المؤلفون: Steel, Judith M, Johnstone, Frank D

المصدر: New Zealand patient management, Feb 1997; v.26 n.2:p.49-57

المؤلفون: Lindsay, Robert S, Walker, James D, Havel, Peter J, Hamilton, Barbara A, Calder, Andrew A, Johnstone, Frank D

المصدر: Diabetes Care. 26(8)

مصطلحات موضوعية: Clinical Research, Diabetes, Obesity, Pediatric, Metabolic and endocrine, Adiponectin, Adipose Tissue, Adult, Birth Weight, Diabetes Mellitus, Type 1, Female, Fetal Blood, Gestational Age, Humans, Infant, Newborn, Insulin, Intercellular Signaling Peptides and Proteins, Leptin, Male, Pregnancy, Pregnancy in Diabetics, Proteins, Scottish Multicentre Study of Diabetes Pregnancy

الوصف: ObjectiveIn adults, adiponectin is reduced in association with excess adiposity, type 2 diabetes, and hyperinsulinemia. We assessed whether adiponectin was 1) present in the fetal circulation, 2) altered in the fetal circulation in the presence of maternal diabetes, and 3) had relations to fetal cord blood insulin or adiposity.Research design and methodsWe assessed adiponectin in cord blood in a large cohort of singleton offspring of diabetic mothers (ODM; n = 134) and control mothers (n = 45).ResultsAdiponectin was present in cord blood and, in ODM, was higher in those delivered at later gestational ages (Spearman r = 0.18, P = 0.03). Adiponectin was slightly lower in ODM than control subjects (ODM 19.7 +/- 6.1 vs. control 21.8 +/- 5.3 micro g/ml; P = 0.04), although this difference could potentially reflect different gestational ages in the two groups (ODM 37.6 +/- 1.5 and control 40.1 +/- 1.1 weeks). In contrast to adults, adiponectin levels in the fetus were unrelated to the degree of adiposity, blood insulin, or leptin in either control subjects or ODM.ConclusionsAdiponectin is present in cord blood but does not show expected physiological relations with adiposity as observed in adults.

وصف الملف: application/pdf

الوصول الحر: https://escholarship.org/uc/item/0fv3173jTest

المؤلفون: Simpson, Wendy M., Johnstone, Frank D., Goldberg, David J., Gormley, Siobhan M., Hart, Graham J.

المصدر: BMJ: British Medical Journal, 1999 Jun . 318(7199), 1660-1661.

الوصول الحر: https://www.jstor.org/stable/25184987Test

المؤلفون: Simpson, Wendy M., Johnstone, Frank D., Boyd, Fiona M., Goldberg, David J., Hart, Graham J., Prescott, Robin J.

المصدر: BMJ: British Medical Journal, 1998 Jan . 316(7127), 262-267.

الوصول الحر: https://www.jstor.org/stable/25176843Test

المؤلفون: Simpson, Wendy M, Johnstone, Frank D, Goldberg, David J, Gormley, Siobhan M, Hart, Graham J

مصطلحات موضوعية: PAPERS

وصف الملف: text/html

العلاقة: http://www.bmj.com/cgi/content/short/318/7199/1660Test; http://dx.doi.org/10.1136/bmj.318.7199.1660Test

الإتاحة: https://doi.org/10.1136/bmj.318.7199.1660Test
http://www.bmj.com/cgi/content/short/318/7199/1660Test

المؤلفون: Simpson, Wendy M, Johnstone, Frank D, Boyd, Fiona M, Goldberg, David J, Hart, Graham J, Prescott, Robin J

مصطلحات موضوعية: PAPERS

الوصف: Objective: To determine the uptake and acceptability of different methods of a universal offer of voluntary HIV testing to pregnant women. Design: Randomised controlled trial involving four combinations of written and verbal communication, followed by the direct offer of a test. The control group received no information and no direct offer of a test, although testing was available on request. Setting: Hospital antenatal clinic covering most of the population of the city of Edinburgh. Subjects: 3024 pregnant women booking at the clinic over a 10 month period. Main outcome measures: Uptake of HIV testing and women’s knowledge, satisfaction, and anxiety. Results: Uptake rates were 6% for those in the control group and 35% for those directly offered the test. Neither the style of leaflet nor the length of discussion had an effect on uptake. Significant independent predictors of uptake were a direct test offer; the midwife seen; and being unmarried, previously tested, and younger age. Knowledge of the specific benefits of testing increased with the amount of information given, but neither satisfaction nor anxiety was affected by the type of offer. Conclusions: The universal offer of HIV testing is not intrusive and is acceptable to pregnant women. A policy of offering the HIV test to all women resulted in higher uptake and did not increase anxiety or dissatisfaction. Uptake depends more on the midwife than the method of offering the test. Low uptake rates and inadequate detection of HIV infection point to the need to assess a more routine approach to testing. Key messages HIV testing in pregnancy is beneficial, but uptake rates are not high Offering the test to women attending antenatal clinics increases uptake without increasing anxiety or dissatisfaction The extent of information given is not important in terms of whether women take the test and whether they find the procedure acceptable Uptake depends more on the midwife than the method of offering the test Low uptake rates and inadequate ...

وصف الملف: text/html

العلاقة: http://www.bmj.com/cgi/content/short/316/7127/262Test; http://dx.doi.org/10.1136/bmj.316.7127.262Test

الإتاحة: https://doi.org/10.1136/bmj.316.7127.262Test
http://www.bmj.com/cgi/content/short/316/7127/262Test

المؤلفون: Adiotomre, Pauline N A, Johnstone, Frank D, Laing, Ian A

مصطلحات موضوعية: Original articles

وصف الملف: text/html

العلاقة: http://fn.bmj.com/cgi/content/short/76/1/F35Test; http://dx.doi.org/10.1136/fn.76.1.F35Test

الإتاحة: https://doi.org/10.1136/fn.76.1.F35Test
http://fn.bmj.com/cgi/content/short/76/1/F35Test

المؤلفون: Johnstone, Frank D

المصدر: International Journal of STD & AIDS ; volume 3, issue 2, page 79-86 ; ISSN 0956-4624 1758-1052

مصطلحات موضوعية: Infectious Diseases, Pharmacology (medical), Public Health, Environmental and Occupational Health, Dermatology

الإتاحة: https://doi.org/10.1177/095646249200300201Test

المؤلفون: Johnstone, Frank D., Maccallum, Linda, Brettle, Ray, Inglis, J. M., Peutherer, John F.

المصدر: British Medical Journal (Clinical Research Edition), 1988 Feb . 296(6620), 467-467.

الوصول الحر: https://www.jstor.org/stable/29529764Test

المؤلفون: Steel, Judith M., Steel, C. Michael, Johnstone, Frank D.

المصدر: British Medical Journal (Clinical Research Edition), 1987 Oct . 295(6606), 1135-1136.

الوصول الحر: https://www.jstor.org/stable/29528714Test