المؤلفون: Cong Qiu, John Cookson, Peter Mutton

المصدر: Journal of Modern Transportation, Vol 25, Iss 4, Pp 261-267 (2017)

مصطلحات موضوعية: Heavy haul wheels, Wheel damage, Microstructure, Thermal/mechanical stability, Alloying effect, Hydraulic engineering, TC1-978, Transportation engineering, TA1001-1280

الوصف: Abstract Thermal or thermo-mechanical loading is one of the major causes of wheel surface damage in Australian heavy haul operations. In addition, multi-wear wheels appear to be particularly sensitive to thermo-mechanical damage during their first service life. Such damage can incur heavy machining penalties or even premature scrapping of wheels. The combination of high contact stresses as well as substantial thermal loading (such as during prolonged periods of tread braking) can lead to severe plastic deformation, thermal fatigue and microstructural deterioration. For some high-strength wheel grades, the increased sensitivity to thermo-mechanical damage observed during the first service period may be attributed to the presence of a near-surface region in which the microstructure is more sensitive to these loading conditions than the underlying material. The standards applicable to wheels used in Australian heavy haul operations are based on the Association of American Railroads (AAR) specification M-107/M-208, which does not include any requirements for microstructure. The implementation of acceptance criteria for the microstructure, in particular that in the near-surface region of the wheel, may be necessary when new wheels are purchased. The stability of wheel microstructures during thermo-mechanical loading and the effects of alloying elements commonly used in wheel manufacturing are reviewed. A brief guide to improving thermal/mechanical stability of the microstructure is also provided.

وصف الملف: electronic resource

العلاقة: http://link.springer.com/article/10.1007/s40534-017-0143-9Test; https://doaj.org/toc/2095-087XTest; https://doaj.org/toc/2196-0577Test

الوصول الحر: https://doaj.org/article/e6386b25b56343e98bc3a4aff84e04bdTest

المؤلفون: John Cookson

المصدر: MedEdPublish, Vol 5, Iss 2 (2016)

مصطلحات موضوعية: undergraduate, postgraduate, curriculum, medical school, Special aspects of education, LC8-6691, Medicine

الوصف: The author has spent 50 years in medical education as student, teacher, educator, academic and manager. Now in his anecdotage, he explores the past five decades, the influences upon him, what he made of them and what decisions he took; some of it based on evidence but much made up as he went along.

وصف الملف: electronic resource

العلاقة: https://www.mededpublish.org/Manuscripts/497Test; https://doaj.org/toc/2312-7996Test

الوصول الحر: https://doaj.org/article/63889e71608a432e9ca7811db09e929bTest

المؤلفون: John Cookson, Jonathan Pimm, Gavin Reynolds

المصدر: BJPsych Advances. 29:158-165

مصطلحات موضوعية: Psychiatry and Mental health

الوصف: SUMMARYPartial agonists of dopamine receptors are used in combination with full antagonists in treating psychosis, either to mitigate side-effects or in the hope of increasing effectiveness. We examine how combinations may affect the occupancy of D2/D3dopamine receptors and explore how these can explain the outcomes in the light of the dopamine hypothesis of psychosis. The combinations considered here are from published studies combining aripiprazole with amisulpride, with risperidone in people with hyperprolactinaemia and with olanzapine to mitigate weight gain. We discuss possible worsening of symptoms by the addition of a partial agonist or switching. We also examine the potentially adverse interaction with a full antagonist such as haloperidol given during a subsequent relapse to control severe agitation.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::bb5b90e4ddd9f58f66316c49118a5aa2Test
https://doi.org/10.1192/bja.2022.86Test

المؤلفون: John Cookson, Jonathan Pimm, Andrew Brentnall

المصدر: BJPsych Advances. 29:151-157

مصطلحات موضوعية: Psychiatry and Mental health

الوصف: SUMMARYPartial agonists such as aripiprazole are often used in addition to a full antagonist such as amisulpride, risperidone or olanzapine in an attempt to mitigate side-effects such as sedation, hyperprolactinaemia and weight gain. However, there can be unintended consequences, including worsening of psychosis. Moreover, previous exposure to a partial agonist may impair the subsequent response to a potent antipsychotic such as haloperidol used to control symptoms of relapse. To understand the mechanisms involved, a method is needed to compare potency in the pharmacological effects of different drugs used in combinations. This article is intended to explore and explain the theoretical principles based on the dopamine hypothesis of schizophrenia. We apply the method to analyse a recently described trial in which two full antagonists (olanzapine and amisulpride) are compared individually and in combination.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::eb42d8c931c121d4451ed82b6533ba90Test
https://doi.org/10.1192/bja.2022.66Test

المؤلفون: John Cookson, Ferdinand Jonsson

المصدر: Lancet (London, England). 400(10369)

مصطلحات موضوعية: Cholinergic Agents, Humans, General Medicine, Muscarinic Antagonists, Receptors, Muscarinic, Antipsychotic Agents

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75d16c320c66a0f61fd8f38486aca0cdTest
https://pubmed.ncbi.nlm.nih.gov/36528376Test

المؤلفون: Jonathan Pimm, John Cookson

المصدر: BJPsych Advances. 29:141-144

مصطلحات موضوعية: Psychiatry and Mental health, Psychosis, business.industry, Dopamine receptor, Medicine, business, medicine.disease, Receptor theory, Partial agonist, Neuroscience, Dopamine hypothesis of schizophrenia

الوصف: SUMMARYThis article discusses dopamine partial agonism, which is the main mechanism of action of the psychiatric drugs aripiprazole, brexpiprazole and cariprazine. It outlines the principles of receptor theory and the structure of dopamine receptors; characterises agonists, antagonists and partial agonists; and summarises the dopamine hypothesis of psychosis and the role of dopamine and serotonin in depression.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::f467bbc56f9b9855ebb7c621f7d81386Test
https://doi.org/10.1192/bja.2021.39Test

المؤلفون: John Cookson, Jonathan Pimm

المصدر: BJPsych Advances. 29:145-150

مصطلحات موضوعية: business.industry, Cariprazine, Pharmacology, Partial agonist, Psychiatry and Mental health, chemistry.chemical_compound, chemistry, Dopamine receptor, mental disorders, medicine, Aripiprazole, business, Brexpiprazole, medicine.drug

الوصف: SUMMARYAripiprazole, brexpiprazole and cariprazine are partial dopamine (and serotonin) agonists developed as novel antipsychotics. This article discusses their pharmacology, evidence on their licensed and off-licence uses (including psychosis, mania, bipolar depression, Tourette syndrome and autism spectrum disorder) and side-effects. In schizophrenia, they have a low risk of Parkinsonism or hyperprolactinaemia, cause modest increases in body weight and are of moderate efficacy.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::b5a1390dcc6c4a3182367c257a4238caTest
https://doi.org/10.1192/bja.2021.49Test

المؤلفون: John Cookson

المصدر: Medical teacher.

مصطلحات موضوعية: General Medicine, Education

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3aedbd7fbc2798eb78e5bbcfe14ec58bTest
https://pubmed.ncbi.nlm.nih.gov/36264771Test

المؤلفون: John Cookson, Jonathan Pimm

المصدر: BJPsych Advances. 29:74-75

مصطلحات موضوعية: Psychiatry and Mental health

الوصف: SUMMARYThis editorial introduces theBJPsych Advancesspecial issue on biological psychiatry.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::cbc366f0d600f08698f71a3af6b32c32Test
https://doi.org/10.1192/bja.2023.1Test

المؤلفون: Yong Pang, Bernard Chen, John Cookson, Anthony Micheletto, Peter Mutton

المصدر: Proceedings of the Institution of Mechanical Engineers, Part F: Journal of Rail and Rapid Transit. 235:1006-1012

مصطلحات موضوعية: Heat-affected zone, Materials science, Mechanical Engineering, Butt welding, Metallurgy, technology, industry, and agriculture, Structural integrity, 02 engineering and technology, Welding, 021001 nanoscience & nanotechnology, Microstructure, law.invention, Flash welding, 020303 mechanical engineering & transports, 0203 mechanical engineering, law, Flash (manufacturing), Ultimate tensile strength, 0210 nano-technology

الوصف: Experimental testing of flash-butt welded premium rail steel samples was undertaken to quantify the variation in strength through the cross-section of the weld, with results showing a general correlation between the width of the heat-affected-zone and the ultimate tensile strength. Microstructural examination and fractography revealed the presence of defects in some samples. Large defects can be identified by non-destructive testing methods as part of routine structural integrity assessment; however, small defects may escape detection but could propagate under cyclic loading in service leading to catastrophic failures. This work demonstrates the requirement for stringent control of heat input to prevent the development of defects in premium rail steels with high alloying content.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::5fe1e17101ee08f936493804fbf453e3Test
https://doi.org/10.1177/0954409720973138Test