يعرض 61 - 70 نتائج من 1,155 نتيجة بحث عن '"K. Link"', وقت الاستعلام: 1.41s تنقيح النتائج
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    دورية أكاديمية

    المؤلفون: A. Aab, P. Abreu, M. Aglietta, I. F. M. Albuquerque, I. Allekotte, A. Almela, J. Alvarez Castillo, J. Alvarez-Muñiz, G. A. Anastasi, L. Anchordoqui, B. Andrada, S. Andringa, C. Aramo, N. Arsene, H. Asorey, P. Assis, G. Avila, A. M. Badescu, A. Balaceanu, F. Barbato, R. J. Barreira Luz, J. J. Beatty, K. H. Becker, J. A. Bellido, C. Berat, M. E. Bertaina, X. Bertou, P. L. Biermann, J. Biteau, S. G. Blaess, A. Blanco, J. Blazek, C. Bleve, M. Boháčová, C. Bonifazi, N. Borodai, A. M. Botti, J. Brack, I. Brancus, T. Bretz, A. Bridgeman, F. L. Briechle, P. Buchholz, A. Bueno, S. Buitink, M. Buscemi, K. S. Caballero-Mora, L. Caccianiga, A. Cancio, F. Canfora, R. Caruso, A. Castellina, F. Catalani, G. Cataldi, L. Cazon, A. G. Chavez, J. A. Chinellato, J. Chudoba, R. W. Clay, A. C. Cobos Cerutti, R. Colalillo, A. Coleman, L. Collica, M. R. Coluccia, R. Conceição, G. Consolati, F. Contreras, M. J. Cooper, S. Coutu, C. E. Covault, J. Cronin, S. D’Amico, B. Daniel, S. Dasso, K. Daumiller, B. R. Dawson, R. M. de Almeida, S. J. de Jong, G. De Mauro, J. R. T. de Mello Neto, I. De Mitri, J. de Oliveira, V. de Souza, J. Debatin, O. Deligny, M. L. Díaz Castro, F. Diogo, C. Dobrigkeit, J. C. D’Olivo, Q. Dorosti, R. C. dos Anjos, M. T. Dova, A. Dundovic, J. Ebr, R. Engel, M. Erdmann, M. Erfani, C. O. Escobar, J. Espadanal, A. Etchegoyen, H. Falcke, J. Farmer, G. Farrar, A. C. Fauth, N. Fazzini, F. Fenu, B. Fick, J. M. Figueira, A. Filipčič, M. M. Freire, T. Fujii, A. Fuster, R. Gaïor, B. García, F. Gaté, H. Gemmeke, A. Gherghel-Lascu, P. L. Ghia, U. Giaccari, M. Giammarchi, M. Giller, D. Głas, C. Glaser, G. Golup, M. Gómez Berisso, P. F. Gómez Vitale, N. González, A. Gorgi, A. F. Grillo, T. D. Grubb, F. Guarino, G. P. Guedes, R. Halliday, M. R. Hampel, P. Hansen, D. Harari, T. A. Harrison, A. Haungs, T. Hebbeker, D. Heck, P. Heimann, A. E. Herve, G. C. Hill, C. Hojvat, E. Holt, P. Homola, J. R. Hörandel, P. Horvath, M. Hrabovský, T. Huege, J. Hulsman, A. Insolia, P. G. Isar, I. Jandt, J. A. Johnsen, M. Josebachuili, J. Jurysek, A. Kääpä, O. Kambeitz, K. H. Kampert, B. Keilhauer, N. Kemmerich, E. Kemp, J. Kemp, R. M. Kieckhafer, H. O. Klages, M. Kleifges, J. Kleinfeller, R. Krause, N. Krohm, D. Kuempel, G. Kukec Mezek, N. Kunka, A. Kuotb Awad, B. L. Lago, D. LaHurd, R. G. Lang, M. Lauscher, R. Legumina, M. A. Leigui de Oliveira, A. Letessier-Selvon, I. Lhenry-Yvon, K. Link, D. Lo Presti, L. Lopes, R. López, A. López Casado, R. Lorek, Q. Luce, A. Lucero, M. Malacari, M. Mallamaci, D. Mandat, P. Mantsch, A. G. Mariazzi, I. C. Mariş, G. Marsella, D. Martello, H. Martinez, O. Martínez Bravo, J. J. Masías Meza, H. J. Mathes, S. Mathys, J. Matthews, G. Matthiae, E. Mayotte, P. O. Mazur, C. Medina, G. Medina-Tanco, D. Melo, A. Menshikov, K. -D. Merenda, S. Michal, M. I. Micheletti, L. Middendorf, L. Miramonti, B. Mitrica, D. Mockler, S. Mollerach, F. Montanet, C. Morello, G. Morlino, M. Mostafá, A. L. Müller, G. Müller, M. A. Muller, S. Müller, R. Mussa, I. Naranjo, L. Nellen, P. H. Nguyen, M. Niculescu-Oglinzanu, M. Niechciol, L. Niemietz, T. Niggemann, D. Nitz, D. Nosek, V. Novotny, L. Nožka, L. A. Núñez, F. Oikonomou, A. Olinto, M. Palatka, J. Pallotta, P. Papenbreer, G. Parente, A. Parra, T. Paul, M. Pech, F. Pedreira, J. Pȩkala, R. Pelayo, J. Peña-Rodriguez, L. A. S. Pereira, M. Perlin, L. Perrone, C. Peters, S. Petrera, J. Phuntsok, T. Pierog, M. Pimenta, V. Pirronello, M. Platino, M. Plum, J. Poh, C. Porowski, R. R. Prado, P. Privitera, M. Prouza, E. J. Quel, S. Querchfeld, S. Quinn, R. Ramos-Pollan, J. Rautenberg, D. Ravignani, J. Ridky, F. Riehn, M. Risse, P. Ristori, V. Rizi, W. Rodrigues de Carvalho, G. Rodriguez Fernandez, J. Rodriguez Rojo, M. J. Roncoroni, M. Roth, E. Roulet, A. C. Rovero, P. Ruehl, S. J. Saffi, A. Saftoiu, F. Salamida, H. Salazar, A. Saleh, G. Salina, F. Sánchez, P. Sanchez-Lucas, E. M. Santos, E. Santos, F. Sarazin, R. Sarmento, C. Sarmiento-Cano, R. Sato, M. Schauer, V. Scherini, H. Schieler, M. Schimp, D. Schmidt, O. Scholten, P. Schovánek, F. G. Schröder, S. Schröder, A. Schulz, J. Schumacher, S. J. Sciutto, A. Segreto, A. Shadkam, R. C. Shellard, G. Sigl, G. Silli, R. Šmída, G. R. Snow, P. Sommers, S. Sonntag, J. F. Soriano, R. Squartini, D. Stanca, S. Stanič, J. Stasielak, P. Stassi, M. Stolpovskiy, F. Strafella, A. Streich, F. Suarez, M. Suarez Durán, T. Sudholz, T. Suomijärvi, A. D. Supanitsky, J. Šupík, J. Swain, Z. Szadkowski, A. Taboada, O. A. Taborda, V. M. Theodoro, C. Timmermans, C. J. Todero Peixoto, L. Tomankova, B. Tomé, G. Torralba Elipe, P. Travnicek, M. Trini, R. Ulrich, M. Unger, M. Urban, J. F. Valdés Galicia, I. Valiño, L. Valore, G. van Aar, P. van Bodegom, A. M. van den Berg, A. van Vliet, E. Varela, B. Vargas Cárdenas, R. A. Vázquez, D. Veberič, C. Ventura, I. D. Vergara Quispe, V. Verzi, J. Vicha, L. Villaseñor, S. Vorobiov, H. Wahlberg, O. Wainberg, D. Walz, A. A. Watson, M. Weber, A. Weindl, M. Wiedeński, L. Wiencke, H. Wilczyński, M. Wirtz, D. Wittkowski, B. Wundheiler, L. Yang, A. Yushkov, E. Zas, D. Zavrtanik, M. Zavrtanik, A. Zepeda, B. Zimmermann, M. Ziolkowski, Z. Zong, F. Zuccarello

    المساهمون: A. Aab, P. Abreu, M. Aglietta, I.F.M. Albuquerque, I. Allekotte, A. Almela, J. Alvarez Castillo, J. Alvarez-Muñiz, G.A. Anastasi, L. Anchordoqui, B. Andrada, S. Andringa, C. Aramo, N. Arsene, H. Asorey, P.A. G. Avila, A.M. Badescu, A. Balaceanu, F. Barbato, R.J. Barreira Luz, J.J. Beatty, K.H. Becker, J.A. Bellido, C. Berat, M.E. Bertaina, X. Bertou, P.L. Biermann, J. Biteau, S.G. Blae, A. Blanco, J. Blazek, C. Bleve, M. Boháčová, C. Bonifazi, N. Borodai, A.M. Botti, J.B. I. Brancu, T. Bretz, A. Bridgeman, F.L. Briechle, P. Buchholz, A. Bueno, S. Buitink, M. Buscemi, K.S. Caballero-Mora, L. Caccianiga, A. Cancio, F.C. R. Caruso, A. Castellina, F. Catalani, G. Cataldi, L. Cazon, A.G. Chavez, J.A. Chinellato, J. Chudoba, R.W. Clay, A.C. Cobos Cerutti, R. Colalillo, A. Coleman, L. Collica, M.R. Coluccia, R.C. G. Consolati, F. Contrera, M.J. Cooper, S. Coutu, C.E. Covault, J. Cronin, S. D’Amico, B.D. S. Dasso, K. Daumiller, B.R. Dawson, R.M. de Almeida, S.J. de Jong, G.D.M. J. R. T. de Mello Neto, I. De Mitri, J. de Oliveira, V. de Souza, J. Debatin, O. Deligny, M.L. Díaz Castro, F. Diogo, C. Dobrigkeit, J.C. D’Olivo, Q. Dorosti, R.C. dos Anjo, M.T. Dova, A. Dundovic, J. Ebr, R. Engel, M. Erdmann, M. Erfani, C.O. Escobar, J. Espadanal, A. Etchegoyen, H. Falcke, J. Farmer, G. Farrar, A.C. Fauth, N. Fazzini, F. Fenu

    العلاقة: info:eu-repo/semantics/altIdentifier/wos/WOS:000424053800003; volume:853; issue:2; numberofpages:10; journal:THE ASTROPHYSICAL JOURNAL LETTERS; http://hdl.handle.net/2434/549406Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85041621635

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    دورية أكاديمية

    المؤلفون: S. Jafarov, K. Link H.

    المصدر: Siberian journal of oncology; Том 17, № 4 (2018); 88-98 ; Сибирский онкологический журнал; Том 17, № 4 (2018); 88-98 ; 2312-3168 ; 1814-4861 ; 10.21294/1814-4861-2018-17-4

    وصف الملف: application/pdf

    العلاقة: https://www.siboncoj.ru/jour/article/view/821/559Test; Link K.H., Kornmann M., Staib L., Redenbacher M., Kron M., Beger H.G.; Study Group Oncology of Gastrointestinal Tumors. Increase of survival benefit in advanced resectable colon cancer by extent of adjuvant treatment. Ann Surg. 2005 Aug; 242(2): 178–87.; Kornmann M., Staib L., Wiegel T., Kreuser E.D., Kron M., Baumann W., Henne-Bruns D., Link K.H. Adjuvant chemoradiotherapy of advanced resectable rectal cancer: results of a randomised trial comparing modulation of 5-fluoruracil with acid or with interferon- alpha. Br J Cancer. 2010 Oct 12; 103(8): 1163–72. doi:10.1038/sj.bjc.6605871.; Pox C., Aretz S., Bischoff S., Graeven U., Hass M., Heußner P., Hohenberger W., Holstege A., Hübner J., Kolligs F., Kreis M., Lux P., Ockenga J., Porschen R., Post S., Rahner N., Reinacher-Schick A., Riemann J., Sauer R., Sieg A., Scheppach W., Schmitt W., Schmoll H.J., Schulmann K., Tannapfel A., Schmiegel W. S3-Leitlinie „Kolorektales Karzinom“. Z Gastroenterol. 2013; 51: 753–854.; Heald R.J., Moran B.J. Embryology and anatomy oft the rectum. Semin Surg Oncol. 1998; 15: 66–71.; Köckerling F., Lippert H., Gastinger I. Fortschritte in der kolorektalen Chirurgie. Hannover, Science Med, 2002. 204.; Winkler R., Otto P., Schiedeck T. Proktologie: Ein Leitfaden für die Praxis. 2. Aufl. Stuttgart, Thieme, 2011. 7.; Barleben A., Mills S. Anorectal anatomy and physiology. Surg Clin North Am. 2010 Feb; 90(1): 1–15. doi:10.1016/j.suc.2009.09.001.; Dujovny N., Quiros R.M., Saclarides T.J. Anorectal anatomy and embryology. Surg Oncol Clin N Am. 2004 Apr; 13(2): 277‑93.; Kornmann M., Staib L., Wiegel T., Kron M., Henne-Bruns D., Link K.H., Formentini A.; Study Group Oncology of Gastrointestinal Tumors (FOGT). Differences in colon and rectal cancer chemosensitivity. Colorectal Cancer 2014; 3: 93–105.; Jafarov S., Kornmann M., Scheele J., Farah G., Hübener P., Link K.H. Differences between colon and rectal cancer. Internationaler Kongress ICRCC; Ulm. 9 Oktober 2014.; Paulsen F., Waschke J. Sobotta, Atlas der Anatomie des Menschen. 23. Aufl. München: Elsevier, 2010. 99–100.; Willis S., Schumpelick V. Rektumkarzinom. in Onkologische Chirurgie. 3. Aufl. Berlin, Heidelberg: Springer, 2010. 713–732.; Schumacher G.H., Aumüller G. Topographische Anatomie des Menschen. 7. Auf. München: Elsevier, 2004. 256–296.; Henne-Bruns D., Dürig M., Kremer B. Chirurgie. 3. Aufl. Stuttgart: Thieme, 2008. 201–221.; Schünke M., Schulte E., Schumacher U. Prometheus – Innere Organe: LernAtlas der Anatomie. 4. Aufl. Stuttgart: Thieme, 2015. 512.; Hiddemann W., Bartram C.R. Die Onkologie. 2. Aufl. Heidelberg: Springer-Medizin, 2010. 854.; Hamilton S.R., Aaltonen L.A. World Health Organisation. Classification of tumours. Pathology and genetics of tumours of the digestive system. Lyon, IARC, 2000. 314.; Werner M. Allgemein Onkogenese und Tumorpathologie. in Onkologische Chirurgie. 3. Aufl. Berlin,Heidelberg: Springer, 2010. 4–10.; Hermanek P., Mansmann P.U., Altendorf-Hofmann A., Hermanek P.Jr., Riedl St., Staimmer D. Vergleichende Beurteilung der onkologischen Ergebnisqualität beim colorectalen Carcinom. Klinikvergleiche anhand von Surrogatendpunkten? Der Chirurg 1999; 70: 407–414.; Wittekind C. Tumorklassifikationen. in Siewert JR, Rothmund M, Schumpelick V (eds): Onkologische Chirurgie. 3. Aufl. Berlin, Heidelberg: Springer, 2010. 20–28.; Tannapfel A. Präkanzerösen und molekulare Marker. in Onkologische Chirurgie. 3. Aufl. Berlin, Heidelberg: Springer, 2010. 14–17.; Ferlay J., Autier P., Boniol M., Heanue M., Colombet M., Boyle P. Estimates of the cancer incidence and mortality in Europe in 2006. Ann Oncol 2007; 18: 581–592.; WHO Mortality Database 2009 [Internet]. URL: https://www.health.govt.nz/system/files/documents/publications/mortality-andTest- demographic-data-2009.pdf (cited 12.02.2014).; Riboli E. Nutrition and cancer: background and rationale of the European Prospective Investigation into Cancer and Nutrition (EPIC). Ann Oncol. 1992; 10: 783–791.; Ruf G., Hopt U., Otto F., Deschler B., Werner M., Barke A., Langer M., Schäfer O., Moser E., Brink I., Henß H. Kolorektales Karzinom, Empfehlungen zur standardisierten Diagnostik, Therapie und Nachsorge. Tumorzentrum Freiburg am Universitätsklinikum, 2005.; Schmidt-Decker S., Brannath J., Teichmann W. Häufigkeit und Lokalisation kolorektaler Adenome und Karzinome bei 4109 Patienten. Dtsch med Wochenschr 1990; 115(48): 1819–1824. doi:10.1055/s-2008-1065231.; Mostafa G., Matthews B.D., Norton H.J., Kercher K.W., Sing R.F., Heniford B.T. Influence of demographics on colorectal cancer. Ann Surg 2004; 70: 259–264.; Benedix F., Meyer F., Kube R., Gastinger I., Lippert H. Right- and left-sided colonic cancer – different tumour entities. Zentralbl Chir. 2010 Aug; 135(4): 312–7. doi:10.1055/s-0030-1247471.; Siegel R., Ma J., Zou Z., Jemal A. Cancer Statistics, 2014. CA: Cancer J Clin 2014; 64: 9–29.; Link K.H., Coy P., Roitman M., Link C., Kornmann M., Staib L. Minimum volume discussion in the treatment of colon and rectal cancer: a review of the current status and relevance of surgeon and hospital volume regarding result quality and the impact on health economics. Visc Med. 2017 May; 33(2): 140–147. doi:10.1159/000456044.; American Cancer Society: Cancer Facts and Figures 2015. Atlanta, Ga: American Cancer Society, 2015. [Internet] http://www.cancer.org/acs/groups/content/@editorial/documents/document/acspcTest- 044552.pdf(cited 07.01.2015).; Konishi K., Fujii T., Boku N., Kato S., Koba I., Ohtsu A., Tajiri H., Ochiai A., Yoshida S. Clinicopathological differences between colonic and rectal carcinomas: are they based on the same mechanism of carcinogenesis? Gut 1999; 45: 818–821.; Lynch H.T., Smyrk T.C. Classification of familial adenomatous polyposis: a diagnostic nightmare. Am J Hum Genet 1998; 62: 1288–1289.; Lynch H.T., Lynch J.F., Shaw T.G., Lubinski J. HNPCC (Lynch Syndrome): differential diagnosis, molecular genetics and management – a review. Hered Cancer Clin Pract 2003; 1: 7–18.; Nawa T., Kato J., Kawamoto H., Okada H., Yamamoto H., Kohno H., Endo H., Shiratori Y. Differences between right- and left-sided colon cancer in patient characteristics, cancer morphology and histology. J Gastroenterol Hepatol. 2008 Mar; 23(3): 418–23. doi:10.1111/j.1440-1746.2007.04923.x.; Schmiegel W., Reinacher-Schick A., Arnold D., Graeven U., Heinemann V., Porschen R., Riemann J., Rödel C., Sauer R., Wieser M., Schmitt W., Schmoll H-J., Seufferlein T., Kopp I., Pox C. S3-Leitlinie „Kolorektales Karzinom“. Z Gastroenterol 2008; 46: 799–840.; Lynch H.T., Smyrk T., McGinn T., Lanspa S., Cavalieri J., Lynch J., Slominski-Castor S., Cayouette M.C., Priluck I., Luce M.C. Attenuated familial adenomatous polyposis (AFAP). A phenotypically and genotypically distinctive variant of FAP. Cancer 1995; 76: 2427–2433.; Jafarov S., Kornmann M., Knoefel W.T., Link K.H. Unterschiede zwischen Kolonkarzinom und Rektumkarzinom. Z Gastroenterol 2016; 54: KV393.; Jass J.R. Classification of colorectal cancer based on correlation of clinical, morphological and molecular features. Histopathology 2007; 50: 113–130.; Tian S., Roepman P., Popovici V., Michaut M., Majewski I., Salazar R., Santos C., Rosenberg R., Nitsche U., Mesker W.E., Bruin S., Tejpar S., Delorenzi M., Bernards R., Simon I. A robust genomic signature for the detection of colorectal cancer patients with microsatellite instability phenotype and high mutation frequency. J Pathol. 2012 Dec; 228(4): 586–95. doi:10.1002/path.4092.; Budinska E., Popovici V., Tejpar S., D’Ario G., Lapique N., Sikora K.O., Di Narzo A.F., Yan P., Hodgson J.G., Weinrich S., Bosman F., Roth A., Delorenzi M. Gene expression patterns unveil a new level of molecular heterogeneity in colorectal cancer. J Pathol. 2013 Sep; 231(1): 63–76. doi:10.1002/path.4212.; Nehls O., Okech T., Hsieh C.J., Enzinger T., Sarbia M., Borchard F., Gruenagel H.H., Gaco V., Hass H.G., Arkenau H.T., Hartmann J.T., Porschen R., Gregor M., Klump B. Studies on p53, BAX and Bcl-2 protein expression and microsatellite instability in stage III (UICC) colon cancer treated by adjuvant chemotherapy: major prognostic impact of proapoptotic BAX. Br J Cancer 2007; 96: 1409–1418.; Reimers M.S., Zeestraten E.C.M., Kuppen P.J.K., Liefers G.J., van de Velde C.J.H. Biomarkers in precision therapy in colorectal cancer. Gastroenterol Rep (Oxf). 2013 Nov; 1(3): 166–83. doi:10.1093/gastro/got022.; Peltomaki P., Vasen H.F. Mutations predisposing to hereditary nonpolyposis colorectal cancer: database and results of a collaborative study. The International Collaborative Group on Hereditary Nonpolyposis Colorectal Cancer. Gastroenterology. 1997 Oct; 113(4): 1146–58.; Vogelsang H., Holinski-Feder E., Gross M., Keller G., Keller M., Kopp R., Lohse P., Müller-Koch Y., Neutzling A. Hereditäre Tumorerkrankungen des Gastrointestinaltrakts. in Manual Gastrointestinale Tumoren. 6. Aufl. München, Zuckschwerdt, 2001. 261–283.; Kullmann F., Bocker T., Schölmerich J., Rüschoff J. Microsatellite instability – a new aspect in genetics and molecular biology of hereditary nonpolyposis and sporadic colorectal tumors. Z Gastroenterol 1996; 34(12): 813–822.; Rad R., Cadinanos J., Rad L., Varela I., Strong A., Kriegl L., Constantino-Casas F., Eser S., Hieber M., Seidler B., Price S., Fraga M.F., Calvanese V., Hoffman G., Ponstingl H., Schneider G., Yusa K., Grove C., Schmid R.M., Wang W., Vassiliou G., Kirchner T., McDermott U., Liu P., Saur D., Bradley A. A genetic progression model of Braf (V600E)-induced intestinal tumorigenesis reveals targets for therapeutic intervention. Cancer Cell 2013; 24: 15–29. doi:10.1016/j.ccr.2013.05.014.; Popovici V., Budinska E., Tejpar S., Weinrich S., Estrella H., Hodgson G., Van Cutsem E., Xie T., Bosman F.T., Roth A.D., Delorenzi M. Identification of a poor-prognosis BRAF-mutant-like population of patients with colon cancer. J Clin Oncol. 2012 Apr 20; 30(12): 1288–95. doi:10.1200/JCO.2011.39.5814.; Ogino S., Goel A. Molecular classification and correlates in colorectal cancer. J Mol Diagn. 2008 Jan; 10(1): 13–27. doi:10.2353/jmoldx.2008.070082.; Sanz-Pamplona R., Cordero D., Berenguer A., Lejbkowicz F., Rennert H., Salazar R., Biondo S., Sanjuan X., Pujana M.A., Rozek L., Giordano T.J., Ben-Izhak O., Cohen H.I., Trougouboff P., Bejhar J., Sova Y., Rennert G., Gruber S.B., Moreno V. Gene expression differences between colon and rectal tumors. Clin Cancer Res. 2011 Dec 1; 17(23): 7303–12. doi:10.1158/1078-0432.CCR-11-1570.; Markowitz S.D., Bertagnolli M.M. Molecular origins of cancer: Molecular basis of colorectal cancer. N Engl J Med. 2009 Dec 17; 361(25): 2449–60. doi:10.1056/NEJMra0804588.; Rozek L.S., Lipkin S.M., Fearon E.R., Hanash S., Giordano T.J., Greenson J.K., Kuick R., Misek D.E., Taylor J.M., Douglas J.A., Rennert G., Gruber S.B. CDX2 polymorphisms, RNA expression, and risk of colorectal cancer. Cancer Res 2005; 65: 5488–5492. doi:10.1158/0008-5472.CAN-04-3645.; Slattery M.L., Potter J.D., Caan B., Edwards S., Coates A., Ma K.N., Berry T.D. Energy balance and colon cancer – beyond physical activity. Cancer Res 1997; 57: 75–80.; Iacopetta B. Are there two sides to colorectal cancer? Int J Cancer. 2002 Oct 10; 101(5): 403–8. doi:10.1002/ijc.10635.; Watanabe T., Kobunai T., Toda E., Yamamoto Y., Kanazawa T., Kazama Y., Tanaka J., Tanaka T., Konishi T., Okayama Y., Sugimoto Y., Oka T., Sasaki S., Muto T., Nagawa H. Distal colorectal cancers with microsatellite instability (MSI) display distinct gene expression profiles that are different from proximal MSI cancers. Cancer Res. 2006 Oct 15; 66(20): 9804–8.; Smith K.J., Johnson K.A., Bryan T.M., Hill D.E., Markowitz S., Willson J.K., Paraskeva C., Petersen G.M., Hamilton S.R., Vogelstein B. The APC gene product in normal and tumor cells. Proc Natl Acad Sci U S A. 1993 Apr 1; 90(7): 2846–50.; Missiaglia E., Jacobs B., D’Ario G., Di Narzo A.F., Soneson C., Budinska E., Popovici V., Vecchione L., Gerster S., Yan P., Roth A.D., Klingbiel D., Bosman F.T., Delorenzi M., Tejpar S. Distal and proximal colon cancers differ in terms of molecular, pathological, and clinical features. Ann Oncol. 2014 Oct; 25(10): 1995–2001. doi:10.1093/annonc/mdu275.; Klump B., Nehls O., Okech T., Hsieh C.J., Gaco V., Gittinger F.S., Sarbia M., Borchard F., Greschniok A., Gruenagel H.H., Porschen R., Gregor M. Molecular lesions in colorectal cancer: impact on prognosis? Int J Colorectal Dis. 2004 Jan; 19(1): 23–42. doi:10.1007/s00384-003-0499-7.; Slattery M.L., Curtin K., Wolff R.K., Boucher K.M., Sweeney C., Edwards S., Caan B.J., Samowitz W. A comparison of colon and rectal somatic DNA alterations. Dis Colon Rectum. 2009 Jul; 52(7): 1304–11. doi:10.1007/DCR.0b013e3181a0e5df.; Aamodt R., Jonsdottir K., Andersen S.N., Bondi J., Bukholm G., Bukholm I.R.K. Differences in protein expression and gene amplification of cyclins between colon and rectal adenocarcinomas. Gastroenterol Res Pract. 2009; 2009: 285830. doi:10.1155/2009/285830.; Chung D.C. The genetic basis of colorectal cancer: Insights into critical pathways of tumorigenesis. Gastroenterology. 2000 Sep; 119(3): 854–65.; Mann B., Gelos M., Siedow A., Hanski M.L., Gratchev A., Ilyas M., Bodmer W.F., Moyer M.P., Riecken E.O., Buhr H.J., Hanski C. Target genes of beta-catenin-T cell- factor/lymphoid-enhancer-factor signalling in human colorectal carcinomas. Proc Natl Acad Sci USA. 1999 Feb 16; 96(4): 1603–8.; Harris C.C., Hollstein M. Clinical implications of the p53 tumorsuppressor gene. N Engl J Med 1993; 329: 1318–1327. doi:10.1056/NEJM199310283291807.; Spears C.P., Gustavsson B.G., Berne M., Frösing R., Bernstein L., Hayes A.A. Mechanisms of innate resistance to thymidylate synthase inhibition after 5-fluorouracil. Cancer Res. 1988 Oct 15; 48(20): 5894–900.; Lenz H.J., Danenberg K.D., Leichman C.G., Florentine B., Johnston P.G., Groshen S., Zhou L., Xiong Y.P., Danenberg P.V., Leichman L.P. p53 and thymidylate synthase expression in untreated stage II colon cancer: associations with recurrence, survival, and site. Clin Cancer Res 1998; 4: 1227–1234.; Takenou T., Nagawa H., Matsuda K., Fuji S., Nita M.E., Hatano K., Kitayama J., Tsuruo Y., Muto T. Relation between thymidylate synthase expression and survival in colon carcinoma, and determination of appropriate application of 5-fluorouracil by immunohistochemical method. Ann Surg Oncol 2000; 7: 193–198.; Kornmann M., Schwabe W., Sander S., Kron M., Sträter J., Polat S., Kettner E., Weiser H.F., Baumann W., Schramm H., Häusler P., Ott K., Behnke D., Staib L., Beger H.G., Link K.H. Thymidylate synthase and dihydropyrimidine dehydrogenase mRNA expression levels. Predictors for survival in colorectal cancer patients receiving adjuvant 5-fluorouracil. Clin Cancer Res 2003; 9: 4116–4124.; Donada M., Bonin S., Nardon E., De Pellegrin A., Decorti G., Stanta G. Thymidilate synthase expression predicts longer survival in patients with stage II colon cancer treated with 5-fluorouracil independently of microsatellite instability. J Cancer Res Clin Oncol. 2011 Feb; 137(2):201–10. doi:10.1007/s00432-010-0872-1.; Edler D., Kressner U., Ragnhammar P., Johnston P.G., Magnusson I., Glimelius B., Pahlman L., Lindmark G., Blomgren H. Immunohistochemically detected thymidylate synthase in colorectal cancer: an independent prognostic factor of survival. Clin Cancer Res 2000: 6: 488–492.; Edler D., Hallström M., Johnston P.G., Magnusson I., Ragnhammar P., Blomgren H. Thymidylate synthase expression: an independent prognostic factor for local recurrence, distant metastasis, disease-free and overall survival in rectal cancer. Clin Cancer Res 2000; 6: 1378–1384.; Liersch T., Langer C., Ghadimi B.M., Kulle B., Aust D.E., Baretton G.B., Schwabe W., Häusler P., Becker H., Jakob C. Lymph node status and TS gene expression are prognostic markers in stage II/III rectal cancer after neoadjuvant fluorouracil-based chemoradiotherapy. J Clin Oncol 2006; 24: 4062–4068.; Jakob C., Liersch T., Meyer W.,Baretton G.B., Schwabe W., Häusler P., Kulle B., Becker H., Aust D.E. Prognostic value of histologic tumor regression, thymidylate synthase, thymidine phosphorylase, and dihydropyrimidine dehydrogenase in rectal cancer UICC Stage II/III after neoadjuvant chemoradiotherapy. Am J Surg Pathol 2006; 30: 1169–1174. doi:10.1097/01.pas.0000213302.13435.6e.; Conradi L.C., Bleckmann A., Schirmer M., Sprenger T., Jo P., Homayounfar K., Wolff H.A., Rothe H., Middel P., Becker H., Ghadimi M.B., Beissbarth T., Liersch T. Thymidylate synthase as a prognostic biomarker for locally advanced rectal cancer after multimodal treatment. Ann Surg Oncol. 2011 Sep; 18(9): 2442–52. doi:10.1245/s10434-011-1608-4.; Rijcken F.E., Hollema H., Kleibeuker J.H. Proximal adenomas in hereditary non- polyposis colorectal cancer are prone to rapid malignant transformation. Gut 2002; 50: 382–386.; Petersen G.M. Knowledge of the adenomatous polyposis coli gene and its clinical application. Ann Med 1994; 26: 205–208.; Kinzler K.W., Vogelstein B. Lessons from hereditary colorectal cancer. Cell 1996; 87: 159–170.; Guinney J., Dienstmann R., Wang X., de Reyniès A., Schlicker A., Soneson C., Marisa L., Roepman P., Nyamundanda G., Angelino P., Bot B.M., Morris J.S., Simon I.M., Gerster S., Fessler E., De Sousa E., Melo F., Missiaglia E., Ramay H., Barras D., Homicsko K., Maru D., Manyam G.C., Broom B., Boige V., Perez-Villamil B., Laderas T., Salazar R., Gray J.W., Hanahan D., Tabernero J., Bernards R., Friend S.H., Laurent- Puig P., Medema J.P., Sadanandam A., Wessels L., Delorenzi M., Kopetz S., Vermeulen L., Tejpar S. The consensus molecular subtypes of colorectal cancer. Nat Med. 2015 Nov; 21(11): 1350–6. doi:10.1038/nm.3967.; Hu W., Yang Y., Li X., Huang M., Xu F., Ge W., Zhang S., Zheng S. Multi-omics approach reveals distinct differences in left- and right-sided colon cancer. Mol Cancer Res. 2018 Mar; 16(3): 476–485. doi:10.1158/1541-7786.MCR-17-0483.; Link K.H., Heeckt P., Klein D., Schatz M. Ernährung & Krebs, Einfluss der Diät bei der Entstehung und Behandlung von Tumorerkrankungen. Ulm: Fabri-Verlag, 2000. 128.; Macfarlane G.J., Lowenfels A.B. Physical activity and colon cancer. Eur J Cancer Prev. 1994; 3: 393–398.; Halle M., Schoenberg M.H. Körperliche Aktivität in der Prävention und Therapie des kolorektalen Karzinoms. Dtsch Arztebl Int 2009; 106: 722–727.; McTiernan A. Physical activity after cancer: physiologic outcomes. Cancer Invest 2004; 22: 68–81.; Giovannucci E., Ascherio A., Rimm E.B., Colditz G.A., Stampfer M.J., Willett W.C. Physical activity, obesitiy and risk for colon cancer and adenoma in men. Ann Intern Med. 1995 Mar 1; 122(5): 327–34.; Gerhardsson de Verdier M., Steineck G., Hagman U., Rieger A., Norell S.E. Physical activity and colon cancer: a case-referent study in Stockholm. Int J Cancer. 1990; 46: 985–989.; Chao A., Connell C.J., Jacobs E.J., McCullough M.L., Patel A.V., Calle E.E., Cokkinides V.E., Thun M.J. Amount, type, and timing of recreational physical activity in relation to colon and rectal cancer in older adults: the Cancer Prevention Study II Nutrition Cohort. Cancer Epidemiol Biomarkers Prev. 2004 Dec; 13(12): 2187–95.; Larsson S.C., Wolk A. Obesity and colon and rectal cancer risk: a meta-analysis of prospective studies. Am J Clin Nutr 2007; 86: 556–565.; Friedenreich C., Norat T., Steindorf K., Boutron-Ruault M.C., Pischon T., Mazuir M., Clavel-Chapelon F., Linseisen J., Boeing H., Bergman M., Johnsen N.F., Tjonneland A., Overvad K., Mendez M., Quiros J.R., Martinez C., Dorronsoro M., Navarro C., Gurrea A.B., Bingham S., Khaw K.T., Allen N., Key T., Trichopoulou A., Trichopoulos D., Orfanou N., Krogh V., Palli D., Tumino R., Panico S., Vineis P., Bueno-de-Mesquita H.B., Peeters P.H., Monninkhof E., Berglund G., Manjer J., Ferrari P., Slimani N., Kaaks R., Riboli E. Physical activity and risk of colon and rectal cancers: the European prospective investigation into cancer and nutrition. Cancer Epidemiol Biomarkers Prev. 2006 Dec; 15(12): 2398–407.; Steinbach G., Lynch P.M., Phillips R.K., Wallace M.H., Hawk E., Gordon G.B., Wakabayashi N., Saunders B., Shen Y., Fujimura T., Su L.K., Levin B., Godio L., Patterson S., Rodriguez-Bigas M.A., Jester S.L., King K.L., Schumacher M., Abbruzzese J., DuBois R.N., Hittelman W.N., Zimmerman S., Sherman J.W., Kelloff G. The effect of celecoxib, a cyclooxygenase-2 inhibitor, in familial adenomatous polyposis. N Engl J Med. 2000 Jun 29; 342(26): 1946–52.; Higuchi T., Iwama T., Yoshinaga K., Toyooka M., Taketo M.M., Sugihara K. A randomized, double-blind, placebo-controlled trial of the effects of rofecoxib, a selective cyclooxygenase-2 inhibitor, on rectal polyps in familial adenomatous polyposis patients. Clin Cancer Res. 2003 Oct 15; 9(13): 4756–60.; Almendingen K., Larsen L.N., Fausa O., Bratlie J., Hostmark A.T., Aabakken L. Selective COX-2 inhibition affects fatty acids, but not COX mRNA expression in patients with FAP. Fam Cancer. 2010 Dec; 9(4): 571–80. doi:10.1007/s10689-010-9365-2.; Rothwell P.M., Wilson M., Elwin C.E., Norrving B., Algra A., Warlow C.P., Meade T.W. Long-term effect of aspirin on colorectal cancer incidence and mortality: 20-year follow-up of five randomised trials. Lancet. 2010 Nov 20; 376(9754): 1741–50. doi:10.1016/S0140-6736(10)61543-7.; Ritz J.P., Buhr H.J. Kolonkarzinom. in Onkologische Chirurgie. 3. Aufl. Berlin, Heidelberg: Springer, 2010. 694–711.; Weitz J., Koch M., Debus J., Höhler T., Galle P.R., Büchler M.W. Colorectal cancer. Lancet 2005; 365: 153–165. doi:10.1016/S0140-6736-(05)17706-X.; Senninger N., Colombo-Benkmann M. Chirurgie von Kolon- und Rektum: Aktuelle Trends und Therapie. Münster: Philippka, 2002. 9.; Vogelstein B., Fearon E.R., Hamilton S.R., Kern S.E., Preisinger A.C., Leppert M., Nakamura Y., White R., Smits A.M., Bos J.L. Genetic alterations during colorectal-tumor development. N Engl J Med. 1988 Sep 1; 319(9): 525–32.; Toribara N.W., Sleisenger M.H. Screening for colorectal cancer. N Engl J Med. 1995; 332: 861–867. doi:10.1056/NEJM199503303321306.; Vasen H.F., Moslein G., Alonso A., Bernstein I., Bertario L., Blan-co I., Burn J., Capella G., Engel C., Frayling I., Friedl W., Hes F.J., Hodgson S., Mecklin J.P., Moller P., Nagengast F., Parc Y., Renkonen- Sinisalo L., Sampson J.R., Stormorken A., Wijnen J. Guidelines for the clinical management of Lynch syndrome (hereditary non-polyposis cancer). J Med Genet. 2007; 44: 353–362. doi:10.1136/jmg.2007.048991.; Vasen H.F., Watson P., Mecklin J.P., Lynch H.T. New clinical criteria for hereditary nonpolyposis colorectal cancer (HNPCC, Lynch syndrome) proposed by the International Collaborative group on HNPCC. Gastroenterology 1999; 116: 1453–1456.; Holch J.W., Ricard I., Stintzing S., Modest D.P., Heinemann V. The relevance of primary tumour location in patients with metastatic colorectal cancer: A meta-analysis of first-line clinical trials. Eur J Cancer 2017; 70: 87–98.; Siegmund-Schultze N. Kolorektale Karzinome: Die Lage des Primarius zählt. Dtsch Arztebl 2017; 114: 20.; Johnston P.G., Fischer E.R., Rockette H.E., Fisher B., Wolmark N., Drake J.C., Chabner B.A., Allegra C.J. The role of thymidylate synthase expression in prognosis and outcome of adjuvant chemotherapy in patients with rectal cancer. J Clin Oncol. 1994 Dec; 12(12): 2640–7.; Edler D., Glimelius B., Hallström M., Jakobsen A., Johnston P.G., Magnusson I., Ragnhammar P., Blomgren H. Thymidylate synthase expression in colorectal cancer: a prognostic and predictive marker of benefit from adjuvant fluorouracil-based chemotherapy. J Clin Oncol 2002; 20: 1721–1728. doi:10.1200/JCO.2002.07.039.; Kornmann M., Link K.H., Lenz H.J., Pillasch J., Metzger R., Butzer U., Leder G.H., Weindel M., Safi F., Danenberg K.D., Beger H.G., Danenberg P.V. Thymidylate synthase is a predictor for response and resistance in hepatic artery infusion chemotherapy. Cancer Lett 1997; 118: 29–35.; Kornmann M., Hebart H., Danenberg K., Goeb R., Staib L., Kron M., Henne-Bruns D., Danenberg P., Link K.H. Response prediction in metastasised colorectal cancer using intratumoural thymidylate synthase: results of a randomised multicentre trial. Eur J Cancer 2012; 48: 1443–1451. doi:10.1016/j.ejca.2011.11.007.; https://www.siboncoj.ru/jour/article/view/821Test

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    دورية أكاديمية

    المصدر: Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)

    مصطلحات موضوعية: Science

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