المؤلفون: Timothy Wang, Detlef Bockenhauer, Isabelle Scheers, Tristan Richardson, John A. McKnight, Malachi J. McKenna, Treena Cranston, Sarah A. Howles, M Andrew Nesbit, Tony Hulse, Clare E Thakker, Ken Darzy, Fadil Hannan, Angela Rogers, Zulf Mughal, Simon H. S. Pearce, Dhavendra Kumar, Rajesh Thakker, Rosalind S. Brown, Sarah Ehtisham, Jacqueline Cook

المصدر: Endocrine Abstracts.

مصطلحات موضوعية: Genetics, Protein subunit, Signal transducing adaptor protein, Identification (biology), Familial hypocalciuric hypercalcaemia, Biology, Bioinformatics, Phenotype

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::4b4d58a262ddaaa7d6aff25bae9c747eTest
https://doi.org/10.1530/endoabs.34.p15Test

المؤلفون: C. A. McIntyre, Andrew I. Elliott, C H Buckley, Brent C. Williams, Patrick W. F. Hadoke, Gareth R. Jones, John A. McKnight, Thekkepat C. Sandeep, Gillian A. Gray, Robert Andrews, Brian R. Walker

المصدر: British Journal of Pharmacology. 133:902-908

مصطلحات موضوعية: Pharmacology, medicine.medical_specialty, Endothelium-derived hyperpolarizing factor, Prostaglandin, Vasodilation, Anatomy, Apamin, Potassium channel, Ouabain, chemistry.chemical_compound, Nitroarginine, Endocrinology, chemistry, Internal medicine, medicine, Myograph, medicine.drug

الوصف: This investigation examined the hypothesis that release of K(+) accounts for EDHF activity by comparing relaxant responses produced by ACh and KCl in human subcutaneous resistance arteries. Resistance arteries (internal diameter 244+/-12 microm, n=48) from human subcutaneous fat biopsies were suspended in a wire myograph. Cumulative concentration-response curves were obtained for ACh (10(-9) - 3x10(-5) M) and KCl (2.5 - 25 mM) following contraction with noradrenaline (NA; 0.1 - 3 microM). ACh (E(max) 99.07+/-9.61%; -LogIC(50) 7.03+/-0.22; n=9) and KCl (E(max) 74.14+/-5.61%; -LogIC(50) 2.12+/-0.07; n=10)-induced relaxations were attenuated (P

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::89c9d0430143705c0d72e9b5d5a8945fTest
https://doi.org/10.1038/sj.bjp.0704143Test

المؤلفون: Carol-Ann Mcintyre, Andrew I. Elliott, Patrick W. F. Hadoke, R. Mark Lindsay, John A. McKnight, Brent C. Williams

المصدر: Clinical Science. 100:311-318

مصطلحات موضوعية: medicine.medical_specialty, Endothelium, Vascular disease, business.industry, Vasodilation, General Medicine, medicine.disease, Endothelin 1, medicine.anatomical_structure, Endocrinology, Internal medicine, Diabetes mellitus, medicine, Vascular resistance, business, Myograph, Artery

الوصف: Type I diabetes mellitus is associated with abnormal vascular function, but few studies have documented its effects on human resistance arteries. This study aimed to determine whether endothelial cell and smooth muscle cell function was impaired in resistance arteries isolated from patients with this condition. Biopsies of subcutaneous gluteal fat were taken from 12 patients with Type I diabetes (age 32.3±1.9 years; duration of diabetes 13.9±2.5 years) and 12 matched controls (age 31.5±2.2 years). Levels of glycosylated haemoglobin were higher (P < 0.0001) in patients (9.38±0.35%) than in controls (5.48±0.11%), but most (11 out of 12) patients showed no evidence of microvascular disease. Small resistance arteries were isolated from the biopsies, and isometric responses to vasoconstrictors and vasodilators were measured in a small-vessel myograph. The magnitude and sensitivity of responses to noradrenaline and potassium were not different in diabetic patients compared with controls. In contrast, the sensitivity (pD2; negative logarithm of the concentration of the vasoconstrictor required to produce 50% of the maximum effect), but not the magnitude, of contraction in response to endothelin-1 in vessels from patients (8.87±0.12) was significantly (P = 0.02) greater than in those from controls (8.40±0.13). Endothelium-dependent (acetylcholine, bradykinin, A23187) and -independent (3´-morpholinosydnonimine) relaxation responses were unaltered in patients with Type I diabetes. These results suggest a selective alteration in receptor activity in the endothelium, and contrast strikingly with the considerable evidence of impaired endothelium-dependent relaxation in Type I diabetes. The present study indicates, therefore, that endothelial cell function is largely maintained in resistance arteries from patients with well controlled Type I diabetes. The increased response to endothelin-1 supports the possibility that more significant abnormalities would be evident in patients with severe microvascular complications.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::815bb9fd3e501298d2deaa7632a7fa02Test
https://doi.org/10.1042/cs1000311Test

المؤلفون: Robert S. Lindsay, Alan W. Patrick, John A. McKnight, Helen C. Looker, Stuart J. McGurnaghan, Shona Livingstone, Colin N. A. Palmer, Donald W. M. Pearson, Tahira Akbar, James D. Walker, John Chalmers, Helen M. Colhoun, John R. Petrie

المصدر: International Journal of Epidemiology. :dyw152

مصطلحات موضوعية: Male, 0301 basic medicine, medicine.medical_specialty, Type 1 diabetes, Epidemiology, business.industry, 030209 endocrinology & metabolism, General Medicine, medicine.disease, Article, Cohort Studies, 03 medical and health sciences, Diabetes Mellitus, Type 1, 030104 developmental biology, 0302 clinical medicine, Scotland, Internal medicine, Diabetes mellitus, Cohort, medicine, Health Resources, Humans, Female, business, Biological Specimen Banks

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1672d216c63dc53ac30ab60ee277e88Test
https://doi.org/10.1093/ije/dyw152Test

المؤلفون: John A. McKnight, Stephanie H. Read, Sarah H. Wild, Rory J. McCrimmon, Naveed Sattar, Robert S. Lindsay, Colin Fischbacher, David A. McAllister, John R. Petrie, Helen M. Colhoun, Joannes J Kerssens

المصدر: Diabetologia. 59:2492-2492

مصطلحات موضوعية: Male, Endocrinology, Diabetes and Metabolism, 030209 endocrinology & metabolism, Type 2 diabetes, 03 medical and health sciences, Sex Factors, 0302 clinical medicine, Prevalence, Internal Medicine, medicine, Humans, 030212 general & internal medicine, Aged, business.industry, Incidence, Incidence (epidemiology), Age Factors, Human physiology, Middle Aged, medicine.disease, Diabetes Mellitus, Type 2, Scotland, Socioeconomic Factors, Female, Erratum, business, Demography

الوصف: The relative contribution of increasing incidence and declining mortality to increasing prevalence of type 2 diabetes in Scotland is unclear. Trends in incidence and mortality rates are described for type 2 diabetes in Scotland between 2004 and 2013 by age, sex and socioeconomic deprivation.Data for incident and prevalent cases of type 2 diabetes were obtained from the Scottish national diabetes register with number of deaths identified from linkage to mortality records. Population size and death data for Scotland by age, sex and socioeconomic deprivation were obtained from National Records of Scotland. Age- and sex-specific incidence and mortality rates stratified by year and deciles of socioeconomic status were calculated using Poisson models.There were 180,290 incident cases of type 2 diabetes in Scotland between 2004 and 2013. Overall, incidence of type 2 diabetes remained stable over time and was 4.88 (95% CI 4.84, 4.90) and 3.33 (3.28, 3.32) per 1000 in men and women, respectively. However, incidence increased among young men, remained stable in young women, and declined in older men and women. Incidence rates declined in all socioeconomic groups but increased after 2008 in the most deprived groups. Standardised mortality ratios associated with diabetes, adjusted for age and socioeconomic group, were 1.38 (1.36, 1.41) in men and 1.49 (1.45, 1.52) in women, and remained constant over time.Incidence of type 2 diabetes has stabilised in recent years suggesting that increasing prevalence may be primarily attributed to declining mortality. Prevention of type 2 diabetes remains important, particularly among socioeconomically deprived populations.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20eef4c386ef27f05f9047b493ba3a5dTest
https://doi.org/10.1007/s00125-016-4089-yTest

المؤلفون: R. M. Lindsay, Brent C. Williams, C. A. McIntyre, John A. McKnight, Patrick W. F. Hadoke

المصدر: British Journal of Pharmacology. 123:1555-1560

مصطلحات موضوعية: Pharmacology, medicine.medical_specialty, Vascular smooth muscle, Cold storage, Vasodilation, Anatomy, Biology, medicine.anatomical_structure, Endocrinology, Internal medicine, Circulatory system, medicine, medicine.symptom, Mesenteric arteries, Vasoconstriction, Blood vessel, Myograph

الوصف: 1. The use of isolated blood vessels to investigate the physiological and pharmacological control of the vasculature is limited by the requirement to use freshly isolated vessels. Hence, the aim of this study was to determine whether vascular smooth muscle and endothelial cell function could be preserved in resistance arteries by storing them in physiological salt solution (PSS) at 4 degrees C. 2. Third order mesenteric resistance arteries (mean internal diameter 237+/-6 microm) were dissected from the mesenteric bed of male Cob-Wistar rats. The vessel segments were mounted in a small vessel myograph for measurement of isometric tension, and equilibrated at their optimum resting force. Contractile responses to noradrenaline (NA; 1 x 10(-9) - 3 x 10(-5) M), phenylephrine (PE, 1 x 10(-9)-3 x 10(-5) M), potassium chloride (KCI; 2.5-140 mM) and endothelin (ET-1, 1 x 10(-11)-3 x 10(-7) M) and relaxant responses to acetylcholine (ACh; 1 x 10(-9) - 3 x 10(-5) M) and 3-morpholinosydnonimine (SIN-1; 1 x 10(-9) - 1 x 10(-4) M) were obtained in arteries, immediately after dissection (day 0) and following one to four days storage (day 1-day 4). 3. All arteries produced concentration-dependent contractions in response to each of the vasoconstrictors. There were no significant differences in the magnitude or sensitivity (pD2) of the vasoconstrictor responses between fresh and stored vessels. 4. Arteries precontracted with NA to approximately 80% of the maximum response, relaxed in a concentration-dependent manner in response to ACh and SIN-1. Vessel storage for up to three days resulted in no change in response to ACh or SIN-1. 5. Vessels analysed after four days of storage demonstrated a significant increase in sensitivity to ACh and SIN-1 (-logIC50 (M) values; ACh; day 0, 7.46+/-0.13 vs day 4, 7.97+/-0.11, P

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::a688431bdb3023d34e50559033f2e7d5Test
https://doi.org/10.1038/sj.bjp.0701768Test

المؤلفون: John A. McKnight, M. W. J. Strachan, J Charlton, KA Adamson

المصدر: Practical Diabetes International. 23:166-168

مصطلحات موضوعية: medicine.medical_specialty, Pediatrics, Type 1 diabetes, business.product_category, business.industry, Endocrinology, Diabetes and Metabolism, interests, General surgery, medicine.disease, Ketoacidosis, Body piercing, Current practice, Diabetes mellitus, Hospital admission, Internal Medicine, Medicine, Tongue piercing, business, interests.hobby

الوصف: Body piercing is becoming increasingly common, but is not without complications. We present the cases of two patients with type 1 diabetes who required hospital admission following tongue piercing. These cases led us to survey the current practice of piercing establishments in the Lothian area. This revealed inconsistencies and a lack of information regarding the management of diabetes following piercing. As a result of this, an information leaflet was produced which is now available to all patients with diabetes who have a piercing performed. Copyright © 2006 John Wiley & Sons, Ltd.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::3204991a6733f2b264e606aa092dcf85Test
https://doi.org/10.1002/pdi.935Test

المؤلفون: Janet Hanley, John A. McKnight, Sarah Wild, Lucy McCloughan, Paul L. Padfield, Brian McKinstry, Mary Paterson, Hilary Pinnock, Stephanie Lewis

المصدر: Wild, S, Hanley, J, Lewis, S, Mcknight, J, Mccloughan, L, Padfield, P, Pinnock, H, Mckinstry, B & Paterson, M 2013, ' The impact of supported telemetric monitoring in people with type 2 diabetes: study protocol for a randomised controlled trial ', Trials, vol. 14, no. 1, 198 . https://doi.org/10.1186/1745-6215-14-198Test
Trials

مصطلحات موضوعية: Research design, Blood Glucose, Time Factors, Cost-Benefit Analysis, Medicine (miscellaneous), Blood Pressure, Type 2 diabetes, law.invention, Study Protocol, Randomized controlled trial, Diabetes, hypertension, glycaemic control, blood pressure, weight, self-management, telehealth, Clinical Protocols, law, Weight loss, 610.73 Nursing, Glycaemic control, Telemetry, Pharmacology (medical), Diabetes, Equipment Design, Health Care Costs, Telemedicine, Treatment Outcome, Research Design, Hypertension, Quality-Adjusted Life Years, medicine.symptom, Wireless Technology, RT Nursing, medicine.medical_specialty, Predictive Value of Tests, Diabetes mellitus, Weight Loss, medicine, Self-management, Humans, Intensive care medicine, Glycemic, Glycated Hemoglobin, business.industry, Blood Glucose Self-Monitoring, Blood Pressure Determination, medicine.disease, Weight, United Kingdom, Quality-adjusted life year, Self Care, Blood pressure, Telehealth, Diabetes Mellitus, Type 2, Emergency medicine, business, Risk Reduction Behavior, Biomarkers

الوصف: BackgroundDiabetes prevalence is increasing and current methods of management are unsustainable. Effective approaches to supporting self-management are required. The aim of this randomized controlled trial is to establish whether supported telemetric monitoring of glycemic control and blood pressure results in reductions in glycosylated hemoglobin (HbA1c; the primary outcome of a measure of long-term glycemic control) and secondary outcomes of blood pressure and weight among people with poorly controlled diabetes compared to a control group receiving usual care.Methods/DesignDesign: multi-center, randomized controlled trial with embedded qualitative study.Setting: primary care in Lothian, Kent, Glasgow and Borders regions in the UK.Participants: people with type 2 diabetes and confirmed HbA1c >7.5% (58 mmol/mol).Intervention/comparison: randomization to intervention or control groups will be performed by the Edinburgh Clinical Trials Unit. Participants in the intervention group will be shown how to use blood glucose and blood pressure monitors and weighing scales which use Bluetooth wireless technology to transmit readings via modem to a remote server. These participants will be asked to provide at least twice weekly measurements of morning and evening blood glucose and weekly measurements of weight and blood pressure. Measurements will be checked at least weekly by practice nurses who will contact the patients to adjust therapy according to guidelines and reinforce lifestyle advice. Participants in the control group will receive usual care. All participants will receive an individual education session.Follow-up: measurements will be performed at practices 9 months after randomization by research nurses blinded to allocation. The primary outcome measure is HbA1c and secondary outcomes measure are daytime systolic and diastolic blood pressure, weight and cost per quality-adjusted life year.Analysis: intention-to-treat analyses will be performed. The sample size of 320 participants allows for 20% drop-out and has 80% power at 5% significance to detect a 0.5% absolute (6 mmol/mol) fall in HbA1c in the intervention group. The qualitative study will explore the experiences of patients and professionals using the intervention.

وصف الملف: application/pdf; PDF

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96e895f822286e8297eecdaafdbd3ffeTest
https://hdl.handle.net/20.500.11820/cdfccba0-9a88-495d-bde6-f3391bac1d34Test

المؤلفون: Aziz Sheikh, Jason M.R. Gill, Naveed Sattar, Gordon D Murray, Anu Sharma, Sunita Wallia, Anne Douglas, RS Bhopal, Sarah H. Wild, John A. McKnight, Raj Bhopal, John F. Forbes

المصدر: BMJ Open
Douglas, A, Bhopal, R, Bhopal, R, Forbes, J, Gill, J M R, McKnight, J, Murray, G, Sattar, N, Sharma, A, Wallia, S, Wild, S & Sheikh, A 2013, ' Design and baseline characteristics of the PODOSA (Prevention of Diabetes & Obesity in South Asians) trial: a cluster, randomised lifestyle intervention in Indian and Pakistani adults with impaired glycaemia at high risk of developing type 2 diabetes ', BMJ Open, vol. 3, no. 2, e002226 . https://doi.org/10.1136/bmjopen-2012-002226Test

مصطلحات موضوعية: Gerontology, Pediatrics, medicine.medical_specialty, Waist, Population, Psychological intervention, 030209 endocrinology & metabolism, Type 2 diabetes, ethnic groups, law.invention, 03 medical and health sciences, 0302 clinical medicine, Randomized controlled trial, law, Intervention (counseling), medicine, 030212 general & internal medicine, education, 2. Zero hunger, Medicine(all), education.field_of_study, business.industry, Public health, Research, Prevention, General Medicine, medicine.disease, 3. Good health, Diabetes and Endocrinology, business, Body mass index, randomised controlled trial, diabetes mellitus, Type 2

الوصف: Objectives To describe the design and baseline population characteristics of an adapted lifestyle intervention trial aimed at reducing weight and increasing physical activity in people of Indian and Pakistani origin at high risk of developing type 2 diabetes. Design Cluster, randomised controlled trial. Setting Community-based in Edinburgh and Glasgow, Scotland, UK. Participants 156 families, comprising 171 people with impaired glycaemia, and waist sizes ≥90 cm (men) and ≥80 cm (women), plus 124 family volunteers. Interventions Families were randomised into either an intensive intervention of 15 dietitian visits providing lifestyle advice, or a light (control) intervention of four visits, over a period of 3 years. Outcome measures The primary outcome is a change in mean weight between baseline and 3 years. Secondary outcomes are changes in waist, hip, body mass index, plasma blood glucose and physical activity. The cost of the intervention will be measured. Qualitative work will seek to understand factors that motivated participation and retention in the trial and families’ experience of adhering to the interventions. Results Between July 2007 and October 2009, 171 people with impaired glycaemia, along with 124 family volunteers, were randomised. In total, 95% (171/196) of eligible participants agreed to proceed to the 3-year trial. Only 13 of the 156 families contained more than one recruit with impaired glycaemia. We have recruited sufficient participants to undertake an adequately powered trial to detect a mean difference in weight of 2.5 kg between the intensive and light intervention groups at the 5% significance level. Over half the families include family volunteers. The main participants have a mean age of 52 years and 64% are women. Conclusions Prevention of Diabetes & Obesity in South Asians (PODOSA) is one of the first community-based, randomised lifestyle intervention trials in a UK South Asian population. The main trial results will be submitted for publication during 2013. Trial registration Current controlled trials ISRCTN25729565 (http://www.controlled-trials.com/isrctnTest/).

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e9ec3a5eb399c82506143b3691868ffTest
http://europepmc.org/articles/PMC3586081Test

المؤلفون: John Kretzmann, John P. McKnight

المصدر: National Civic Review. 85:23-29

مصطلحات موضوعية: Economic growth, Asset-based community development, Sociology, Community development

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::f3995467ac15c2cee3a91a3260c85bc5Test
https://doi.org/10.1002/ncr.4100850405Test