المؤلفون: Justin C. Galvin, Arul Earnest, Jacob Egwunye, Rohan W. Essex, Adrian T. Fung, Rohan Essex, Susannah Ahern, Penny Allen, Fred Chen, Ben Clarke, Stewart Lake, Matthew Simunovic, Robert Charles Andrew Symons, Joel Yap, Jolly Gilhotra, Weng Chan

المصدر: Ophthalmology Retina. 6:985-991

مصطلحات موضوعية: Ophthalmology

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::4a2303fe64c45943804a9d220dd81cc1Test
https://doi.org/10.1016/j.oret.2022.05.025Test

المؤلفون: Robyn H. Guymer, Caroline M. Markey, Ian L. McAllister, Mark C. Gillies, Alex P. Hunyor, Jennifer J. Arnold, Andrew Chang, Adil Syed, Geoffrey Broadhead, Thomas Pham, Thomas Hong, Lily Wong, Meidong Zhu, Shelley Burnett, Nichole Joachim, Wijeyanthy Wijeyakumar, Gabriel Manalang, Cleopatra Mhlanga, Nicole Joachim, Kimperly Spooner, Paul Mitchell, Suriya Foran, Christabel Wilson, Victoria Cossatto, Laskshmi Waniganayke, Vivien Mai, Rabiya Atif, Lakshmi Wa, Sapna Maharaj, David Liong, Christine Matic, Katherine Tran, Sheenal Jas, Danielle Gibbs, Sanj Wickremasinghe, Robyn Guymer, Lyndell Lim, Sukhpal Sandhu, Thanh Nguyen, Dania Qatarneh, Hessom Razavi, Elaine Chong, Matthew Little, Gaurav Bhardwau, Michael Ayres, Michael Chen, Daini Ong, Katarina Creese, Tricia Drew, Carly D'Sylva Parfett, Tanya Pejnovic, Thuy Chau, Sutha Sanmugasundram, Maria Kolic, Elizabeth Glatz, Tina-Marie Tonder, Alan Luckie, Stephen Heery, Timothy Steele, Jennifer Arnold, Bryan Matthews, Julie Croft, Alex Breen, Bronwyn Gabriel, Maegan Anderson, Michelle Dodds, Marcus Dwyer, Bev Brown, Jacinta Dwyer, Ivan Fu, Helen Macauley, James Wong, Rajeev Chalasani, Charmaine Lim, Son Huynh, Timothy Nolan, James Leong, Kit Lau, Swas Kumar, Trang Nguyen, Joseph Bitar, Hannah Ahern, Arooj Ali, Nuria Zamora, Angela Lai, Randa Moussa, Carmen Do, Nitin Verma, Guy Bylsma, Andrew Traill, Beverley Curry, Amy Paprotny, Alfonso Ayesa, Alyse Johns, Zanobia Ujjainwala, Andrew Maver, Derek Chan, John Chang, Hyong Kwon Kang, Gavin Stringfellow, Terence Tan, Helen Cass, Trish Forsyth, Anh Nguyen, Angela Chung, Harriette Ayson, Catherine Severino, Caroline Chahine, Lara Collis, Anita Cristy, Mona Mohmodian, Selina Webb, Muradiya Payir, Mara Garibaldi, Trazia Mekhail, Brendan Vote, Tze'Yo Toh, Nima Pakrou, Jennie Rossetto, Shannon Harris, Rachael Adams, Rachael Groves, Maddie Johns, Kristie Richards, Eliza Jenkins, Natalie Daley, James Baker, Mark Gorbatov, Lavaniya Rajanayagam, Ludmila Jitskaia, Jenny Xie, Anthony Nguyen, Ian McAllister, Fred Chen, Tim Isaacs, Tracey-Anne Dickens, Rachel Matthews, Amelia Jason, Ivy Tang, Gareth Lingham, Holly Brown, Alla Soloshenko, Max Cuypers, Anne McSweeney, Jolly Gilhotra, Shane Durkin, James Muecke, Kerin Haywood, Cathy Brko, Rinty Vincent, Carolyn Luscombe, Alex Hunyor, Christine Younan, Robert Chong, Rohan Merani, Adrian Fung, I-Van Ho, Gerald Liew, Vinnci Lee, Gerald Chan, Sarah Liu, Tharini Ganess, Susanthy Rajasundaran, Maryam Sadat, Godfrey Quin, Stephen Ong, Claire Hooper, Vivien Dihn, Ward Al-Ghurani, Sally Ngai, Maria Choi, Gordana Tisma, Anton Van Heerden, Anthony Hall, Kira Michalova, Natalie Coleman, Allanah Price, Mercy Nguyen, Clodia Hanna, Camille Collins, Elaina Dickeson, Annie Lee, Mela Bilyk, Theresa Lee, John Downie, Naggi Assaad, Leanne Cooper, Catherine Le, Amanda Armanssen, Zena Khalil

المصدر: Ophthalmology. 126:723-734

مصطلحات موضوعية: medicine.medical_specialty, Visual acuity, genetic structures, Bevacizumab, law.invention, 03 medical and health sciences, 0302 clinical medicine, Randomized controlled trial, law, Ophthalmology, Medicine, Prospective cohort study, 030304 developmental biology, 0303 health sciences, medicine.diagnostic_test, business.industry, Retrospective cohort study, Macular degeneration, Fluorescein angiography, medicine.disease, 030221 ophthalmology & optometry, medicine.symptom, Ranibizumab, business, medicine.drug

الوصف: Purpose To test the hypothesis that tolerating some subretinal fluid (SRF) in patients with neovascular age-related macular degeneration (nAMD) treated with ranibizumab using a treat-and-extend (TE intensive arm: SRF intolerant) or resolution of all IRF only (relaxed arm: SRF tolerant except for SRF >200 μm at the foveal center) before extending treatment intervals. A 5-letter noninferiority margin was applied to the primary outcome. Main Outcome Measures Mean change in best-corrected VA (BCVA), and central subfield thickness and number of injections from baseline to month 24. Results Of the 349 participants randomized (intensive arm, n = 174; relaxed arm, n = 175), 279 (79.9%) completed the month 24. The mean change in BCVA from baseline to month 24 was 3.0 letters (standard deviation, 16.3 letters) in the intensive group and 2.6 letters (standard deviation, 16.3 letters) in the relaxed group, demonstrating noninferiority of the relaxed compared with the intensive treatment (P = 0.99). Similar proportions of both groups achieved 20/40 or better VA (53.5% and 56.6%, respectively; P = 0.92) and 20/200 or worse VA (8.7% and 8.1%, respectively; P = 0.52). Participants in the relaxed group received fewer ranibizumab injections over 24 months (mean, 15.8 [standard deviation, 5.9]) than those in the intensive group (mean, 17 [standard deviation, 6.5]; P = 0.001). Significantly more participants in the intensive group never extended beyond 4-week treatment intervals (13.5%) than in the relaxed group (2.8%; P = 0.003), and significantly more participants in the relaxed group extended to and maintained 12-week treatment intervals (29.6%) than the intensive group (15.0%; P = 0.005). Conclusions Patients treated with a ranibizumab T&E protocol who tolerated some SRF achieved VA that is comparable, with fewer injections, with that achieved when treatment aimed to resolve all SRF completely.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::6f4e58757b22fd68b8620ac18ddf7063Test
https://doi.org/10.1016/j.ophtha.2018.11.025Test

المؤلفون: Bishwanath Pal, Ebony Liu, Rohan W Essex, Sotoodeh Abhary, Georgia Kaidonis, Jamie E Craig, Mark C Gillies, Alicia J. Jenkins, Ecosse L. Lamoureux, Jonathan M. Gleadle, John H Chang, Jolly Gilhotra, Kathryn P. Burdon, Nikolai Petrovsky, Mark Daniell, Alex W. Hewitt, Stewart Lake

المصدر: Scientific Reports, Vol 9, Iss 1, Pp 1-7 (2019)
Scientific Reports

مصطلحات موضوعية: Male, 0301 basic medicine, endocrine system diseases, genetic structures, lcsh:Medicine, Type 2 diabetes, Severity of Illness Index, Haplogroup, 0302 clinical medicine, Polymorphism (computer science), 10. No inequality, lcsh:Science, Aged, 80 and over, Multidisciplinary, Diabetic retinopathy, Middle Aged, Mitochondria, Phenotype, Female, Adult, medicine.medical_specialty, Adolescent, Genotype, Single-nucleotide polymorphism, Polymorphism, Single Nucleotide, Macular Edema, White People, Article, Young Adult, 03 medical and health sciences, Internal medicine, Diabetes mellitus, medicine, Humans, Aged, Glycated Hemoglobin, Diabetic Retinopathy, business.industry, lcsh:R, Australia, Case-control study, medicine.disease, United Kingdom, eye diseases, Diabetes Mellitus, Type 1, 030104 developmental biology, Diabetes Mellitus, Type 2, Case-Control Studies, lcsh:Q, business, 030217 neurology & neurosurgery, Human mitochondrial DNA haplogroup

الوصف: Mitochondrial haplogroups H1, H2 and UK have previously been reported to be associated with proliferative diabetic retinopathy (PDR) in Caucasian patients with diabetes. We aimed to replicate this finding with a larger sample and expand the analysis to include different severities of DR, and diabetic macular edema (DME). Caucasian participants (n = 2935) with either type 1 or type 2 diabetes from the Australian Registry of Advanced Diabetic Retinopathy were enrolled in this study. Twenty-two mitochondrial single nucleotide polymorphisms were genotyped by MassArray and haplogroups reconstructed using Haplogrep. Chi square tests and logistic regressions were used to test associations between haplogroup and DR phenotypes including any DR, non-proliferative DR (NPDR), proliferative DR (PDR) and DME. After stratifying the samples in type 1 and type 2 diabetes groups, and adjusting for sex, age, diabetes duration, concurrent HbA1c and hypertension, neither haplogroups H1, H2, UK, K or JT were associated with any DR, NPDR, PDR or DME.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d24796f4c0fbd3b73adca8cd063fcd3Test
http://link.springer.com/article/10.1038/s41598-018-37388-8Test

المؤلفون: Jamie Craig (11354748), Ebony Liu (11358891), Georgia Kaidonis (5185217), Mark Gilles (11358894), Sotoodeh Abhary (252379), Rohan Essex (5185220), John Chang (364595), Bishwanath Pal (5185214), Mark Daniell (506570), Stewart Lake (10997922), Jolly Gilhotra (11358897), Nikolai Petrovsky (11354802), Alex Hewitt (3457262), Alicia Jenkins (804281), Ecosse Lamoureux (827837), Jonathan Gleadle (11354757), Kathryn Burdon (11354766)

مصطلحات موضوعية: Ophthalmology, mitochondrial haplogroup, diabetic retinopathy, caucasian

الوصف: This dataset has information on approximately 3000 de-identified individuals. Information includes: mitochondrial haplogroup as determined by genotyping and Haplogrep, demographic and clinical information such as diabetic retinopathy grading. Data is expressed in numbers. Unless otherwise specified in the headings, “-9” means unknown, “1” means no and “2” means yes. Further details regarding the methodology can be found in our manuscript “Mitochondrial haplogroups are not associated with diabetic retinopathy in a large Australian and British Caucasian sample” published by Scientific Reports 2018. Date coverage: 2006-01-01 - 2018-07-03 Location: Various hospitals in Australia and United Kingdom

العلاقة: https://figshare.com/articles/dataset/Mitochondrial_haplogroups_in_an_Australian_and_British_Caucasian_diabetic_sample_with_and_without_retinopathy/16545603Test

الإتاحة: https://doi.org/10.25957/5c060cbdb9162Test

المؤلفون: Shyalle, Kahawita, Sumu, Simon, Jolly, Gilhotra

المصدر: Australian family physician. 43(4)

مصطلحات موضوعية: Diagnosis, Differential, Vitreous Body, Ophthalmology, Risk Factors, General Practice, Retinal Detachment, Humans, Retinal Perforations, Referral and Consultation

الوصف: Flashes and floaters are common ophthalmic issues for which patients may initially present to their general practitioner. It may be a sign of benign, age-related changes of the vitreous or more serious retinal detachment.This article provides a guide to the assessment and management of a patient presenting with flashes and floaters.Although most patients presenting with flashes and floaters have benign age-related changes, they must be referred to an ophthalmologist to rule out sight-threatening conditions. Key examination features include the nature of the flashes and floaters, whether one or both eyes are affected and changes in visual acuity or visual field.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=pmid________::7a6b704efbda50e7a1fcdc476cf6d1e9Test
https://pubmed.ncbi.nlm.nih.gov/25551879Test

المساهمون: Alex Hewitt (hasCollector), Alicia Jenkins (hasCollector), Bishwanath Pal (hasCollector), Ebony Liu (hasCollector), Ecosse Lamoureux (hasCollector), Georgia Kaidonis (hasCollector), Jamie Craig (hasCollector), John Chang (hasCollector), Jolly Gilhotra (hasCollector), Jonathan Gleadle (hasCollector), Kathryn Penelope Burdon (hasCollector), Mark Daniell (hasCollector), Mark Gilles (hasCollector), Nikolai Petrovsky (hasCollector), Rohan Essex (hasCollector), Sotoodeh Abhary (hasCollector), stewart lake (hasCollector)

المصدر: Flinders University

مصطلحات موضوعية: mitochondrial haplogroup, diabetic retinopathy, caucasian, Ophthalmology

الوصف: This dataset has information on approximately 3000 de-identified individuals. Information includes: mitochondrial haplogroup as determined by genotyping and Haplogrep, demographic and clinical information such as diabetic retinopathy grading. Data is expressed in numbers. Unless otherwise specified in the headings, “-9” means unknown, “1” means no and “2” means yes. Further details regarding the methodology can be found in our manuscript “Mitochondrial haplogroups are not associated with diabetic retinopathy in a large Australian and British Caucasian sample” published by Scientific Reports 2018. Date coverage: 2006-01-01 - 2018-07-03 Location: Various hospitals in Australia and United Kingdom

العلاقة: https://researchdata.edu.au/mitochondrial-haplogroups-an-sample-retinopathy/1793328Test; https://doi.org/10.25957/5c060cbdb9162Test

الإتاحة: https://doi.org/10.25957/5c060cbdb9162Test
https://researchdata.edu.au/mitochondrial-haplogroups-an-sample-retinopathy/1793328Test