, Thompson PM, Medland SE, Sachdev PS, Kremen WS, Wardlaw JM, Villringer A, van Duijn CM, Grabe HJ, Longstreth WT, Fornage M, Paus T, Debette S, Ikram MA, Schmidt H, Schmidt R, Seshadri S, Ching CRK (2020). Genetic correlations and genome-wide associations of cortical structure in general population samples of 22,824 adults. Nature Communications. 11(1). 4796-.; https://hdl.handle.net/10092/102191Test; http://doi.org/10.1038/s41467-020-18367-yTest
-
3دورية أكاديمية
المؤلفون: Boughachiche, F, Rachedi, K, Zerizer, H, Duran, R, Karama, S, Biaci, M, Aknouche, Z, Bouchina, S, Boulahrouf, A
المصدر: Journal of Bio-Science; Vol. 29 No. 1 (2021); 33-48 ; 2408-8595 ; 1023-8654
مصطلحات موضوعية: Optimization, Protease, Solid state fermentation, Streptomyces, Wheat bran
الوصف: Proteases are a group of enzymes that catalyse the degradation of proteins resulting in the production of their amino acid constituents. In the present study newly isolated Streptomyces sp. was subjected to produce proteases through solid state fermentation while wheat bran was used as substrate. To produce proteases, a local strain Streptomyces sp. was isolated from a soil sample of Ezzemouls saltpan, located in Ain M'lila (East of Algeria). The phenotypic and phylogenetic studies of this strain showed that it represents probably a new species. The SSF production medium for Streptomyces sp. was optimized using Plackett and Burman statistical methods. The results showed a maximum activity on basal wheat bran medium supplemented with 1% fructose. The best SSF humidifying solution was pH 9.0 phosphate buffer at 50% moisture. Protease has an optimum at pH 7.0, which is a typical characteristic of neutral proteases. The optimum temperature was 60°C and proved stable up to 80°C. The results showed that the novel Streptomyces sp. isolate is a good producer of extracellular neutral protease on wheat bran, which can be beneficial for industries. J. Bio-Sci. 29(1): 33-48, 2021 (June)
وصف الملف: application/pdf
-
4دورية أكاديمية
المؤلفون: Shin, J, Ma, S, Hofer, E, Patel, Y, Vosberg, DE, Tilley, S, Roshchupkin, Gennady, Sousa, AMM, Jian, X, Gottesman, R, Mosley, TH, Jr, Fornage, M, Saba, Y, Pirpamer, L, Schmidt, R, Schmidt, H, Carrion-Castillo, A, Crivello, F, Mazoyer, B, Bis, JCM, Li, S, Yang, Q, Luciano, M, Karama, S, Lewis, L, Bastin, ME, Harris, MA, Wardlaw, JM, Deary, IE, Scholz, M (Markus), Loeffler, M, Witte, AV, Beyer, F, Villringer, A, Armstrong, NJ, Mather, KA, Ames, D, Jiang, J, Kwok, JB, Schofield, PR, Thalamuthu, A, Trollor, JN, Wright, MJ, Brodaty, H, Wen, W, Sachdev, PS, Terzikhan, Natalie, Evans, Tavia, Adams, Hieab, Ikram, Arfan
المصدر: Shin , J , Ma , S , Hofer , E , Patel , Y , Vosberg , DE , Tilley , S , Roshchupkin , G , Sousa , AMM , Jian , X , Gottesman , R , Mosley , TH J , Fornage , M , Saba , Y , Pirpamer , L , Schmidt , R , Schmidt , H , Carrion-Castillo , A , Crivello , F , Mazoyer , B , Bis , JCM , Li , S , Yang , Q , Luciano , M , Karama , S , Lewis , ....
الوصف: We have carried out meta-analyses of genome-wide association studies (GWAS) (n = 23 784) of the first two principal components (PCs) that group together cortical regions with shared variance in their surface area. PC1 (global) captured variations of most regions, whereas PC2 (visual) was specific to the primary and secondary visual cortices. We identified a total of 18 (PC1) and 17 (PC2) independent loci, which were replicated in another 25 746 individuals. The loci of the global PC1 included those associated previously with intracranial volume and/or general cognitive function, such as MAPT and IGF2BP1. The loci of the visual PC2 included DAAM1, a key player in the planar-cell-polarity pathway. We then tested associations with occupational aptitudes and, as predicted, found that the global PC1 was associated with General Learning Ability, and the visual PC2 was associated with the Form Perception aptitude. These results suggest that interindividual variations in global and regional development of the human cerebral cortex (and its molecular architecture) cascade-albeit in a very limited manner-to behaviors as complex as the choice of one's occupation.
الإتاحة: https://doi.org/10.1093/CERCOR/BHAA035Test
https://pure.eur.nl/en/publications/72d5930b-a0bc-44d8-8d56-fd3f2f98dfc8Test
http://www.scopus.com/inward/record.url?scp=85085903970&partnerID=8YFLogxKTest -
5دورية أكاديمية
المؤلفون: Hofer, E, Roshchupkin, GV, Adams, HHH, Knol, MJ, Lin, H, Li, S, Zare, H, Ahmad, S, Armstrong, NJ, Satizabal, CL, Bernard, M, Bis, JC, Gillespie, NA, Luciano, M, Mishra, A, Scholz, M, Teumer, A, Xia, R, Jian, X, Mosley, TH, Saba, Y, Pirpamer, L, Seiler, S, Becker, JT, Carmichael, O, Rotter, JI, Psaty, BM, Lopez, OL, Amin, N, van der Lee, SJ, Yang, Q, Himali, JJ, Maillard, P, Beiser, AS, Decarli, C, Karama, S, Lewis, L, Harris, M, Bastin, ME, Deary, IJ, Witte, AV, Beyer, F, Loeffler, M, Mather, KA, Schofield, PR, Thalamuthu, A, Kwok, JB, Wright, MJ, Ames, D, Trollor, J, Jiang, J, Brodaty, H, Wen, W, Vernooij, MW, Hofman, A, Uitterlinden, AG, Niessen, WJ, Wittfeld, K, Bülow, R, Völker, U, Pausova, Z, Pike, GB, Maingault, S, Crivello, F, Tzourio, C, Amouyel, P, Mazoyer, B, Neale, MC, Franz, CE, Lyons, MJ, Panizzon, MS, Andreassen, OA, Dale, AM, Logue, M, Grasby, KL, Jahanshad, N, Painter, JN, Colodro-Conde, L, Bralten, J, Hibar, DP, Lind, PA, Pizzagalli, F, Stein, JL, Thompson, PM, Medland, SE, Sachdev, PS, Kremen, WS, Wardlaw, JM, Villringer, A, van Duijn, CM, Grabe, HJ, Longstreth, WT, Fornage, M, Paus, T, Debette, S, Ikram, MA, Schmidt, H, Schmidt, R, Seshadri, S, Ching, CRK, Sachdev, Perminder, Reppermund, Simone
المصدر: urn:ISSN:2041-1723 ; Nature Communications, 11, 1, 4796
مصطلحات موضوعية: Aging, Genetics, Biotechnology, Human Genome, Brain Disorders, Neurosciences, 1.1 Normal biological development and functioning, 1 Underpinning research, 2 Aetiology, 2.1 Biological and endogenous factors, Neurological, Adult, Aged, 80 and over, Brain, Chromosome Structures, Cognition, Female, Genome-Wide Association Study, Genomics, Humans, Male, Mental Disorders, Middle Aged, Neurodegenerative Diseases, Phenotype, Polymorphism, Single Nucleotide, ENIGMA consortium
الوصف: Cortical thickness, surface area and volumes vary with age and cognitive function, and in neurological and psychiatric diseases. Here we report heritability, genetic correlations and genome-wide associations of these cortical measures across the whole cortex, and in 34 anatomically predefined regions. Our discovery sample comprises 22,824 individuals from 20 cohorts within the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium and the UK Biobank. We identify genetic heterogeneity between cortical measures and brain regions, and 160 genome-wide significant associations pointing to wnt/β-catenin, TGF-β and sonic hedgehog pathways. There is enrichment for genes involved in anthropometric traits, hindbrain development, vascular and neurodegenerative disease and psychiatric conditions. These data are a rich resource for studies of the biological mechanisms behind cortical development and aging.
وصف الملف: application/pdf
العلاقة: http://hdl.handle.net/1959.4/unsworks_73629Test; https://unsworks.unsw.edu.au/bitstreams/37275486-f286-4d82-8f7c-a180e0b360e2/downloadTest; https://doi.org/10.1038/s41467-020-18367-yTest
الإتاحة: https://doi.org/10.1038/s41467-020-18367-yTest
http://hdl.handle.net/1959.4/unsworks_73629Test
https://unsworks.unsw.edu.au/bitstreams/37275486-f286-4d82-8f7c-a180e0b360e2/downloadTest -
6دورية أكاديمية
المؤلفون: Hofer, E., Roshchupkin, G., Adams, H., Knol, M., Lin, H., Li, S., Zare, H., Ahmad, S., Armstrong, N., Satizabal, C., Bernard, M., Bis, J., Gillespie, N., Luciano, M., Mishra, A., Scholz, M., Teumer, A., Xia, R., Jian, X., Mosley, T., Saba, Y., Pirpamer, L., Seiler, S., Becker, J., Carmichael, O., Rotter, J., Psaty, B., Lopez, O., Amin, N., van der Lee, S., Yang, Q., Himali, J., Maillard, P., Beiser, A., DeCarli, C., Karama, S., Lewis, L., Harris, M., Bastin, M., Deary, I., Witte, A., Beyer, F., Loeffler, M., Mather, K., Schofield, P., Thalamuthu, A., Kwok, J., Wright, M., Ames, D., Trollor, J., Jiang, J., Brodaty, H., Wen, W., Vernooij, M., Hofman, A., Uitterlinden, A., Niessen, W., Wittfeld, K., Bülow, R., Völker, U., Pausova, Z., Bruce Pike, G., Maingault, S., Crivello, F., Tzourio, C., Amouyel, P., Mazoyer, B., Neale, M., Franz, C., Lyons, M., Panizzon, M., Andreassen, O., Dale, A., Logue, M., Grasby, K., Jahanshad, N., Painter, J., Colodro-Conde, L., Bralten, J., Hibar, D., Lind, P., Pizzagalli, F., Stein, J., Thompson, P., Medland, S., Sachdev, P., Kremen, W., Wardlaw, J., Villringer, A., van Duijn, C., Grabe, H., Longstreth, W., Fornage, M., Paus, T., Debette, S., Arfan Ikram, M., Schmidt, H., Schmidt, R., Seshadri, S.
المصدر: Nature Communications
الوصف: Cortical thickness, surface area and volumes vary with age and cognitive function, and in neurological and psychiatric diseases. Here we report heritability, genetic correlations and genome-wide associations of these cortical measures across the whole cortex, and in 34 anatomically predefined regions. Our discovery sample comprises 22,824 individuals from 20 cohorts within the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium and the UK Biobank. We identify genetic heterogeneity between cortical measures and brain regions, and 160 genome-wide significant associations pointing to wnt/β-catenin, TGF-β and sonic hedgehog pathways. There is enrichment for genes involved in anthropometric traits, hindbrain development, vascular and neurodegenerative disease and psychiatric conditions. These data are a rich resource for studies of the biological mechanisms behind cortical development and aging.
وصف الملف: application/pdf
العلاقة: info:eu-repo/semantics/altIdentifier/pmid/32963231; http://hdl.handle.net/21.11116/0000-0007-4999-BTest; http://hdl.handle.net/21.11116/0000-0007-499B-9Test
-
7دورية أكاديمية
المؤلفون: Shin, J., Ma, S., Hofer, E., Patel, Y., Vosberg, D., Tilley, S., Roshchupkin, G., Sousa, A., Jian, X., Gottesman, R., Mosley, T., Fornage, M., Saba, Y., Pirpamer, L., Schmidt, R., Schmidt , H., Carrion Castillo, A., Crivello, F., Mazoyer, B., Bis, J., Li, S., Yang, Q., Luciano, M., Karama, S., Lewis, L., Bastin, M., Harris, M., Wardlaw, J., Deary, I., Scholz , M., Loeffler, M., Witte, A., Beyer, F., Villringer, A., Armstrong, N., Mather, K., Ames, D., Jiang, J., Kwok, J., Schofield, P., Thalamuthu, A., Trollor, J., Wright, M., Brodaty, H., Wen, W., Sachdev, P., Terzikhan, N., Evans, T., Adams, H., Ikram, M., Frenzel, S., Van der Auwera-Palitschka, S., Wittfeld, K., Bülow, R., Grabe, H., Tzourio, C., Mishra, A., Maingault, S., Debette, S., Gillespie, N., Franz, C., Kremen, W., Ding, L., Jahanshad, N., Sestan, N., Pausova, Z., Seshadri, S., Paus, T.
المساهمون: the ENIGMA Consortium, the neuroCHARGE Working Group
المصدر: Cerebral Cortex
الوصف: We have carried out meta-analyses of genome-wide association studies (GWAS) (n = 23 784) of the first two principal components (PCs) that group together cortical regions with shared variance in their surface area. PC1 (global) captured variations of most regions, whereas PC2 (visual) was specific to the primary and secondary visual cortices. We identified a total of 18 (PC1) and 17 (PC2) independent loci, which were replicated in another 25 746 individuals. The loci of the global PC1 included those associated previously with intracranial volume and/or general cognitive function, such as MAPT and IGF2BP1. The loci of the visual PC2 included DAAM1, a key player in the planar-cell-polarity pathway. We then tested associations with occupational aptitudes and, as predicted, found that the global PC1 was associated with General Learning Ability, and the visual PC2 was associated with the Form Perception aptitude. These results suggest that interindividual variations in global and regional development of the human cerebral cortex (and its molecular architecture) cascade—albeit in a very limited manner—to behaviors as complex as the choice of one’s occupation.
وصف الملف: application/pdf; application/vnd.openxmlformats-officedocument.presentationml.presentation; application/vnd.openxmlformats-officedocument.spreadsheetml.sheet
العلاقة: http://hdl.handle.net/21.11116/0000-0007-42B4-3Test; http://hdl.handle.net/21.11116/0000-0007-42B6-1Test; http://hdl.handle.net/21.11116/0000-0007-42B7-0Test; http://hdl.handle.net/21.11116/0000-0007-42B8-FTest
-
8دورية أكاديمية
المؤلفون: Alhusaini, S, Karama, S, Star, JM, Bastin, ME, Wardlaw, JM, Deary, IJ, Ducharme, S
المصدر: Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques ; volume 45, issue s2, page S8-S8 ; ISSN 0317-1671 2057-0155
مصطلحات موضوعية: Neurology (clinical), Neurology, General Medicine
الوصف: Background: Carotid atherosclerosis is a significant risk factor for stroke and has been associated with cognitive decline and dementia. Methods: We assessed 554 community-dwelling subjects from the Lothian Birth Cohort of 1936 (LBC1936) who underwent brain MRI and carotid Doppler ultrasound studies at age 73 years. The relationship between carotid stenosis and cerebral cortical thickness was examined cross-sectionally, controlling for gender, extensive vascular risk factors (VRFs), and IQ at age 11 (IQ-11). The association between carotid stenosis and a composite measure of fluid intelligence was also investigated. Results: A widespread negative association was identified between carotid stenosis and cerebral cortical thickness at age 73 years, independent of the side of carotid stenosis, other carotid measures, VRFs, or IQ-11. This association increased in an almost dose-response relationship from mild to severe degrees of carotid stenosis. A negative association was also noted between carotid stenosis and fluid intelligence, which appeared partly mediated by carotid stenosis-related thinning of the cerebral cortex. Conclusions: Carotid stenosis is associated with thinner cerebral cortex and lower fluid cognitive abilities at age 73. The findings suggest that carotid stenosis represents a marker of vascular processes that accelerate cortical aging with a negative impact on cognition, independent of measurable VRFs.
الإتاحة: https://doi.org/10.1017/cjn.2018.77Test
https://www.cambridge.org/core/services/aop-cambridge-core/content/view/S031716711800077XTest -
9تقرير
المؤلفون: Shin, J., Ma, S., Hofer, E., Patel, Y., Roshchupkin, G., Sousa, A., Jian, X., Gottesman, R., Mosley, T., Fornage, M., Saba, Y., Pirpamer, L., Schmidt, R., Schmidt, H., Carrion-Castillo, A., Crivello, F., Mazoyer, B., Bis, J., Li, S., Yang, Q., Luciano, M., Karama, S., Lewis, L., Bastin, M., Harris, M., Wardlaw, J., Deary, I., Scholz, M., Loeffler, M., Witte, A., Beyer, F., Villringer, A., Armstrong, N., Mather, K., Ames, D., Jiang, J., Kwok, J., Schofield, P., Thalamuthu, A., Trollor, J., Wright, M., Brodaty, H., Wen, W., Sachdev, P., Terzikhan, N., Evans, T., Adams, H., Ikram, M., Frenzel, S., van der Auwera-Palitschka, S., Wittfeld, K., Bülow, R., Grabe, H., Tzourio, C., Mishra , A., Maingault, S., Debette, S., Gillespie, N., Franz, C., Kremen, W., Ding, L., Jahanshad, N., Sestan, N., Pausova, Z., Seshadri, S., Paus, T.
المساهمون: ENIGMA Consortium, neuroCHARGE Working Group
المصدر: bioRxiv
الوصف: The radial unit hypothesis provides a framework for global (proliferation) and regional (distribution) expansion of the primate cerebral cortex. Using principal component analysis (PCA), we have identified cortical regions with shared variance in their surface area and cortical thickness, respectively, segmented from magnetic resonance images obtained in 23,800 participants. We then carried out meta-analyses of genome-wide association studies of the first two principal components for each phenotype. For surface area (but not cortical thickness), we have detected strong associations between each of the components and single nucleotide polymorphisms in a number of gene loci. The first (global) component was associated mainly with loci on chromosome 17 (9.5e-32 ≤ p ≤ 2.8e-10), including those detected previously as linked with intracranial volume and/or general cognitive function. The second (regional) component captured shared variation in the surface area of the primary and adjacent secondary visual cortices and showed a robust association with polymorphisms in a locus on chromosome 14 containing Disheveled Associated Activator of Morphogenesis 1 (DAAM1; p=2.4e-34). DAAM1 is a key component in the planar-cell-polarity signaling pathway. In follow-up studies, we have focused on the latter finding and established that: (1) DAAM1 is highly expressed between 12th and 22nd post-conception weeks in the human cerebral cortex; (2) genes co-expressed with DAAM1 in the primary visual cortex are enriched in mitochondria-related pathways; and (3) volume of the lateral geniculate nucleus, which projects to regions of the visual cortex staining for cytochrome oxidase (a mitochondrial enzyme), correlates with the surface area of the visual cortex in major-allele homozygotes but not in carriers of the minor allele. Altogether, we speculate that, in concert with thalamocortical input to cortical subplate, DAAM1 enables migration of neurons to cytochrome-oxidase rich regions of the visual cortex, and, in turn, facilitates regional ...
وصف الملف: application/pdf
العلاقة: http://hdl.handle.net/21.11116/0000-0004-D5CA-8Test; http://hdl.handle.net/21.11116/0000-000C-3F26-4Test
-
10تقرير
المؤلفون: Hofer, E., Roshchupkin, G., Adams, H., Knol, M., Lin, H., Li, S., Zare, H., Ahmad, S., Armstrong, N., Satizabal, C., Bernard, M., Bis, J., Gillespie, N., Luciano, M., Mishra, A., Scholz, M., Teumer, A., Xia, R., Jian, X., Mosley, T., Saba, Y., Pirpamer, L., Seiler, S., Becker, J., Carmichael, O., Rotter, J., Psaty, B., Lopez, O., Amin, N., van der Lee, S., Yang, Q., Himali, J., Maillard, P., Beiser, A., DeCarli, C., Karama, S., Lewis, L., Harris, M., Bastin, M., Deary, I., Witte, A., Beyer, F., Loeffler, M., Mather, K., Schofield, P., Thalamuthu, A., Kwok, J., Wright, M., Ames, D., Trollor, J., Jiang, J., Brodaty, H., Wen, W., Vernooij, M., Hofman, A., Uitterlinden, A., Niessen, W., Wittfeld, K., Bülow, R., Völker, U., Pausova, Z., Pike, G., Maingault, S., Crivello, F., Tzourio, C., Amouye, P., Mazoyer, B., Neale, M., Franz, C., Lyons, M., Panizzon, M., Andreassen, O., Dale, A., Logue, M., Grasby, K., Jahanshad, N., Painter, J., Colodro-Conde, L., Bralten, J., Hibar, D., Lind, P., Pizzagalli, F., Stein, J., Thompson, P., Medland, S., Sachdev, P., Kremen, W., Wardlaw, J., Villringer, A., van Duijn, C., Grabe, H., Longstreth Jr., W., Fornage, M., Paus, T., Debette, S., Ikram, M., Schmidt, H., Schmid, R., Seshadr, S.
المساهمون: ENIGMA consortium
المصدر: bioRxiv
الوصف: Cortical thickness, surface area and volumes (MRI cortical measures) vary with age and cognitive function, and in neurological and psychiatric diseases. We examined heritability, genetic correlations and genome-wide associations of cortical measures across the whole cortex, and in 34 anatomically predefined regions. Our discovery sample comprised 22,824 individuals from 20 cohorts within the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium and the United Kingdom Biobank. Significant associations were replicated in the Enhancing Neuroimaging Genetics through Meta-analysis (ENIGMA) consortium, and their biological implications explored using bioinformatic annotation and pathway analyses. We identified genetic heterogeneity between cortical measures and brain regions, and 160 genome-wide significant associations pointing to wnt/β-catenin, TGF-β and sonic hedgehog pathways. There was enrichment for genes involved in anthropometric traits, hindbrain development, vascular and neurodegenerative disease and psychiatric conditions. These data are a rich resource for studies of the biological mechanisms behind cortical development and aging.
وصف الملف: application/pdf
العلاقة: http://hdl.handle.net/21.11116/0000-0004-D554-DTest; http://hdl.handle.net/21.11116/0000-0004-D556-BTest
النص الكامل