المؤلفون: Qihua Jiang, Hai Hu, Jing Liao, Zhi-hua Li, Juntao Tan

المصدر: Scientific Reports, Vol 14, Iss 1, Pp 1-9 (2024)

مصطلحات موضوعية: Breast cancer-related lymphedema, Risk factors, Nomogram, Predictive model, Medicine, Science

الوصف: Abstract To establish and validate a predictive model for breast cancer-related lymphedema (BCRL) among Chinese patients to facilitate individualized risk assessment. We retrospectively analyzed data from breast cancer patients treated at a major single-center breast hospital in China. From 2020 to 2022, we identified risk factors for BCRL through logistic regression and developed and validated a nomogram using R software (version 4.1.2). Model validation was achieved through the application of receiver operating characteristic curve (ROC), a calibration plot, and decision curve analysis (DCA), with further evaluated by internal validation. Among 1485 patients analyzed, 360 developed lymphedema (24.2%). The nomogram incorporated body mass index, operative time, lymph node count, axillary dissection level, surgical site infection, and radiotherapy as predictors. The AUCs for training (N = 1038) and validation (N = 447) cohorts were 0.779 and 0.724, respectively, indicating good discriminative ability. Calibration and decision curve analysis confirmed the model’s clinical utility. Our nomogram provides an accurate tool for predicting BCRL risk, with potential to enhance personalized management in breast cancer survivors. Further prospective validation across multiple centers is warranted.

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/2045-2322Test

الوصول الحر: https://doaj.org/article/6e3a2b40bc514a8e9f0627b4cf64d824Test

المؤلفون: Xin Zhou, Huayan Chen, Dong Huang, Guixian Guan, Xiaoli Ma, Weiming Cai, Jing Liao, Tangming Guan

المصدر: Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)

مصطلحات موضوعية: Cathepsin F function, Prognosis, Renal cell carcinoma biomarker, Tumor microenvironment, Medicine, Science

الوصف: Abstract Abnormalities in the extracellular matrix (ECM) play important roles in the regulation and progression of clear cell renal cell carcinoma (ccRCC). The cysteine cathepsin is one of the major proteases involved in ECM remodeling and has been shown to be aberrantly expressed in multiple cancer types. However, the clinical significance and biological function of distinct cysteine cathepsins in ccRCC remain poorly understood. In this study, several bioinformatics databases, including UALCAN, TIMER, GEPIA and the Human Protein Atlas datasets, were used to analyze the expression and prognostic value of different cysteine cathepsin family members in ccRCC. We found that the expression level of CTSF was downregulated in tumor tissues and closely related to the poor survival of ccRCC patients. Further in vitro experiments suggested that CTSF overexpression suppressed the proliferation and migration of ccRCC cells. Moreover, the expression of CTSF was shown to be associated with several immune-infiltrating cells and immunomodulators in ccRCC. These results indicated that CTSF might be a promising diagnostic and prognostic marker in ccRCC.

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/2045-2322Test

الوصول الحر: https://doaj.org/article/ff68307a7b994369b484e0d5d7bd4bfeTest

المؤلفون: Yixuan Liu, Xinyuan Gao, Yongjin Zhang, Minrui Zeng, Yuyang Liu, Yanjuan Wu, Weihua Hu, Yingsi Lai, Jing Liao

المصدر: The Lancet Regional Health. Western Pacific, Vol 47, Iss , Pp 101117- (2024)

مصطلحات موضوعية: Dementia, Prevalence, Geographical analysis, China, Public aspects of medicine, RA1-1270

الوصف: Summary: Background: Dementia poses great health and social challenges in China. Dementia prevalence may vary across geographic areas, while comparable estimations on provincial level is lacking. This study aims to estimate dementia prevalence by provinces across China, taking into account risk factors of individual level and potential spatial correlation of provinces. Methods: In this study, 17,176 adults aged 50 years or older were included from the fourth wave of the China Health and Retirement Longitudinal Study (CHARLS 2018), covering 28 provinces, autonomous regions and municipalities. To improve provincial representativeness, we constructed provincial survey weights based on China 7th census (2020). The prevalence of dementia and 95% Bayesian credible intervals (BCIs) were estimated using a Bayesian conditional autoregressive (CAR) model with spatially varying coefficients of covariates. Findings: The weighted prevalence of dementia at provincial level in China in 2018 ranged from 2.62% (95%BCI: 1.70%, 3.91%) to 13.53% (95%BCI: 8.82%, 20.93%). High dementia prevalence was concentrated in North China, with a prominent high–high cluster, while provinces of low prevalence were concentrated on East and South China, characterized by a low–low cluster. Ordered by the median estimation of prevalence, the top 10% of provinces, include Xinjiang, Jilin, and Beijing. Meanwhile, Fujian, Zhejiang, and Guangdong rank among the last. The association between dementia prevalence and drinking, smoking, social isolation, physical inactivity, hearing impairment, hypertension, and diabetes exhibits provincial variation. Interpretation: Our study identifies a geospatial disparity in dementia prevalence and risk factor effects across China’s provinces, with high–high and low–low clusters in some northern and southern provinces, respectively. The findings emphasize the need for targeted strategies, such as addressing hypertension and hearing impairment, in specific regions for more effective dementia prevention and treatment. Funding: National Science Foundation of China/the Economic and Social Research Council, UK Research and Innovation joint call: Understanding and Addressing Health and Social Challenges for Ageing in the UK and China. UK-China Health And Social Challenges Ageing Project (UKCHASCAP): present and future burden of dementia, and policy responses (grant number 72061137003, ES/T014377/1).

وصف الملف: electronic resource

العلاقة: http://www.sciencedirect.com/science/article/pii/S2666606524001111Test; https://doaj.org/toc/2666-6065Test

الوصول الحر: https://doaj.org/article/0f0a4e71490848b7a2f1cd646a89c119Test

المؤلفون: Rui-Han Luo, Feng Su, Xin-Yue Zhao, Tian-Hui Cao, Jing Liao, Yan-Xue Xue, Geng-Di Huang, Jian-Li Yang

المصدر: Frontiers in Psychology, Vol 15 (2024)

مصطلحات موضوعية: fear conditioning, associative learning, depression, skin conductance response, hybrid model, Psychology, BF1-990

الوصف: BackgroundDepression is one of the primary global public health issues, and there has been a dramatic increase in depression levels among young people over the past decade. The neuroplasticity theory of depression postulates that a malfunction in neural plasticity, which is responsible for learning, memory, and adaptive behavior, is the primary source of the disorder's clinical manifestations. Nevertheless, the impact of depression symptoms on associative learning remains underexplored.MethodsWe used the differential fear conditioning paradigm to investigate the effects of depressive symptoms on fear acquisition and extinction learning. Skin conductance response (SCR) is an objective evaluation indicator, and ratings of nervousness, likeability, and unconditioned stimuli (US) expectancy are subjective evaluation indicators. In addition, we used associability generated by a computational reinforcement learning model to characterize the skin conductance response.ResultsThe findings indicate that individuals with depressive symptoms exhibited significant impairment in fear acquisition learning compared to those without depressive symptoms based on the results of the skin conductance response. Moreover, in the discrimination fear learning task, the skin conductance response was positively correlated with associability, as estimated by the hybrid model in the group without depressive symptoms. Additionally, the likeability rating scores improved post-extinction learning in the group without depressive symptoms, and no such increase was observed in the group with depressive symptoms.ConclusionThe study highlights that individuals with pronounced depressive symptoms exhibit impaired fear acquisition and extinction learning, suggesting a possible deficit in associative learning. Employing the hybrid model to analyze the learning process offers a deeper insight into the associative learning processes of humans, thus allowing for improved comprehension and treatment of these mental health problems.

وصف الملف: electronic resource

العلاقة: https://www.frontiersin.org/articles/10.3389/fpsyg.2024.1384053/fullTest; https://doaj.org/toc/1664-1078Test

الوصول الحر: https://doaj.org/article/3169e267cd0949098feba103cf459363Test

المؤلفون: Zhou Zhao, Hancong Li, Xiangcheng Pan, Chaoyong Shen, Mingchun Mu, Xiaonan Yin, Jing Liao, Zhaolun Cai, Bo Zhang

المصدر: Systematic Reviews, Vol 13, Iss 1, Pp 1-6 (2024)

مصطلحات موضوعية: Billroth I, Billroth II, Gastric cancer, Network meta-analysis, Reconstruction, Roux-en-Y, Medicine

الوصف: Abstract Background Distal gastrectomy (DG) is a commonly used surgical procedure for gastric cancer (GC), with three reconstruction methods available: Billroth I, Billroth II, and Roux-en-Y. In 2018, our team published a systematic review to provide guidance for clinical practice on the optimal reconstruction method after DG for GC. However, since then, new evidence from several randomized controlled trials (RCTs) has emerged, prompting us to conduct an updated systematic review and network meta-analysis to provide the latest comparative estimates of the efficacy and safety of the three reconstruction methods after DG for GC. Method This systematic review and network meta-analysis update followed the PRISMA-P guidelines and will include a search of PubMed, Embase, and the Cochrane Library for RCTs comparing the outcomes of Billroth I, Billroth II, or Roux-en-Y reconstruction after DG for patients with GC. Two independent reviewers will screen the titles and abstracts based on predefined eligibility criteria, and two reviewers will assess the full texts of relevant studies. The Bayesian network meta-analysis will evaluate various outcomes, including quality of life after surgery, anastomotic leakage within 30 days after surgery, operation time, intraoperative blood loss, major postoperative complications within 30 days after surgery, incidence and severity of bile reflux, and loss of body weight from baseline. Ethics and dissemination The review does not require ethical approval. The findings of the review will be disseminated through publication in an academic journal, presentations at conferences, and various media outlets. INPLASY registration number INPLASY2021100060.

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/2046-4053Test

الوصول الحر: https://doaj.org/article/2f5706a7985c424e8d6600c9b7bb11daTest

المؤلفون: Yiyuan Cai, Pengfei Guo, Jiong Tu, Mengyao Hu, Lingrui Liu, Bridget L. Ryan, Jing Liao, Rubee Dev, Yiran Li, Tianyu Huang, Ruilin Wang, Li Kuang, Ruonan Huang, Xinfang Li, Edmundo Roberto Melipillán, Shuaixiang Zhao, Wenjun He, Xiaohui Wang, Nan Zhang, Dong (Roman) Xu

المصدر: BMC Primary Care, Vol 25, Iss 1, Pp 1-13 (2024)

مصطلحات موضوعية: Patients-Centeredness Care, Quality of health care, Factor analysis, Localization and Validation, Medicine (General), R5-920

الوصف: Abstract Background An English version of the Patient Perception of Patient-Centeredness (PPPC) scale was recently revised, and it is necessary to test this instrument in different primary care populations. Aim This study aimed to assess the validity and reliability of a Chinese version of the PPPC scale. Design A mixed method was used in this study. The Delphi method was used to collect qualitative and quantitative data to address the content validity of the PPPC scale by calculating the Content Validity Index, Content Validity Ratio, the adjusted Kappa, and the Item Impact Score. Confirmatory factor analysis (CFA) and exploratory factor analysis (EFA) were used to assess the construct validity of the PPPC scale through a cross-sectional survey. The internal consistency was also assessed. Setting/participants In the Delphi consultation, seven experts were consulted through a questionnaire sent by email. The cross-sectional survey interviewed 188 outpatients in Guangzhou city and 108 outpatients in Hohhot City from community health service centers or stations face-to-face. Results The 21 items in the scale were relevant to their component. The Item-level Content Validity Index for each item was higher than 0.79, and the average Scale-level content validity index was 0.97 in each evaluation round. The initial proposed 4-factor CFA model did not fit adequately. Still, we found a 3-factor solution based on our EFA model and the validation via the CFA model (model fit: $${\chi }^{2}=294.573$$ χ 2 = 294.573 , P

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/2731-4553Test

الوصول الحر: https://doaj.org/article/7176ff0ce135451e91fb09dbca37fddaTest

المؤلفون: Jing Zhang, Conghui Yang, Yixuan Liu, Dadong Wu, Lingrui Liu, Huiqiong Zheng, Dong (Roman) Xu, Jing Liao

المصدر: BMC Geriatrics, Vol 23, Iss 1, Pp 1-11 (2023)

مصطلحات موضوعية: Qualitative comparative analysis, Older people, Couple-based management, Community management, Geriatrics, RC952-954.6

الوصف: Abstract Background Diabetes mellitus is a prevalent and potentially devastating chronic illness affecting many older adults. Given spousal involvement in many aspects of diabetes management, coping with their partners is increasingly seen as a potential solution to make up for limited resources. This study aimed to identify the key conditions for optimal implementation of couple-based collaborative management model (CCMM) among Chinese older couples with type 2 diabetes mellitus. Methods Older couples and community healthcare practitioners were selected according to couples’ joint intervention attendance rate and community’s average attendance rate. This mixed methods research consisted of a qualitative phase and a quantitative phase. In the qualitative phase, in-depth interviews were conducted among 12 pairs of couples in the intervention group and 4 corresponding practitioners, in the follow-up period of the multicentered RCT from January to April 2022. Qualitative comparative analysis (QCA) in the quantitative phase to identify conditions influencing CCMM’s implementation and to explore necessary and sufficient combinations of conditions (i.e., solutions) for improving patients’ glycated hemoglobin (HbA1c) control (outcome). Results Key conditions included implementation process, couple’s role in diabetes management, their belief and perception of CCMM, as well as objective obstacles and subjective initiative for behavior change. Accordingly, major barriers in CCMM’s implementation were patients’ strong autonomy (particularly among husbands), misbelief and misperception about diabetes management as a result of low literacy, and mistrust of the practitioners. QCA further revealed that no single condition was necessary for effective HbA1c control, while three types of their combinations would be sufficient. Solution 1 and 2 both comprised the presence of spousal willingness to help, plus correct belief and perception of diabetes management, well embodying the utility of couple collaborative management in supporting patients’ HbA1c control. On the other hand, solution 3 indicated that high-quality implementation even without spousal support, can promote the patient’s subjective initiative to overcome objective obstacles, suggesting enhanced self-management for HbA1c control. Conclusions Tailored CCMM should be implemented in reference to older couple’s preferences and literacy levels, to ensure intervention fidelity, and establish correct understanding of collaborative management among them.

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/1471-2318Test

الوصول الحر: https://doaj.org/article/1d47a2196af04910bb15ac4f5bcdaae0Test

المؤلفون: Jing Liao, Miaomiao Yuan, Ziqiang Xu, Youbin Zheng, Zhe Wang, Qitong Huang

المصدر: Frontiers in Bioengineering and Biotechnology, Vol 12 (2024)

مصطلحات موضوعية: smart nanomaterials, biosensing, nanozyme, cancer therapies, intelligent drug-delivery system, early-diagnosis, Biotechnology, TP248.13-248.65

وصف الملف: electronic resource

العلاقة: https://www.frontiersin.org/articles/10.3389/fbioe.2024.1387969/fullTest; https://doaj.org/toc/2296-4185Test

الوصول الحر: https://doaj.org/article/ccb4d86ad4ae48fa895004c31e986b45Test

المؤلفون: Jing Liao, Fan Zhang, Yan Bai, Liuyan Huang, Yifei Zhong, Zixuan Zhang

المصدر: BMJ Open, Vol 14, Iss 3 (2024)

مصطلحات موضوعية: Medicine

الوصف: Introduction Haemodialysis is the most common treatment option for patients with life-sustaining end-stage kidney disease (ESKD). In recent years, haemodiafiltration or haemofiltration has been widely used in patients with ESKD, and there are still conflicting findings as to whether both are superior to traditional haemodialysis. This systematic review and meta-analysis were designed to determine whether haemodiafiltration or haemofiltration is more effective than haemodialysis in reducing all-cause mortality risk in patients with ESKD.Methods and analysis We will perform a systematic PubMed, Embase, Cochrane Central Register of Controlled Trials (CENTRAL) in The Cochrane Library and Scopus search, including studies published before September 2023. Randomised controlled trials will be included exploring the effects of haemodiafiltration or haemofiltration compared with haemodialysis on prognosis in patients with ESKD. Outcomes of interest include all-cause mortality, cardiovascular events, dialysis adequacy and adverse effects. The Cochrane Collaboration tools (ROB-2) will assess the bias risk. Available data will be used to calculate effect sizes. Heterogeneity between studies will be evaluated with I2. The trial sequential analysis will be used to eliminate false-positive results. The certainty of the evidence will be assessed using Grading of Recommendations, Assessment, Development and Evaluation criteria.Ethics and dissemination This systematic review and meta-analysis was deemed exempt from ethics review. Results will be disseminated through publication in peer-reviewed journals and research conferences.PROSPERO registration number CRD42023464509.

وصف الملف: electronic resource

العلاقة: https://bmjopen.bmj.com/content/14/3/e080541.fullTest; https://doaj.org/toc/2044-6055Test

الوصول الحر: https://doaj.org/article/8ea34c7255fb4f31a61c65af6d8bab8fTest

المؤلفون: Guangyi Huang, Shaoyang Zhang, Jing Liao, Yuanjun Qin, Yiyi Hong, Qi Chen, Yunru Lin, Yue Li, Lin Lan, Wen Hu, Kongqian Huang, Fen Tang, Ningning Tang, Li Jiang, Chaolan Shen, Ling Cui, Haibin Zhong, Min Li, Peng Lu, Qinmeng Shu, Yantao Wei, Fan Xu

المصدر: Heliyon, Vol 10, Iss 5, Pp e27114- (2024)

مصطلحات موضوعية: BMX, Apoptosis, Ischemia/reperfusion, Inflammation, Neuroprotection, Retina, Science (General), Q1-390, Social sciences (General), H1-99

الوصف: Aims: Retinal ischemia/reperfusion (I/R) injury is implicated in the etiology of various ocular disorders. Prior research has demonstrated that bone marrow tyrosine kinase on chromosome X (BMX) contributes to the advancement of ischemic disease and inflammatory reactions. Consequently, the current investigation aims to evaluate BMX's impact on retinal I/R injury and clarify its implied mechanism of action. Main methods: This study utilized male and female systemic BMX knockout (BMX−/−) mice to conduct experiments. The utilization of Western blot assay and immunofluorescence labeling techniques was employed to investigate variations in the expression of protein and tissue localization. Histomorphological changes were observed through H&E staining and SD-OCT examination. Visual function changes were assessed through electrophysiological experiments. Furthermore, apoptosis in the retina was identified using the TUNEL assay, as well as the ELISA technique, which has been utilized to determine the inflammatory factors level. Key findings: Our investigation results revealed that the knockdown of BMX did not yield a significant effect on mouse retina. In mice, BMX knockdown mitigated the negative impact of I/R injury on retinal tissue structure and visual function. BMX knockdown effectively reduced apoptosis, suppressed inflammatory responses, and decreased inflammatory factors subsequent to I/R injury. The outcomes of the current investigation revealed that BMX knockdown partially protected the retina through downregulating phosphorylation of AKT/ERK/STAT3 pathway. Significance: Our investigation showed that BMX−/− reduces AKT, ERK, and STAT3 phosphorylation, reducing apoptosis and inflammation. Thus, this strategy protected the retina from structural and functional damage after I/R injury.

وصف الملف: electronic resource

العلاقة: http://www.sciencedirect.com/science/article/pii/S2405844024031451Test; https://doaj.org/toc/2405-8440Test

الوصول الحر: https://doaj.org/article/1319880ac19b478090b2661fb2434c49Test