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1دورية أكاديمية
المؤلفون: Strumila, Robertas, Lengvenytė, Aistė, Zdanavičius, Linas, Badaras, Robertas, Dlugauskas, Edgaras, Lesinskienė, Sigita, Matiekus, Eimantas, Marcinkevičius, Martynas, Vencevičienė, Lina, Utkus, Algirdas, Kaminskas, Andrius, Petrėnas, Tomas, Songailienė, Jurgita, Vitkus, Dalius, Ambrozaitytė, Laima
المصدر: Comprehensive psychoneuroendocrinology., Amsterdam : Elsevier, 2024, vol. 19, art. no. 100235, p. [1-8]. ; eISSN 2666-4976
مصطلحات موضوعية: suicidal ideation, adrenocorticotropic hormone (ACTH), hypothalamic-pituitary-adrenal (HPA) axis, cortisol, antidepressants, major depressive disarded (MDD), biomarkers, inflammation (IL6 and TNF alpha), stress response, beck scale for suicide ideation/suicide severity, index (BSS/SSI)
الوصف: Introduction Suicidal ideation, an important risk factor for suicide attempts, has an unclear neurobiological basis and is potentially linked to the dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis and immune-inflammatory systems. While inflammatory markers have been associated with suicide attempts and, to a lower extent suicidal ideation, the data on the role of a stress-response system is less robust, with most studies carried out with cortisol showing inconsistent results. The present study extends on the previous studies implicating stress-response and immune-inflammatory systems in suicidal thoughts and behaviours, focusing on the associations of several stress-response (adrenocorticotropic hormone (ACTH), cortisol, and dehydroepiandrosterone (DHEA)) and immune-inflammatory (C-reactive protein (CRP),interle ukin-6 (IL-6), and tumour necrosis factor-alpha (TNF-alpha)) with suicidal ideation severity in recent suicide attempters, patients with major depressive disorder, and non-psychiatric controls. Methods This observational study included 156 adults from three Vilnius hospitals, recruited into one of the three groups in equal parts: recent suicide attempters, patients with major depressive disorder in current depressive episode, and non-psychiatric controls. Measures included the Hamilton Depression Rating Scale (HDRS-17) and the Beck Scale for Suicide Ideation/Suicide Severity Index (BSS/SSI), alongside sociodemographic data, alcohol, tobacco use, and morning blood samples, measuring plasma ACTH, cortisol, DHEA, CRP, and IL-6. Data were analysed with non-parametric tests, Kendall's tau correlation, and multivariate linear regression adjusted for confounders. Results We found a negative correlation between the plasma ACTH levels and suicidal ideation severity (tau = −0.130, p = 0.033), which was driven by the patients with major depressive disorder (tau = −0.237, p = 0.031). Suicidal ideation severity was also negatively correlated with TNF-alpha (tau = −0.231; p < 0.001), positively ...
وصف الملف: application/pdf
العلاقة: https://epublications.vu.lt/object/elaba:195453450/195453450.pdfTest; https://repository.vu.lt/VU:ELABAPDB195453450&prefLang=en_USTest
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المؤلفون: Mažeikienė, Asta, Bekesiene, Svajone, Karčiauskaitė, Dovilė, Mazgelytė, Eglė, Larsson, Gerry, Professor, 1952, Petrėnas, Tomas, Kaminskas, Andrius, Songailienė, Jurgita, Utkus, Algirdas, Vaičaitienė, Ramutė, Smaliukienė, Rasa
المصدر: International Journal of Environmental Research and Public Health. 18(22):1-18
مصطلحات موضوعية: chronic stress biomarkers, cortisol, cortisone, dehydroepiandrosterone, hair steroid hormones, military conscripts, military training, social environmental factors, testosterone, Ledarskap under påfrestande förhållanden
وصف الملف: print
الوصول الحر: https://urn.kb.se/resolve?urn=urn:nbn:se:fhs:diva-10541Test
https://doi.org/10.3390/ijerph182212239Test -
3دورية أكاديمية
المؤلفون: Strumila, Robertas, Lengvenyte, Aiste, Zdanavicius, Linas, Badaras, Robertas, Dlugauskas, Edgaras, Lesinskiene, Sigita, Matiekus, Eimantas, Marcinkevicius, Martynas, Venceviciene, Lina, Utkus, Algirdas, Kaminskas, Andrius, Petrenas, Tomas, Songailiene, Jurgita, Ambrozaityte, Laima
المصدر: Journal of Psychiatric Research ; volume 158, page 245-254 ; ISSN 0022-3956
مصطلحات موضوعية: Biological Psychiatry, Psychiatry and Mental health
الإتاحة: https://doi.org/10.1016/j.jpsychires.2022.12.043Test
https://api.elsevier.com/content/article/PII:S0022395622007269?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S0022395622007269?httpAccept=text/plainTest -
4دورية أكاديمية
المؤلفون: Mazgelytė, Eglė, Zagorskaja, Julija, Dereškevičiūtė, Edita, Petrėnas, Tomas, Kaminskas, Andrius, Songailienė, Jurgita, Utkus, Algirdas, Chomentauskas, Gintaras, Karčiauskaitė, Dovilė
المصدر: Behavioral sciences., Basel : MDPI, 2022, vol. 12, no. 12, art. no. 482, p. [1-13]. ; eISSN 2076-328X
مصطلحات موضوعية: respiratory biofeedback, respiratory sinus arrhythmia, stress reduction, virtual reality
الوصف: Psychological stress exposure is associated with long-lasting health effects including memory problems, depression, aches and pains, eating disorders, and alcohol or drug use. Thus, there is a need to develop effective stress management strategies that are easy to learn and practice. Respiratory biofeedback is an evidence-based stress management technique presenting breathing-related information to help subjects learn specific breathing skills for relaxation. It is suggested that the use of biofeedback techniques in conjunction with virtual reality makes biofeedback training an even more effective tool for stress management. The current study aimed to investigate dynamics of distinct stress indicators before, after, as well as during one brief virtual reality-based respiratory biofeedback session. Thirty-nine healthy volunteers participated in the study. Individuals provided their saliva samples and evaluated their mood status, fatigue, and strain level before and after the session. The subjects’ heart and respiratory rate, heart rate variability, and galvanic skin response measures were recorded during the session. The results showed that after single 12 min relaxation session, there was a significant decrease in salivary cortisol concentration, heart and respiratory rate, as well as decrease in skin conductance values. Self-reported strain, fatigue level, and mood status also significantly improved. VR-based respiratory-biofeedback-assisted relaxation sessions might serve as an effective stress management strategy, as even single session had positive effects on subjects’ autonomic nervous system (ANS) and hypothalamicpituitary–adrenal (HPA) axis activity, as well as self-reported fatigue, strain level, and mood status.
وصف الملف: application/pdf
العلاقة: https://epublications.vu.lt/object/elaba:147436029/147436029.pdfTest; https://repository.vu.lt/VU:ELABAPDB147436029&prefLang=en_USTest
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5دورية أكاديمية
المؤلفون: Mazgelytė, Eglė, Burokienė, Neringa, Vysocka, Agata, Narkevičius, Martynas, Petrėnas, Tomas, Kaminskas, Andrius, Songailienė, Jurgita, Utkus, Algirdas, Karčiauskaitė, Dovilė
المصدر: Journal of cardiovascular development and disease., Basel : MDPI, 2022, vol. 9, no. 3, art. no. 70, p. [1-17]. ; eISSN 2308-3425
مصطلحات موضوعية: cardiovascular disease risk, chronic stress, hair steroid hormones
الوصف: Cardiovascular diseases (CVDs) are the major cause of death worldwide. Although the importance of conventional CVD risk factors, including older age, male gender, hypertension, obesity, dyslipidemia and hyperglycemia, is well-studied, psychosocial stress, which is considered an independent CVD risk factor, requires further investigation. Thus, we aimed to investigate the association between long-term secretion of stress-related steroid hormones, including cortisol, cortisone and dehydroepiandrosterone, and the 10-year fatal and non-fatal CVD risk estimated by the SCORE2 risk prediction algorithm, as well as traditional CVD risk factors in a group of apparently healthy women. A total of 145 women (aged 50–64 years) participating in the national CVD prevention program were enrolled in the study. Sociodemographic, lifestyle, health-related characteristics, stress, anxiety and sleep quality indicators were evaluated using specific questionnaires. Anthropometric and arterial blood pressure measures were assessed by trained personnel, lipid and glucose metabolism biomarkers were measured using routine methods, and hair steroid hormone levels were determined by ultra-high-performance liquid chromatography-tandem mass spectrometry. The results showed that higher levels of hair cortisol and cortisone are associated with increased SCORE2 values. Moreover, significant associations between hair glucocorticoids and individual cardiovascular risk factors, including obesity, hypertension, dyslipidemia and hyperglycemia, were found. These findings indicate that stress-related hair steroid hormones might be valuable biomarkers for CVD prediction and prevention.
وصف الملف: application/pdf
العلاقة: https://epublications.vu.lt/object/elaba:121862565/121862565.pdfTest; https://repository.vu.lt/VU:ELABAPDB121862565&prefLang=en_USTest
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6دورية أكاديمية
المصدر: Heterocyclic communications., Berlin, 2003, vol. 9, no. 1, p. 89-94. ; ISSN 0793-0283 ; eISSN 2191-0197
الوصف: Treatment of 4,6-dichloro-2-methylthiopyrimidine-5-carbaldehyde (1) with (1H-benzimidazol-2-yl)methanethiol afforded 6-(1H-benzimidazol-2-yl)-4-chloro-2-methylthiothieno[2,3-d]pyrimidine (g). Reaction of 1 with ethyl mercaptoacetate depending on its amount gave ethyl (4-chloro-2-methylthio-5-formylpyrimidin-6- ylthio)acetate (4) or 4,6-bis(ethoxycarbonylmethylthio)pyrimidine-5-carbaldehyde (g). Heating 4, in dimethyl sulfoxide or ethanol in the presence of base afforded ethyl 4-oxo-3,4-dihydro- (6) and 4-ethoxycarbonylmethylthiothieno[2,3-d]pyrimidine-6-carboxylates(7), respectively.
وصف الملف: application/pdf
العلاقة: https://epublications.vu.lt/object/elaba:3255278/3255278.pdfTest; https://repository.vu.lt/VU:ELABAPDB3255278&prefLang=en_USTest
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7دورية أكاديمية
المؤلفون: Tumkevičius, Sigitas, Kaminskas, Andrius
المصدر: Chemija, 2003, t. 14, Nr. 4, p. 223-225 ; ISSN 0235-7216
مصطلحات موضوعية: 6,7,8,9-tetrahydro-2-thia-3,5,6,9-tetraazabenz[cd]azulenes, thiones Lawesson's reagent, synthesis
الوصف: Reactions of ethyl 6-substituted 4-methylthio-8-oxo-6,7,8,9-tetrahydro-2- thia-3,5,6,9-tetraazabenz[cd|azuIene-l-carboxylates with Lawesson's reagent, hydrazine hydrate and lithium aluminum hydride are described.
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8دورية أكاديمية
المؤلفون: Tumkevičius, Sigitas, Kaminskas, Andrius
المصدر: Химия гетероциклических соединений, 2002, no. 5, p. 765-769 ; ISSN 0132-6244
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9دورية أكاديمية
المؤلفون: Dailidė, Mindaugas, Kaminskas, Andrius, Tumkevičius, Sigitas
المصدر: Organinė chemija : mokslinės konferencijos pranešimų medžiaga [2003, balandžio 24, Kaunas], Kaunas : Technologija, 2003, p. 9-10 ; ISBN 9955094117
الوصف: Synthesis of novel 2-amino-4,6-disubstituted thieno- and pyrrolo[2,3-d] pyrimidines as potential lipophilic antifolates from 2-amino-4,6-dichloropyrimidine-5-carbaldehyde is described.
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10دورية أكاديمية
المؤلفون: Tumkevičius, Sigitas, Agrofoglio, Luigi A., Kaminskas, Andrius, Urbelis, Gintaras, Zevaco, Thomas A., Walter, Olaf
المصدر: Tetrahedron letters, 2002, vol. 43, no. 4, p. 695-697 ; ISSN 0040-4039
الوصف: Derivatives of 6,9-dihydro- and 6,7,8,9-tetrahydro-2-thia-3,5,6,7,9-pentaazabenz[cd]azulenes representing a new hetero-cyclic system have been prepared by the cyclocondensation reaction of ethyl 5-amino-4-(1-methylhydrazino)-2-methylthio-thieno[2,3-d]-pyrimidine-6-carboxylate with ethyl orthoformate and various aldehydes.
