المؤلفون: Satoshi Ikeda, Masahiro Tsuboi, Kazuko Sakai, Toshihiro Misumi, Hiroaki Akamatsu, Hiroyasu Shoda, Noriaki Sakakura, Atsushi Nakamura, Yasuhisa Ohde, Hidetoshi Hayashi, Kyoichi Okishio, Morihito Okada, Ichiro Yoshino, Jiro Okami, Kazuhisa Takahashi, Norihiko Ikeda, Masayuki Tanahashi, Yuichi Tambo, Haruhiro Saito, Shinichi Toyooka, Hidetoshi Inokawa, Toyofumi Chen‐Yoshikawa, Toshihide Yokoyama, Tatsuro Okamoto, Noriko Yanagitani, Masahide Oki, Makoto Takahama, Kenji Sawa, Hirohito Tada, Kazuhiko Nakagawa, Tetsuya Mitsudomi, Kazuto Nishio

المصدر: Molecular Oncology, Vol 18, Iss 2, Pp 305-316 (2024)

مصطلحات موضوعية: adjuvant therapy, early‐stage, epidermal growth factor receptor, non‐small cell lung cancer, tyrosine kinase inhibitor, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

الوصف: The phase III IMPACT study (UMIN000044738) compared adjuvant gefitinib with cisplatin plus vinorelbine (cis/vin) in completely resected epidermal growth factor receptor (EGFR)‐mutated non‐small cell lung cancer (NSCLC). Although the primary endpoint of disease‐free survival (DFS) was not met, we searched for molecular predictors of adjuvant gefitinib efficacy. Of 234 patients enrolled in the IMPACT study, 202 patients were analyzed for 409 cancer‐related gene mutations and tumor mutation burden using resected lung cancer specimens. Frequent somatic mutations included tumor protein p53 (TP53; 58.4%), CUB and Sushi multiple domains 3 (CSMD3; 11.8%), and NOTCH1 (9.9%). Multivariate analysis showed that NOTCH1 co‐mutation was a significant poor prognostic factor for overall survival (OS) in the gefitinib group and cAMP response element binding protein (CREBBP) co‐mutation for DFS and OS in the cis/vin group. In patients with NOTCH1 co‐mutations, gefitinib group had a shorter OS than cis/vin group (Hazard ratio 5.49, 95% CI 1.07–28.00), with a significant interaction (P for interaction = 0.039). In patients with CREBBP co‐mutations, the gefitinib group had a longer DFS than the cis/vin group, with a significant interaction (P for interaction = 0.058). In completely resected EGFR‐mutated NSCLC, NOTCH1 and CREBBP mutations might predict poor outcome in patients treated with gefitinib and cis/vin, respectively.

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/1574-7891Test; https://doaj.org/toc/1878-0261Test

الوصول الحر: https://doaj.org/article/5ef9670861fa45fda1c2e13f031a8170Test

المؤلفون: Kei Kunimasa, Shingo Matsumoto, Keiichiro Honma, Motohiro Tamiya, Takako Inoue, Takahisa Kawamura, Satoshi Tanada, Akito Miyazaki, Ryu Kanzaki, Tomohiro Maniwa, Jiro Okami, Yuji Matsumoto, Koichi Goto, Kazumi Nishino

المصدر: BMC Pulmonary Medicine, Vol 23, Iss 1, Pp 1-11 (2023)

مصطلحات موضوعية: Lung cancer diagnosis, Next-generation sequencing, Sampling method, NGS success rate, Re-biopsy, Diseases of the respiratory system, RC705-779

الوصف: Abstract Background It is essential to collect a sufficient amount of tumor tissue for successful next-generation sequencing (NGS) analysis. In this study, we investigated the clinical risk factors for avoiding re-biopsy for NGS analysis (re-genome biopsy) in cases where a sufficient amount of tumor tissue could not be collected by bronchoscopy. Methods We investigated the association between clinical factors and the risk of re-genome biopsy in patients who underwent transbronchial biopsy (TBB) or endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) and required re-genome biopsy in cases enrolled in LC-SCRUM Asia, a prospective nationwide genome screening project in Japan. We also examined whether the frequency of re-genome biopsy decreased between the first and second halves of the enrolment period. Results Of the 572 eligible patients, 236 underwent TBB, and 134 underwent EBUS-TBNA. Twenty-four TBBs required re-genome biopsy, and multivariate analysis showed that the risk of re-genome biopsy was significantly increased in lesions where the tumor lesion was centrally located. In these cases, EBUS-TBNA should be utilized even if the lesion is a pulmonary lesion. However, it should be noted that even with EBUS-TBNA, lung field lesions are at a higher risk of re-canalization than mediastinal lymph node lesions. It was also found that even when tumor cells were detected in rapid on-site evaluation, a sufficient amount of tumor tissue was not always collected. Conclusions For centrally located pulmonary mass lesions, EBUS-TBNA, rather than TBB, can be used to obtain tumor tissues that can be analyzed by NGS.

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/1471-2466Test

الوصول الحر: https://doaj.org/article/8068f32a5bac4be8b8a6cb9cbd42ca65Test

المؤلفون: Akiisa Omura, Hirokazu Watari, Jiro Okami, Ryo Tanaka, Ryu Kanzaki, Sachi Kawagishi, Tomohiro Maniwa, 大村 彰勲, 岡見 次郎, 川岸 紗千, 渡 洋和, 田中 諒, 神崎 隆, 馬庭 知弘

المصدر: 日本呼吸器外科学会雑誌 / The Journal of the Japanese Association for Chest Surgery. 2023, 37(6):502

المؤلفون: Hidefumi Takei, MD, Hideo Kunitoh, MD, Masashi Wakabayashi, MSc, Tomoko Kataoka, DDS, Yuta Sekino, MD, Tomonori Mizutani, MD, Masahiro Tsuboi, MD, Norihiko Ikeda, MD, Hisao Asamura, MD, Morihito Okada, MD, Makoto Takahama, MD, Yasuhisa Ohde, MD, Jiro Okami, MD, Satoshi Shiono, MD, Keijyu Aokage, MD, Shun-ichi Watanabe, MD, H. Fukuda, T. Shibata

المصدر: JTO Clinical and Research Reports, Vol 4, Iss 8, Pp 100550- (2023)

مصطلحات موضوعية: Non–small cell, surgery, Elderly patients, Activities of daily living, Quality of life, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

الوصف: Introduction: To determine the rate of deteriorating activities of daily living (ADL) and to investigate predictive factors in elderly patients undergoing surgery for NSCLC. Methods: Patients with NSCLC aged 75 years or older who underwent curative surgical resection were evaluated using the Tokyo Metropolitan Institute of Gerontology Index of Competence Instrumental ADL (TMIG-IADL) and the Japanese version of EuroQol 5-dimensions 5-level (EQ-5D-5L) quality-of-life scale administered at baseline and at 6 months postoperative. The primary end point was the rate of living patients without substantial deterioration of TMIG-IADL, defined as a decline greater than or equal to three points. Multivariable logistic regression was performed to determine risk factors for deteriorating ADL. Results: Between May 2019 and May 2020, 876 of the 986 screened patients enrolled from 47 institutions were eligible and included in the analysis. TMIG-IADL and EQ-5D-5L scores were obtained from 96.0% and 92.6% of the patients, respectively. At 6 months postoperative, 745 patients (85.1%, 95% confidence interval: 82.5%–87.3%) reported no significant ADL deterioration, and 96 of 841 patients (11.4%) with postoperative score data reported significant deterioration. The social domain was the most frequently affected activity. In multivariable analysis, poor performance status, low G8 geriatric screening score, segmentectomy (versus wedge resection), and surgery lasting less than 3 hours were associated with deteriorating ADL. Worsening EQ-5D-5L scores by minimally important difference or more were observed in 22.1% of the patients. Changes in TMIG-IADL and EQ-5D-5L scores were poorly correlated. Conclusions: Approximately 15% of elderly patients with NSCLC experienced significant ADL deterioration at 6 months postoperative.

وصف الملف: electronic resource

العلاقة: http://www.sciencedirect.com/science/article/pii/S2666364323000930Test; https://doaj.org/toc/2666-3643Test

الوصول الحر: https://doaj.org/article/47b0110453164a91a29e671cfdd4fcebTest

المؤلفون: Kei Kunimasa, Shingo Matsumoto, Kazumi Nishino, Keiichiro Honma, Noboru Maeda, Hanako Kuhara, Motohiro Tamiya, Takako Inoue, Takahisa Kawamura, Toru Kimura, Tomohiro Maniwa, Jiro Okami, Koichi Goto, Toru Kumagai

المصدر: Cancer Medicine, Vol 11, Iss 14, Pp 2744-2754 (2022)

مصطلحات موضوعية: lung cancer, next generation sequencing, NGS success rate, re‐biopsy, sampling method, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

الوصف: Abstract Introduction Success of next generation sequencing (NGS) analysis is becoming indispensable in the treatment of advanced lung cancer. However, the advantages and disadvantages of each sampling method in the NGS analysis have not yet been clarified. Methods We compared the success rates of NGS analysis, and DNA and RNA yields for transbronchial biopsy (TBB), endobronchial ultrasound‐guided transbronchial needle aspiration (EBUS‐TBNA), computed tomography (CT)‐guided biopsy, fluid sample, and surgical biopsy for NGS analysis in patients through the lung cancer genomic screening project for individualized medicine (LC‐SCRUM)‐Asia, a nationwide NGS screening project. In case, sufficient samples could not be collected by TBB and EBUS‐TBNA, re‐biopsy (genome re‐biopsy) was performed. Results A total of 223 patients were enrolled and success rates of NGS analysis were not different between samples obtained through TBB, EBUS‐TBNA, and CT‐guided biopsy; however, success rates for fluid samples and surgical biopsy samples were significantly higher than those of other methods. The risk of genome re‐biopsy was higher with TBB for centrally located lesions. CT‐guided biopsy yielded more samples but had a lower success rate for analysis of RNA‐based NGS than TBB. Conclusions TBB is the mainstay of sampling methods, but for centrally located lesions, EBUS‐TBNA may be a better strategy. For CT‐guided biopsy, the success rate of RNA‐based NGS analysis is low. Fluid samples are expected to yield successful results as surgical biopsy samples, but the latter are better for sample preservation. Determining the optimal method for genome biopsy for each case is important.

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/2045-7634Test

الوصول الحر: https://doaj.org/article/978e7bbf0f754bd9ad62e1525b8d6435Test

المؤلفون: Jiro Okami, Masayuki Ohue, Tomohiro Maniwa, Yasushi Shintani

المصدر: Annals of Thoracic and Cardiovascular Surgery. 2023, 29(6):271

المؤلفون: Sachi Kawagishi, Tomohiro Maniwa, Hirokazu Watari, Ryuhei Sakata, Akiisa Omura, Ryo Tanaka, Toru Kimura, Keiichiro Honma, Jiro Okami

المصدر: Surgical Case Reports, Vol 8, Iss 1, Pp 1-6 (2022)

مصطلحات موضوعية: Atypical type A thymoma, Thymus, Pulmonary metastasis, Anterior mediastinal tumor, Surgery, RD1-811

الوصف: Abstract Background Type A thymomas comprise a homogenous population of neoplastic epithelial cells that are characterized by a spindle/oval shape without nuclear atypia. They may be accompanied by few non-neoplastic lymphocytes. Most type A thymomas are detected in the earlier Masaoka stages. Compared to other thymoma subtypes, they rarely metastasize or recur. There have been some reports of patients with type A thymomas with pulmonary metastasis; however, these thymomas were 20 mm or more in size. Herein, we report the case of a patient who underwent surgical resection for a small-sized type A thymoma (12 mm) with pulmonary metastasis. Case presentation A 62-year-old patient presented with an abnormal shadow in the left lung on plain chest radiography during a medical checkup. Chest computed tomography revealed a 12-mm tumor in the anterior mediastinum and a 13-mm nodule in the left lower lobe. 18F-fluorodeoxyglucose positron emission tomography/computed tomography revealed uptake in the anterior mediastinal tumor, but did not show a significant uptake in the pulmonary nodule. The patient underwent surgical resection on two separate occasions, and was diagnosed with an atypical type A thymoma and pulmonary metastasis. The TNM classification was p-T1aN0M1b stage IVb, and it was stage IVb according to the Masaoka staging system. No recurrence was observed during the follow-up. Conclusions We report a case of the smallest type A thymoma with pulmonary metastasis. Pulmonary metastasis secondary to a type A thymoma should be considered even if the thymoma is small in size (

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/2198-7793Test

الوصول الحر: https://doaj.org/article/2920851a2641464cbea411d9f318ccb0Test

المؤلفون: Kei Kunimasa, MD, PhD, Tomohiro Maniwa, MD, PhD, Motohiro Tamiya, MD, Takako Inoue, MD, Takahisa Kawamura, MD, PhD, Jiro Okami, MD, PhD, Kazumi Nishino, MD, PhD

المصدر: JTO Clinical and Research Reports, Vol 3, Iss 9, Pp 100380- (2022)

مصطلحات موضوعية: Lung squamous cell carcinoma, Immune-chemotherapy, Pleuritis, Adverse event, Case report, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

الوصف: Immunochemotherapy is widely used as the primary treatment for advanced lung cancer and is currently being investigated in the perioperative setting. Immunochemotherapy can produce marked tumor shrinkage and long-term anticancer effects that are not achieved with conventional anticancer drugs. Herein, we present the cases of two patients with relatively large advanced primary lung squamous cell carcinomas located just below the pleura, who developed pleuritis immediately after the initiation of immunochemotherapy, probably owing to leakage of tumor contents after marked tumor shrinkage. Treatment of pleuritis necessitates discontinuation of chemotherapy, and special attention to secondary pleuritis may be required after initiation of immunochemotherapy in patients with lung tumors located just below the pleura.

وصف الملف: electronic resource

العلاقة: http://www.sciencedirect.com/science/article/pii/S2666364322001047Test; https://doaj.org/toc/2666-3643Test

الوصول الحر: https://doaj.org/article/af29d31283dd4fed9d90dbb7726610e0Test

المؤلفون: Toru Kimura, Masahiko Higashiyama, Keiichiro Honma, Harumi Nakamura, Tomohiro Maniwa, Jiro Okami

المصدر: Surgical Case Reports, Vol 7, Iss 1, Pp 1-4 (2021)

مصطلحات موضوعية: Thymic carcinoma, Postoperative recurrence, Disseminated pleural nodules, Long-term survival, Surgery, RD1-811

الوصف: Abstract Background We report a patient with thymic squamous cell carcinoma who underwent multiple rounds of surgical resection and definitive radiotherapy for both primary tumor and postoperative recurrence. However, the patient remains well and healthy 18 years after initial diagnosis. Since long-term survival after postoperative recurrence of thymic carcinoma is extremely rare, we also present her immunohistochemical staining results, which suggested indolent disease. Case presentation A 42-year-old woman with thymic squamous cell carcinoma underwent en bloc resection of the tumor and thymus gland. Pleural dissemination was noted in the right thoracic cavity 3, 10, and 16 years postoperatively. Where possible, the nodules were resected surgically: during the postoperative 3rd and 16th years. Definitive radiotherapy was administered for all nodules that could not be excised during the postoperative 3rd and 10th years. Disease-free survival is 25 months. Conclusions Local control of pleural dissemination may be beneficial in the treatment of postoperative recurrence of thymic carcinoma in limited cases of indolent disease.

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/2198-7793Test

الوصول الحر: https://doaj.org/article/94c651b912274ab5becf327f16f738e7Test

المؤلفون: Kei Kunimasa, MD, PhD, Yosuke Hirotsu, PhD, Kenji Amemiya, MSH, Harumi Nakamura, MD, PhD, Kazumi Nishino, MD, PhD, Keiichiro Honma, MD, PhD, Jiro Okami, MD, PhD, Masao Omata, MD, PhD, Toru Kumagai, MD, PhD

المصدر: JTO Clinical and Research Reports, Vol 3, Iss 5, Pp 100305- (2022)

مصطلحات موضوعية: EGFR-mutated lung adenocarcinoma, Small cell lung cancer, Transformation, TP53 mutation, Loss of heterozygosity, Case report, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

الوصف: SCLC transformation in EGFR-mutated lung adenocarcinoma is one of the major phenotypic changes that is observed during the resistance to EGFR tyrosine kinase inhibitors. However, the mechanism of this transformation remains unclear. In this study, we found a small de novo SCLC component in surgically resected specimens of EGFR-mutated lung adenocarcinoma before EGFR tyrosine kinase inhibitor treatment. By using laser microdissection and whole-exome sequencing, TP53 loss of heterozygosity was found to be possibly involved in SCLC transformation.

وصف الملف: electronic resource

العلاقة: http://www.sciencedirect.com/science/article/pii/S2666364322000297Test; https://doaj.org/toc/2666-3643Test

الوصول الحر: https://doaj.org/article/28f84f778f764a779dbbe2d0cf8ba522Test