المؤلفون: Kos Z., Roblin E., Kim R. S., Michiels S., Gallas B. D., Chen W., van de Vijver K. K., Goel S., Adams S., Demaria S., Viale G., Nielsen T. O., Badve S. S., Symmans W. F., Sotiriou C., Rimm D. L., Hewitt S., Denkert C., Loibl S., Luen S. J., Bartlett J. M. S., Savas P., Pruneri G., Dillon D. A., Cheang M. C. U., Tutt A., Hall J. A., Kok M., Horlings H. M., Madabhushi A., van der Laak J., Ciompi F., Laenkholm A. -V., Bellolio E., Gruosso T., Fox S. B., Araya J. C., Floris G., Hudecek J., Voorwerk L., Beck A. H., Kerner J., Larsimont D., Declercq S., Van den Eynden G., Pusztai L., Ehinger A., Yang W., AbdulJabbar K., Yuan Y., Singh R., Hiley C., Bakir M., Lazar A. J., Naber S., Wienert S., Castillo M., Curigliano G., Dieci M. -V., Andre F., Swanton C., Reis-Filho J., Sparano J., Balslev E., Chen I. -C., Stovgaard E. I. S., Pogue-Geile K., Blenman K. R. M., Penault-Llorca F., Schnitt S., Lakhani S. R., Vincent-Salomon A., Rojo F., Braybrooke J. P., Hanna M. G., Soler-Monso M. T., Bethmann D., Castaneda C. A., Willard-Gallo K., Sharma A., Lien H. -C., Fineberg S., Thagaard J., Comerma L., Gonzalez-Ericsson P., Brogi E., Loi S., Saltz J., Klaushen F., Cooper L., Amgad M., Moore D. A., Salgado R., Hyytiainen A., Hida A. I., Thompson A., Lefevre A., Gown A., Lo A., Sapino A., Moreira A. M., Richardson A., Vingiani A., Bellizzi A. M., Guerrero A., Grigoriadis A., Garrido-Castro A. C., Cimino-Mathews A., Srinivasan A., Acs B., Singh B., Calhoun B., Haibe-Kans B., Solomon B., Thapa B., Nelson B. H., Ballesteroes-Merino C., Criscitiello C., Boeckx C., Colpaert C., Quinn C., Chennubhotla C. S., Solinas C., Drubay D., Sabanathan D., Peeters D., Zardavas D., Hoflmayer D., Johnson D. B., Thompson E. A., Perez E., ElGabry E. A., Blackley E. F., Reisenbichler E., Chmielik E., Gaire F., Lu F. -I., Azmoudeh-Ardalan F., Peale F., Hirsch F. R., Acosta-Haab G., Farshid G., Broeckx G., Koeppen H., Haynes H. R., McArthur H., Joensuu H., Olofsson H., Cree I., Nederlof I., Frahm I., Brcic I., Chan J., Ziai J., Brock J., Weseling J., Giltnane J., Lemonnier J., Zha J., Ribeiro J., Lennerz J. K., Carter J. M., Hartman J., Hainfellner J., Le Quesne J., Juco J. W., van den Berg J., Sanchez J., Cucherousset J., Adam J., Balko J. M., Saeger K., Siziopikou K., Sikorska K., Weber K., Steele K. E., Emancipator K., El Bairi K., Allison K. H., Korski K., Buisseret L., Shi L., Kooreman L. F. S., Molinero L., Estrada M. V., Van Seijen M., Lacroix-Triki M., Sebastian M. M., Balancin M. L., Mathieu M. -C., van de Vijver M., Rebelatto M. C., Piccart M., Goetz M. P., Preusser M., Khojasteh M., Sanders M. E., Regan M. M., Barnes M., Christie M., Misialek M., Ignatiadis M., de Maaker M., Van Bockstal M., Harbeck N., Tung N., Laudus N., Sirtaine N., Burchardi N., Ternes N., Radosevic-Robin N., Gluz O., Grimm O., Nuciforo P., Jank P., Kirtani P., Watson P. H., Jelinic P., Francis P. A., Russell P. A., Pierce R. H., Hills R., Leon-Ferre R., de Wind R., Shui R., Leung S., Tabbarah S., Souza S. C., O'Toole S., Swain S., Dudgeon S., Willis S., Ely S., Bedri S., Irshad S., Liu S., Hendry S., Bianchi S., Braganca S., Paik S., Luz S., Gevaert T., d'Alfons T., John T., Sugie T., Kurkure U., Bossuyt V., Manem V., Camaea V. P., Tong W., Tran W. T., Wang Y., Allory Y., Husain Z., Bago-Horvath Z.

المساهمون: Kos Z., Roblin E., Kim R.S., Michiels S., Gallas B.D., Chen W., van de Vijver K.K., Goel S., Adams S., Demaria S., Viale G., Nielsen T.O., Badve S.S., Symmans W.F., Sotiriou C., Rimm D.L., Hewitt S., Denkert C., Loibl S., Luen S.J., Bartlett J.M.S., Savas P., Pruneri G., Dillon D.A., Cheang M.C.U., Tutt A., Hall J.A., Kok M., Horlings H.M., Madabhushi A., van der Laak J., Ciompi F., Laenkholm A.-V., Bellolio E., Gruosso T., Fox S.B., Araya J.C., Floris G., Hudecek J., Voorwerk L., Beck A.H., Kerner J., Larsimont D., Declercq S., Van den Eynden G., Pusztai L., Ehinger A., Yang W., AbdulJabbar K., Yuan Y., Singh R., Hiley C., Bakir M., Lazar A.J., Naber S., Wienert S., Castillo M., Curigliano G., Dieci M.-V., Andre F., Swanton C., Reis-Filho J., Sparano J., Balslev E., Chen I.-C., Stovgaard E.I.S., Pogue-Geile K., Blenman K.R.M., Penault-Llorca F., Schnitt S., Lakhani S.R., Vincent-Salomon A., Rojo F., Braybrooke J.P., Hanna M.G., Soler-Monso M.T., Bethmann D., Castaneda C.A., Willard-Gallo K., Sharma A., Lien H.-C., Fineberg S., Thagaard J., Comerma L., Gonzalez-Ericsson P., Brogi E., Loi S., Saltz J., Klaushen F., Cooper L., Amgad M., Moore D.A., Salgado R., Hyytiainen A., Hida A.I., Thompson A., Lefevre A., Gown A., Lo A., Sapino A.

مصطلحات موضوعية: Immunosurveillance, Prognostic markers

الوصف: Stromal tumor-infiltrating lymphocytes (sTILs) are important prognostic and predictive biomarkers in triple-negative (TNBC) and HER2-positive breast cancer. Incorporating sTILs into clinical practice necessitates reproducible assessment. Previously developed standardized scoring guidelines have been widely embraced by the clinical and research communities. We evaluated sources of variability in sTIL assessment by pathologists in three previous sTIL ring studies. We identify common challenges and evaluate impact of discrepancies on outcome estimates in early TNBC using a newly-developed prognostic tool. Discordant sTIL assessment is driven by heterogeneity in lymphocyte distribution. Additional factors include: technical slide-related issues; scoring outside the tumor boundary; tumors with minimal assessable stroma; including lymphocytes associated with other structures; and including other inflammatory cells. Small variations in sTIL assessment modestly alter risk estimation in early TNBC but have the potential to affect treatment selection if cutpoints are employed. Scoring and averaging multiple areas, as well as use of reference images, improve consistency of sTIL evaluation. Moreover, to assist in avoiding the pitfalls identified in this analysis, we developed an educational resource available at www.tilsinbreastcancer.org/pitfalls.

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/32411819; info:eu-repo/semantics/altIdentifier/wos/WOS:000544983100003; volume:6; issue:1; firstpage:17; lastpage:N/A; numberofpages:na; journal:NPJ BREAST CANCER; http://hdl.handle.net/2318/1768074Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85083460348

الإتاحة: https://doi.org/10.1038/s41523-020-0156-0Test
http://hdl.handle.net/2318/1768074Test

المؤلفون: Hudecek J., Voorwerk L., van Seijen M., Nederlof I., de Maaker M., van den Berg J., van de Vijver K. K., Sikorska K., Adams S., Demaria S., Viale G., Nielsen T. O., Badve S. S., Michiels S., Symmans W. F., Sotiriou C., Rimm D. L., Hewitt S. M., Denkert C., Loibl S., Loi S., Bartlett J. M. S., Pruneri G., Dillon D. A., Cheang M. C. U., Tutt A., Hall J. A., Kos Z., Salgado R., Kok M., Horlings H. M., Hyytiainen A., Hida A. I., Thompson A., Lefevre A., Lazar A. J., Gown A., Lo A., Sapino A., Madabhushi A., Moreira A., Richardson A., Vingiani A., Beck A. H., Bellizzi A. M., Guerrero A., Grigoriadis A., Ehinger A., Garrido-Castro A., Vincent-Salomon A., Laenkholm A. -V., Sharma A., Cimino-Mathews A., Srinivasan A., Acs B., Singh B., Calhoun B., Haibe-Kans B., Solomon B., Thapa B., Nelson B. H., Gallas B. D., Castaneda C., Ballesteros-Merino C., Criscitiello C., Boeckx C., Colpaert C., Quinn C., Chennubhotla C. S., Swanton C., Solinas C., Hiley C., Drubay D., Bethmann D., Moore D. A., Larsimont D., Sabanathan D., Peeters D., Zardavas D., Hoflmayer D., Johnson D. B., Thompson E. A., Brogi E., Perez E., ElGabry E. A., Stovgaard E. S., Blackley E. F., Roblin E., Reisenbichler E., Bellolio E., Balslev E., Chmielik E., Gaire F., Andre F., Lu F. -I., Azmoudeh-Ardalan F., Rojo F., Gruosso T., Ciompi F., Peale F., Hirsch F. R., Klauschen F., Penault-Llorca F., Acosta Haab G., Farshid G., van den Eynden G., Curigliano G., Floris G., Broeckx G., Gonzalez-Ericsson, Koeppen H., Haynes H. R., McArthur H., Joensuu H., Olofsson H., Lien H. -C., Chen I. -C., Cree I., Frahm I., Brcic I., Chan J., Ziai J., Brock J., Wesseling J., Giltnane J., Kerner J. K., Thagaard J., Braybrooke J. P., van der Laak J. A. W. M., Lemonnier J., Zha J., Ribeiro J., Lennerz J. K., Carter J. M., Saltz J., Hartman J., Hainfellner J., Quesne J. L., Juco J. W., Reis-Filho J., Sanchez J., Sparano J., Cucherousset J., Araya J. C., Adam J., Balko J. M., Saeger K., Siziopikou K., Willard-Gallo K., Weber K., Pogue-Geile K. L., Steele K. E., Emancipator K., AbdulJabbar K., El Bairi K., Blenman K. R. M., Allison K. H., Korski K., Pusztai L., Comerma L., Buisseret L., Cooper L. A. D., Shi L., Kooreman L. F. S., Molinero L., Estrada M. V., Lacroix-Triki M., Al Bakir M., Sebastian M. M., van de Vijver M., Balancin M. L., Dieci M. V., Mathieu M. -C., Rebelatto M. C., Piccart M., Hanna M. G., Goetz M. P., Preusser M., Khojasteh M., Sanders M. E., Regan M. M., Barnes M., Christie M., Misialek M., Ignatiadis M., van Bockstal M., Castillo M., Amgad M., Harbeck N., Tung N., Laudus N., Sirtaine N., Burchardi N., Ternes N., Radosevic-Robin N., Gluz O., Grimm O., Nuciforo P., Jank P., Gonzalez-Ericsson P., Kirtani P., Jelinic P., Watson P. H., Savas P., Francis P. A., Russell P. A., Singh R., Kim R. S., Pierce R. H., Hills R., Leon-Ferre R., de Wind R., Shui R., De Clercq S., Leung S., Tabbarah S., Souza S. C., O'Toole S., Swain S., Dudgeon S., Willis S., Ely S., Kim S. -R., Bedri S., Irshad S., Liu S. -W., Goel S., Hendry S., Bianchi S., Braganca S., Paik S., Wienert S., Fox S. B., Luen S. J., Naber S., Schnitt S. J., Sua L. F., Lakhani S. R., Fineberg S., Soler T., Gevaert T., D'Alfonso T., John T., Sugie T., Kurkure U., Bossuyt V., Manem V., Camara V. P., Tong W., Chen W., Yang W., Tran W. T., Wang Y., Yuan Y., Allory Y., Husain Z., Bago-Horvath Z.

المساهمون: Hudecek J., Voorwerk L., van Seijen M., Nederlof I., de Maaker M., van den Berg J., van de Vijver K.K., Sikorska K., Adams S., Demaria S., Viale G., Nielsen T.O., Badve S.S., Michiels S., Symmans W.F., Sotiriou C., Rimm D.L., Hewitt S.M., Denkert C., Loibl S., Loi S., Bartlett J.M.S., Pruneri G., Dillon D.A., Cheang M.C.U., Tutt A., Hall J.A., Kos Z., Salgado R., Kok M., Horlings H.M., Hyytiainen A., Hida A.I., Thompson A., Lefevre A., Lazar A.J., Gown A., Lo A., Sapino A., Madabhushi A., Moreira A., Richardson A., Vingiani A., Beck A.H., Bellizzi A.M., Guerrero A., Grigoriadis A., Ehinger A., Garrido-Castro A., Vincent-Salomon A., Laenkholm A.-V., Sharma A., Cimino-Mathews A., Srinivasan A., Acs B., Singh B., Calhoun B., Haibe-Kans B., Solomon B., Thapa B., Nelson B.H., Gallas B.D., Castaneda C., Ballesteros-Merino C., Criscitiello C., Boeckx C., Colpaert C., Quinn C., Chennubhotla C.S., Swanton C., Solinas C., Hiley C., Drubay D., Bethmann D., Moore D.A., Larsimont D., Sabanathan D., Peeters D., Zardavas D., Hoflmayer D., Johnson D.B., Thompson E.A., Brogi E., Perez E., ElGabry E.A., Stovgaard E.S., Blackley E.F., Roblin E., Reisenbichler E., Bellolio E., Balslev E., Chmielik E., Gaire F., Andre F., Lu F.-I., Azmoudeh-Ardalan F., Rojo F., Gruosso T., Ciompi F., Peale F.

مصطلحات موضوعية: Biomarker, Breast cancer, Tumour biomarker, Tumour immunology

الوصف: Stromal tumor-infiltrating lymphocytes (sTILs) are a potential predictive biomarker for immunotherapy response in metastatic triple-negative breast cancer (TNBC). To incorporate sTILs into clinical trials and diagnostics, reliable assessment is essential. In this review, we propose a new concept, namely the implementation of a risk-management framework that enables the use of sTILs as a stratification factor in clinical trials. We present the design of a biomarker risk-mitigation workflow that can be applied to any biomarker incorporation in clinical trials. We demonstrate the implementation of this concept using sTILs as an integral biomarker in a single-center phase II immunotherapy trial for metastatic TNBC (TONIC trial, NCT02499367), using this workflow to mitigate risks of suboptimal inclusion of sTILs in this specific trial. In this review, we demonstrate that a web-based scoring platform can mitigate potential risk factors when including sTILs in clinical trials, and we argue that this framework can be applied for any future biomarker-driven clinical trial setting.

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/32436923; info:eu-repo/semantics/altIdentifier/wos/WOS:000544983100001; volume:6; issue:1; firstpage:15; lastpage:N/A; numberofpages:na; journal:NPJ BREAST CANCER; http://hdl.handle.net/2318/1768068Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85083420171

الإتاحة: https://doi.org/10.1038/s41523-020-0155-1Test
http://hdl.handle.net/2318/1768068Test

المؤلفون: Gonzalez-Ericsson P. I., Stovgaard E. S., Sua L. F., Reisenbichler E., Kos Z., Carter J. M., Michiels S., Le Quesne J., Nielsen T. O., Laenkholm A. -V., Fox S. B., Adam J., Bartlett J. M. S., Rimm D. L., Quinn C., Peeters D., Dieci M. V., Vincent-Salomon A., Cree I., Hida A. I., Balko J. M., Haynes H. R., Frahm I., Acosta-Haab G., Balancin M., Bellolio E., Yang W., Kirtani P., Sugie T., Ehinger A., Castaneda C. A., Kok M., McArthur H., Siziopikou K., Badve S., Fineberg S., Gown A., Viale G., Schnitt S. J., Pruneri G., Penault-Llorca F., Hewitt S., Thompson E. A., Allison K. H., Symmans W. F., Bellizzi A. M., Brogi E., Moore D. A., Larsimont D., Dillon D. A., Lazar A., Lien H., Goetz M. P., Broeckx G., El Bairi K., Harbeck N., Cimino-Mathews A., Sotiriou C., Adams S., Liu S. -W., Loibl S., Chen I. -C., Lakhani S. R., Juco J. W., Denkert C., Blackley E. F., Demaria S., Leon-Ferre R., Gluz O., Zardavas D., Emancipator K., Ely S., Loi S., Salgado R., Sanders M.

المساهمون: P.I. Gonzalez-Ericsson, E.S. Stovgaard, L.F. Sua, E. Reisenbichler, Z. Ko, J.M. Carter, S. Michiel, J. Le Quesne, T.O. Nielsen, A.-. Laenkholm, S.B. Fox, J. Adam, J.M.S. Bartlett, D.L. Rimm, C. Quinn, D. Peeter, M.V. Dieci, A. Vincent-Salomon, I. Cree, A.I. Hida, J.M. Balko, H.R. Hayne, I. Frahm, G. Acosta-Haab, M. Balancin, E. Bellolio, W. Yang, P. Kirtani, T. Sugie, A. Ehinger, C.A. Castaneda, M. Kok, H. Mcarthur, K. Siziopikou, S. Badve, S. Fineberg, A. Gown, G. Viale, S.J. Schnitt, G. Pruneri, F. Penault-Llorca, S. Hewitt, E.A. Thompson, K.H. Allison, W.F. Symman, A.M. Bellizzi, E. Brogi, D.A. Moore, D. Larsimont, D.A. Dillon, A. Lazar, H. Lien, M.P. Goetz, G. Broeckx, K. El Bairi, N. Harbeck, A. Cimino-Mathew, C. Sotiriou, S. Adam, S.-. Liu, S. Loibl, I.-. Chen, S.R. Lakhani, J.W. Juco, C. Denkert, E.F. Blackley, S. Demaria, R. Leon-Ferre, O. Gluz, D. Zardava, K. Emancipator, S. Ely, S. Loi, R. Salgado, M. Sanders

مصطلحات موضوعية: biomarker risk-management, breast cancer, immunotherapy, PD-L1, TILs, Settore MED/08 - Anatomia Patologica

الوصف: Immune checkpoint inhibitor therapies targeting PD-1/PD-L1 are now the standard of care in oncology across several hematologic and solid tumor types, including triple negative breast cancer (TNBC). Patients with metastatic or locally advanced TNBC with PD-L1 expression on immune cells occupying ≥1% of tumor area demonstrated survival benefit with the addition of atezolizumab to nab-paclitaxel. However, concerns regarding variability between immunohistochemical PD-L1 assay performance and inter-reader reproducibility have been raised. High tumor-infiltrating lymphocytes (TILs) have also been associated with response to PD-1/PD-L1 inhibitors in patients with breast cancer (BC). TILs can be easily assessed on hematoxylin and eosin–stained slides and have shown reliable inter-reader reproducibility. As an established prognostic factor in early stage TNBC, TILs are soon anticipated to be reported in daily practice in many pathology laboratories worldwide. Because TILs and PD-L1 are parts of an immunological spectrum in BC, we propose the systematic implementation of combined PD-L1 and TIL analyses as a more comprehensive immuno-oncological biomarker for patient selection for PD-1/PD-L1 inhibition-based therapy in patients with BC. Although practical and regulatory considerations differ by jurisdiction, the pathology community has the responsibility to patients to implement assays that lead to optimal patient selection. We propose herewith a risk-management framework that may help mitigate the risks of suboptimal patient selection for immuno-therapeutic approaches in clinical trials and daily practice based on combined TILs/PD-L1 assessment in BC. © 2020 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/32129476; info:eu-repo/semantics/altIdentifier/wos/WOS:000529190600016; volume:250; issue:5; firstpage:667; lastpage:684; numberofpages:18; journal:JOURNAL OF PATHOLOGY; http://hdl.handle.net/2434/734794Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85083463990

الإتاحة: https://doi.org/10.1002/path.5406Test
http://hdl.handle.net/2434/734794Test

المؤلفون: Kos, Z., Roblin, E., Kim, R. S., Michiels, S., Gallas, B. D., Chen, W., van de Vijver, K. K., Goel, S., Adams, S., Demaria, S., Viale, G., Nielsen, T. O., Badve, S. S., Symmans, W. F., Sotiriou, C., Rimm, D. L., Hewitt, S., Denkert, C., Loibl, S., Luen, S. J., Bartlett, J. M. S., Savas, P., Pruneri, G., Dillon, D. A., Cheang, M. C. U., Tutt, A., Hall, J. A., Kok, M., Horlings, H. M., Madabhushi, A., van der Laak, J., Ciompi, F., Laenkholm, A. -V., Bellolio, E., Gruosso, T., Fox, S. B., Araya, J. C., Floris, G., Hudecek, J., Voorwerk, L., Beck, A. H., Kerner, J., Larsimont, D., Declercq, S., Van den Eynden, G., Pusztai, L., Ehinger, A., Yang, W., Abduljabbar, K., Yuan, Y., Singh, R., Hiley, C., Bakir, M., Lazar, A. J., Naber, S., Wienert, S., Castillo, M., Curigliano, G., Dieci, M. -V., Andre, F., Swanton, C., Reis-Filho, J., Sparano, J., Balslev, E., Chen, I. -C., Stovgaard, E. I. S., Pogue-Geile, K., Blenman, K. R. M., Penault-Llorca, F., Schnitt, S., Lakhani, S. R., Vincent-Salomon, A., Rojo, F., Braybrooke, J. P., Hanna, M. G., Soler-Monso, M. T., Bethmann, D., Castaneda, C. A., Willard-Gallo, K., Sharma, A., Lien, H. -C., Fineberg, S., Thagaard, J., Comerma, L., Gonzalez-Ericsson, P., Brogi, E., Loi, S., Saltz, J., Klaushen, F., Cooper, L., Amgad, M., Moore, D. A., Salgado, R., Hyytiainen, A., Hida, A. I., Thompson, A., Lefevre, A., Gown, A., Lo, A., Sapino, A., Moreira, A. M., Richardson, A., Vingiani, A., Bellizzi, A. M., Guerrero, A., Grigoriadis, A., Garrido-Castro, A. C., Cimino-Mathews, A., Srinivasan, A., Acs, B., Singh, B., Calhoun, B., Haibe-Kans, B., Solomon, B., Thapa, B., Nelson, B. H., Ballesteroes-Merino, C., Criscitiello, C., Boeckx, C., Colpaert, C., Quinn, C., Chennubhotla, C. S., Solinas, C., Drubay, D., Sabanathan, D., Peeters, D., Zardavas, D., Hoflmayer, D., Johnson, D. B., Thompson, E. A., Perez, E., Elgabry, E. A., Blackley, E. F., Reisenbichler, E., Chmielik, E., Gaire, F., F. -I., Lu, Azmoudeh-Ardalan, F., Peale, F., Hirsch, F. R., Acosta-Haab, G., Farshid, G., Broeckx, G., Koeppen, H., Haynes, H. R., Mcarthur, H., Joensuu, H., Olofsson, H., Cree, I., Nederlof, I., Frahm, I., Brcic, I., Chan, J., Ziai, J., Brock, J., Weseling, J., Giltnane, J., Lemonnier, J., Zha, J., Ribeiro, J., Lennerz, J. K., Carter, J. M., Hartman, J., Hainfellner, J., Le Quesne, J., Juco, J. W., van den Berg, J., Sanchez, J., Cucherousset, J., Adam, J., Balko, J. M., Saeger, K., Siziopikou, K., Sikorska, K., Weber, K., Steele, K. E., Emancipator, K., El Bairi, K., Allison, K. H., Korski, K., Buisseret, L., Shi, L., Kooreman, L. F. S., Molinero, L., Estrada, M. V., Van Seijen, M., Lacroix-Triki, M., Sebastian, M. M., Balancin, M. L., Mathieu, M. -C., van de Vijver, M., Rebelatto, M. C., Piccart, M., Goetz, M. P., Preusser, M., Khojasteh, M., Sanders, M. E., Regan, M. M., Barnes, M., Christie, M., Misialek, M., Ignatiadis, M., de Maaker, M., Van Bockstal, M., Harbeck, N., Tung, N., Laudus, N., Sirtaine, N., Burchardi, N., Ternes, N., Radosevic-Robin, N., Gluz, O., Grimm, O., Nuciforo, P., Jank, P., Kirtani, P., Watson, P. H., Jelinic, P., Francis, P. A., Russell, P. A., Pierce, R. H., Hills, R., Leon-Ferre, R., de Wind, R., Shui, R., Leung, S., Tabbarah, S., Souza, S. C., O'Toole, S., Swain, S., Dudgeon, S., Willis, S., Ely, S., Bedri, S., Irshad, S., Liu, S., Hendry, S., Bianchi, S., Braganca, S., Paik, S., Luz, S., Gevaert, T., D'Alfons, T., John, T., Sugie, T., Kurkure, U., Bossuyt, V., Manem, V., Camaea, V. P., Tong, W., Tran, W. T., Wang, Y., Allory, Y., Husain, Z., Bago-Horvath, Z.

المساهمون: Service de biostatistique et d'épidémiologie (SBE), Direction de la recherche clinique [Gustave Roussy], Institut Gustave Roussy (IGR)-Institut Gustave Roussy (IGR), Institut Gustave Roussy (IGR), Division of Pathology and Laboratory Medicine, Università degli Studi di Milano [Milano] (UNIMI)-European Institute of Oncology [Milan] (ESMO), Institut Jules Bordet [Bruxelles], Faculté de Médecine [Bruxelles] (ULB), Université libre de Bruxelles (ULB)-Université libre de Bruxelles (ULB), Charité, Institute of Pathology, Translational Tumorpathology Unit, German Breast Group, University of the Sunshine Coast (USC), European Institute of Oncology [Milan] (ESMO), Breakthrough Breast Cancer Centre, London Institute of Cancer, Department of Pathology, The Netherlands Cancer Institute, Division of Experimental Therapy, The Netherlands Cancer Institute NKI/AvL, Odense University Hospital, Unité de génétique et biologie des cancers (U830), Université Paris Descartes - Paris 5 (UPD5)-Institut Curie [Paris]-Institut National de la Santé et de la Recherche Médicale (INSERM), Department of Breast Medical Oncology [Houston], The University of Texas M.D. Anderson Cancer Center [Houston], Helsingborg Hospital, Division of Experimental Therapeutics [Milan, Italy], Département de médecine oncologique [Gustave Roussy], Cancer Research UK Lung Cancer Centre of Excellence [Londres, Royaume-Uni], University College of London [London] (UCL), Memorial Sloane Kettering Cancer Center [New York], Herlev and Gentofte Hospital, Centre Jean Perrin [Clermont-Ferrand] (UNICANCER/CJP), UNICANCER, Imagerie Moléculaire et Stratégies Théranostiques (IMoST), Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-Institut National de la Santé et de la Recherche Médicale (INSERM), University of Southern Queensland (USQ), Pharmacogenomics Unit [Paris], Department of Genetics [Paris], Institut Curie [Paris]-Institut Curie [Paris], Instituto de Física Teórica UAM/CSIC (IFT), Universidad Autonoma de Madrid (UAM)-Consejo Superior de Investigaciones Científicas [Madrid] (CSIC), Ctr Biomol Struct & Org, University of Maryland [College Park], University of Maryland System-University of Maryland System, The University of Sydney, Breast Cancer Translational Research Laboratory, Université libre de Bruxelles (ULB)-Université libre de Bruxelles (ULB)-Faculté de Médecine [Bruxelles] (ULB), Innovation North - Faculty of Information and Technology, Leeds Metropolitan University, Int Immuno-Oncology Biomarker, Graduate School, CCA - Cancer biology and immunology, Pathology, Centre de recherche en épidémiologie et santé des populations (CESP), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay, Oncostat (U1018 (Équipe 2)), Institut Gustave Roussy (IGR)-Centre de recherche en épidémiologie et santé des populations (CESP), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay, Università degli Studi di Milano = University of Milan (UNIMI)-European Institute of Oncology [Milan] (ESMO), German Breast Group (GBG), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020]), Universidad Autónoma de Madrid (UAM)-Consejo Superior de Investigaciones Científicas [Madrid] (CSIC), Gallas, Brandon D [0000-0001-7332-1620], van de Vijver, Koen K [0000-0002-2026-9790], Demaria, Sandra [0000-0003-4426-0499], Badve, Sunil S [0000-0001-8861-9980], Symmans, W Fraser [0000-0002-1526-184X], Rimm, David L [0000-0001-5820-4397], Savas, Peter [0000-0001-5999-428X], Hall, Jacqueline A [0000-0003-0708-1360], Horlings, Hugo M [0000-0003-4782-8828], van der Laak, Jeroen [0000-0001-7982-0754], Bellolio, Enrique [0000-0003-0079-5264], Araya, Juan Carlos [0000-0003-3501-8203], Floris, Giuseppe [0000-0003-2391-5425], Hudeček, Jan [0000-0003-1071-5686], Ehinger, Anna [0000-0001-9225-7396], Lazar, Alexander J [0000-0002-6395-4499], Castillo, Miluska [0000-0002-0111-3176], Curigliano, Giuseppe [0000-0003-1781-2518], Sparano, Joseph [0000-0002-9031-2010], Braybrooke, Jeremy P [0000-0003-1943-7360], Hanna, Matthew G [0000-0002-7536-1746], Willard-Gallo, Karen [0000-0002-1150-1295], Sharma, Ashish [0000-0002-1011-6504], Comerma, Laura [0000-0002-0249-4636], Gonzalez-Ericsson, Paula [0000-0002-6292-6963], Loi, Sherene [0000-0001-6137-9171], Cooper, Lee [0000-0002-3504-4965], Apollo - University of Cambridge Repository, Research Programs Unit, Heikki Joensuu / Principal Investigator, HUS Comprehensive Cancer Center, Department of Oncology, Medicum, Gallas, Brandon D. [0000-0001-7332-1620], van de Vijver, Koen K. [0000-0002-2026-9790], Badve, Sunil S. [0000-0001-8861-9980], Symmans, W. Fraser [0000-0002-1526-184X], Rimm, David L. [0000-0001-5820-4397], Hall, Jacqueline A. [0000-0003-0708-1360], Horlings, Hugo M. [0000-0003-4782-8828], Lazar, Alexander J. [0000-0002-6395-4499], Braybrooke, Jeremy P. [0000-0003-1943-7360], Hanna, Matthew G. [0000-0002-7536-1746]

المصدر: npj Breast Cancer
npj Breast Cancer, Nature, 2020, 6 (1), pp.17. ⟨10.1038/s41523-020-0156-0⟩
NPJ BREAST CANCER
NPJ breast cancer, 6, 1
Dipòsit Digital de la UB
Universidad de Barcelona
npj Breast Cancer, 6(1):17. Nature Publishing Group
The International Immuno-Oncology Biomarker Working Group 2020, ' Pitfalls in assessing stromal tumor infiltrating lymphocytes (sTILs) in breast cancer ', npj Breast Cancer, vol. 6, no. 1, 17 . https://doi.org/10.1038/s41523-020-0156-0Test
NPJ breast cancer, 6
Kos, Z, Roblin, E, Kim, R S, Michiels, S, Gallas, B D, Chen, W, van de Vijver, K K, Goel, S, Adams, S, Demaria, S, Viale, G, Nielsen, T O, Badve, S S, Symmans, W F, Sotiriou, C, Rimm, D L, Hewitt, S, Denkert, C, Loibl, S, Luen, S J, Bartlett, J M S, Savas, P, Pruneri, G, Dillon, D A, Cheang, M C U, Tutt, A, Hall, J A, Kok, M, Horlings, H M, Madabhushi, A, van der Laak, J, Ciompi, F, Laenkholm, A-V, Bellolio, E, Gruosso, T, Fox, S B, Araya, J C, Floris, G, Hudeček, J, Voorwerk, L, Beck, A H, Kerner, J, Larsimont, D, Declercq, S, Van den Eynden, G, Pusztai, L, Ehinger, A, Singh, R, Balslev, E, Stovgaard, E I S & International Immuno-Oncology Biomarker Working Group 2020, ' Pitfalls in assessing stromal tumor infiltrating lymphocytes (sTILs) in breast cancer ', npj Breast Cancer, vol. 6, pp. 17 . https://doi.org/10.1038/s41523-020-0156-0Test
NPJ Breast Cancer
npj Breast Cancer, Vol 6, Iss 1, Pp 1-16 (2020)
npj Breast Cancer, 2020, 6 (1), pp.17. ⟨10.1038/s41523-020-0156-0⟩
2020, ' Pitfalls in Assessing Stromal Tumor Infiltrating Lymphocytes (sTILs) in Breast Cancer ', NPJ Breast Cancer . https://doi.org/10.1038/s41523-020-0156-0Test

مصطلحات موضوعية: Oncology, [SDV]Life Sciences [q-bio], THERAPY, Tumours of the digestive tract Radboud Institute for Health Sciences [Radboudumc 14], Prognostic markers, 0302 clinical medicine, Breast cancer, Medicine and Health Sciences, Pharmacology (medical), Lymphocytes, Stromal tumor, health care economics and organizations, 0303 health sciences, CHEMOTHERAPY, Sciences bio-médicales et agricoles, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, 3. Good health, Women's cancers Radboud Institute for Health Sciences [Radboudumc 17], PROGNOSTIC VALUE, Clinical Practice, 030220 oncology & carcinogenesis, Educational resources, Immunosurveillance, medicine.medical_specialty, 3122 Cancers, [SDV.CAN]Life Sciences [q-bio]/Cancer, IMMUNITY, lcsh:RC254-282, Article, Limfòcits, Càncer de mama, 03 medical and health sciences, Gastrointestinal cancer, SDG 3 - Good Health and Well-being, Internal medicine, 692/53/2422, medicine, Radiology, Nuclear Medicine and imaging, Càncer gastrointestinal, 030304 developmental biology, Predictive biomarker, Tumor-infiltrating lymphocytes, business.industry, Médecine pathologie humaine, medicine.disease, Cancérologie, Human medicine, business, SYSTEM, 631/67/580/1884

الوصف: Stromal tumor-infiltrating lymphocytes (sTILs) are important prognostic and predictive biomarkers in triple-negative (TNBC) and HER2-positive breast cancer. Incorporating sTILs into clinical practice necessitates reproducible assessment. Previously developed standardized scoring guidelines have been widely embraced by the clinical and research communities. We evaluated sources of variability in sTIL assessment by pathologists in three previous sTIL ring studies. We identify common challenges and evaluate impact of discrepancies on outcome estimates in early TNBC using a newly-developed prognostic tool. Discordant sTIL assessment is driven by heterogeneity in lymphocyte distribution. Additional factors include: technical slide-related issues; scoring outside the tumor boundary; tumors with minimal assessable stroma; including lymphocytes associated with other structures; and including other inflammatory cells. Small variations in sTIL assessment modestly alter risk estimation in early TNBC but have the potential to affect treatment selection if cutpoints are employed. Scoring and averaging multiple areas, as well as use of reference images, improve consistency of sTIL evaluation. Moreover, to assist in avoiding the pitfalls identified in this analysis, we developed an educational resource available at www.tilsinbreastcancer.org/pitfalls.
info:eu-repo/semantics/published

وصف الملف: Electronic-eCollection; application/pdf; text/xml; 2 full-text file(s): application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4063f2cd24ffe1264c2ae53c506385acTest
https://lirias.kuleuven.be/handle/123456789/655365Test

المؤلفون: Hudecek, J., Voorwerk, L., van Seijen, M., Nederlof, I., de Maaker, M., van den Berg, J., van de Vijver, K. K., Sikorska, K., Adams, S., Demaria, S., Viale, G., Nielsen, T. O., Badve, S. S., Michiels, S., Symmans, W. F., Sotiriou, C., Rimm, D. L., Hewitt, S. M., Denkert, C., Loibl, S., Loi, S., Bartlett, J. M. S., Pruneri, G., Dillon, D. A., Cheang, M. C. U., Tutt, A., Hall, J. A., Kos, Z., Salgado, R., Kok, M., Horlings, H. M., Hyytiainen, A., Hida, A. I., Thompson, A., Lefevre, A., Lazar, A. J., Gown, A., Lo, A., Sapino, A., Madabhushi, A., Moreira, A., Richardson, A., Vingiani, A., Beck, A. H., Bellizzi, A. M., Guerrero, A., Grigoriadis, A., Ehinger, A., Garrido-Castro, A., Vincent-Salomon, A., Laenkholm, A. -V., Sharma, A., Cimino-Mathews, A., Srinivasan, A., Acs, B., Singh, B., Calhoun, B., Haibe-Kans, B., Solomon, B., Thapa, B., Nelson, B. H., Gallas, B. D., Castaneda, C., Ballesteros-Merino, C., Criscitiello, C., Boeckx, C., Colpaert, C., Quinn, C., Chennubhotla, C. S., Swanton, C., Solinas, C., Hiley, C., Drubay, D., Bethmann, D., Moore, D. A., Larsimont, D., Sabanathan, D., Peeters, D., Zardavas, D., Hoflmayer, D., Johnson, D. B., Thompson, E. A., Brogi, E., Perez, E., Elgabry, E. A., Stovgaard, E. S., Blackley, E. F., Roblin, E., Reisenbichler, E., Bellolio, E., Balslev, E., Chmielik, E., Gaire, F., Andre, F., F. -I., Lu, Azmoudeh-Ardalan, F., Rojo, F., Gruosso, T., Ciompi, F., Peale, F., Hirsch, F. R., Klauschen, F., Penault-Llorca, F., Acosta Haab, G., Farshid, G., van den Eynden, G., Curigliano, G., Floris, G., Broeckx, G., Gonzalez-Ericsson, Koeppen, H., Haynes, H. R., Mcarthur, H., Joensuu, H., Olofsson, H., Lien, H. -C., Chen, I. -C., Cree, I., Frahm, I., Brcic, I., Chan, J., Ziai, J., Brock, J., Wesseling, J., Giltnane, J., Kerner, J. K., Thagaard, J., Braybrooke, J. P., van der Laak, J. A. W. M., Lemonnier, J., Zha, J., Ribeiro, J., Lennerz, J. K., Carter, J. M., Saltz, J., Hartman, J., Hainfellner, J., Quesne, J. L., Juco, J. W., Reis-Filho, J., Sanchez, J., Sparano, J., Cucherousset, J., Araya, J. C., Adam, J., Balko, J. M., Saeger, K., Siziopikou, K., Willard-Gallo, K., Weber, K., Pogue-Geile, K. L., Steele, K. E., Emancipator, K., Abduljabbar, K., El Bairi, K., Blenman, K. R. M., Allison, K. H., Korski, K., Pusztai, L., Comerma, L., Buisseret, L., Cooper, L. A. D., Shi, L., Kooreman, L. F. S., Molinero, L., Estrada, M. V., Lacroix-Triki, M., Al Bakir, M., Sebastian, M. M., van de Vijver, M., Balancin, M. L., Dieci, M. V., Mathieu, M. -C., Rebelatto, M. C., Piccart, M., Hanna, M. G., Goetz, M. P., Preusser, M., Khojasteh, M., Sanders, M. E., Regan, M. M., Barnes, M., Christie, M., Misialek, M., Ignatiadis, M., van Bockstal, M., Castillo, M., Amgad, M., Harbeck, N., Tung, N., Laudus, N., Sirtaine, N., Burchardi, N., Ternes, N., Radosevic-Robin, N., Gluz, O., Grimm, O., Nuciforo, P., Jank, P., Gonzalez-Ericsson, P., Kirtani, P., Jelinic, P., Watson, P. H., Savas, P., Francis, P. A., Russell, P. A., Singh, R., Kim, R. S., Pierce, R. H., Hills, R., Leon-Ferre, R., de Wind, R., Shui, R., De Clercq, S., Leung, S., Tabbarah, S., Souza, S. C., O'Toole, S., Swain, S., Dudgeon, S., Willis, S., Ely, S., Kim, S. -R., Bedri, S., Irshad, S., Liu, S. -W., Goel, S., Hendry, S., Bianchi, S., Braganca, S., Paik, S., Wienert, S., Fox, S. B., Luen, S. J., Naber, S., Schnitt, S. J., Sua, L. F., Lakhani, S. R., Fineberg, S., Soler, T., Gevaert, T., D'Alfonso, T., John, T., Sugie, T., Kurkure, U., Bossuyt, V., Manem, V., Camara, V. P., Tong, W., Chen, W., Yang, W., Tran, W. T., Wang, Y., Yuan, Y., Allory, Y., Husain, Z., Bago-Horvath, Z.

المساهمون: Division of Pathology and Laboratory Medicine, Università degli Studi di Milano [Milano] (UNIMI)-European Institute of Oncology [Milan] (ESMO), Service de biostatistique et d'épidémiologie (SBE), Direction de la recherche clinique [Gustave Roussy], Institut Gustave Roussy (IGR)-Institut Gustave Roussy (IGR), Institut Gustave Roussy (IGR), Institut Jules Bordet [Bruxelles], Faculté de Médecine [Bruxelles] (ULB), Université libre de Bruxelles (ULB)-Université libre de Bruxelles (ULB), Charité, Institute of Pathology, Translational Tumorpathology Unit, German Breast Group, Breast Cancer Translational Research Laboratory, Université libre de Bruxelles (ULB)-Université libre de Bruxelles (ULB)-Faculté de Médecine [Bruxelles] (ULB), University of the Sunshine Coast (USC), European Institute of Oncology [Milan] (ESMO), Breakthrough Breast Cancer Centre, London Institute of Cancer, Department of Pathology, The Netherlands Cancer Institute, Division of Experimental Therapy, The Netherlands Cancer Institute NKI/AvL, Imagerie Moléculaire et Stratégies Théranostiques (IMoST), Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre Jean Perrin [Clermont-Ferrand] (UNICANCER/CJP), UNICANCER, Hudeček, Jan [0000-0003-1071-5686], van de Vijver, Koen K [0000-0002-2026-9790], Demaria, Sandra [0000-0003-4426-0499], Badve, Sunil S [0000-0001-8861-9980], Symmans, William Fraser [0000-0002-1526-184X], Rimm, David L [0000-0001-5820-4397], Loi, Sherene [0000-0001-6137-9171], Hall, Jacqueline A [0000-0003-0708-1360], Horlings, Hugo M [0000-0003-4782-8828], Apollo - University of Cambridge Repository, van de Vijver, Koen K. [0000-0002-2026-9790], Badve, Sunil S. [0000-0001-8861-9980], Rimm, David L. [0000-0001-5820-4397], Hall, Jacqueline A. [0000-0003-0708-1360], Horlings, Hugo M. [0000-0003-4782-8828], Università degli Studi di Milano = University of Milan (UNIMI)-European Institute of Oncology [Milan] (ESMO), Centre de recherche en épidémiologie et santé des populations (CESP), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay, Oncostat (U1018 (Équipe 2)), Institut Gustave Roussy (IGR)-Centre de recherche en épidémiologie et santé des populations (CESP), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay, German Breast Group (GBG), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020])

المصدر: NPJ breast cancer, 6
npj Breast Cancer
npj Breast Cancer, Nature, 2020, 6 (1), pp.15. ⟨10.1038/s41523-020-0155-1⟩
NPJ Breast Cancer
npj Breast Cancer, Vol 6, Iss 1, Pp 1-8 (2020)
2020, ' Application of a risk-management framework for integration of stromal Tumor Infiltrating Lymphocytes in clinical trials ', NPJ Breast Cancer . https://doi.org/10.1038/s41523-020-0155-1Test
NPJ BREAST CANCER
npj Breast Cancer, 2020, 6 (1), pp.15. ⟨10.1038/s41523-020-0155-1⟩

مصطلحات موضوعية: 0301 basic medicine, Oncology, medicine.medical_specialty, [SDV]Life Sciences [q-bio], medicine.medical_treatment, MEDLINE, [SDV.CAN]Life Sciences [q-bio]/Cancer, Review Article, lcsh:RC254-282, 631/67/1857, Tumour biomarkers, Tumours of the digestive tract Radboud Institute for Health Sciences [Radboudumc 14], 03 medical and health sciences, 0302 clinical medicine, Breast cancer, 692/53, Internal medicine, Medicine and Health Sciences, medicine, Pharmacology (medical), Radiology, Nuclear Medicine and imaging, 692/4028/67/580, Stromal tumor, Biomarkers, Tumour immunology, business.industry, Risk management framework, review-article, Médecine pathologie humaine, 631/67/1347, Immunotherapy, Sciences bio-médicales et agricoles, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, medicine.disease, Women's cancers Radboud Institute for Health Sciences [Radboudumc 17], 3. Good health, Review article, Clinical trial, Cancérologie, 030104 developmental biology, 030220 oncology & carcinogenesis, Biomarker (medicine), business

الوصف: Stromal tumor-infiltrating lymphocytes (sTILs) are a potential predictive biomarker for immunotherapy response in metastatic triple-negative breast cancer (TNBC). To incorporate sTILs into clinical trials and diagnostics, reliable assessment is essential. In this review, we propose a new concept, namely the implementation of a risk-management framework that enables the use of sTILs as a stratification factor in clinical trials. We present the design of a biomarker risk-mitigation workflow that can be applied to any biomarker incorporation in clinical trials. We demonstrate the implementation of this concept using sTILs as an integral biomarker in a single-center phase II immunotherapy trial for metastatic TNBC (TONIC trial, NCT02499367), using this workflow to mitigate risks of suboptimal inclusion of sTILs in this specific trial. In this review, we demonstrate that a web-based scoring platform can mitigate potential risk factors when including sTILs in clinical trials, and we argue that this framework can be applied for any future biomarker-driven clinical trial setting.
info:eu-repo/semantics/published

وصف الملف: 3 full-text file(s): application/pdf; application/pdf; text/xml

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5cc0eed7935fac67e7046bd597e941f6Test
http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/317463Test

المؤلفون: Dickson, B. C., Srigley, J. R., Aaron Pollett, Blackstein, M. E., Honey, J. D., Juco, J. W.

المصدر: ResearcherID

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::8a4ea3300da629033ac039594739ed63Test
http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000261638800015&KeyUID=WOS:000261638800015Test