المؤلفون: Henning Johannes Drews, Sebastian Wallot, Philip Brysch, Hannah Berger-Johannsen, Sara Lena Weinhold, Panagiotis Mitkidis, Paul Christian Baier, Julia Lechinger, Andreas Roepstorff, Robert Göder

المصدر: Frontiers in Psychiatry, Vol 11 (2020)

مصطلحات موضوعية: co-sleep, REM sleep, synchronization, bed-sharing, physiological coupling, sociality, Psychiatry, RC435-571

الوصف: Background/ObjectivesSharing the bed with a partner is common among adults and impacts sleep quality with potential implications for mental health. However, hitherto findings are contradictory and particularly polysomnographic data on co-sleeping couples are extremely rare. The present study aimed to investigate the effects of a bed partner's presence on individual and dyadic sleep neurophysiology.MethodsYoung healthy heterosexual couples underwent sleep-lab-based polysomnography of two sleeping arrangements: individual sleep and co-sleep. Individual and dyadic sleep parameters (i.e., synchronization of sleep stages) were collected. The latter were assessed using cross-recurrence quantification analysis. Additionally, subjective sleep quality, relationship characteristics, and chronotype were monitored. Data were analyzed comparing co-sleep vs. individual sleep. Interaction effects of the sleeping arrangement with gender, chronotype, or relationship characteristics were moreover tested.ResultsAs compared to sleeping individually, co-sleeping was associated with about 10% more REM sleep, less fragmented REM sleep (p = 0.008), longer undisturbed REM fragments (p = 0.0006), and more limb movements (p = 0.007). None of the other sleep stages was significantly altered. Social support interacted with sleeping arrangement in a way that individuals with suboptimal social support showed the biggest impact of the sleeping arrangement on REM sleep. Sleep architectures were more synchronized between partners during co-sleep (p = 0.005) even if wake phases were excluded (p = 0.022). Moreover, sleep architectures are significantly coupled across a lag of ± 5min. Depth of relationship represented an additional significant main effect regarding synchronization, reflecting a positive association between the two. Neither REM sleep nor synchronization was influenced by gender, chronotype, or other relationship characteristics.ConclusionDepending on the sleeping arrangement, couple's sleep architecture and synchronization show alterations that are modified by relationship characteristics. We discuss that these alterations could be part of a self-enhancing feedback loop of REM sleep and sociality and a mechanism through which sociality prevents mental illness.

وصف الملف: electronic resource

العلاقة: https://www.frontiersin.org/article/10.3389/fpsyt.2020.00583/fullTest; https://doaj.org/toc/1664-0640Test

الوصول الحر: https://doaj.org/article/3f187e63366e462a9dd0fe9211d5f2b9Test

المؤلفون: Dieter Benninghoven, Denise Hamann, Yskert von Kodolitsch, Meike Rybczynski, Julia Lechinger, Friedrich Schroeder, Marina Vogler, Eike Hoberg

المصدر: Orphanet Journal of Rare Diseases, Vol 12, Iss 1, Pp 1-9 (2017)

مصطلحات موضوعية: Marfan syndrome, Congenital heart defect, Inpatient rehabilitation, Multidisciplinary rehabilitation, Quality of life, Medicine

الوصف: Abstract Background Advances in medical, interventional and surgical treatment have increased average life expectancy of patients with congenital heart defects. As a result a new group of adult patients with congenital cardiac defects requires medical rehabilitation. Patients with Marfan syndrome (MFS) are a relevant group among these patients. So far, no reports on the effectiveness of specialized rehabilitation programmes for MFS patients exist. We implemented an inpatient 3-week rehabilitation program for MFS patients at the Muehlenberg-Clinic for rehabilitation and assessed the medical safety as well as the impact of the program on physical fitness and psychological wellbeing of participants by means of an observational pilot study. The comprehensive multidisciplinary program included medical, physiotherapeutic, psychological and social issues. Two groups including 8 and 10 individuals with verified MFS attended the programme. Medically adverse events that occurred during the rehabilitation were registered. Adverse events were defined as: any new cardiac arrhythmias such as atrial fibrillation, ventricular tachycardia, cardiac syncope or any complications located at the aorta. Psychological assessment was performed using Short Form-36 (SF-36), hospital anxiety and depression scale and other psychometric questionnaires. Medical examinations included assessment of maximum power in bicycle ergometry. All assessments were performed at the beginning and at the end of the rehabilitation. Psychometric assessments were repeated 1 year after the end of the programme for both groups, respectively. Results Patients were highly satisfied with the programme and improved in almost all psychological and physical fitness assessments. The pre-post-comparison resulted in significant positive changes for mental health (p

وصف الملف: electronic resource

العلاقة: http://link.springer.com/article/10.1186/s13023-017-0679-0Test; https://doaj.org/toc/1750-1172Test

الوصول الحر: https://doaj.org/article/0544955b311f4abb9175824ccc646687Test

المؤلفون: Malgorzata Wislowska, Renata del Giudice, Julia Lechinger, Tomasz Wielek, Dominik P. J. Heib, Alain Pitiot, Gerald Pichler, Gabriele Michitsch, Johann Donis, Manuel Schabus

المصدر: Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)

مصطلحات موضوعية: Medicine, Science

الوصف: Abstract Brain injuries substantially change the entire landscape of oscillatory dynamics and render detection of typical sleep patterns difficult. Yet, sleep is characterized not only by specific EEG waveforms, but also by its circadian organization. In the present study we investigated whether brain dynamics of patients with disorders of consciousness systematically change between day and night. We recorded ~24 h EEG at the bedside of 18 patients diagnosed to be vigilant but unaware (Unresponsive Wakefulness Syndrome) and 17 patients revealing signs of fluctuating consciousness (Minimally Conscious State). The day-to-night changes in (i) spectral power, (ii) sleep-specific oscillatory patterns and (iii) signal complexity were analyzed and compared to 26 healthy control subjects. Surprisingly, the prevalence of sleep spindles and slow waves did not systematically vary between day and night in patients, whereas day-night changes in EEG power spectra and signal complexity were revealed in minimally conscious but not unaware patients.

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/2045-2322Test

الوصول الحر: https://doaj.org/article/2dfdc18ab8c24c8eb48a8c45ac768d5aTest

المؤلفون: Tomasz Wielek, Julia Lechinger, Malgorzata Wislowska, Christine Blume, Peter Ott, Stefan Wegenkittl, Renata Del Giudice, Dominik P J Heib, Helmut A Mayer, Steven Laureys, Gerald Pichler, Manuel Schabus

المصدر: PLoS ONE, Vol 13, Iss 1, p e0190458 (2018)

مصطلحات موضوعية: Medicine, Science

الوصف: Sleep has been proposed to indicate preserved residual brain functioning in patients suffering from disorders of consciousness (DOC) after awakening from coma. However, a reliable characterization of sleep patterns in this clinical population continues to be challenging given severely altered brain oscillations, frequent and extended artifacts in clinical recordings and the absence of established staging criteria. In the present study, we try to address these issues and investigate the usefulness of a multivariate machine learning technique based on permutation entropy, a complexity measure. Specifically, we used long-term polysomnography (PSG), along with video recordings in day and night periods in a sample of 23 DOC; 12 patients were diagnosed as Unresponsive Wakefulness Syndrome (UWS) and 11 were diagnosed as Minimally Conscious State (MCS). Eight hour PSG recordings of healthy sleepers (N = 26) were additionally used for training and setting parameters of supervised and unsupervised model, respectively. In DOC, the supervised classification (wake, N1, N2, N3 or REM) was validated using simultaneous videos which identified periods with prolonged eye opening or eye closure.The supervised classification revealed that out of the 23 subjects, 11 patients (5 MCS and 6 UWS) yielded highly accurate classification with an average F1-score of 0.87 representing high overlap between the classifier predicting sleep (i.e. one of the 4 sleep stages) and closed eyes. Furthermore, the unsupervised approach revealed a more complex pattern of sleep-wake stages during the night period in the MCS group, as evidenced by the presence of several distinct clusters. In contrast, in UWS patients no such clustering was found. Altogether, we present a novel data-driven method, based on machine learning that can be used to gain new and unambiguous insights into sleep organization and residual brain functioning of patients with DOC.

وصف الملف: electronic resource

العلاقة: http://europepmc.org/articles/PMC5749793?pdf=renderTest; https://doaj.org/toc/1932-6203Test

الوصول الحر: https://doaj.org/article/85c84ee2a22349e89c8be807f188e004Test

المؤلفون: Hermann Griessenberger, Dominik P J Heib, Julia Lechinger, Nikolina Luketina, Marit Petzka, Tina Moeckel, Kerstin Hoedlmoser, Manuel Schabus

المصدر: PLoS ONE, Vol 8, Iss 2, p e57394 (2013)

مصطلحات موضوعية: Medicine, Science

الوصف: Sleep has been shown to stabilize memory traces and to protect against competing interference in both the procedural and declarative memory domain. Here, we focused on an interference learning paradigm by testing patients with primary insomnia (N = 27) and healthy control subjects (N = 21). In two separate experimental nights with full polysomnography it was revealed that after morning interference procedural memory performance (using a finger tapping task) was not impaired in insomnia patients while declarative memory (word pair association) was decreased following interference. More specifically, we demonstrate robust associations of central sleep spindles (in N3) with motor memory susceptibility to interference as well as (cortically more widespread) fast spindle associations with declarative memory susceptibility. In general the results suggest that insufficient sleep quality does not necessarily show up in worse overnight consolidation in insomnia but may only become evident (in the declarative memory domain) when interference is imposed.

وصف الملف: electronic resource

العلاقة: http://europepmc.org/articles/PMC3581453?pdf=renderTest; https://doaj.org/toc/1932-6203Test

الوصول الحر: https://doaj.org/article/82a183766e4d498a9566965e04a66954Test

المؤلفون: Sara Lena Weinhold, Robert Göder, Julia Lechinger, Klaus Junghanns, Jasper Ittel, Henning Johannes Drews, Romina Ritzenhoff

المصدر: Neuropsychobiology. 81:104-115

مصطلحات موضوعية: medicine.medical_specialty, medicine.diagnostic_test, business.industry, Electroencephalography, Sleep spindle, Polysomnography, Audiology, Sleep, Slow-Wave, medicine.disease, Psychiatry and Mental health, Delta wave, Neuropsychology and Physiological Psychology, Schizophrenia, Quality of Life, Humans, Medicine, Sleep and memory, Memory consolidation, Verbal memory, Sleep, business, Biological Psychiatry, Memory Consolidation, Slow-wave sleep

الوصف: Introduction: Memory deficiency has been shown in schizophrenia patients, but results on the role of sleep parameters in overnight consolidation of associative verbal memory are still missing. Therefore, the aim of our study was to elucidate underlying processes of impaired sleep-related consolidation of associative word pairs in schizophrenia including standard sleep parameters as well as sleep spindle counts and spectral analysis. Methods: Eighteen stably medicated schizophrenia patients and 24 healthy age-matched controls performed an associative declarative memory task before and after polysomnographic recordings. Part of the participants expected verbal associative memory testing in the morning, while the others did not. Furthermore, participants filled in self-rating questionnaires of schizophrenia-typical experiences (Eppendorf Schizophrenia Inventory [ESI] and Psychotic Symptom Rating Scale). Results: Schizophrenia patients performed worse in verbal declarative memory in the evening as well as in overnight consolidation (morning compared to evening performance). While duration of slow-wave sleep was nearly comparable between groups, schizophrenia patients showed lower sleep spindle count, reduced delta power during slow-wave sleep, and reduced spindle power during the slow oscillation (SO) up-state. In healthy but not in schizophrenia patients, a linear relationship between overnight memory consolidation and slow-wave sleep duration as well as delta power was evident. No significant effect with respect to the expectation of memory retrieval was evident in our data. Additionally, we observed a negative linear relationship between total number of sleep spindles and ESI score in healthy participants. Discussion/Conclusion: As expected, schizophrenia patients showed deficient overnight verbal declarative memory consolidation as compared to healthy controls. Reduced sleep spindles, delta power, and spindle power during the SO up-state may link sleep and memory deficiency in schizophrenia. Additionally, the absence of a linear relationship between sleep-related memory consolidation and slow-wave sleep as well as delta power suggests further functional impairments in schizophrenia. Note that this conclusion is based on observational data. Future studies should investigate if stimulation of delta waves during sleep could improve memory performance and thereby quality of life in schizophrenia.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49c192b297ab7790a5f7f862492115e3Test
https://doi.org/10.1159/000517858Test

المؤلفون: Sara Lena Weinhold, Julia Lechinger, Nele Timm, Anja Hansen, Hong‐Viet V. Ngo, Robert Göder

المصدر: Journal of Sleep Research. 31

مصطلحات موضوعية: Behavioral Neuroscience, Acoustic Stimulation, Cognitive Neuroscience, Schizophrenia, Humans, Electroencephalography, General Medicine, Sleep, Memory Consolidation

الوصف: Sleep-dependent memory consolidation is disturbed in patients with schizophrenia, who furthermore show reductions in sleep spindles and probably also in delta power during sleep. The memory dysfunction in these patients is one of the strongest markers for worse long-term functional outcome. However, therapeutic interventions to normalise memory functions, e.g., with medication, still do not exist. Against this backdrop, we investigated to what extent a non-invasive approach enhancing sleep with real-time auditory stimulation in-phase with slow oscillations might affect overnight memory consolidation in patients with schizophrenia. To this end, we examined 18 patients with stably medicated schizophrenia in a double-blinded sham-controlled design. Memory performance was assessed by a verbal (word list) and a non-verbal (complex figure) declarative memory task. In comparison to a sham condition without auditory stimuli, we found that in patients with schizophrenia, auditory stimulation evokes an electrophysiological response similar to that in healthy participants leading to an increase in slow wave and temporally coupled sleep spindle activity during stimulation. Despite this finding, patients did not show any beneficial effect on the overnight change in memory performance by stimulation. Although the stimulation in our study did not improve the patient's memory, the electrophysiological response gives hope that auditory stimulation could enable us to provide better treatment for sleep-related detriments in these patients in the future.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0187db2128ada909a08d5dc23b71a261Test
https://doi.org/10.1111/jsr.13636Test

المؤلفون: Julia Lechinger, Charlotte Vogel, Kamila Jauch-Chara, Robert Göder, Sarah Bares, Sara Lena Weinhold, Heidi Böttcher, Henning Johannes Drews

المصدر: Sleep Medicine. 77:367-373

مصطلحات موضوعية: medicine.medical_specialty, Sleep spindle, Sleep medicine, Pittsburgh Sleep Quality Index, 03 medical and health sciences, Sleep Apnea Syndromes, 0302 clinical medicine, Sleep Initiation and Maintenance Disorders, medicine, Insomnia, Humans, Psychiatric Status Rating Scales, Sleep Apnea, Obstructive, Sleep disorder, business.industry, Beck Depression Inventory, Sleep apnea, General Medicine, medicine.disease, Obstructive sleep apnea, 030228 respiratory system, medicine.symptom, Sleep, business, 030217 neurology & neurosurgery, Clinical psychology

الوصف: Objectives There are strong links between sleep and psychotic-like experiences (PLE), such as magical ideations or persecutory ideas. Sleep disturbances seem to play an important role in the occurrence of such symptoms, but studies investigating PLE in patients with sleep disorders are lacking. Methods We studied 24 subjects with insomnia disorder (41 ± 13 years) and 47 participants with obstructive sleep apnea (OSA, 47 ± 11 years) in the sleep laboratory and 33 healthy controls. Sleep in patients with sleep disorders was recorded and scored according to standard criteria of the American Academy of Sleep Medicine. PLE were measured by the Magical Ideation Scale (MIS, short form with 10 items) and by the Peters et al., Delusions Inventory (PDI, 21 items). Additionally, cognitive tests and further psychological self-rating tests such as the Beck Depression Inventory (BDI) and the Pittsburgh Sleep Quality Index (PSQI) were administered. Results Patients with insomnia had significantly higher scores of magical and delusional ideations compared to healthy controls. Sleep apnea patients showed a tendency of a higher score of delusional beliefs in comparison to controls. Magical ideations in insomnia subjects were significantly negatively correlated with the number of sleep spindles. In a subgroup of insomnia patients without antidepressants, delusional beliefs were negatively associated with rapid eye movement (REM)-sleep. Conclusions As there are indications that diminutions of sleep spindles are a biomarker for dysfunctional thalamo-cortical circuits underlying the neuropathology of psychosis, we conclude that there might be a sub-group of insomnia patients with fewer sleep spindles which is more vulnerable to developing a psychotic disorder in the future.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e7afb3431aa92bacc63cdd45d1af927Test
https://doi.org/10.1016/j.sleep.2020.04.015Test

المؤلفون: Julia Lechinger, Milena Braun, Mareen Seeck-Hirschner, Karoline Stingele, Henning Johannes Drews, Christian Huchzermeier, Jakob M. Koch, Josef B. Aldenhoff, Sara Lena Weinhold, Cornelia Kropp-Näf, Robert Göder

المصدر: Journal of psychiatric research. 133

مصطلحات موضوعية: Psychotherapist, medicine.medical_treatment, Polysomnography, 03 medical and health sciences, 0302 clinical medicine, Pharmacotherapy, medicine, Humans, Biological Psychiatry, Depression (differential diagnoses), Depressive Disorder, Major, medicine.diagnostic_test, business.industry, Depression, Sleep in non-human animals, Antidepressive Agents, 030227 psychiatry, Psychotherapy, Psychiatry and Mental health, Endophenotype, Interpersonal psychotherapy, Antidepressant, business, Reuptake inhibitor, 030217 neurology & neurosurgery, Selective Serotonin Reuptake Inhibitors

الوصف: Major depression is one of the most common psychiatric illnesses. Interestingly, a few studies have indicated the existence of depression subgroups, which respond differently to the available treatment options. Previously, sleep abnormalities have been suggested to indicate amenability to different treatment regimens. Thereby, especially REM-sleep parameters seem to play a prominent role, and REM-sleep dysregulation has been repeatedly discussed as a potential endophenotype of depression. With that said, estimating therapy outcome in order to choose the best line of treatment is of utmost importance to patients suffering from depression. The present study looks deeper into these clues by investigating the capability of polysomnographic sleep parameters to predict treatment response in depressed patients to either pharmacotherapy or psychotherapy. Moderately to severely depressed patients (n = 38) were randomly assigned to either psychotherapy (i.e. interpersonal psychotherapy) or pharmacotherapy (i.e., monotherapy with selective serotonin reuptake inhibitors, SSRI, or selective serotonin noradrenalin reuptake inhibitors, SSNRI). Prior to treatment, all patients underwent polysomnography in the sleep laboratory. After treatment, responders and non-responders of both treatment groups were compared regarding their baseline sleep parameters. Higher baseline REM density, i.e. the amount of rapid eye movements during REM sleep, predicted better response to antidepressant pharmacotherapy. In the psychotherapy group, the effect seemed reversed but was not statistically significant. No other sleep parameter predicted treatment response. Our findings support the notion that REM-sleep dysregulation is indeed indicative of a distinct endophenotype of depression and that pharmacotherapy with SSRI/SSNRI might be superior to psychotherapy in these patients.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afebe556ae8fc8a052084a08d5d83892Test
https://pubmed.ncbi.nlm.nih.gov/33310502Test

المؤلفون: Julia Lechinger, Gerald Pichler, Manuel Schabus, Gabriele Michitsch, Walter Roland Gruber, Christine Blume, Johann Donis, Tomasz Wielek

المصدر: Journal of Neurology

مصطلحات موضوعية: Adult, Male, medicine.medical_specialty, Neurology, Clinical Neurology, Audiology, Stimulus (physiology), Electroencephalography, Phase connectivity, Brain mapping, 050105 experimental psychology, Developmental psychology, 03 medical and health sciences, Young Adult, 0302 clinical medicine, medicine, Humans, Names, 0501 psychology and cognitive sciences, In patient, Attention, EEG, Aged, Disorders of consciousness, Analysis of Variance, Brain Mapping, Original Communication, medicine.diagnostic_test, 05 social sciences, Cognition, Auditory own name paradigm, Middle Aged, Time–frequency analysis, Brain Waves, Self Concept, Acoustic Stimulation, Consciousness Disorders, Wakefulness, Female, Neurology (clinical), Psychology, Cognition Disorders, 030217 neurology & neurosurgery

الوصف: Estimating cognitive abilities in patients suffering from Disorders of Consciousness remains challenging. One cognitive task to address this issue is the so-called own name paradigm, in which subjects are presented with first names including the own name. In the active condition, a specific target name has to be silently counted. We recorded EEG during this task in 24 healthy controls, 8 patients suffering from Unresponsive Wakefulness Syndrome (UWS) and 7 minimally conscious (MCS) patients. EEG was analysed with respect to amplitude as well as phase modulations and connectivity. Results showed that general reactivity in the delta, theta and alpha frequency (event-related de-synchronisation, ERS/ERD, and phase locking between trials and electrodes) toward auditory stimulation was higher in controls than in patients. In controls, delta ERS and lower alpha ERD indexed the focus of attention in both conditions, late theta ERS only in the active condition. Additionally, phase locking between trials and delta phase connectivity was highest for own names in the passive and targets in the active condition. In patients, clear stimulus-specific differences could not be detected. However, MCS patients could reliably be differentiated from UWS patients based on their general event-related delta and theta increase independent of the type of stimulus. In conclusion, the EEG signature of the active own name paradigm revealed instruction-following in healthy participants. On the other hand, DOC patients did not show clear stimulus-specific processing. General reactivity toward any auditory input, however, allowed for a reliable differentiation between MCS and UWS patients. Electronic supplementary material The online version of this article (doi:10.1007/s00415-016-8150-z) contains supplementary material, which is available to authorized users.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0acbe9c4678bcb68a0a845ab087e711fTest
http://europepmc.org/articles/PMC4971049Test