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1دورية أكاديمية
المؤلفون: Manish Kumar, Abhishek Jha, Kanchan Bharti, Manjit, Brahmeshwar Mishra
المصدر: Chemical Physics Impact, Vol 8, Iss , Pp 100644- (2024)
مصطلحات موضوعية: Nanocrystals, Solubility, Pulmonary drug delivery, Nanomedicine, Solid state characterization, Physics, QC1-999, Chemistry, QD1-999
الوصف: Biopolymer based nanomedicine for pulmonary delivery is safe and effective in lung cancer therapy. Current work addressed marine polysaccharide fucoidan fabricated bosutinib nanocrystals (FBNC) as dry powder for inhalation (DPI). Microscopic characterization uncovered the cubic-shaped amorphous nanocrystals of about 150 nm with high homogeneity (polydispersity index < 0.3). The lyophilized nanocrystals were stable for 6 months at 4 ℃ and contained approximately 50 % drug. The solid-state characterization of FBNC including FTIR, XRD, DSC, XPS, solid-state NMR and BET revealed the conversion of crystalline bosutinib to amorphous nanocrystals with about 10-fold increase in surface area and saturation solubility. An in-vitro drug release study in simulated lung fluid showed over five-fold improvement in drug dissolution by nanocrystals than coarse drugs. The mucus permeation efficiency of nanocrystal also increased over five-times than coarse drug. The flow property analysis and aerosolization investigation revealed excellent flowability and good aerosolization performance (ED: 70–80 % and FPD: 40–60 %) indicating the nanocrystals capability in drug delivery to deep lungs. In conclusion, polysaccharide fucoidan stabilized bosutinib nanocrystals can be a novel drug delivery system for pulmonary administration as dry powder for inhalation.
وصف الملف: electronic resource
العلاقة: http://www.sciencedirect.com/science/article/pii/S2667022424001889Test; https://doaj.org/toc/2667-0224Test
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المؤلفون: Abhishek Jha, Manish Kumar, Kanchan Bharti, Manjit Manjit, Brahmeshwar Mishra
مصطلحات موضوعية: Nanomedicine, biopolymers, cancer therapy, stimuli-responsive, targeted nanomedicine, tumor microenvironment
الوصف: Nanomedicine has opened up new avenues for cancer treatment by enhancing drug solubility, permeability and targeted delivery to cancer cells. Despite its numerous advantages over conventional therapies, nanomedicine may exhibit off-target drug distribution, harming nontarget regions. The increased permeation and retention effect of nanomedicine in tumor sites also has its limitations, as abnormal tumor vasculature, dense stroma structure and altered tumor microenvironment (TME) may result in limited intratumor distribution and therapeutic failure. However, TME-responsive nanomedicine has exhibited immense potential for efficient, safe and precise delivery of therapeutics utilizing stimuli specific to the TME. This review discusses the mechanistic aspects of various TME-responsive biopolymers and their application in developing various types of TME-responsive nanomedicine.
الإتاحة: https://doi.org/10.25402/nnm.25348447.v1Test
https://figshare.com/articles/dataset/Biopolymer-based_tumor_microenvironment-responsive_nanomedicine_for_targeted_cancer_therapy/25348447Test -
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المؤلفون: Manish Kumar, Abhishek Jha, Kanchan Bharti, Gourav Parmar, Brahmeshwar Mishra
المصدر: Nanomedicine. 17:913-934
مصطلحات موضوعية: Drug Delivery Systems, Nanomedicine, Pulmonary Fibrosis, Biomedical Engineering, Humans, Nanoparticles, Medicine (miscellaneous), General Materials Science, Bioengineering, Development, Lipids, Lung
الوصف: Inflammatory lung disorders have become one of the fastest growing global healthcare concerns, with more than 500 million annual cases of disorders such as chronic obstructive pulmonary disease, asthma and pulmonary fibrosis. Owing to environmental changes and socioeconomic disparity, the numbers are expected to grow even more in years to come. The therapeutic strategies and approved drugs currently employed in the management of inflammatory lung disorders show dose-dependent resistance and pharmacokinetic limitations. This review comprehensively discusses lipid-based pulmonary nanomedicine as a potential platform to overcome these barriers while ensuring site-specific drug delivery and minimal side effects in nontargeted tissues for the management of noninfectious inflammatory lung disorders.
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0bc9e21a4b919b841957a2851035a5cTest
https://doi.org/10.2217/nnm-2021-0389Test -
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المؤلفون: Kanchan Bharti, Sarvendra Kumar Singh, S. K. Jha, Rahul Gupta
المصدر: 2023 International Conference on Intelligent and Innovative Technologies in Computing, Electrical and Electronics (IITCEE).
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::a818d37c22d9dc9b1c8c92151dedd4c6Test
https://doi.org/10.1109/iitcee57236.2023.10091075Test -
5صورة
المؤلفون: Manish Kumar, Krishan Kumar, Abhishek Jha, Kanchan Bharti, Zinnu Rain, Pradyot Prakash, Brahmeshwar Mishra, Manjit Manjit
مصطلحات موضوعية: Clinical pharmacology and therapeutics, diabetic wound, drug delivery, electrospinning, nanofibrous scaffolds, wound healing
الوصف: Supplementary figure
الإتاحة: https://doi.org/10.25402/tde.24884817.v1Test
https://figshare.com/articles/figure/Fabrication_of_dual_drug-loaded_polycaprolactone_gelatin_composite_nanofibers_for_full_thickness_diabetic_wound_healing/24884817Test -
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المؤلفون: Devara Meghanadh, Kanchan Bharti, Vipin Kumar Maurya, Ramji Dwivedi
المصدر: IGARSS 2022 - 2022 IEEE International Geoscience and Remote Sensing Symposium.
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::8bf39c9834e746308dcf6325d804bd7fTest
https://doi.org/10.1109/igarss46834.2022.9884550Test -
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المؤلفون: Adedayo Adeyanju, Abdul Ahad, Naveed Ahmed, Tayyaba Ali, Fahad I. Al-Jenoobi, Abdullah M. Al-Mohizea, Nafiu Aminu, Rahat Andleeb, Sophia G. Antimisiaris, Mohd. Aqil, Kholoud K. Arafa, Asma Ashraf, null Asim-ur-Rehman, Evren Atlihan-Gundogdu, Syed Awais Attique, Suzana Aulic, Nagma Banjare, Zulqarnain Baqar, Kanchan Bharti, Bolay Bhattacharya, Muhammad Bilal, Ana Castejon, Petrou C. Christos, Bhaskar Das, Biswarup Das, Shilpa Das, Pooja Das Bidla, Arnab De, Galatou Eleftheria, Mourelatou Elena, Ibrahim M. El-Sherbiny, Shohreh Fahimirad, Ifi Favour, Alice Fermeglia, Maria Gazouli, Aislaitner Georgios, Monira Ghoniem, Santanu Ghosh, Hazal Ezgi Gültekin, Dipak Kumar Gupta, Prem N. Gupta, Nazim Hussain, Muhammad Umar Ijaz, Miray İlhan, Sanjay K. Jain, Abhishek Jha, Jithu Joseph, Merve Karpuz, Hector Katifelis, Manish Kumar, Young Kwon, Erik Laurini, Zacharia C. Lefteris, Kai Ma, Subrata Mallick, Domenico Marson, Plioukas Michael, Brahmeshwar Mishra, Mehvish Mumtaz, Evangelos Natsaridis, Amit Kumar Nayak, Shabana Naz, Yadollah Omidi, Hossein Omidian, Ezgi Oner, Emre Ozgenc, Pritish K. Panda, Kamla Pathak, Gourav Paudwal, Natassa Pippa, Stergios Pispas, Sabrina Pricl, Rida Rafi, Sarjana Raikwar, Muhammad Asad Sajid, Amalesh Samanta, Sonalinandini Samanta, Samuel Eshorame Sanni, Theodore Sentoukas, Athanasios Skandalis, Qurat ul ain, Amit Verma, Reshu Virmani, Tarun Virmani, Ayesha Waheed, Chaobo Yang, Derya Karataş Yeni, Sarigiannis Yiannis, Amna Zafar, Hongda Zhu, Zeynep Şenyiğit
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::97c8c3925691afe5c26424974177d6a4Test
https://doi.org/10.1016/b978-0-323-91865-7.00031-6Test -
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المؤلفون: Kanchan Bharti, Brahmeshwar Mishra
المصدر: Functional Biomaterials ISBN: 9789811671517
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::a250dd631999e10e3fb602f5fca38c4aTest
https://doi.org/10.1007/978-981-16-7152-4_2Test
النص الكامل