المؤلفون: Wensong Wu, Fan Chang, Jianghui Zhang, Shuai Tang, Zhen Lv, Fangmin Chen

المصدر: Scientific Reports, Vol 13, Iss 1, Pp 1-12 (2023)

مصطلحات موضوعية: Medicine, Science

الوصف: Abstract Renal cell cancer is associated with the coagulation system. Long non-coding RNA (lncRNA) expression is closely associated with the development of clear cell renal cell carcinoma (ccRCC). The aim of this study was to build a novel lncRNA model to predict the prognosis and immunological state of ccRCC. The transcriptomic data and clinical data of ccRCC were retrieved from TCGA database, subsequently, the lasso regression and lambda spectra were used to filter prognostic lncRNAs. ROC curves and the C-index were used to confirm the predictive effectiveness of this model. We also explored the difference in immune infiltration, immune checkpoints, tumor mutation burden (TMB) and drug sensitivity between the high- and low-risk groups. We created an 8 lncRNA model for predicting the outcome of ccRCC. Multivariate Cox regression analysis showed that age, tumor grade, and risk score are independent prognostic factors for ccRCC patients. ROC curve and C-index revealed the model had a good performance in predicting prognosis of ccRCC. GO and KEGG analysis showed that coagulation related genes were related to immune response. In addition, high risk group had greater TMB level and higher immune checkpoints expression. Sorafenib, Imatinib, Pazopanib, and etoposide had higher half maximal inhibitory concentration (IC50) in the high risk group whereas Sunitinib and Bosutinib had lower IC50. This novel coagulation-related long noncoding RNAs model could predict the prognosis of patients with ccRCC, and coagulation-related lncRNA may be connected to the tumor microenvironment and gene mutation of ccRCC.

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/2045-2322Test

الوصول الحر: https://doaj.org/article/c1c2909f869149ea802d61b4dd53f5ddTest

المؤلفون: Haoyuan Deng, Xuehui Zhang, Nan Cheng, Jianghui Zhang, Chongwei Song, Yunrui Sun, Zhongxin Hou, Yi Li, Qian Wang, Jianzhong Yin, Qiong Meng

المصدر: BMC Public Health, Vol 23, Iss 1, Pp 1-11 (2023)

مصطلحات موضوعية: Nephrolithiasis, Serum uric acid, Cross-sectional study, Restricted cubic splines, Public aspects of medicine, RA1-1270

الوصف: Abstract Background Existing evidence shows that there is an independent correlation between nephrolithiasis and gout, and hyperuricemia is the most important risk factor for gout. However, hyperuricemia was often used as an accompanying symptom of gout to explore its association with nephrolithiasis, there were few studies to explore whether hyperuricemia itself or serum uric acid (SUA) is related to the risk of nephrolithiasis. Evidence on the relationship between hyperuricemia and nephrolithiasis is still insufficient. Methods A total of 22,303 participants aged 30 to 79 years who participated in the China Multi-Ethnic Cohort (CMEC) study in Yunnan Province from May 2018 to September 2019 were included in the study. All participants received standardized face-to-face interviews, medical examinations, and biochemical examinations. Logistic regression was used to estimate the association between hyperuricemia and nephrolithiasis, and a restricted cubic spline (RCS) model was used to explore the dose–response relationship between SUA and the risk of nephrolithiasis. Results 14.5% of all participants were diagnosed with hyperuricemia, and 12.1% were diagnosed with nephrolithiasis. After adjusting for all potential confounders, the OR (95%CI) for nephrolithiasis in participants with hyperuricemia compared with participants without hyperuricemia was 1.464 (1.312,1.633), p

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/1471-2458Test

الوصول الحر: https://doaj.org/article/0eddea7b43144529a1e035902fa9dbfbTest

المؤلفون: Ge Li, Yuyang Shan, Yungang Bai, Weibo Nie, Qian Wang, Jianghui Zhang, Hongbo Liu, Yu Ding, Xiaoyan Wang, Hongqin Lu

المصدر: Agronomy, Vol 14, Iss 5, p 994 (2024)

مصطلحات موضوعية: soil amendments, dry sowing and wet emergence, soil quality, water–heat–salt environment, yield, Agriculture

الوصف: Soil amendments such as humic acid (HA), a biochar-based microbial agent (M), and vermicompost (V) can improve soil quality and promote crop growth. However, it remains unclear whether the co-application of the three soil amendments (HMV) has a synergistic effect on alleviating soil quality deterioration obstacles caused by dry sowing and wet emergence technology in Xinjiang cotton fields. A three-year field experiment was conducted in saline–alkali soils using plastic-film-mulched drip irrigation in Xinjiang, China. Through the orthogonal experiment method, the application amounts of HA, M and V were 75 kg ha−1, 75 kg ha−1 and 225 kg ha−1 respectively in 2021. In 2022, three application amount gradients were used for HA, M and V: 60 kg ha−1, 90 kg ha−1 and 120 kg ha−1 respectively. In 2023, the application amounts of HA, M, and V were 60 kg ha−1, 120 kg ha−1, and 120 kg ha−1. It should be pointed out that V contains HA in the range of 20–35%. This study aimed to explore the improvement effect of a single or combined application of HA, M, and V on soil quality and cotton emergence rate using dry sowing and wet emergence technology in Xinjiang cotton fields. The results showed that the single and combined applications of HA, M, and V improved the soil quality and water–heat–salt environment of the cultivated layer. In the combined application, the cotton seedling emergence rate and yield increased by 1.9–22.8% and 7.0–54.1%. Therefore, it is recommended to jointly apply HA, M, and V to promote cotton seedling emergence and increase yield using dry sowing and wet emergence technology in Xinjiang cotton fields.

وصف الملف: electronic resource

العلاقة: https://www.mdpi.com/2073-4395/14/5/994Test; https://doaj.org/toc/2073-4395Test

الوصول الحر: https://doaj.org/article/618235d444514ecbbafbe67d5e490673Test

المؤلفون: Zhihui Zhu, Jianghui Zhang, Guojing Yuan, Meng Jiang, Xueqing Zhang, Kexin Zhang, Xiaoyan Lu, Haiyun Guo, Huayu Yang, Guifang Jin, Haiyan Shi, Jun Du, Wenzhuo Xu, Sainan Wang, Hao Guo, Kele Jiang, Zhihua Zhang

المصدر: Frontiers in Microbiology, Vol 14 (2023)

مصطلحات موضوعية: mobile phone addiction, sleep disorder, gut microbiota, college student, epidemiology, Microbiology, QR1-502

الوصف: Bidirectional communication between the gut microbiota and the brain has sparked interest in exploring the link between mobile phone addiction (MPA) and sleep disorders (SD) in microbiome research. However, investigating the role of gut microbiota in this relationship using animal models presents challenges due to the unique nature of MPA, and human research in this area is scarce. We recruited 99 healthy college students to evaluate the gut microbiome using 16S rRNA gene amplicon sequencing and assess MPA and SD at baseline and after a two-month follow-up. Multiple covariate-adjusted statistical models, including linear regression, permutational multivariate analysis of variance and so on, were employed to determine microbiome associations with MPA at baseline and changes in SD at follow-up. Our findings revealed negative associations between MPA and three alpha diversity metrics, along with alterations in bacterial composition. MPA showed negative associations with the relative abundance of Bacteroidetes, while displaying positive associations with Actinobacteria and Bifidobacteriales. Conversely, Actinobacteria exhibited a negative association with increased SD. This study has established a significant link between MPA and a decrease in the alpha diversity of the gut microbiota. Actinobacteria was associated with MPA and SD, respectively. Additional investigation is needed to fully comprehend the relationship between comorbid behavioral disorders and the gut microbiota.

وصف الملف: electronic resource

العلاقة: https://www.frontiersin.org/articles/10.3389/fmicb.2023.1323116/fullTest; https://doaj.org/toc/1664-302XTest

الوصول الحر: https://doaj.org/article/0e1eff0924ec40d2a54b6268818649e8Test

المؤلفون: Qian Wang, Yi Li, Jianzhong Yin, Qiong Meng, Yunrui Sun, Xiaoyu Han, Zhongxin Hou, Haoyuan Deng, Nan Cheng, Nishang Zhang, Jianghui Zhang

المصدر: BMJ Open, Vol 13, Iss 12 (2023)

مصطلحات موضوعية: Medicine

الوصف: Objective Sedentary behaviour is associated with a variety of adverse health outcomes, including obesity, oestrogen metabolism and chronic inflammation, all of which are related to the pathogenesis of uterine fibroids (UFs). This study aimed to explore the relationship between leisure sedentary time (LST) and UFs.Design Cross-sectional.Setting We conducted a cross-sectional analysis of data from patients from the Yunnan region in the China Multi-Ethnic Cohort Study.Participants A total of 6623 non-menopausal women aged 30–55 years old were recruited. Menstrual status was self-reported. Participants who lacked a unique national identity card, suffered from serious mental illness, did not have a clear diagnosis of UFs, or provided incomplete information were excluded.Primary and secondary outcome UFs were diagnosed by abdominal B-ultrasound. Leisure sedentary behaviour was assessed by using a face-to-face questionnaire interview. Logistic regression and restricted cubic spline were employed to explore the relationship between LST and UFs.Results A total of 562 participants had UFs, with a prevalence rate of 8.5% (7.8%, 9.2%). Multivariate adjusted logistic regression analysis showed that the risk of UFs in women with LST≥6 hour/day was 2.008 times that in women with LST0.05). According to the results of the stratified analysis for menstrual status and body mass index (BMI), there was a correlation between LST and the prevalence of UFs only in women with a BMI

وصف الملف: electronic resource

العلاقة: https://bmjopen.bmj.com/content/13/12/e073592.fullTest; https://doaj.org/toc/2044-6055Test

الوصول الحر: https://doaj.org/article/ea5cad33dfa74e77b73b7ae47d7dabc6Test

المؤلفون: Jianqin Ma, Yu Ding, Jianghui Zhang, Yungang Bai, Bifeng Cui, Xiuping Hao, Ming Zheng, Bangxin Ding, Shuoguo Yang

المصدر: Agronomy, Vol 14, Iss 4, p 734 (2024)

مصطلحات موضوعية: water management, dry sowing and wet emergence, dry matter accumulation, chlorophyll fluorescence, yield, water productivity, Agriculture

الوصف: Determining a suitable “dry sowing and wet emergence” water control program for cotton fields in the arid regions of Northwest China is of great significance in saving water resources, improving economic efficiency, and promoting sustainable development of agriculture. The objective of this study was to analyze the effects of different “dry sowing and wet emergence” water control treatments on dry matter accumulation, chlorophyll fluorescence, yield quality, and water productivity of cotton, and to determine the optimal “dry sowing and wet emergence” water control program for cotton growth in arid areas. A two-year experiment was carried out in 2021 and 2022 in mulched drip-irrigated cotton fields, with a total of 13 treatments of different seedling water quantities (2021: 67.5 mm, 90 mm, 112.5 mm; 2022: 6 mm, 10.5 mm, 15 mm) and different drip frequencies (frequencies means number of drops at seedling stage) (2021: one, two, three times; 2022: two times, four times) in the “dry sowing and wet emergence”. Results indicated a positive correlation between increased seedling water quantity and growth indexes. High seedling water quantity treatment demonstrated a 14.33% higher cotton yield than the low seedling water quantity treatment. In comparison with low-frequency treatment, the high-frequency treatment exhibited significantly larger cotton plant height, dry matter accumulation, and yield. Over two years, the average values increased by 8.69%, 16.4%, and 15.91%, respectively, with a 14.55% increase in the coefficient of photochemical quenching of the leaf blade (qP). The high frequency and larger amount of seedling water quantity treatments showed significantly higher irrigation water productivity, with increases of 39.2% and 70.2% compared to the winter irrigation control treatment. In summary, the appropriate “dry sowing wet emergence” water regulation mode (the first drip: 15 mm, the second drip: 4.5 mm, the third drip: 22.5 mm, the fourth drip: 15 mm) can ensure crop yield quality under the premise of significantly reducing the agricultural irrigation water, which can provide certain theoretical support for the green, efficient, and sustainable development of the local cotton industry.

وصف الملف: electronic resource

العلاقة: https://www.mdpi.com/2073-4395/14/4/734Test; https://doaj.org/toc/2073-4395Test

الوصول الحر: https://doaj.org/article/d6c98a7a292f4659ac8638e323ef4f69Test

المؤلفون: Xiaowei Chi, Jianghui Zhang, Yuanyuan Chen, Qiang Fu

المصدر: Asian Journal of Surgery, Vol 46, Iss 7, Pp 2991-2993 (2023)

مصطلحات موضوعية: Surgery, RD1-811

وصف الملف: electronic resource

العلاقة: http://www.sciencedirect.com/science/article/pii/S101595842300218XTest; https://doaj.org/toc/1015-9584Test

الوصول الحر: https://doaj.org/article/66f0cc5720164006ac922820ff3c08e7Test

المؤلفون: Na Gao PhD, Taoao Li PhD, Wei Cui BS, Limin Zhao BS, Jianghui Zhang PhD, Lili Pan PhD

المصدر: Clinical and Applied Thrombosis/Hemostasis, Vol 29 (2023)

مصطلحات موضوعية: Diseases of the circulatory (Cardiovascular) system, RC666-701

الوصف: Objectives This study aims to investigate whether PD-1 expressions are abnormal in patients with TAK. Methods PD-1 expression was analyzed by flow cytometry. Serum cytokines IL-10, IL-7, IL-2, IL-15, CCL2, CCL3, and CXCL10 were detected using a cytokine cytometric bead array. Immunohistochemistry staining analysis was used to test PD-1 and programmed death-ligand 1 (PD-L1) expression in the aorta of three patients with TAK and three patients with atherosclerosis as controls. Results The mean fluorescence intensity of PD-1 in CD4 + PD-1 + cells was decreased in patients with TAK and the frequency of CD4 + Foxp3 − PD-1 + cells among CD4 + T cells was also decreased in peripheral blood relative to healthy controls ( P .05). Patients with TAK had higher serum levels of IL-10, IL-7, CCL2, and CCL3 ( P

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/1938-2723Test

الوصول الحر: https://doaj.org/article/878bcede14234368a3daa4b3fa9b3263Test

المؤلفون: Qin Zhou, Yungang Bai, Zhongping Chai, Jianghui Zhang, Ming Zheng

المصدر: Engenharia Agrícola, Vol 43, Iss 2 (2023)

مصطلحات موضوعية: seedling emergence, soil water content, soil temperature, growth index, oxidoreductase, soil microorganisms, Agriculture (General), S1-972

الوصف: ABSTRACT Clay soil results in higher crop yield and quality than sandy soil. However, irrigation causes clay soil to slump easily, increasing compactness and decreasing soil oxygen content. This study investigated the effects of dry seeding and wet emergence on the soil microenvironment and cotton growth promotion in Xinjiang silt loam fields. The experimental design included three aerated and three non-aerated treatments. The results showed that aerated irrigation decreased dry density of the 0–20 cm soil layer to different degrees, the field capacity increased to different degrees, and the dry density and field capacity of the 20-30 cm soil layer did not change among the different treatments. The dry density and field capacity of WP2 treatment changed the most, the dry density of 0-10 cm and 10-20 cm soil layer were respectively 1.28 g cm-3 and 1.27 g cm-3, and the field capacity were respectively 35.23% and 35.7%. Under the same irrigation quota, the soil water content of the aerated treatments was lower than that of the non-aerated treatments. Aerated irrigation inhibited the horizontal diffusion of water and facilitated downward water transport. The WP2 treatment had the highest peak soil temperature at depths of 10 and 20 cm, and the WP2 treatment had the highest numbers of bacteria, fungi, actinomycetes, urease, and catalase activities, seedling emergence, primary root length, plant height, and stem thickness.

وصف الملف: electronic resource

العلاقة: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-69162023000200212&lng=en&tlng=enTest; http://www.scielo.br/pdf/eagri/v43n2/1809-4430-eagri-43-02-e20220129.pdfTest; https://doaj.org/toc/0100-6916Test

الوصول الحر: https://doaj.org/article/de6332b6f54243a3bc743b507442357dTest

المؤلفون: Kexin Zhang, Haiyun Guo, Tianli Wang, Jianghui Zhang, Guojing Yuan, Juan Ren, Xueqing Zhang, Huayu Yang, Xiaoyan Lu, Zhihui Zhu, Jun Du, Haiyan Shi, Guifang Jin, Jiahu Hao, Ying Sun, Puyu Su, Zhihua Zhang

المصدر: Frontiers in Public Health, Vol 11 (2023)

مصطلحات موضوعية: smartphone addiction, depression, college students, longitudinal study, cross-lagged panel model (CLPM), Public aspects of medicine, RA1-1270

الوصف: BackgroundSmartphone addiction (SA) is associated with adverse consequences, especially for freshmen. Evidence indicates that SA is associated with depression, and it is necessary to conduct a longitudinal study to explore the association further.MethodsSA (measured by the Smartphone Addiction Scale-Short Version) and depression (measured by the Zung's Self-Rating Depression Scale) among 1,186 freshmen were surveyed at baseline and a respective 12-month follow-up for each participant. The application of a cross-lagged panel model approach (CLPM) revealed an association between SA and depression after adjusting for demographic variables.ResultsThe CLPM results showed a significant path from baseline SA to follow-up depression (β = 0.08, P < 0.001) and a significant path from baseline depression to follow-up SA (β = 0.08, P < 0.001). Compared with the overall cross-lagged model, the cross-lagged coefficient of the path from baseline SA to follow-up depression increased in the female group (β = 0.10, P = 0.015), and the cross-lagged coefficient of the path from baseline depression to follow-up SA also increased significantly (β = 0.15, P < 0.001). In contrast, the cross-lagged model in the male group showed no predictive effect between SA and depression (P > 0.05).ConclusionsThe current study showed a significant bidirectional association between smartphone addiction and depression among freshmen, but only in the female population.

وصف الملف: electronic resource

العلاقة: https://www.frontiersin.org/articles/10.3389/fpubh.2023.1083856/fullTest; https://doaj.org/toc/2296-2565Test

الوصول الحر: https://doaj.org/article/2f3da6c5330842e08e57d97808a04ae8Test