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1دورية أكاديمية
المؤلفون: Hailong Lyu, Huimin Huang, Jiadong He, Sheng Zhu, Wanchu Hong, Jianbo Lai, Tongsheng Gao, Jiamin Shao, Jianfeng Zhu, Yubo Li, Shaohua Hu
المصدر: Translational Psychiatry, Vol 14, Iss 1, Pp 1-8 (2024)
مصطلحات موضوعية: Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571
الوصف: Abstract Early detection of bipolar depression (BPD) and major depressive disorder (MDD) has been challenging due to the lack of reliable and easily measurable biological markers. This study aimed to investigate the accuracy of discriminating patients with mood disorders from healthy controls based on task state skin potential characteristics and their correlation with individual indicators of oxidative stress. A total of 77 patients with BPD, 53 patients with MDD, and 79 healthy controls were recruited. A custom-made device, previously shown to be sufficiently accurate, was used to collect skin potential data during six emotion-inducing tasks involving video, pictorial, or textual stimuli. Blood indicators reflecting individual levels of oxidative stress were collected. A discriminant model based on the support vector machine (SVM) algorithm was constructed for discriminant analysis. MDD and BPD patients were found to have abnormal skin potential characteristics on most tasks. The accuracy of the SVM model built with SP features to discriminate MDD patients from healthy controls was 78% (sensitivity 78%, specificity 82%). The SVM model gave an accuracy of 59% (sensitivity 59%, specificity 79%) in classifying BPD patients, MDD patients, and healthy controls into three groups. Significant correlations were also found between oxidative stress indicators in the blood of patients and certain SP features. Patients with depression and bipolar depression have abnormalities in task-state skin potential that partially reflect the pathological mechanism of the illness, and the abnormalities are potential biological markers of affective disorders.
وصف الملف: electronic resource
العلاقة: https://doaj.org/toc/2158-3188Test
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2دورية أكاديمية
المؤلفون: Jianlin Wu, Jun Zhu, Jinbin Zhang, Pei Dang, Weilian Li, Yukun Guo, Lin Fu, Jianbo Lai, Jigang You, YaKun Xie, Ce Liang
المصدر: International Journal of Digital Earth, Vol 16, Iss 1, Pp 2404-2425 (2023)
مصطلحات موضوعية: bridge construction, digital twins, holographic scene, adaptive segmentation, rendering optimization, Mathematical geography. Cartography, GA1-1776
الوصف: Holographic projection technology can provide a more intuitive and efficient visualization effect for a digital twin bridge construction scene. However, pre-rendering methods in the existing research work are usually used to implement holographic visualization, which is static display. The above-mentioned methods for static display have many shortcomings, such as poor adaptability, low rendering efficiency and lack of real-time. A dynamic holographic modelling approach is proposed for the augmented visualization of digital twin scenes for bridge construction. Firstly, a dynamic segmentation algorithm with adaptive screen size was designed to high-efficiently generate holographic scenes. Secondly, a motion blur control method was designed to improve the rendering efficiency of holographic scenes according to human visual characteristics. Finally, a prototype system was developed, and the corresponding experimental analysis was completed. The experimental results show that the method proposed in this article can support adaptive screen size image segmentation and real-time generation of holographic scenes for bridge construction. The amount of scene data can be reduced to more than 30%, which significantly improves rendering efficiency and reduces glare.
وصف الملف: electronic resource
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3دورية أكاديمية
المؤلفون: Shaoli Li, Chenyue Xu, Shaohua Hu, Jianbo Lai
المصدر: European Psychiatry, Vol 67 (2024)
مصطلحات موضوعية: atypical antipsychotic, bipolar disorder, efficacy, network meta-analysis, tolerability, Psychiatry, RC435-571
الوصف: We employed a Bayesian network meta-analysis for comparison of the efficacy and tolerability of US Food and Drug Administration (FDA)-approved atypical antipsychotics (AAPs) for the treatment of bipolar patients with depressive episodes. Sixteen randomized controlled trials with 7234 patients treated by one of the five AAPs (cariprazine, lumateperone, lurasidone, olanzapine, and quetiapine) were included. For the response rate (defined as an improvement of ≥50% from baseline on the Montgomery-Åsberg Depression Rating Scale [MADRS]), all AAPs were more efficacious than placebo. For the remission rate (defined as the endpoint of MADRS ≤12 or ≤ 10), cariprazine, lurasidone, olanzapine, and quetiapine had higher remission rates than placebo. In terms of tolerability, olanzapine was unexpectedly associated with lower odds of all-cause discontinuation in comparison with placebo, whereas quetiapine was associated with higher odds of discontinuation due to adverse events than placebo. Compared with placebo, lumateperone, olanzapine, and quetiapine showed higher odds of somnolence. Lumateperone had a lower rate of ≥ weight gain of 7% than placebo and other treatments. Olanzapine was associated with a significant increase from baseline in total cholesterol and triglycerides than placebo. These findings inform individualized prescriptions of AAPs for treating bipolar depression in clinical practice.
وصف الملف: electronic resource
العلاقة: https://www.cambridge.org/core/product/identifier/S0924933824000257/type/journal_articleTest; https://doaj.org/toc/0924-9338Test; https://doaj.org/toc/1778-3585Test
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4دورية أكاديمية
المؤلفون: Yuting Shen, Lingzhuo Kong, Jianbo Lai, Shaohua Hu
المصدر: BMC Psychiatry, Vol 23, Iss 1, Pp 1-6 (2023)
مصطلحات موضوعية: Autoimmune diseases, Bipolar disorder, Immunological disturbance, Drug efficacy, Case report, Psychiatry, RC435-571
الوصف: Abstract Autoimmune diseases (AID) cause inflammatory changes in the peripheral blood, which might be a predisposing factor for the development of comorbid bipolar disorder (BD). The levels of peripheral inflammatory indicators and cytokines may also serve as potential biomarkers for predicting BD susceptibility and the efficacy of antipsychotics in patients with AID. Herein, we present the case of a 43-year-old female who has suffered from AID for over 16 years and was recently diagnosed with “bipolar and related disorder due to another medical condition”.
وصف الملف: electronic resource
العلاقة: https://doaj.org/toc/1471-244XTest
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5دورية أكاديمية
المؤلفون: Yanmeng Pan, Huaizhi Wang, Yimeng Geng, Jianbo Lai, Shaohua Hu
المصدر: Behavioral Sciences, Vol 14, Iss 5, p 360 (2024)
مصطلحات موضوعية: bipolar disorder, latent profile analysis, suicidal ideation, Psychology, BF1-990
الوصف: Individuals with bipolar disorder (BD) have a greater suicide risk than the general population. In this study, we employed latent profile analysis (LPA) to explore whether Chinese individuals with different phases of BD differed at the levels of suicidal ideation. We recruited 517 patients. Depressive symptoms were measured using the 24-item Hamilton Depression Rating Scale (HAMD-24), and manic symptoms were evaluated using the Young Mania Rating Scale (YMRS). The extent of suicidal thoughts was determined through the Beck Scale for Suicide Ideation (BSSI). The scores of HAMD and YMRS were used to perform LPA. LPA categorized participants into three classes: one exhibiting severe depressive and mild manic symptomatology, another showing severe depressive and severe manic symptomatology, and the third one displaying severe depressive and intermediate manic symptomatology. Suicidal ideation levels were found to be remarkably elevated across all three classes. Additionally, the three classes showed no significant differences in terms of suicidal ideation. Our research confirms the link between depressive symptoms and suicide, independent of the manic symptoms. These findings carry meaning as they provide insight into the suicide risk profiles within different phases of BD.
وصف الملف: electronic resource
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6دورية أكاديمية
المؤلفون: Ce Liang, Jun Zhu, Jinbin Zhang, Qing Zhu, Jingyi Lu, Jianbo Lai, Jianlin Wu
المصدر: ISPRS International Journal of Geo-Information, Vol 13, Iss 3, p 78 (2024)
مصطلحات موضوعية: geographic digital twins, knowledge graph, tunnel excavation profile, geometric deformation diagnosis, fusion visualization, Geography (General), G1-922
الوصف: It is essential to establish a digital twin scene, which helps to depict the dynamically changing geographical environment accurately. Digital twins could improve the refined management level of intelligent tunnel construction; however, research on geographical twin models primarily focuses on modeling and visual description, which has low analysis efficiency. This paper proposes a knowledge-guided intelligent analysis method for the geometric deformation of tunnel excavation profile twins. Firstly, a dynamic data-driven knowledge graph of tunnel excavation twin scenes was constructed to describe tunnel excavation profile twin scenes accurately. Secondly, an intelligent diagnosis algorithm for geometric deformation of tunnel excavation contour twins was designed by knowledge guidance. Thirdly, multiple visual variables were jointly used to support scene fusion visualization of tunnel excavation profile twin scenes. Finally, a case was selected to implement the experimental analysis. The experimental results demonstrate that the method in this article can achieve an accurate description of objects and their relationships in tunnel excavation twin scenes, which supports rapid geometric deformation analysis of the tunnel excavation profile twin. The speed of geometric deformation diagnosis is increased by more than 90% and the cognitive efficiency is improved by 70%. The complexity and difficulty of the deformation analysis operation are reduced, and the diagnostic analysis ability and standardization of the geographic digital twin model are effectively improved.
وصف الملف: electronic resource
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7دورية أكاديمية
المؤلفون: Naiyun Chen, Shaoli Li, Shu Huang, Jianbo Lai, Duo Lv
المصدر: Brain and Behavior, Vol 13, Iss 7, Pp n/a-n/a (2023)
مصطلحات موضوعية: drug overdose, emergency care, mental illness, suicide, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571
الوصف: Abstract Objective Individuals with mental illnesses are exposed to an increased risk of suicide. In this study, we aimed to investigate the clinical characteristics and outcome of psychiatric patients who attempted suicide by drug overdose and required emergency care. Methods A retrospective study was carried out in the Department of Emergency, the First Affiliated Hospital, Zhejiang University School of Medicine. Electronic medical records of psychiatric patients who were hospitalized due to suicide attempts from March 2019 to February 2022, with a discharge diagnosis of drug overdose were reviewed. Suicide‐related data of patients were collected, including suicide month, time from suicide to admission, type of drugs, the number of tablets taken, as well as demographic and clinical profiles (e.g., gender, age, marital status, profession, physical comorbidities, and diagnosis of mental illness). Results In the results, half of the patients were young people, female patients accounted for a higher proportion (72.5%), and the incidence of suicide was higher in winter than other seasons. Among the 109 psychiatric patients, 60 patients (55.0%) had a history of major depressive disorder, and 86 patients (78.9%) committed suicide with various psychotropic drugs, among which anxiolytics were the most commonly used drugs. Thirty‐seven patients (33.9%) experienced severe physical complications caused by drug overdose, with lung infections being the most common. The clinical outcome of most patients was favorable following emergent treatment, while 2 patients (1.8%) older than 80 failed to survive. Conclusion A better understanding of psychiatric patients referred to emergency care due to suicide by drug overdose helps to improve the clinical management and prognosis of patients.
وصف الملف: electronic resource
العلاقة: https://doaj.org/toc/2162-3279Test
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8دورية أكاديمية
المؤلفون: Jun Zhu, Niya Luo, Zhihao Guo, Jianbo Lai, Li Zuo, Chuanjun Zhang, Yukun Guo, Ya Hu
المصدر: International Journal of Digital Earth, Vol 17, Iss 1 (2024)
مصطلحات موضوعية: Feature-constrained, bridge digital twins, geometric deformation, automatic diagnostic analysis, improved Hausdorff algorithm, Mathematical geography. Cartography, GA1-1776
الوصف: ABSTRACTIt is very important to construct digital twin scenes, which can accurately describe the dynamically changing geographical environment and improve the level of refined management in bridge construction. This article proposes a feature constrained automatic diagnostic analysis method for geometric deformation of bridge digital twins. The geometric deformation feature library of bridge twins was first created to accurately describe structural relationships and behavior characteristics. Secondly, line surface feature constraints were used to extract geometric deformation information from bridge digital twins. Then, a geometric deformation diagnosis algorithm was designed based on an improved Hausdorff method. Finally, a case study was conducted to implement experimental analysis. The experimental results show that the method proposed in this paper can automatically extract the geometric morphology and rapidly calculate line and surface deformations for point cloud bridge digital twins. It achieves an efficiency improvement above 90% and with millimeter-level accuracy, which effectively enhances the diagnostic analysis capabilities for geographical digital twin models.
وصف الملف: electronic resource
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9دورية أكاديمية
المؤلفون: Shaoli Li, Ruili Zhang, Shaohua Hu, Jianbo Lai
المصدر: Frontiers in Psychiatry, Vol 13 (2022)
مصطلحات موضوعية: schizophrenia, orexin-A, meta-analysis, medication, cognitive deficits, Psychiatry, RC435-571
الوصف: BackgroundOrexins are polypeptides regulating appetite, sleep-wake cycle, and cognition functions, which are commonly disrupted in patients with schizophrenia. Patients with schizophrenia show a decreased connectivity between the prefrontal cortex and midline-anterior thalamus, and orexin can directly activate the axon terminal of cells within the prefrontal cortex and selectively depolarize neurons in the midline intralaminar nuclei of the thalamus. To address the relationship between orexin and schizophrenia, this study performed a meta-analysis on the alteration of plasma orexin-A levels in patients with schizophrenia.MethodWe searched eligible studies in PubMed, Embase, Cochrane, and China National Knowledge Infrastructure (CNKI) from 1998 to September 3, 2021. A total of 8 case-control studies were included in the meta-analyses, providing data on 597 patients with schizophrenia and 370 healthy controls. The Stata version 16.0 software was used to calculate the Hedges's adjusted g with 95% confidence intervals (CI).ResultsThe plasma orexin-A levels were not altered in subjects with schizophrenia (n = 597) when compared to healthy controls (n = 370). Subgroup analyses of gender (male and female vs. only male), country (China vs. other countries), medication (medication vs. non-medication), and the measurement of plasma orexin-A (Enzyme-linked immunosorbent assay vs. radioimmunoassay) revealed heterogeneity ranging from 30.15 to 98.15%, but none showed a significant alteration of plasma orexin-A levels in patients with schizophrenia. Heterogeneity was lower in the other countries and radioimmunoassay subgroup, while other subgroups remained to be highly heterogeneous. No significant evidence of publication bias was found either in Begg's test or the Egger's test.ConclusionThe present meta-analysis indicated that patients with schizophrenia did not show abnormal plasma levels of orexin-A.Systematic Review Registrationhttps://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42021283455, identifier: CRD42021283455.
وصف الملف: electronic resource
العلاقة: https://www.frontiersin.org/articles/10.3389/fpsyt.2022.879414/fullTest; https://doaj.org/toc/1664-0640Test
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10دورية أكاديمية
المؤلفون: Ruili Zhang, Jianbo Lai, Huafen Wang
المصدر: Brain Sciences, Vol 13, Iss 3, p 466 (2023)
مصطلحات موضوعية: non-suicidal self-injury, adolescent, epidemiology, risk factor, nursing care, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571
الوصف: Background: Non-suicidal self-injury (NSSI) refers to the intentional and repeated physical trauma of an individual without explicit suicidal intent, which has negative effects on the physical and mental well-being of an individual, especially for adolescents. Timely and accessible nursing care may play an important role in the survival and rehabilitation process of NSSI. Methods: In this review, we systematically discuss the nursing care of NSSI behavior and provide recommendations based on an integrated nursing model for NSSI management. Results: As reported in previous studies, a variety of factors can contribute to NSSI behavior, such as personality traits, current psychological status, history of mental illnesses, as well as family and social factors. In-hospital care is the most necessary and effective care during acute episodes of NSSI behavior. To effectively manage inpatients with NSSI behaviors, nurses should first understand the motivation of NSSI, and provide comprehensive and multi-level care through nurse-patient communication, individualized psychological care, and multidisciplinary cooperation with other professionals. While the purpose of out-of-hospital nursing is to reduce the frequency of NSSI behaviors by screening high-risk individuals, providing psychological support, promoting health education, and improving self-awareness. Conclusions: An integrative model of in-hospital and out-of-hospital nursing care can help improve the clinical management and long-term prognosis of patients with NSSI and minimize the risk of suicidal ideation or suicidal behavior.
وصف الملف: electronic resource
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