نتائج البحث - "Joseph C. Kong"

1

دورية أكاديمية

Molecular and genomic characterisation of a panel of human anal cancer cell lines

المصدر: Cell Death and Disease, Vol 12, Iss 11, Pp 1-15 (2021)

مصطلحات موضوعية: Cytology, QH573-671

الوصف: Abstract Anal cancer is a rare disease that has doubled in incidence over the last four decades. Current treatment and survival of patients with this disease has not changed substantially over this period of time, due, in part, to a paucity of preclinical models to assess new therapeutic options. To address this hiatus, we set-out to establish, validate and characterise a panel of human anal squamous cell carcinoma (ASCC) cell lines by employing an explant technique using fresh human ASCC tumour tissue. The panel of five human ASCC cell lines were validated to confirm their origin, squamous features and tumourigenicity, followed by molecular and genomic (whole-exome sequencing) characterisation. This panel recapitulates the genetic and molecular characteristics previously described in ASCC including phosphoinositide-3-kinase (PI3K) mutations in three of the human papillomavirus (HPV) positive lines and TP53 mutations in the HPV negative line. The cell lines demonstrate the ability to form tumouroids and retain their tumourigenic potential upon xenotransplantation, with varied inducible expression of major histocompatibility complex class I (MHC class I) and Programmed cell death ligand 1 (PD-L1). We observed differential responses to standard chemotherapy, radiotherapy and a PI3K specific molecular targeted agent in vitro, which correlated with the clinical response of the patient tumours from which they were derived. We anticipate this novel panel of human ASCC cell lines will form a valuable resource for future studies into the biology and therapeutics of this rare disease.

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/2041-4889Test

الوصول الحر: https://doaj.org/article/f18d31fc26fb4a7987f5b99e3a2cb440Test

View record in DOAJ

النص الكامل

2

دورية أكاديمية

A cohort study and meta-analysis of the evidence for consideration of Lauren subtype when prescribing adjuvant or palliative chemotherapy for gastric cancer

المؤلفون: Kunning Wang, Enxiao Li, Rita A. Busuttil, Joseph C. Kong, Sharon Pattison, Joseph J. Y. Sung, Jun Yu, Emad M. El-Omar, Julie A. Simpson, Alex Boussioutas

المصدر: Therapeutic Advances in Medical Oncology, Vol 12 (2020)

مصطلحات موضوعية: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

الوصف: Background: The association between the survival or efficacy of chemotherapy and the Lauren subtype of gastric cancer (GC) remains unclear. We aimed to clarify whether patients with different Lauren subtypes have different survival after treatment with systemic chemotherapy: intestinal gastric cancer (IGC) patients survived better than patients with mixed type gastric cancer (MGC) or diffuse gastric cancer (DGC) after treatment with systemic chemotherapy. Patients & methods: Relevant studies for the meta-analysis were identified through searching Pubmed, Embase, Cochrane and Ovid up to March 2020. We also included our own prospectively collected cohort of patients that were followed over a 10-year period. Sub-group and sensitivity analyses were also performed. Results: In our prospective cohort, the overall survival (OS) of IGC patients receiving systemic chemotherapy (chemoIGC) [median OS 5.01 years, interquartile range (IQR) 2.63–6.71] was significantly higher than that of DGC patients receiving the same chemotherapy (chemoDGC) (median OS 1.33 years, IQR 0.78–3.33, p = 0.0001). After adjusting for age, gender and cancer stage, there was a significant difference in OS in patients treated with chemotherapy based on the Lauren classification of GC {hazard ratio (HR) for OS of the IGC versus DGC 0.33, [95% confidence interval (CI), 0.17–0.65; p

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/1758-8359Test

الوصول الحر: https://doaj.org/article/6ded05bf87f341dab3ff14d0b5f963efTest

View record in DOAJ

النص الكامل

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Predictive Factors for Anastomotic Leak in Colorectal Surgery: A Bi-National Database Study

المؤلفون: Swetha Prabhakaran, Sowmya Prabhakaran, Wei Mou Lim, Glen Guerra, Alexander G. Heriot, Joseph C. Kong

المصدر: Polish Journal of Surgery. 95:1-5

مصطلحات موضوعية: Surgery, General Medicine

الوصف: Introduction Anastomotic leak (AL) is a serious complication following colorectal surgery. This study aimed to identify factors associated with the development of AL and analyze its impact on survival. Materials and Methods All consecutive adult colorectal cancer resections with curative intent and anastomosis formation were included from a prospectively maintained bi-national database between 2007 and 2020. The primary outcome measure was the rate of AL. The secondary outcome measure was 5-year overall survival (OS). Results There were 7566 eligible patients. The rate of AL was 2.3% and 4.4% in patients with colon and rectal cancer respectively. AL was a significant independent predictor of reduced 5-year OS in patients who underwent curative surgery for rectal cancer (Odds ratio 1.999, p = 0.017). Emergency surgery (p = 0.013), surgery at a public hospital (p < 0.01), and an open surgical approach (p = 0.002) were all significantly associated with a higher risk of AL in patients with colon cancer, with higher rates of AL noted in left colectomies as compared to right hemicolectomies (6.8% vs 1.6%, p < 0.05). In rectal cancer patients, ultra-low anterior resections had the highest risk of AL (4.6%), and associations were found with neoadjuvant chemotherapy (p = 0.011), surgery in a public hospital (p = 0.019), and an open approach (p = 0.035). Anastomosis formation technique (hand-sewn vs stapled) did not impact on rate of AL. Discussion Clinicians should be cognizant of the predictive factors for AL and consider early intervention for patients at risk of this.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::884306753af703533ba8e5c0e840366aTest
https://doi.org/10.5604/01.3001.0016.1602Test

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Metabolic and magnetic resonance imaging: complementary modalities for the preoperative assessment of lateral pelvic lymph nodes in rectal cancer

المؤلفون: Benjamin I. Cribb, Joseph C. Kong, James S. Kay, Teng H. Tan, Geertje D. Noe, Bibiche Gest, Allan B. Lee, Sheng F. Oon, Satish K. Warrier, Alexander G. Heriot

المصدر: ANZ Journal of Surgery. 93:196-205

مصطلحات موضوعية: Surgery, General Medicine

الوصف: The management of lateral pelvic lymph nodes for rectal cancer is a topical and controversial issue. The aim of this study was to assess the relationship between lateral pelvic lymph node features on magnetic resonance imaging (MRI) and positron emission tomography-computed tomography (PET-CT) with oncological outcomes in patients with rectal cancer.A retrospective analysis of 284 patients with primary locally advanced rectal cancer treated with neoadjuvant therapy and surgical resection with curative intent between January 2003 and Dec 2018 was undertaken. From this study population, a select cohort of 77 patients with abnormal lateral pelvic lymph nodes on preoperative imaging had imaging re-analysed by radiologists blinded to clinical outcomes. Pre and post neoadjuvant therapy MRI and PET-CT lateral pelvic lymph node features were correlated with oncological outcomes.A lateral pelvic lymph node short axis size ≥5 mm on post neoadjuvant therapy MRI was a significant predictor of worse 3-year local recurrence free survival (HR 8.35, P = 0.001). Lateral pelvic lymph node avidity on post neoadjuvant therapy PET-CT was a significant predictor of worse 3-year distant recurrence free survival (HR 5.62, P = 0.001). No correlation of oncological outcomes with overall survival was identified.Lateral pelvic lymph node imaging features on post-neoadjuvant therapy MRI and PET-CT predicted those at risk of rectal cancer recurrence. Further studies are required to confirm these findings that suggest restaging MRI and PET-CT are complementary modalities for the preoperative assessment of lateral pelvic lymph nodes in rectal cancer.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0c973c9da72afd89bbec7038eb55042Test
https://doi.org/10.1111/ans.18020Test

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Exercise and colorectal cancer survival: an updated systematic review and meta-analysis

المؤلفون: Kay T. Choy, Kenneth Lam, Joseph C. Kong

المصدر: International Journal of Colorectal Disease. 37:1751-1758

مصطلحات موضوعية: Gastroenterology

الوصف: Purpose The benefit of exercise to colorectal cancer patients has been advocated. However, comparative data to quantify the survival benefit is lacking. The aim of this review was to assess the effect of exercise on colorectal cancer survival. Methods An up-to-date systematic review was performed on the available literature between 2000 and 2021 on PubMed, EMBASE, Medline, and Cochrane Library databases. All studies reporting on the impact of exercise and colorectal cancer outcomes in patients treated for non-metastatic colorectal cancer were analysed. The main outcome measures were the overall survival (OS), cancer specific survival (CSS) and disease free survival (DFS). Results A total of 13 prospective observational studies were included, accounting for 19,135 patients. Compared to negligible physical activity, overall survival (OS) was significantly increased for both moderate and highest activity group (HR 0.82, 95% CI: 0.74–0.90, p p Conclusion Exercise was associated with an increased in overall survival after a colorectal cancer resection. This would support the promotion of exercise interventions amongst colorectal cancer patients.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::3763dce089c86ad0efad31d53c982804Test
https://doi.org/10.1007/s00384-022-04224-5Test

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Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy for colorectal peritoneal metastases in an elderly population: outcomes from a single centre

المؤلفون: Michael P. Flood, Vignesh Narasimhan, Peadar S. Waters, Joseph C. Kong, Robert Ramsay, Michael Michael, Jeanne Tie, Jacob J. McCormick, Satish K. Warrier, Alexander G. Heriot

المصدر: ANZ Journal of Surgery. 92:2192-2198

مصطلحات موضوعية: Aged, 80 and over, Cytoreduction Surgical Procedures, Hyperthermia, Induced, Hyperthermic Intraperitoneal Chemotherapy, General Medicine, Combined Modality Therapy, Survival Rate, Percutaneous Coronary Intervention, Antineoplastic Combined Chemotherapy Protocols, Humans, Surgery, Colorectal Neoplasms, Peritoneal Neoplasms, Aged, Retrospective Studies

الوصف: The prevalence of elderly patients with resectable colorectal peritoneal metastases (CRPM) is increasing. This study aimed to compare short and long-term outcomes of cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) for CRPM in patients above and below 70 years of age.This was a retrospective, 10-year analysis of 90-day major morbidity and mortality, and long-term survival.Thirty-two (21.3%) of 150 consecutive patients who underwent CRS and HIPEC during the study period were aged 70 and older. PCI (P = 0.04), perioperative chemotherapy use (P 0.01) and organ resections (rectum P = 0.04, diaphragm P = 0.03) were less in the over 70 group. There was no significant differences in major morbidity (P = 0.19) and mortality (P = 0.32). There was also no difference in 5-year overall survival (OS) (≥70: 26% vs.70: 39%; P = 0.68) and disease-free survival (DFS) (≥70: 25% vs.70: 14%; P = 0.22). Age above 70 was not independently associated with worse OS (HR 1.55, P = 0.20) and DFS (HR 1.07, P = 0.81).The surgical management of CRPM appears safe and feasible in this elderly population. Appropriate selection of elderly patients for such radical intervention is reinforced by the comparable survival with those under 70.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d64eae71ae305889ee54fad5fba2a97bTest
https://doi.org/10.1111/ans.17761Test

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Robotic colon surgery in obese patients: a systematic review and meta‐analysis

المؤلفون: Jason Wang, Nicholas W. Johnson, Laura Casey, Peter W. G. Carne, Stephen Bell, Martin Chin, Paul Simpson, Joseph C. Kong

المصدر: ANZ Journal of Surgery. 93:35-41

مصطلحات موضوعية: Surgery, General Medicine

الوصف: Colon cancer resection can be technically difficult in the obese (OB) population. Robotic surgery is a promising technique but its benefits remain uncertain in OB patients. The aim of this study is to compare OB versus non-obese (NOB) patients undergoing robotic colon surgery, as well as OB patients undergoing robotic versus open or laparoscopic colonic surgery.A systematic review and meta-analysis was performed. Primary outcome measures included length of stay (LOS), surgical site infection (SSI) rate, complications, anastomotic leak and oncological outcomes.A total of eight studies were included, with five comparing OB and NOB patients undergoing robotic colon surgery included in meta-analysis. A total of 263 OB patients and 400 NOB patients formed the sample for meta-analysis. There was no significant difference between the two groups in operative time, conversion to open, LOS, lymph node yield, anastomotic leak and postoperative ileus. There was a trend towards a significant increase in overall complications and SSI in the OB group (32.3% OB versus 26.8% NOB for complications, 14.2% OB versus 9.9% NOB for SSI). The three included studies comparing surgical techniques were too heterogeneous to undergo meta-analysis.Robotic colon surgery is safe in obese patients, but high-quality prospective evidence is lacking. Future studies should report on oncological safety and the cost-effectiveness of adopting the robotic technique in these challenging patients.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49de78eb2bee9bd0feeed2eb50d6faa7Test
https://doi.org/10.1111/ans.17749Test