المؤلفون: Jun Li, Carl Armon, Frank J Palella, Richard M Novak, Douglas Ward, Stacey Purinton, Marcus Durham, Kate Buchacz, Marcus D Durham, Cheryl Akridge, Nabil Rayeed, Selom Agbobil-Nuwoaty, Kalliope Chagaris, Kimberly Carlson, Linda Battalora, Jonathan Mahnken, Saira Jahangir, Conor Daniel Flaherty, Patricia Bustamante, John Hammer, Kenneth S Greenberg, Barbara Widick, Rosa Franklin, Douglas J Ward, Troy Thomas, Cheryl Stewart, Jack Fuhrer, Linda Ording-Bauer, Rita Kelly, Jane Esteves, Ellen M Tedaldi, Ramona A Christian, Faye Ruley, Dania Beadle, Princess Davenport, Andrea Wendrow, Stockton Mayer, Mia Scott, Billie Thomas, Loraine Van Slyke, Cynthia Mayer, Terry Beitler, Karen Maroney, Denise Franklin

المصدر: Clinical Infectious Diseases. 71:1824-1835

مصطلحات موضوعية: Male, Microbiology (medical), medicine.medical_specialty, Gonorrhea, Human immunodeficiency virus (HIV), Rectum, HIV Infections, medicine.disease_cause, Men who have sex with men, Sexual and Gender Minorities, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, Outpatients, medicine, Humans, Mass Screening, 030212 general & internal medicine, Homosexuality, Male, Reproductive health, 030505 public health, Chlamydia, business.industry, Incidence, Medical record, Incidence (epidemiology), HIV, Chlamydia Infections, medicine.disease, United States, Infectious Diseases, medicine.anatomical_structure, 0305 other medical science, business

الوصف: Background Although chlamydia (CT) and gonorrhea (GC) infections are increasing in the United States, there are limited data on their incidence, testing rates, and associated risk factors among persons living with HIV (PLWH), including by anatomic site among men who have sex with men (MSM). Methods We analyzed 2007–2017 medical records data from Human Immunodeficiency Virus (HIV) Outpatient Study (HOPS) participants in care at 9 HIV clinics. We calculated CT (and GC) incidence and testing rates and assessed associations with sociodemographic and clinical factors using log-linear regression. Results Among 4727 PLWH, 397 had 881 CT infections and 331 had 861 GC infections, with an incidence of 2.95 and 2.88 per 100 person-years, respectively. From 2007 to 2017, incidence and testing rates increased by approximately 3.0- and 1.9-fold for CT and GC, respectively. Multivariable factors associated with incident CT (GC) included younger age, MSM, and prior diagnoses of sexually transmitted diseases (STDs). Among 1159 MSM, 583 (50.3%) had 844 CT and 843 GC tests during 2016–2017, and 26.6% of tests were 3-site (urethra, rectum, and pharynx), yielding the highest rates of CT (GC) detection. Multivariable factors associated with CT (GC) testing included younger age, non-Hispanic/Latino black race, and having prior STDs. Conclusions Recent CT and GC incidence and testing increased among PLWH; however, only half of MSM were tested for CT or GC during 2016–2017 and less than a third of tests were 3-site. To promote sexual health and STD prevention among PLWH who are MSM, research regarding the added value of CT and GC testing across 3 anatomic sites is needed.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c150331e393da9c9a2bb80ddd0eb527Test
https://doi.org/10.1093/cid/ciz1085Test

المؤلفون: Cheryl Stewart, Faye Ruley, Carl Armon, Selom Agbobil-Nuwoaty, Saira Jahangir, John A. Hammer, Richard M. Novak, Loraine VanSlyke, Conor Daniel Flaherty, Kimberly Carlson, Rita Kelly, Karen Maroney, Kenneth S. Greenberg, Stacey Purinton, Frank J. Palella, Ellen Tedaldi, Jun Li, Cheryl Akridge, Dania Beadle, Mia Scott, Jonathan D. Mahnken, Patricia Bustamante, Linda Ording-Bauer, Princess Davenport, Jack Fuhrer, Barbara Widick, M. Durham, Terry Beitler, Ramona A. Christian, Andrea Wendrow, Cynthia Mayer, Billie Thomas, Troy Thomas, Linda Battalora, Kate Buchacz, Stockton Mayer, Nabil Rayeed, Douglas Ward, Marcus D. Durham, Denise Franklin, Kansas City, Jane Esteves, Kalliope Chagaris, Rosa Franklin, Douglas J. Ward

المصدر: Open Forum Infect Dis

مصطلحات موضوعية: 0301 basic medicine, medicine.medical_specialty, Pediatrics, business.industry, Human immunodeficiency virus (HIV), MEDLINE, Disease, Review Article, medicine.disease_cause, medicine.disease, 030112 virology, 03 medical and health sciences, 0302 clinical medicine, Infectious Diseases, Oncology, Acquired immunodeficiency syndrome (AIDS), Cohort, Epidemiology, medicine, 030212 general & internal medicine, Lipodystrophy, business, Viral load

الوصف: Background The clinical epidemiology of treated HIV infection in the United States has dramatically changed in the past 25 years. Few sources of longitudinal data exist for people with HIV (PWH) spanning that period. Cohort data enable investigating new exposure and disease associations and monitoring progress along the HIV care continuum. Methods We synthesized key published findings and conducted primary data analyses in the HIV Outpatient Study (HOPS), an open cohort of PWH seen at public and private HIV clinics since 1993. We assessed temporal trends in health outcomes (1993–2017) and mortality (1994–2017) for 10 566 HOPS participants. Results The HOPS contributed to characterizing new conditions (eg, lipodystrophy), demonstrated reduced mortality with earlier HIV treatment, uncovered associations between select antiretroviral agents and cardiovascular disease, and documented remarkable shifts in morbidity from AIDS opportunistic infections to chronic noncommunicable diseases. The median CD4 cell count of participants increased from 244 cells/mm3 to 640 cells/mm3 from 1993 to 2017. Mortality fell from 121 to 16 per 1000 person-years from 1994 to 2017 (P Conclusions Since 1993, the HOPS has been detecting emerging issues and challenges in HIV disease management. HOPS data can also be used for monitoring trends in infectious and chronic diseases, immunologic and viral suppression status, retention in care, and survival, thereby informing progress toward the Ending the HIV Epidemic initiative.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8cf40977f83cab89e7c74d0c298f3449Test
https://pubmed.ncbi.nlm.nih.gov/32455145Test

المؤلفون: Bonnie Dean, Frank J. Palella, John Hammer, Doug Ward, Rachel Hart, John T. Brooks, Benjamin Young, Kathleen C. Wood, Marcus D. Durham, Jerian Denise Dixon-Evans, Dania Beadle, Dana Franklin, Bienvenido G. Yangco, Richard M. Novak, Kate Buchacz, Jane Esteves, Conor Daniel Flaherty, Ellen Tedaldi, Jack Fuhrer, Cheryl Stewart, Faye Ruley, Ramona A. Christian, Thilakavathy Subramanian, Mia Scott, Kenneth S. Greenberg, Princess Graham, Darlene Hankerson, Linda Ording-Bauer, Kalliope Chagaris, Rita Kelly, Kenneth A. Lichtenstein, Rosa Franklin, Andrea Wendrow, Carl Armon, Renata Smith, Barbara Widick, Joan S. Chmiel, Saira Jahangir, Harlen Hays

المصدر: Journal of Antimicrobial Chemotherapy. 70:2337-2346

مصطلحات موضوعية: Adult, Male, Microbiology (medical), medicine.medical_specialty, Genotyping Techniques, Human immunodeficiency virus (HIV), HIV Infections, Microbial Sensitivity Tests, Drug resistance, medicine.disease_cause, ANTIRETROVIRAL AGENTS, Internal medicine, Drug Resistance, Viral, Outpatients, Epidemiology, Genotype, Antiretroviral naive, medicine, Humans, Pharmacology (medical), Longitudinal Studies, Prospective Studies, Temporal change, Aged, Pharmacology, business.industry, HIV, Middle Aged, United States, Infectious Diseases, Immunology, Genotypic resistance, Female, business

الوصف: BackgroundMonitoring antiretroviral drug resistance can inform treatment recommendations; however, there are few such data from US patients before they initiate ART.MethodsWe analysed data from HIV Outpatient Study (HOPS) participants from nine US HIV clinics who were diagnosed with HIV infection during 1999–2011. Using the IAS-USA December 2010 guidelines, we assessed the frequency of major drug resistance mutations (mDRMs) related to antiretroviral agents in viral isolates from patients who underwent commercial genotypic testing (GT) for resistance before initiating ART. We employed general linear regression models to assess factors associated with having undergone GT, and then factors associated with having mDRM.ResultsAmong 1531 eligible patients, 758 (49.5%) underwent GT before first ART, increasing from 15.5% in 1999–2002 to 75.9% in 2009–11 (P 5.0 log10 copies/mL and those with a first HOPS visit in 2006 or later were significantly (P ConclusionsDuring 1999–2011, GT use among antiretroviral-naive patients became more common, but a quarter of patients in recent years remained untested. The frequency of mDRMs remained stable over time at about 15%.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::874c32d64ad4355bc009ecd44e9635afTest
https://doi.org/10.1093/jac/dkv120Test

المؤلفون: C. Armon, Nabil Rayeed, Joan S. Chmiel, J. S. Chmiel, Saira Jahangir, Troy Thomas, Kate Buchacz, M. Durham, R. Hart, John A. Hammer, Thilakavathy Subramanian, Richard M. Novak, Conor Daniel Flaherty, Genevieve Looby, Barbara Widick, Carl Armon, J. T. Brooks, Kathy Wood, Bienvenido G. Yangco, Kalliope Chagaris, John T. Brooks, Stacey Purinton, Ramona A. Christian, B. Dean, Mia Scott, Cheryl Stewart, Doug Ward, Dana Franklin, Rosa Franklin, Princess Davenport, Faye Ruley, B. Yangco, Benjamin Young, Dania Beadle, Harlen Hays, Marcus D. Durham, Rachel Hart, Andrea Wendrow, Rita Kelly, Ellen Tedaldi, Linda Ording-Bauer, Jane Esteves, Frank J. Palella, Jack Fuhrer, Kenneth S. Greenberg, Cheryl Akridge, Kenneth A. Lichtenstein

المصدر: The Journal of antimicrobial chemotherapy. 71(9)

مصطلحات موضوعية: 0301 basic medicine, Microbiology (medical), Adult, CD4-Positive T-Lymphocytes, Male, medicine.medical_specialty, HIV Infections, Biology, Risk Assessment, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, Antiretroviral Therapy, Highly Active, medicine, Humans, Pharmacology (medical), 030212 general & internal medicine, Prospective Studies, Prospective cohort study, Generalized estimating equation, Survival analysis, Cause of death, Pharmacology, Proportional hazards model, Mortality rate, Middle Aged, 030112 virology, Survival Analysis, CD4 Lymphocyte Count, Infectious Diseases, Treatment Outcome, Anti-Retroviral Agents, Immunology, Female, Risk assessment, Cohort study

الوصف: Objectives We sought to evaluate associations between CD4 at ART initiation (AI), achieving CD4 >750 cells/mm3 (CD4 >750), long-term immunological recovery and survival. Methods This was a prospective observational cohort study. We analysed data from ART-naive patients seen in 1996–2012 and followed ≥3 years after AI. We used Kaplan–Meier (KM) methods and log-rank tests to compare time to achieving CD4 >750 by CD4 at AI (CD4-AI); and Cox regression models and generalized estimating equations to identify factors associated with achieving CD4 >750 and mortality risk. Results Of 1327 patients, followed for a median of 7.9 years, >85% received ART for ≥75% of follow-up time; 64 died. KM estimates evaluating likelihood of CD4 >750 during 5 years of follow-up, stratified by CD4-AI 750 [adjusted HR (aHR) = 4.77]. Blacks were less likely than whites to achieve CD4 >750 (33% versus 49%, aHR = 0.77). Mortality rates decreased with increasing CD4-AI (P = 0.004 across CD4 strata for AIDS causes and P = 0.009 for non-AIDS death causes). Among decedents with CD4-AI ≥50, 56% of deaths were due to non-AIDS causes. Conclusions Higher CD4-AI resulted in greater long-term CD4 gains, likelihood of achieving CD4 >750, longer survival and decreased mortality regardless of cause. Over 80% of persons with CD4-AI ≥350 achieved CD4 >750 by 4 years while 75% of persons with CD4-AI

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa479fc29e5d9100167b0ca1ee1787adTest
https://pubmed.ncbi.nlm.nih.gov/27330061Test

المؤلفون: Frank J. Palella, John T. Brooks, Jane Esteves, Jack Fuhrer, Kathleen C. Wood, Ramona A. Christian, Kate Buchacz, Linda Ording-Bauer, Kenneth A. Lichtenstein, Joan S. Chmiel, Andrea Wendrow, Pragna Patel, Harlen Hays, Troy Thomas, Bonnie Dean, Cheryl Stewart, Faye Ruley, Barbara Widick, Conor Daniel Flaherty, Benjamin Young, Doug Ward, Marcus D. Durham, R. Debes, Renata Smith, Richard M. Novak, Princess Graham, Kalliope Chagaris, Rosa Franklin, Kenneth S. Greenberg, John Hammer, Darlene Hankerson, Dania Beadle, Ellen Tedaldi, Carl Armon, Kathy Wood, Saira Jahangir, Rita Kelly, Thilakavathy Subramanian, Jerian Denise Dixon-Evans, Bienvenido G. Yangco, Patricia Avery, Mia Scott

المصدر: Clin Infect Dis

مصطلحات موضوعية: Microbiology (medical), Time Factors, business.industry, Vaccination, Human immunodeficiency virus (HIV), HIV Infections, medicine.disease_cause, Virology, United States, Article, Seasonal influenza, Infectious Diseases, Influenza Vaccines, Environmental health, Influenza, Human, Outpatients, Medicine, Humans, Seasons, business

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9e339165288b39a5bab613ebb7ddc64Test
https://pubmed.ncbi.nlm.nih.gov/25501987Test