المؤلفون: Gürsoy, Bengül, Sürmeli, Cemile D., Alkan, Mustafa, Satıcı, Celal, Altunok, Elif Sargın, Kamat, Sadettin, Demirok, Berna, Demirkol, Mustafa A., Börü, Akaberk

المصدر: Journal of Medical Virology ; volume 93, issue 9, page 5474-5480 ; ISSN 0146-6615 1096-9071

الوصف: In this study, laboratorial parameters of hospitalized novel coronavirus (COVID‐19) patients, who were complicated with severe pneumonia, were compared with the findings of cytokine storm developing in macrophage activation syndrome (MAS)/secondary hemophagocytic lymphohistiocytosis (sHLH). Severe pneumonia occurred as a result of cytokine storm in some patients who needed intensive care unit (ICU), and it is aimed to determine the precursive parameters in this situation. Also in this study, the aim is to identify laboratory criteria that predict worsening disease and ICU intensification, as well as the development of cytokine storm. This article comprises a retrospective cohort study of patients admitted to a single institution with COVID‐19 pneumonia. This study includes 150 confirmed COVID‐19 patients with severe pneumonia. When they were considered as severe pneumonia patients, the clinic and laboratory parameters of this group are compared with H‐score criteria. Patients are divided into two subgroups; patients with worsened symptoms who were transferred into tertiary ICU, and patients with stable symptoms followed in the clinic. For the patients with confirmed COVID‐19 infection, after they become complicated with severe pneumonia, lymphocytopenia (55.3%), anemia (12.0%), thrombocytopenia (19.3%), hyperferritinemia (72.5%), hyperfibrinogenemia (63.7%) and elevated lactate dehydrogenase (LDH) (90.8%), aspartate aminotransaminase (AST) (31.3%), alanine aminotransaminase (ALT) (20.7%) are detected. There were no significant changes in other parameters. Blood parameters between the pre‐ICU period and the ICU period (in which their situation had been worsened and acute respiratory distress syndrome [ARDS] was developed) were also compared. In the latter group lymphocyte levels were found significantly reduced ( p = 0.01), and LDH, highly sensitive troponin (hs‐troponin), procalcitonin, and triglyceride levels were significantly increased ( p < 0.05). In addition, there was no change in hemoglobin, ...

الإتاحة: https://doi.org/10.1002/jmv.27068Test

المؤلفون: Altunok, Elif Sargin, Alkan, Mustafa, Kamat, Sadettin, Demirok, Berna, Satici, Celal, Demirkol, Mustafa Asim, Gursoy, Bengul, Surmeli, Cemile Dilsah, Cengel, Ferhat, Calik, Mustafa, Turkmen, Ulku Aygen

المصدر: Journal of Infection and Chemotherapy ; volume 27, issue 2, page 306-311 ; ISSN 1341-321X

مصطلحات موضوعية: Infectious Diseases, Pharmacology (medical), Microbiology (medical)

الإتاحة: https://doi.org/10.1016/j.jiac.2020.10.020Test
https://api.elsevier.com/content/article/PII:S1341321X20303792?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S1341321X20303792?httpAccept=text/plainTest

المؤلفون: Satici, Celal, Demirkol, Mustafa Asim, Sargin Altunok, Elif, Gursoy, Bengul, Alkan, Mustafa, Kamat, Sadettin, Demirok, Berna, Surmeli, Cemile Dilsah, Calik, Mustafa, Cavus, Zuhal, Esatoglu, Sinem Nihal

المصدر: International Journal of Infectious Diseases ; volume 98, page 84-89 ; ISSN 1201-9712

مصطلحات موضوعية: Infectious Diseases, Microbiology (medical), General Medicine

الإتاحة: https://doi.org/10.1016/j.ijid.2020.06.038Test
https://api.elsevier.com/content/article/PII:S1201971220304732?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S1201971220304732?httpAccept=text/plainTest

المؤلفون: Yazar, Esra Ertan, Aydin, Senay, Gunluoglu, Gulsah, Kamat, Sadettin, Gungen, Adil Can, Yildiz, Pinar

المصدر: Chronic Respiratory Disease ; volume 15, issue 3, page 306-314 ; ISSN 1479-9731 1479-9731

مصطلحات موضوعية: Pulmonary and Respiratory Medicine

الوصف: The aim of this study was to evaluate the clinical effects of cognitive impairment in patients with chronic obstructive pulmonary disease (COPD). A total of 91 patients with stable moderate to very severe COPD were included in this study. Cognitive functions of the patients were evaluated using the mini-mental state examination (MMSE) tool and clock-drawing test. The Brody’s Instrumental Activities of Daily Living (IADL) Questionnaire; COPD assessment test (CAT); body mass index, airflow obstruction, dyspnea, and exercise capacity (BODE); and Charlson comorbidity index were assessed. The patients were divided into two groups as those who were diagnosed with cognitive impairment (group 1, n = 16) and those with normal cognitive functions (group 2, n = 75). Group 1 had a lower arterial partial pressure of oxygen , shorter 6-min walking distance, and higher arterial partial pressure of carbon dioxide (PaCO 2 ) than group 2 ( p = 0.01, p = 0.024, p = 0.018, respectively). In group 1, the IADL score was lower, and CAT and BODE scores were higher than group 2 ( p = 0.002, p = 0.037, p = 0.012, respectively). When we considered all the patients, there was an independent correlation between the IADL score and MMSE score ( p = 0.03). This study revealed that COPD patients with cognitive impairment may have more hypoxemia and limited activities of daily living.

الإتاحة: https://doi.org/10.1177/1479972317743757Test

المؤلفون: Cengiz Elçioğlu, Betul, Kamat, Sadettin, Yurdakul, Selen, Şahin, Şükrü Taylan, Sarper, Altemur, Yıldız, Pınar, Aytekin, Saide

المصدر: Internal Medicine Journal ; volume 52, issue 10, page 1791-1798 ; ISSN 1444-0903 1445-5994

الوصف: Background Patients with chronic obstructive pulmonary disease (COPD) can develop left ventricular (LV) systolic dysfunction and geometric changes due to several reasons. Aim To investigate subclinical LV systolic dysfunction and structural features in patients with COPD, and its correlation with the severity of airway obstruction, identified by GOLD classification. Methods We studied 52 patients with COPD and 29 age and sex‐matched controls, without any cardiac disease. In addition to conventional echocardiographic evaluation speckle tracking echocardiography (STE)‐based strain imaging were performed to analyse sub‐clinical LV systolic dysfunction. Also LV volumes were measured by using three‐dimensional real time echocardiography (3DRTE). All patients underwent spirometry. Results Conventional echocardiographic parameters (LV wall thickness and diameters, LV EF) and LV volume measurements were similar between the groups. LV global longitudinal peak systolic strain (−14.76 ± 2.69% to −20.27 ± 1.41%, P < 0.001) and strain rate (0.75 ± 0.25 1/s to 1.31 ± 0.41 1/s, P < 0.001) were significantly impaired in patients, compared to controls demonstrating sub‐clinical ventricular systolic dysfunction. Significant positive correlation was obtained between LV strain/strain rate and spirometry parameters (FEV1, FEV%, FEV1/FVC, PEF%) ( r = 0.78/0.68, P < 0.001; r = 0.83/0.70, P < 0.001); r = 0.74/0.55, P < 0.001; r = 0.72/0.65, P < 0.001 respectively). In addition, there was significant negative correlation between LV strain/strain rate and GOLD classification ( r = −0.80/ ‐0.69, P < 0.001 respectively). Conclusion Subclinical LV systolic dysfunction can occur in COPD patients despite normal EF. STE is a technique that provides additional information for detailed evaluation of subtle changes in LV myocardial contractility, significantly associated with the severity of the disease in COPD patients.

الإتاحة: https://doi.org/10.1111/imj.15424Test

المؤلفون: Sargin Altunok, Elif, Satici, Celal, Dinc, Veysel, Kamat, Sadettin, Alkan, Mustafa, Demirkol, Mustafa Asim, Toprak, Ilkim Deniz, Kostek, Muhammed Emin, Yazla, Semih, Esatoglu, Sinem Nihal

المصدر: Journal of Medical Virology ; volume 94, issue 1, page 291-297 ; ISSN 0146-6615 1096-9071

الوصف: Due to current advances and growing experience in the management of coronavirus Disease 2019 (COVID‐19), the outcome of COVID‐19 patients with severe/critical illness would be expected to be better in the second wave compared with the first wave. As our hospitalization criteria changed in the second wave, we aimed to investigate whether a favorable outcome occurred in hospitalized COVID‐19 patients with only severe/critical illness. Among 642 laboratory‐confirmed hospitalized COVID‐19 patients in the first wave and 1121 in the second wave, those who met World Health Organization (WHO) definitions for severe or critical illness on admission or during follow‐up were surveyed. Data on demographics, comorbidities, C‐reactive protein (CRP) levels on admission, and outcomes were obtained from an electronic hospital database. Univariate analysis was performed to compare the characteristics of patients in the first and second waves. There were 228 (35.5%) patients with severe/critical illness in the first wave and 681 (60.7%) in the second wave. Both groups were similar in terms of age, gender, and comorbidities, other than chronic kidney disease. Median serum CRP levels were significantly higher in patients in the second wave compared with those in the first wave [109 mg/L (interquartile range [IQR]: 65–157) vs. 87 mg/L (IQR: 39–140); p < 0.001]. However, intensive care unit admission and mortality rates were similar among the waves. Even though a lower mortality rate in the second wave has been reported in previous studies, including all hospitalized COVID‐19 patients, we found similar demographics and outcomes among hospitalized COVID‐19 patients with severe/critical illness in the first and second wave.

الإتاحة: https://doi.org/10.1002/jmv.27319Test

المؤلفون: Altunok, Elif Sargin, Satici, Celal, inc, Veysel, Kamat, Sadettin, Alkan, Mustafa, Demirkol, Mustafa Asim, Toprak, Ilkim Deniz, Kostek, Muhammed Emin, Yazla, Semih, Esatoglu, Sinem Nihal

المصدر: Journal of Medical Virology; Jan2022, Vol. 94 Issue 1, p291-297, 7p

مصطلحات موضوعية: COVID-19, CRITICALLY ill, HOSPITAL patients, CHRONIC kidney failure, INTENSIVE care units

مصطلحات جغرافية: TURKEY

الشركة/الكيان: WORLD Health Organization

مستخلص: Due to current advances and growing experience in the management of coronavirus Disease 2019 (COVID-19), the outcome of COVID-19 patients with severe/critical illness would be expected to be better in the second wave compared with the first wave. As our hospitalization criteria changed in the second wave, we aimed to investigate whether a favorable outcome occurred in hospitalized COVID-19 patients with only severe/critical illness. Among 642 laboratory-confirmed hospitalized COVID-19 patients in the first wave and 1121 in the second wave, those who met World Health Organization (WHO) definitions for severe or critical illness on admission or during follow-up were surveyed. Data on demographics, comorbidities, C-reactive protein (CRP) levels on admission, and outcomes were obtained from an electronic hospital database. Univariate analysis was performed to compare the characteristics of patients in the first and second waves. There were 228 (35.5%) patients with severe/critical illness in the first wave and 681 (60.7%) in the second wave. Both groups were similar in terms of age, gender, and comorbidities, other than chronic kidney disease. Median serum CRP levels were significantly higher in patients in the second wave compared with those in the first wave [109 mg/L (interquartile range [IQR]: 65-157) vs. 87 mg/L (IQR: 39-140); p < 0.001]. However, intensive care unit admission and mortality rates were similar among the waves. Even though a lower mortality rate in the second wave has been reported in previous studies, including all hospitalized COVID-19 patients, we found similar demographics and outcomes among hospitalized COVID-19 patients with severe/critical illness in the first and second wave. [ABSTRACT FROM AUTHOR]

: Copyright of Journal of Medical Virology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

المؤلفون: Cengiz Elçioğlu, Betul¹ (AUTHOR) betulcengiz@yahoo.com, Kamat, Sadettin² (AUTHOR), Yurdakul, Selen¹ (AUTHOR), Şahin, Şükrü Taylan¹ (AUTHOR), Sarper, Altemur³ (AUTHOR), Yıldız, Pınar² (AUTHOR), Aytekin, Saide⁴ (AUTHOR)

المصدر: Internal Medicine Journal. Jun2021, p1. 8p. 5 Illustrations, 3 Charts.

مستخلص: Background Aim Methods Results Conclusion Patients with chronic obstructive pulmonary disease (COPD) can develop left ventricular (LV) systolic dysfunction and geometric changes due to several reasons.To investigate subclinical LV systolic dysfunction and structural features in patients with COPD, and its correlation with the severity of airway obstruction, identified by GOLD classification.We studied 52 patients with COPD and 29 age and sex‐matched controls, without any cardiac disease. In addition to conventional echocardiographic evaluation speckle tracking echocardiography (STE)‐based strain imaging were performed to analyse sub‐clinical LV systolic dysfunction. Also LV volumes were measured by using three‐dimensional real time echocardiography (3DRTE). All patients underwent spirometry.Conventional echocardiographic parameters (LV wall thickness and diameters, LV EF) and LV volume measurements were similar between the groups. LV global longitudinal peak systolic strain (−14.76 ± 2.69% to −20.27 ± 1.41%, P < 0.001) and strain rate (0.75 ± 0.25 1/s to 1.31 ± 0.41 1/s, P < 0.001) were significantly impaired in patients, compared to controls demonstrating sub‐clinical ventricular systolic dysfunction. Significant positive correlation was obtained between LV strain/strain rate and spirometry parameters (FEV1, FEV%, FEV1/FVC, PEF%) (r = 0.78/0.68, P < 0.001; r = 0.83/0.70, P < 0.001); r = 0.74/0.55, P < 0.001; r = 0.72/0.65, P < 0.001 respectively). In addition, there was significant negative correlation between LV strain/strain rate and GOLD classification (r = −0.80/ ‐0.69, P < 0.001 respectively).Subclinical LV systolic dysfunction can occur in COPD patients despite normal EF. STE is a technique that provides additional information for detailed evaluation of subtle changes in LV myocardial contractility, significantly associated with the severity of the disease in COPD patients. [ABSTRACT FROM AUTHOR]

المؤلفون: Yazar, Esra Ertan, Aydin, Senay, Gunluoglu, Gulsah, Kamat, Sadettin, Gungen, Adil Can, Yildiz, Pinar

المصدر: Chronic Respiratory Disease; Aug2018, Vol. 15 Issue 3, p306-314, 9p, 5 Charts, 1 Graph

مستخلص: The aim of this study was to evaluate the clinical effects of cognitive impairment in patients with chronic obstructive pulmonary disease (COPD). A total of 91 patients with stable moderate to very severe COPD were included in this study. Cognitive functions of the patients were evaluated using the mini-mental state examination (MMSE) tool and clock-drawing test. The Brody's Instrumental Activities of Daily Living (IADL) Questionnaire; COPD assessment test (CAT); body mass index, airflow obstruction, dyspnea, and exercise capacity (BODE); and Charlson comorbidity index were assessed. The patients were divided into two groups as those who were diagnosed with cognitive impairment (group 1, n = 16) and those with normal cognitive functions (group 2, n = 75). Group 1 had a lower arterial partial pressure of oxygen , shorter 6-min walking distance, and higher arterial partial pressure of carbon dioxide (PaCO2) than group 2 (p = 0.01, p = 0.024, p = 0.018, respectively). In group 1, the IADL score was lower, and CAT and BODE scores were higher than group 2 (p = 0.002, p = 0.037, p = 0.012, respectively). When we considered all the patients, there was an independent correlation between the IADL score and MMSE score (p = 0.03). This study revealed that COPD patients with cognitive impairment may have more hypoxemia and limited activities of daily living. [ABSTRACT FROM AUTHOR]

: Copyright of Chronic Respiratory Disease is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)