المؤلفون: Haolun Xu, Jianjian Liu, Tongqiang Luo, Yifan Yao, Chen Lv

المصدر: IEEE Access, Vol 12, Pp 45597-45615 (2024)

مصطلحات موضوعية: In-wheel motor technology, model-based design, active suspension, vehicle vertical control, skyhook control, dynamic vibration absorber, Electrical engineering. Electronics. Nuclear engineering, TK1-9971

الوصف: This paper presents an advanced vertical control system using active suspension to stabilize the vertical motion of an in-wheel motor-driven electric vehicle. The design of the control system and conceptualization were carried out by mathematical modeling with integration with the quarter car model. A novel active suspension is developed through the model-based design to control the vehicles to move smoothly and continuously. Even though experimental validation is an effective and more accurate method to evaluate the control system, it is important to reduce the dependency on physical testing. Thus, a reliable simulation framework would be beneficial in the vehicle development process. In this paper, the hydraulic system is designed and simulated by using the Simcenter Amesim. For the dynamic vibration absorber, we are seeking to design a skyhook control to control the damping force by an electric damper, whereas the spring stiffness can be switched by opening and closing the fluid passage to the gas chamber. In the spring stiffness control, the stiff suspension can reach a ratio of 1.3 compared to the soft suspension. The objective of this research work was realized with the proposed simulation framework to test the effectiveness of suspension control system to improve ride and handling in a four in-wheel motor-driven electric vehicle.

وصف الملف: electronic resource

العلاقة: https://ieeexplore.ieee.org/document/10477988Test/; https://doaj.org/toc/2169-3536Test

الوصول الحر: https://doaj.org/article/feb08912bbf2417d8fa6ba08baf40855Test

المؤلفون: Jiarui Chen, Jianjian Liu, Zhaowen Gu, Jiayong Fan, Shuxin Lei, Qia Zhang, Kai Pan, Yongjie Wang

المصدر: Frontiers in Neurology, Vol 15 (2024)

مصطلحات موضوعية: stroke, NHANES, oxidative stress, oxidative balance score, prevention, Neurology. Diseases of the nervous system, RC346-429

الوصف: IntroductionThe relationship between oxidative balance score (OBS), an emerging integrative metric for assessing individual redox homeostasis, and the prevalence of stroke in the general population remains unknown. We aimed to explore these relationships in the National Health and Nutrition Examination Survey (NHANES). We investigated the relationship between the oxidative balance score (OBS) and stroke prevalence using NHANES data from 1999–2018.MethodsWe included eligible individuals from NHANES 1999–2018. OBS calculations were based on previously validated methods, and stroke diagnoses were based on self-reports in questionnaires. Multivariable logistic regression analyses were used to examine the independent associations of overall, dietary, and lifestyle OBS with stroke prevalence. In addition, restricted cubic spline (RCS), stratified analysis, and sensitivity analysis were used.ResultsWe included 25,258 participants aged 20–85 years, in which the prevalence of stroke was 2.66%. After adjusting for all confounders, overall and dietary OBS, but not lifestyle OBS, were inversely associated with the prevalence of stroke [odds ratios and 95% confidence intervals of 0.97 (0.96, 0.99) and 0.98 (0.96, 0.99) for overall and dietary OBS, respectively, both p

وصف الملف: electronic resource

العلاقة: https://www.frontiersin.org/articles/10.3389/fneur.2024.1348011/fullTest; https://doaj.org/toc/1664-2295Test

الوصول الحر: https://doaj.org/article/6839c2c2d0f54d1492f36b39db503f98Test

المؤلفون: Junjie Wang, Quan Du, Jiarui Chen, Jianjian Liu, Zhaowen Gu, Xiaoyu Wang, Anke Zhang, Shiqi Gao, Anwen Shao, Jianmin Zhang, Yongjie Wang

المصدر: Frontiers in Oncology, Vol 14 (2024)

مصطلحات موضوعية: glioblastoma, brain tumor, tumor treating fields, retrospective cohort, survival analysis, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

الوصف: IntroductionTumor treating fields (TTFields) have earned substantial attention in recent years as a novel therapeutic approach with the potential to improve the prognosis of glioblastoma (GBM) patients. However, the impact of TTFields remains a subject of ongoing debate. This study aimed to offer real-world evidence on TTFields therapy for GBM, and to investigate the clinical determinants affecting its efficacy.MethodsWe have reported a retrospective analysis of 81 newly diagnosed Chinese GBM patients who received TTFields/Stupp treatment in the Second Affiliated Hospital of Zhejiang University. Overall survival (OS) and progression-free survival (PFS) were analyzed using Kaplan–Meier method. Cox regression models with time-dependent covariates were utilized to address non-proportional hazards and to assess the influence of clinical variables on PFS and OS.ResultsThe median PFS and OS following TTFields/STUPP treatment was 12.6 months (95% CI 11.0-14.1) and 21.3 months (95% CI 10.0–32.6) respectively. Long-term TTFields treatment (>2 months) exhibits significant improvements in PFS and OS compared to the short-term treatment group (≤2 months). Time-dependent covariate COX analysis revealed that longer TTFields treatment was correlated with enhanced PFS and OS for up to 12 and 13 months, respectively. Higher compliance to TTFields (≥ 0.8) significantly reduced the death risk (HR=0.297, 95%CI 0.108-0.819). Complete surgical resection and MGMT promoter methylation were associated with significantly lower risk of progression (HR=0.337, 95% CI 0.176-0.643; HR=0.156, 95% CI 0.065-0.378) and death (HR=0.276, 95% CI 0.105-0.727; HR=0.249, 95% CI 0.087-0.710).ConclusionThe TTFields/Stupp treatment may prolong median OS and PFS in GBM patients, with long-term TTFields treatment, higher TTFields compliance, complete surgical resection, and MGMT promoter methylation significantly improving prognosis.

وصف الملف: electronic resource

العلاقة: https://www.frontiersin.org/articles/10.3389/fonc.2024.1345190/fullTest; https://doaj.org/toc/2234-943XTest

الوصول الحر: https://doaj.org/article/14b701f3a9c54adeb82c0508ee89e400Test

المؤلفون: Zhiyang Liu, Qi Fan, Jianjian Liu, Luoyu Zhou, Zhengbing Zhang

المصدر: Sensors, Vol 24, Iss 11, p 3607 (2024)

مصطلحات موضوعية: dynamic liquid level monitoring and measurement, noise reduction algorithm, Internet of Things, LoRa, Chemical technology, TP1-1185

الوصف: Dynamic liquid level monitoring and measurement in oil wells is essential in ensuring the safe and efficient operation of oil extraction machinery and formulating rational extraction policies that enhance the productivity of oilfields. This paper presents an intelligent infrasound-based measurement method for oil wells’ dynamic liquid levels; it is designed to address the challenges of conventional measurement methods, including high costs, low precision, low robustness and inadequate real-time performance. Firstly, a novel noise reduction algorithm is introduced to effectively mitigate both periodic and stochastic noise, thereby significantly improving the accuracy of dynamic liquid level detection. Additionally, leveraging the PyQT framework, a software platform for real-time dynamic liquid level monitoring is engineered, capable of generating liquid level profiles, computing the sound velocity and liquid depth and visualizing the monitoring data. To bolster the data storage and analytical capabilities, the system incorporates an around-the-clock unattended monitoring approach, utilizing Internet of Things (IoT) technology to facilitate the transmission of the collected dynamic liquid level data and computed results to the oilfield’s central data repository via LoRa and 4G communication modules. Field trials on dynamic liquid level monitoring and measurement in oil wells demonstrate a measurement range of 600 m to 3000 m, with consistent and reliable results, fulfilling the requirements for oil well dynamic liquid level monitoring and measurement. This innovative system offers a new perspective and methodology for the computation and surveillance of dynamic liquid level depths.

وصف الملف: electronic resource

العلاقة: https://www.mdpi.com/1424-8220/24/11/3607Test; https://doaj.org/toc/1424-8220Test

الوصول الحر: https://doaj.org/article/c4c25bc6c1b64a2888108b40aa356946Test

المؤلفون: Chen Huang, Xia Shi, Xin Ma, Jianjian Liu, Jingjing Huang, Li Deng, Ye Cao, Mingkun Zhao

المصدر: BMC Infectious Diseases, Vol 23, Iss 1, Pp 1-9 (2023)

مصطلحات موضوعية: Ultrasound, HIV, Lymph node, Diagnosis, Nomogram, Infectious and parasitic diseases, RC109-216

الوصف: Abstract Background This study aimed to establish an effective ultrasound diagnostic nomogram for benign or malignant lymph nodes in HIV-infected patients. Methods The nomogram is based on a retrospective study of 131 HIV-infected patients who underwent ultrasound assess at the Shanghai Public Health Clinical Center from December 2017 to July 2022. The nomogram’s predictive accuracy and discriminative ability were determined by concordance index (C-index) and calibration curve analysis. A nomogram combining the lymph node US characteristics were generated based on the multivariate logistic regression results. Results Predictors contained in the ultrasound diagnostic nomogram included age (OR 1.044 95%CI: 1.014–1.074 P = 0.004), number of enlarged lymph node regions (OR 5.445 95%CI: 1.139–26.029 P = 0.034), and color Doppler flow imaging (CDFI) grades (OR 9.614 95%CI: 1.889–48.930 P = 0.006). The model displayed good discrimination with a C (ROC) of 0.775 and good calibration. Conclusions The proposed nomogram may result in more-accurate diagnostic predictions for benign or malignant lymph nodes in patients with HIV infection.

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/1471-2334Test

الوصول الحر: https://doaj.org/article/dcfe7c31af1e42e6b8f3971cead53d3cTest

المؤلفون: Hanyu Liu, Jianjian Liu, Zhenjiao Zhang, Weichao Liu, Qi Zhang, Xing Wang, Chengjie Ren, Gaihe Yang, Xinhui Han

المصدر: Agronomy, Vol 14, Iss 4, p 689 (2024)

مصطلحات موضوعية: soil carbon dynamics, soil carbon-degrading enzyme, soil carbon emission, soil carbon content, agroforestry system, Agriculture

الوصف: In the agroforestry system, the organic matter in the farmland and natural ecosystem enters the farmland soil in a mixed form to improve soil fertility and carbon pool quality. However, it is unclear how soil microbial carbon-degrading enzyme activity responds to carbon dynamics in this process. Therefore, we took farmland in the Loess Plateau as the research object, combining the application of corn straw and Robinia pseudoacacia leaves in a mass ratio of 4:0, 3:1, 2:2, 1:3, and 0:4 for returning to the field. We measured corn grain yield, carbon emission, organic carbon pool component content, and carbon-degrading enzyme activity of the farmland. The results showed that combining corn straw and Robinia pseudoacacia leaves had a significant impact on soil organic carbon components (readily oxidizable organic carbon and recalcitrant organic carbon), carbon-degrading enzymes (polyphenol oxidase, peroxidase, and cellobiohydrolase), and cumulative carbon emissions. The trend of different indicators in different treatments during the corn growth period was similar. We found that soil carbon emissions were closely related to ROC and soil oxidase activity, while soil carbon content was closely related to soil hydrolase activity. Compared to not returning straw to the field, the corn straw and Robinia pseudoacacia leaves returned to the field in a mass ratio of 1:3(Y1C3) can increase corn grain yield by 32.04%. The Y1C3 treatment has the highest soil carbon content and the lowest crop carbon emission efficiency. Soil water content plays a crucial role in the process of carbon pool transformation driven by soil carbon-degrading enzymes. In conclusion, soil carbon dynamics are closely related to the activity of soil carbon-degrading enzymes. Combining the application of corn straw and Robinia pseudoacacia leaves may be a more suitable farming measure for fragile habitats in the Loess Plateau than other solutions.

وصف الملف: electronic resource

العلاقة: https://www.mdpi.com/2073-4395/14/4/689Test; https://doaj.org/toc/2073-4395Test

الوصول الحر: https://doaj.org/article/4ce5a420d39d469e91da795163d81761Test

المؤلفون: Lei Fang, Miaomiao Wang, Xiao Chen, Jianrong Zhao, Jianfei Wang, Jianjian Liu

المصدر: BMC Genomics, Vol 24, Iss 1, Pp 1-15 (2023)

مصطلحات موضوعية: Ammonium, AMT family, Evolution, Arbuscular mycorrhizal symbiosis, Chili pepper, Biotechnology, TP248.13-248.65, Genetics, QH426-470

الوصف: Abstract Background Ammonium (NH4 +) is a key nitrogen source supporting plant growth and development. Proteins in the ammonium transporter (AMT) family mediate the movement of NH4 + across the cell membrane. Although several studies have examined AMT genes in various plant species, few studies of the AMT gene family have been conducted in chili pepper. Results Here, a total of eight AMT genes were identified in chili pepper, and their exon/intron structures, phylogenetic relationships, and expression patterns in response to arbuscular mycorrhizal (AM) colonization were explored. Synteny analyses among chili pepper, tomato, eggplant, soybean, and Medicago revealed that the CaAMT2;1, CaAMT2.4, and CaAMT3;1 have undergone an expansion prior to the divergence of Solanaceae and Leguminosae. The expression of six AMT2 genes was either up-regulated or down-regulated in response to AM colonization. The expression of CaAMT2;1/2;2/2;3 and SlAMT2;1/2;2/2;3 was significantly up-regulated in AM fungi-inoculated roots. A 1,112-bp CaAMT2;1 promoter fragment and a 1,400-bp CaAMT2;2 promoter fragment drove the expression of the β-glucuronidase gene in the cortex of AM roots. Evaluation of AM colonization under different NH4 + concentrations revealed that a sufficient, but not excessive, supply of NH4 + promotes the growth of chili pepper and the colonization of AM. Furthermore, we demonstrated that CaAMT2;2 overexpression could mediate NH4 + uptake in tomato plants. Conclusion In sum, our results provide new insights into the evolutionary relationships and functional divergence of chili pepper AMT genes. We also identified putative AMT genes expressed in AM symbiotic roots.

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/1471-2164Test

الوصول الحر: https://doaj.org/article/8f9af446ee8a4725a5970a80e37a16a4Test

المؤلفون: Jianjian Liu, Mali Zhou, Rui Deng, Pengcheng Zheng, Yonggui Robin Chi

المصدر: Nature Communications, Vol 13, Iss 1, Pp 1-8 (2022)

مصطلحات موضوعية: Science

الوصف: Conformational isomerization of organic molecules can be guided by noncovalent interactions. Here, the authors report the synthesis of chiral sulfoxides catalyzed by N-heterocyclic carbenes; intramolecular chalcogen bonding interactions are key for conformational locking.

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/2041-1723Test

الوصول الحر: https://doaj.org/article/379bc9de074c4d15978864841b2fbcb8Test

المؤلفون: Peng Chen, Hiba Shaghaleh, Yousef Alhaj Hamoud, Jing Wang, Wenxia Pei, Xianfu Yuan, Jianjian Liu, Cece Qiao, Wenhui Xia, Jianfei Wang

المصدر: Life, Vol 13, Iss 9, p 1849 (2023)

مصطلحات موضوعية: selenium, wheat yield, mineral nutrient, heavy metal, Science

الوصف: This study was designed to investigate the effect on wheat yield of applying organic fertilizers (OF) with five different selenium (Se) concentrations. The mineral nutrients, cadmium (Cd) content, and the distribution of Se in wheat plants were also measured. The results showed that wheat yields reached a maximum of 9979.78 kg ha−1 in Mengcheng (MC) County and 8868.97 kg ha−1 in Dingyuan (DY) County, Anhui Province, China when the application amount of selenium-containing organic fertilizer (SOF) was up to 600 kg ha−1. Among the six mineral nutrients measured, only the calcium (Ca) content of the grains significantly increased with an increase in the application amount of SOF in the two regions under study. Cd content showed antagonistic effects with the Se content of wheat grains, and when the SOF was applied at 1200 kg ha−1, the Cd content of the grains was significantly reduced by 30.1% in MC and 67.3% in DY, compared with under the Se0 treatment. After application of SOF, the Se content of different parts of the wheat plant ranked root > grain > spike-stalk > glume > leaf > stem. In summary, SOF application at a suitable concentration could increase wheat yields and significantly promote the Ca content of the grains. Meanwhile, the addition of Se effectively inhibited the level of toxic Cd in the wheat grains.

وصف الملف: electronic resource

العلاقة: https://www.mdpi.com/2075-1729/13/9/1849Test; https://doaj.org/toc/2075-1729Test

الوصول الحر: https://doaj.org/article/812b4396bfd04054838c0efab894da02Test

المؤلفون: Jianan Lu, Huaming Li, Guoqiang Zhang, Fan Yang, Xiaotao Zhang, An Ping, Zhouhan Xu, Yichen Gu, Rui Wang, Dan Ying, Jianjian Liu, Jianmin Zhang, Ligen Shi

المصدر: Research, Vol 6 (2023)

مصطلحات موضوعية: Science

الوصف: Immunosenescence refers to the multifaceted and profound alterations in the immune system brought about by aging, exerting complex influences on the pathophysiological processes of diseases that manifest upon it. Using a combination of single-cell RNA sequencing, cytometry by time of flight, and various immunological assays, we investigated the characteristics of immunosenescence in the peripheral blood of aged mice and its impact on the cerebral immune environment after ischemic stroke. Our results revealed some features of immunosenescence. We observed an increase in neutrophil counts, concurrent with accelerated neutrophil aging, characterized by altered expression of aging-associated markers like CD62L and consequential changes in neutrophil-mediated immune functions. Monocytes/macrophages in aged mice exhibited enhanced antigen-presentation capabilities. T cell profiles shifted from naive to effector or memory states, with a specific rise in T helper 1 cells and T helper 17 cells subpopulations and increased regulatory T cell activation in CD4 T cells. Furthermore, regulatory CD8 T cells marked by Klra decreased with aging, while a subpopulation of exhausted-like CD8 T cells expanded, retaining potent immunostimulatory and proinflammatory functions. Critically, these inherent disparities not only persisted but were further amplified within the ischemic hemispheres following stroke. In summary, our comprehensive insights into the key attributes of peripheral immunosenescence provide a vital theoretical foundation for understanding not only ischemic strokes but also other age-associated diseases.

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/2639-5274Test

الوصول الحر: https://doaj.org/article/95c4d43eb375422493c302e53562b10cTest