المؤلفون: Masatomo Shimizu, Taiji Yokote, Jun Hatooka, Yuuki Kinoshita, Akihisa Imagawa, Emi Yasuda

المصدر: Case Reports in Oncology, Vol 17, Iss 1, Pp 602-607 (2024)

مصطلحات موضوعية: adult t-cell leukemia/lymphoma, cc chemokine receptor 4, immunomodulatory drug, lenalidomide, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

الوصف: Introduction: CC chemokine receptor 4 (CCR4), which is involved in leukocyte migration, is expressed in most tumor cells in patients with adult T-cell leukemia/lymphoma (ATLL). Case Presentation: Here we report the case of a 78-year-old man diagnosed with lymphoma-type ATLL expressing CCR4. The patient was administered two cycles of lenalidomide but died because of sepsis 5 months after the initial diagnosis. Autopsy revealed ATLL cells at several sites. Immunohistochemical analysis revealed that these ATLL cells had reduced CCR4 expression. Conclusion: The present case suggests that treatment should be carefully determined in ATLL with reference to a history of lenalidomide use and CCR4 expression.

وصف الملف: electronic resource

العلاقة: https://beta.karger.com/Article/FullText/539122Test; https://doaj.org/toc/1662-6575Test

الوصول الحر: https://doaj.org/article/4478b1b60e744b6c8f560f69e2c86b7fTest

المؤلفون: Masatomo Shimizu, Akihisa Imagawa, Yuki Kinoshita, Takuji Miyoshi, Toshikazu Akioka, Kazuki Tanabe, Taiji Yokote, Yui Arita, Tomoyuki Yamada, Yuki Masuda, Mitsuya Ueda, Jun Hatooka, Mayumi Fujimoto, Uta Nishiwaki, Kazuki Iwaki

المصدر: Leukemia & Lymphoma. 61:707-713

مصطلحات موضوعية: Oncology, Cancer Research, medicine.medical_specialty, animal structures, Antineoplastic Agents, Bortezomib, Electrocardiography, 03 medical and health sciences, 0302 clinical medicine, immune system diseases, hemic and lymphatic diseases, Internal medicine, Plasma Cell Myeloma, Humans, Medicine, In patient, skin and connective tissue diseases, Retrospective Studies, urogenital system, business.industry, Peripheral Nervous System Diseases, Retrospective cohort study, Hematology, medicine.disease, R-R Interval, Peripheral neuropathy, 030220 oncology & carcinogenesis, Toxicity, Multiple Myeloma, business, 030215 immunology, medicine.drug

الوصف: Bortezomib-induced peripheral neuropathy (BIPN) is a key dose-limiting toxicity in patients with plasma cell myeloma (PCM). This study examined 56 patients with PCM treated with bortezomib to determine the possible predisposing factors to BIPN with the R-R interval variation (RRIV) of the electrocardiogram (ECG). Of all, 17 patients developed Clinically obvious BIPN, grades 2-4 or grade worsening from the baseline neuropathy per the National Cancer Institute's Common Terminology Criteria for Adverse Events (v5.0). In the receiver operating characteristic curve analysis, the optimal RRIV cutoff value to distinguish patients with and without risk to develop BIPN was 1.391. A lower RRIV before bortezomib treatment independently correlated with the onset of Clinically obvious BIPN (

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c31fda2cfe8f3b9eba37fc9c7c751e80Test
https://doi.org/10.1080/10428194.2019.1678152Test

المؤلفون: Uta Nishiwaki, Ayami Fumimoto, Nobuya Hiraoka, Yuki Masuda, Taiji Yokote, Motomu Tsuji, Takuji Miyoshi, Jun Hatooka, Kazuki Iwaki, Mayumi Fujimoto, Yasuichiro Nishimura, Shoko Nakayama, Toshikazu Akioka

المصدر: Human Pathology. 62:180-186

مصطلحات موضوعية: Male, 0301 basic medicine, Pathology, medicine.medical_specialty, CD34, Fluorescent Antibody Technique, Tryptase, Pathology and Forensic Medicine, 03 medical and health sciences, 0302 clinical medicine, Bone Marrow, Transforming Growth Factor beta, Fibrosis, Humans, Medicine, Mast Cells, Myelofibrosis, Aged, Aged, 80 and over, Interleukin-13, biology, business.industry, Interleukin, Middle Aged, medicine.disease, 030104 developmental biology, medicine.anatomical_structure, Primary Myelofibrosis, Case-Control Studies, Myelodysplastic Syndromes, 030220 oncology & carcinogenesis, Interleukin 13, biology.protein, Female, Bone marrow, business, Megakaryocytes, Thrombocythemia, Essential, Transforming growth factor

الوصف: Although bone marrow fibrosis is a lethal condition, its underlying mechanism is not fully understood. This study aimed to investigate the pathogenesis of fibrosis in the bone marrow through histologic examination of mast cell infiltration and the expression of fibrosis-associated cytokines. We analyzed 22 bone marrows with fibrosis (8 primary myelofibrosis [PMF], 5 post-essential thrombocythemia [ET], myelofibrosis, and 9 myelodysplastic syndrome [MDS] with bone marrow fibrosis [BMF]). Immunohistochemical and immunofluorescence stainings were performed using anti-mast cell tryptase, interleukin (IL) 13, transforming growth factor β (TGF-β), CD34, and CD42b antibodies. The number of mast cells in bone marrows with fibrosis was significantly higher than that in controls (P

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9475a9e314cb977a714e04137b1fb5adTest
https://doi.org/10.1016/j.humpath.2017.01.007Test

المؤلفون: Kazuki Iwaki, Uta Nishiwaki, Mayumi Fujimoto, Shoko Nakayama, Taiji Yokote, Ayami Takayama, Yasuichiro Nishimura, Toshikazu Akioka, Motomu Tsuji, Takuji Miyoshi, Jun Hatooka, Nobuya Hiraoka, Yuki Masuda

المصدر: Blood Advances. 1:486-493

مصطلحات موضوعية: education.field_of_study, Lymphoid Neoplasia, Population, FOXP3, hemic and immune systems, chemical and pharmacologic phenomena, Hematology, Biology, medicine.disease, Lymphoma, 03 medical and health sciences, 0302 clinical medicine, International Prognostic Index, Antigen, Tumor progression, 030220 oncology & carcinogenesis, mental disorders, Immunology, medicine, Cytotoxic T cell, education, Diffuse large B-cell lymphoma, psychological phenomena and processes, 030215 immunology

الوصف: Regulatory T cells (Tregs) specifically express the transcription factor forkhead box P3 (FOXP3) and contribute to tumor progression. FOXP3-positive cells have been recently proven to be heterogeneous in phenotype and function, including effector Tregs (eTregs), naive Tregs, and non-Tregs, which harbor no suppressive function. Therefore, it is crucial to investigate the “true Treg (eTreg)” population, rather than the entire FOXP3 population, with regards to their effect on tumor immunity. In particular, in diffuse large B-cell lymphoma, not otherwise specified (DLBCL, NOS), FOXP3-positive cells correlated with a better prognosis. The present study sought to evaluate the relationship between the prognosis of DLBCL, NOS patients and the infiltration of true Tregs by employing dual immunostaining with FOXP3 and cytotoxic T-lymphocyte–associated antigen 4 (CTLA-4). CTLA-4 is a negative immunomodulatory known to be expressed by eTregs, but not by non-Tregs. Lymph nodes from 82 nodal DLBCL, NOS patients were stained with anti-FOXP3 and anti–CTLA-4 antibodies. A high infiltration of FOXP3-positive cells was associated with a significantly better prognosis than patients with low levels of FOXP3-positive cells for overall survival (OS) ( P = .0233). In sharp contrast, a high infiltration of FOXP3/CTLA-4 double-positive cells was significantly associated with a poor prognosis than patients with low levels of FOXP3/CTLA-4 double-positive cells for OS ( P = .0121) and progression-free survival ( P = .0171), independent of the international prognostic index. FOXP3/CTLA-4 double-positive cells, eTregs, play an important role in DLBCL, NOS progression.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4467f8383348ede3a7076602e750e7ecTest
https://doi.org/10.1182/bloodadvances.2016000885Test

المؤلفون: Jun Hatooka, Nobukazu Ishizaka, Kazushi Sakane, Jun Tanigawa

المصدر: Internal medicine (Tokyo, Japan). 54(8)

مصطلحات موضوعية: Coronary angiography, Male, medicine.medical_specialty, business.industry, Left circumflex artery, Subclavian Artery, General Medicine, Coronary Angiography, Coronary Vessels, Internal medicine, medicine.artery, Thyrocervical trunk, Internal Medicine, medicine, Cardiology, Photography, Humans, business, Neck, Aged

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46f39ccca28aae80894a9c28be4a51ccTest
https://pubmed.ncbi.nlm.nih.gov/25876587Test

المؤلفون: Taiji Yokote, Uta Nishiwaki, Motomu Tsuji, Ayami Fumimoto, Jun Hatooka, Toshiaki Hanafusa, Nobuya Hiraoka, Yuji Hirata, Mayumi Fujimoto, Yuki Masuda, Kazuki Iwaki, Toshikazu Akioka, Shoko Nakayama, Takuji Miyoshi

المصدر: Annals of Hematology. 95:1369-1370

مصطلحات موضوعية: 0301 basic medicine, medicine.medical_specialty, Hematology, business.industry, medicine.medical_treatment, Primary cutaneous anaplastic large cell lymphoma, General Medicine, medicine.disease, 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, Cytokine, 030220 oncology & carcinogenesis, Internal medicine, medicine, Cancer research, business

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::70350b80c93cb4ba8174efa5f8517c08Test
https://doi.org/10.1007/s00277-016-2714-yTest

المؤلفون: Kazuki Iwaki, Mayumi Fujimoto, Toshikazu Akioka, Shoko Nakayama, Takuji Miyoshi, Motomu Tsuji, Uta Nishiwaki, Nobuya Hiraoka, Jun Hatooka, Ayami Fumimoto, Yuki Masuda, Taiji Yokote

المصدر: Blood. 128:3112-3112

مصطلحات موضوعية: Pathology, medicine.medical_specialty, medicine.diagnostic_test, Essential thrombocythemia, business.industry, Growth factor, medicine.medical_treatment, Immunology, Interleukin, Cell Biology, Hematology, medicine.disease, Immunofluorescence, Biochemistry, medicine.anatomical_structure, Fibrosis, medicine, Immunohistochemistry, Bone marrow, business, Myelofibrosis

الوصف: Background: Fibrosis in bone marrow is a lethal condition, which currently has no effective treatments. Transforming growth factor (TGF)-β, produced by megakaryocytes and blasts in myelodisplastic syndrome (MDS) with bone marrow fibrosis, is reportedly linked to this condition; however, the underlying mechanism of fibrosis in bone marrow remains uncharacterized. Recently, interleukin (IL)-13- and TGF-β- producing mast cells have been reported to participate in the development of fibrosis in certain fibrotic diseases, such as the IgG4-related diseases. Aim: This study aimed to investigate the pathogenesis of fibrosis in bone marrow through histological examination of mast cell infiltration and the expression of cytokines associated with fibrosis. Methods: We analyzed 22 bone marrow samples from patients with confirmed fibrosis; of these, eight patients had been diagnosed with primary myelofibrosis (PMF), five with post-polycythemia vera (PV)/essential thrombocythemia (ET) MF, and nine with MDS with bone marrow fibrosis. These were compared with 15 control bone marrow samples, using immunohistochemical staining of mast cell tryptase, IL-13, and TGF-β, as well as using dual immunofluorescence assays for the following pairs: mast cell tryptase/ IL-13 and mast cell tryptase/ TGF-β. The extent of fibrosis in bone marrow samples was analyzed by Masson's trichrome staining and silver impregnation staining. Results: Among eight PMF cases, five were identified as grade 2 and three as grade 3; among five post-PV/ET cases, four were grade 2 and one was grade 3; and among nine MDS patients with bone marrow fibrosis, six were grade 2 and three were grade 3. Grading was performed according to the European consensus on grading of bone marrow fibrosis. The number of mast cells in bone marrow samples was significantly higher in cases with fibrosis than in controls, as analyzed by t-test (p < 0.0001) (Figure 1A). Each group of bone marrow samples with fibrosis (primary MF, post-PV/ET MF, and MDS with bone marrow fibrosis) also had significantly more infiltrating mast cells than controls, using multiple comparison with the Tukey's honestly significant difference test (p = 0.0470, < 0.0001, 0.0005, respectively) (Figure 1B). Bone marrow samples with higher fibrotic grades exhibited greater amounts of infiltrating mast cells; for instance, bone marrows with fibrotic grades of 2 or 3 had more infiltrating mast cells than controls (p = 0.0010, < 0.0001, respectively). In addition, bone marrows with a fibrotic grade of 3 had more infiltrating mast cells than those with fibrotic grade 2 (p = 0.0010) (Figure 2). Mast cells were positive for IL-13 (Figure 3) and TGF-β (Figure 4) in dual immunofluorescence assays of mast cell tryptase and IL-13 or TGF-β; however, megakaryocytes and blasts of MDS with bone marrow fibrosis were negative for IL-13 and TGF-β. Conclusion: Based on these findings, we hypothesize that IL-13- and TGF-β- producing mast cells are key elements in the development of fibrosis in bone marrow. Therefore, mast cells are potential therapeutic targets for the treatment of fibrosis in bone marrow. Disclosures Nakayama: the promotion and mutual aid corporation for private schools of Japan: Research Funding.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::c5e9986c5f3e6b78ecfb09810a0be9adTest
https://doi.org/10.1182/blood.v128.22.3112.3112Test

المؤلفون: Shoko, Nakayama, Motomu, Tsuji, Taiji, Yokote, Toshikazu, Akioka, Takuji, Miyoshi, Nobuya, Hiraoka, Yuji, Hirata, Kazuki, Iwaki, Ayami, Takayama, Uta, Nishiwaki, Yuki, Masuda, Jun, Hatooka, Toshiaki, Hanafusa, Hiroyoshi, Nishikawa

المصدر: Blood; December 2015, Vol. 126 Issue: 23 p3884-3884, 1p

مستخلص: (Background) Regulatory T cells (Tregs) are the focus of interest as one of the tumor microenvironmental factors because of their critical role in the modification of immune response, such as suppression of tumor-associated antigen-reactive lymphocytes. Tregs-mediated immunosuppression contributes to the progression of tumors and poor prognosis of patients. Forkhead box P3 (FOXP3) had been regarded as a specific marker of Tregs, but recently, FOXP3-positive cells were proved to be heterogeneous in phenotype and function. FOXP3-positive cells include effector Tregs (eTregs), naïve Tregs, and non-Tregs. Of them, eTregs have a substantial immunosuppressive effect. So far, no study has investigated the relationship between infiltration of eTregs and prognosis of patients with lymphoma.