المؤلفون: Yi Chun, Dubois Xu, Alexandre, Hertig, Edith, Baugey, Nacéra, Ouali, Julie, Peltier, Chantal, Jouanneau, Eric, Rondeau, Zhang, Xiaoliang, Jin, Yansheng, Miravete, Mathieu, Dissard, Romain, Klein, Julie, Gonzalez, Julien, Caubet, Cécile, Pecher, Christiane, Pipy, Bernard, Bascands, Jean-Loup, Mercier-Bonin, Muriel, Schanstra, Joost, Buffin-Meyer, Bénédicte, Claire, Rigothier, Rigothier, Claire, Richard, Daculsi, Sébastien, Lepreux, Moin, Saleem, Chantal, Bourget, Christian, Combe, Jean, Ripoche, Migliori, Massimiliano, Cantaluppi, Vincenzo, Mannari, Claudio, Medica, Davide, Giovannini, Luca, Panichi, Vincenzo, Goldwich, Andreas, Alexander, Steinkasserer, André, Gessner, Amann, Kerstin, Migliorini, Adriana, Sagrinati, Costanza, Angelotti, Maria Lucia, Mulay, Shrikant R., Ronconi, Elisa, Peired, Anna, Romagnani, Paola, Anders, Hans-Joachim, Chiang, Wen Chih, Lai, Chun Fu, Peng, Wei-Hao, Wu, Ching Fang, Chang, Fan-Chi, Chen, Yi-Ting, Lin, Shuei-Liong, Chen, Yung Ming, Wu, Kwan Dun, Lu, Kuo-Shyan, Tsai, Tun Jun, Virgine, Ory, Qing Feng, Fan, Zhang, Shao-Yu, Dominique, Desvaux, Vincent, Audard, Marina, Candelier, Philippe, Lang, Georges, Guellaen, Pawlak, Andre, Sahali, Djillali, Matsumoto, Sachiko, Kiyomoto, Hideyasu, Ichimura, Atsuhiro, Dan, Takashi, Nakamichi, Takashi, Tsujita, Tadashi, Akahori, Koji, Ito, Sadayoshi, Miyata, Tosho, Xie, Shaoting, Zhang, Bin, Shi, Wei, Yang, Yun, Nagasu, Hajime, Satoh, Minoru, Kidokoro, Kengo, Nishi, Yuko, Ihoriya, Chieko, Kadoya, Hiroyuki, Sasaki, Tamaki, Kashihara, Naoki, Wu, Ching-Fang, Chou, Yu-Hsiang, Duffield, Jeremy, Rocca, Chiara, Gregorini, Marilena, Corradetti, Valeria, Valsania, Teresa, Bedino, Giulia, Bosio, Francesca, Pattonieri, Eleonora Francesca, Esposito, Pasquale, Sepe, Vincenzo, Libetta, Carmelo, Rampino, Teresa, Dal Canton, Antonio, Omori, Hiroki, Kawada, Noritaka, Inoue, Kazunori, Ueda, Yoshiyasu, Yamamoto, Ryohei, Matsui, Isao, Kaimori, Jyunya, Takabatake, Yoshitsugu, Moriyama, Toshiki, Isaka, Yoshitaka, Rakugi, Hiromi, Wasilewska, Anna, Taranta-Janusz, Katarzyna, Deebek, Wojciech, Kuroczycka-Saniutycz, Elzbieta, Lee, Ae Sin, Lee, Jung Eun, Jung, Yu Jin, Kang, Kyung Pyo, Lee, Sik, Kim, Won, Arfian, Nur, Emoto, Noriaki, Yagi, Keiko, Nakayama, Kazuhiko, Hartopo, Anggoro Budi, Nugrahaningsih, Dwi Aris, Yanagisawa, Masashi, Hirata, Ken-Ichi, Muñoz-Félix, JoséManuel, Lopez-Novoa, Jose M., Martinez-Salgado, Carlos, Oujo, Barbara, Arevalo, Miguel, Bernabeu, Carmelo, Perez-Barriocanal, Fernando, Jesper, Kers, Nathalie, Vittoz, Pierre, Galichon, Iyoda, Masayuki, Shibata, Takanori, Matsumoto, Kei, Shindo-Hirai, Yuki, Kuno, Yoshihiro, Wada, Yukihiro, Akizawa, Tadao, Schwartz, Idit, Schwartz, Doron, Prot Bertoye, Caroline, Terryn, Sara, Claver, Julien, Beghdadi, Walid Beghdadi, Monteiro, Renato, Blank, Uli, Devuyst, Olivier, Daugas, Eric, Van Beneden, Katrien, Geers, Caroline, Pauwels, Marina, Mannaerts, Inge, Van den Branden, Christiane, Van Grunsven, Leo A., Seckin, Ismail, Pekpak, Meltem, Uzunalan, Mumin, Uruluer, Bulent, Köktürk, Sibel, Öztürk, Zeynep, Sönmez, Hüseyin, Yaprak, Elif, Furuno, Yumi, Tsutsui, Masato, Morishita, Tsuyoshi, Shimokawa, Hiroaki, Otsuji, Yutaka, Yanagihara, Nobuyuki, Kabashima, Narutoshi, Ryota, Serino, Kanegae, Kaori, Miyamoto, Tetsu, Nakamata, Junichi, Ishimatsu, Nana, Tamura, Masahito, Nakagawa, Taizo, Ichikawa, Kumi, Miyamoto, Mayumi, Takabayashi, Daisuke, Yamazaki, Hidenori, Kakeshita, Kouta, Koike, Tsutomu, Kagitani, Satoshi, Tomoda, Fumihiro, Hamashima, Takeru, Ishii, Yoko, Inoue, Hiroshi, Sasahara, Masakiyo, El Machhour, Fala, Kerroch, Monique, Mesnard, Laurent, Chatziantoniou, Christos, Dussaule, Jean-Claude, Inui, Kiyoko, Sasai, Fumihiko, Maruta, Yuichi, Nishiwaki, Hiroki, Kawashima, Eri, Inoue, Yoshihiko, Yoshimura, Ashio, Musacchio, Estella, Priante, Giovanna, Valvason, Chiara, Sartori, Leonardo, Baggio, Bruno, Kim, Ji Hong, Gross, Oliver, Diana, Rubel, Gry, Dihazi H., Asimal, Bibi, Johanna, Temme, Imke, Schmidt-Eylers, Lydia, Weimer, Gerhard-Anton, Müller, Hassan, Dihazi, Cano, Jose Luis, Griera, Mercedes, Olmos, Gemma, Martin, Paloma, Cortes, Maria Alicia, Lopez-Ongil, Susana, Rodriguez-Puyol, Diego, DE Frutos, Sergio, Gonzalez, Marta, Luengo, Alicia, Rodriguez-Puyol, Manuel, Calleros, Laura, Lupica, Rosaria, Lacquaniti, Antonio, Donato, Valentina, Maggio, Rossella, Mastroeni, Claudia, Lucisano, Silvia, Cernaro, Valeria, Fazio, Maria Rosaria, Quartarone, Angelo, Buemi, Michele, Kacik, Michael, Goedicke, Sybell, Eggert, Holger, Hoyer, Joachim Dirk, Wurm, Simone, Steege, Andreas, Banas, Miriam, Kurtz, Armin, Banas, Bernhard, Lasagni, Laura, Lazzeri, Elena, Romoli, Simone, Schaefer, Irini, Teng, Beina, Worthmann, Kirstin, Haller, Hermann, Schiffer, Mario, Prattichizzo, Clelia, Netti, Giuseppe Stefano, Rocchetti, Maria Teresa, Cormio, Luigi, Carrieri, Giuseppe, Stallone, Giovanni, Grandaliano, Giuseppe, Ranieri, Elena, Gesualdo, Loreto, Kucher, Anatoliy, Smirnov, Alexey, Parastayeva, Marina, Beresneva, Olga, Kayukov, Ivan, Zubina, Irina, Ivanova, Galina, Abed, Ahmed, Schlekenbach, Ludwig, Foglia, Bernard, Kwak, Brenda, Chadjichristos, Christos, Queisser, Nina, Schupp, Nicole, Brand, Susanne, Himer, Leonóra, Szebeni, Beáta, Sziksz, Erna, Saijo, Shinobu, Kis, Éva, Prókai, Ágnes, Bánki, Nóra F., Fekete, Andrea, Tulassay, Tivadar, Vannay, Ádám, Hegner, Björn, Schaub, Theres, Lange, Claudia, Dragun, Duska, Klinkhammer, Barbara Mara, Rafael, Kramann, Monika, Mallau, Anna, Makowska, Van Roeyen, Claudia, Boor, Peter, Eva Bettina, Buecher, Simon, Otten, Esther, Stuettgen, Floege, Jürgen, Kunter, Uta, Janke, Daniel, Jankowski, Joachim, Hayashi, Matsuhiko, Takamatsu, Ichiro, Horimai, Chihiro, Yoshida, Tadashi, Seno DI Marco, Giovanna, Koenig, Maximilian, Stock, Christian, Reiermann, Stephanie, Amler, Susanne, Koehler, Gabriele, Fobker, Manfred, Buck, Friedrich, Pavenstaedt, Hermann, Lang, Detlef, Brand, Marcus, Plotnikov, Egor, Morosanova, Maria, Pevzner, Irina, Zorova, Ljubava, Pulkova, Natalya, Zorov, Dmitry, Wörnle, Markus, Ribeiro, Andrea, Belling, Franziska, Merkle, Monika, Nakazawa, Daigo, Nishio, Saori, Shibasaki, Sekiya, Tomaru, Utano, Akihiro, Ishizu, Kobayashi, Ikue, Imanishi, Yasuo, Kurajoh, Masafumi, Nagata, Yuki, Yamagata, Masayo, Emoto, Masanori, Michigami, Toshimi, Ishimura, Eiji, Inaba, Masaaki, Wu, Chiα-Chao, Lu, Kuo-Cheng, Chen, Jin-Shuen, Chu, Pauling, Lin, Yuh-Feng, Eller, Kathrin, Schroll, Andrea, Kirsch, Alexander, Huber, Julia, Weiss, Günter, Theurl, Igor, Rosenkranz, Alexander R., Zawada, Adam, Rogacev, Kyrill, Achenbach, Marina, Fliser, Danilo, Held, Gerhard, Heine, Gunnar Henrik, Miyamoto, Yohei, Iwao, Yasunori, Watanabe, Hiroshi, Kadowaki, Daisuke, Ishima, Yu, Chuang, Victor Tuan Giam, Sato, Keizo, Otagiri, Masaki, Maruyama, Toru, Iwatani, Hirotsugu, Honda, Daisuke, Noguchi, Tsuyoshi, Tanaka, Motoko, Tanaka, Hisae, Fukagawa, Masafumi, Pircher, Joachim, Köppel, Simone, Mannell, Hanna, Krötz, Florian, Virzì, Grazia Maria, Bolin, Chiara, Cruz, Dinna, Scalzotto, Elisa, De Cal, Massimo, Vescovo, Giorgio, Ronco, Claudio, Gröbmayr, Regina, Lech, Maciej, Ryu, MI, Aoshima, Yumie, Mizobuchi, Masahide, Ogata, Hiroaki, Kumata, Chiaki, Nakazawa, Ai, Kondo, Fumiko, Ono, Naoko, Koiwa, Fumihiko, Kinugasa, Eriko, Freisinger, Wolfgang, Lale, Nena, Lampert, Angelika, Ditting, Tilmann, Heinlein, Sonja, Schmieder, Roland E., Veelken, Roland, Nave, Heike, Perthel, Ronny, Suntharalingam, Mayuren, Bode-Böger, Stefanie, Beutel, Gernot, Kielstein, Jan, Rodrigues-Díez, Raquel, Rodrigues-Diez, Raul, Rayego-Mateos, Sandra, Lavoz, Carolina, Stark Aroeira, Luiz Guilherme, Orejudo, Macarena, Alique, Matilde, Ortiz, Alberto, Egido, Jesus, Ruiz-Ortega, Marta, Oskar, Wischnewski, Rusan, Catar, Padberg, Jan-Sören, Wiesinger, Anne, Reuter, Stefan, Grabner, Alexander, Kentrup, Dominik, Lukasz, Alexander, Oberleithner, Hans, Pavenstädt, Hermann, Kümpers, Philipp, Eberhardt, Hannes U, Skerka, Christine, Chen, Qian, Hallstroem, Teresia, Hartmann, Andrea, Kemper, Markus J, Zipfel, Peter F, N'gomé-Sendeyo, Kélhia, Fan, Qing-Feng, Pawlak, André, Toblli, Jorge, Cao, Gabriel, Giani, Jorge Fernando, Dominici, Fernando Pablo, Kim, Jae Seok, Yang, Jae Won, Kim, Min Keun, Han, Byoung Geun, Choi, Seung Ok

مصطلحات موضوعية: Abstracts

الوصف: Introduction and Aims: Interstitial fibrosis and tubular atrophy (IF/TA) are the major mechanisms of long-term renal graft loss, and no treatment can reverse fibrosis once it has developped. Early markers are needed to assess patients at risk of IF/TA and invent early interventions. Our previous studies showed that tubular epithelial phenotype changes (EPC), reminiscent of the epithelial to mesenchymal transition (EMT) process, constitute an early biomarker that predicts late renal graft fibrosis and loss of function. However, the mechanisms that link EPC and tissue fibrosis remain to be identified. The hypothesis that interstitial fibroblasts may be derived from tubular epithelial cells is vividly disputed. In the present study, we wanted to test the hypothesis that activated epithelial cells exhibiting EMT-like changes could, by an autocrine or paracrine signaling mechanism, produce extracellular matrix components and thereby directly contribute to fibrogenesis, even within renal tubules. Methods: Using immunohistochemistry we detected the presence in tubular cells of a) Connective Tissue Growth Factor (CTGF), a key mediator of fibrogenesis, b) HSP47, an important chaperon protein for collagen synthesis, and 3) laminin, a major component of the basement membranes, in 93 renal graft biopsies from 77 patients. We then analyzed the association between these three molecules and the intensity of two EPC/EMT markers (the de novo expression of vimentin and the translocation of β catenin into the cytoplasm). Results: We observed an up-regulated production of CTGF, hsp47, and laminin in the tubular epithelial cells of most renal transplants. These pro-fibrotic molecules colocalized in tubules showing EPC markers. In particular, the score of expression of the mesenchymal cell marker vimentin was significantly correlated with that of CTGF (r=0.79, p<0.0001), HSP47 (r=0.89, p<0.0001) and laminin (r=0.84, p<0.0001). In addition, the expression of vimentin in renal grafts was significantly correlated with the ...

وصف الملف: text/html

العلاقة: http://ndt.oxfordjournals.org/cgi/content/short/27/suppl_2/ii427Test; http://dx.doi.org/10.1093/ndt/gfs241Test

الإتاحة: https://doi.org/10.1093/ndt/gfs241Test
http://ndt.oxfordjournals.org/cgi/content/short/27/suppl_2/ii427Test

المؤلفون: Imai, Enyu, Takenaka, Masaru, Nagasawa, Yasuyuki, Kaimori, Jyunya, Hori, Masatugu

مصطلحات موضوعية: Pathophysiology of Tubulointerstitial Disease

وصف الملف: text/html

العلاقة: http://ndt.oxfordjournals.org/cgi/content/short/15/suppl_6/78Test; http://dx.doi.org/10.1093/ndt/15.suppl_6.78Test

الإتاحة: https://doi.org/10.1093/ndt/15.suppl_6.78Test
http://ndt.oxfordjournals.org/cgi/content/short/15/suppl_6/78Test

المؤلفون: Omori, Hiroki, Kawada, Noritaka, Inoue, Kazunori, Ueda, Yoshiyasu, Yamamoto, Ryohei, Matsui, Isao, Kaimori, Jyunya, Takabatake, Yoshitsugu, Moriyama, Toshiki, Isaka, Yoshitaka, Rakugi, Hiromi

المصدر: Clinical and Experimental Nephrology ; volume 16, issue 4, page 549-556 ; ISSN 1342-1751 1437-7799

مصطلحات موضوعية: Physiology (medical), Nephrology, Physiology

الإتاحة: https://doi.org/10.1007/s10157-012-0609-3Test

المؤلفون: Horio, Masaru, Yasuda, Yoshinari, Kaimori, Jyunya, Ichimaru, Naotsugu, Isaka, Yoshitaka, Takahara, Shiro, Nishi, Shinichi, Uchida, Kazuharu, Takeda, Asami, Hattori, Ryohei, Kitada, Hidehisa, Tsuruya, Kazuhiko, Imai, Enyu, Takahashi, Kota, Watanabe, Tsuyoshi, Matsuo, Seiichi

المصدر: Clinical and Experimental Nephrology ; volume 16, issue 3, page 415-420 ; ISSN 1342-1751 1437-7799

مصطلحات موضوعية: Physiology (medical), Nephrology, Physiology

الإتاحة: https://doi.org/10.1007/s10157-012-0586-6Test

المؤلفون: Imamura, Ryoichi, Isaka, Yoshitaka, Sandoval, Ruben M., Ichimaru, Naotsugu, Abe, Toyofumi, Okumi, Masayoshi, Yazawa, Koji, Kitamura, Harumi, Kaimori, Jyunya, Nonomura, Norio, Rakugi, Hiromi, Molitoris, Bruce A., Takahara, Shiro

المصدر: Clinical and Experimental Nephrology ; volume 16, issue 6, page 852-862 ; ISSN 1342-1751 1437-7799

مصطلحات موضوعية: Physiology (medical), Nephrology, Physiology

الإتاحة: https://doi.org/10.1007/s10157-012-0647-xTest