نتائج البحث - "Jendoubi, Fatma"

1

دورية أكاديمية

The efficacy of anti‐IL‐1 targeted therapy in PAPA and PASH syndrome

المؤلفون: Challamel, Chloé, Girard, Céline, Misery, Laurent, Touhouche, Assia, Fradet, Marion, Severino‐Freire, Maëlla, Livideanu, Cristina B., Konstantinou, Maria P., Jendoubi, Fatma, Paul, Carle

المصدر: JEADV Clinical Practice ; volume 1, issue 3, page 275-280 ; ISSN 2768-6566 2768-6566

الوصف: Introduction Pyogenic arthritis, pyoderma gangrenosum and acne (PAPA) and pyoderma gangrenosum, acne and hidradenitis suppurativa (PASH) are rare autoinflammatory diseases. Treatment of PAPA and PASH is difficult. Conventional immunosuppressants and tumor necrosis factor (TNF) antagonists fail to control skin lesions in many patients. Materials and Methods We conducted a retrospective observational study of patients treated with interleukin‐1 (IL‐1) antagonists for PAPA or PASH syndrome. We included all PASH and PAPA treated with the IL‐1 antagonists canakinumab and anakinra in Toulouse, Brest and Montpellier, France and report on the patients' response to treatment. Results Four patients were treated with anakinra (one patient) and/or canakinumab (three patients) for 6 months to 10 years. Treatment was associated with sustained improvement of skin lesions: hidradenitis suppurativa in four patients including full resolution of skin lesions in three patients, acne with full resolution in one patient, pyoderma gangrenosum in three patients who experienced full resolution of skin lesions. Anti‐IL‐1 treatment was also associated with full resolution of symptoms associated with spondyloarthritis in one patient. One patient who had been receiving oral corticosteroids for years was able to stop treatment while on IL‐1 antagonist. Discussion IL‐1 antagonists, especially canakinumab, are useful alternatives to treat patients with PAPA or PASH syndrome, especially patients who are non‐responders to conventional treatment and TNF antagonists.

الإتاحة: https://doi.org/10.1002/jvc2.52Test

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2

دورية أكاديمية

Longer dupilumab dosing intervals in adult patients with atopic dermatitis: experience from a French multicentre retrospective cohort study

المؤلفون: Jendoubi, Fatma, Shourik, Jason, Seneschal, Julien, Giordano-Labadie, Francoise, Raison-Peyron, Nadia, Du-Thanh, Aurélie, Tetart, Florence, Valois, Aude, Droitcourt, Catherine, Clément, Aude, Nosbaum, Audrey, Crepy, Marie Noelle, Jachiet, Marie, Bouaziz, Jean David, Bernier, Claire, Soria, Angéle, Paul, Carle, Barbarot, Sebastien, Tauber, Marie

المصدر: British Journal of Dermatology ; volume 187, issue 4, page 602-603 ; ISSN 1365-2133 0007-0963

الإتاحة: https://doi.org/10.1111/bjd.21628Test
https://academic.oup.com/bjd/article-pdf/187/4/602/48529788/bjd0602.pdfTest

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3

دورية أكاديمية

Neuropsychiatric, cognitive and sexual impairment in mastocytosis patients

المؤلفون: Jendoubi, Fatma, Severino-Freire, Maella, Negretto, Mathilde, Arbus, Christophe, Paul, Carle, Bulai Livideanu, Cristina

المصدر: Orphanet Journal of Rare Diseases ; volume 16, issue 1 ; ISSN 1750-1172

مصطلحات موضوعية: Pharmacology (medical), Genetics (clinical), General Medicine

الوصف: Background Mastocytosis is a rare disease characterised by the accumulation and/or proliferation of abnormal mast cells (MCs) in one or several organs. It may present with a number of different symptoms that involve various organ systems. The current study aims to assess the prevalence of MC mediator-related symptoms in a cohort of mastocytosis patients with a specific focus on neurological, psychiatric, cognitive and sexual symptoms. We also assessed the impact of the disease on patients’ professional lives. Patients were administered a validated multidimensional questionnaire to collect information on patients’ perception of the severity of their symptoms. From the questionnaires we extracted the neurological, cognitive, psychiatric and sexual symptoms and the impact of the disease on patients’ professional lives as well as their grading. The affective status was assessed using the 17-item version of the Hamilton Depression Rating Scale. Results We included 139 patients. Mastocytosis was classified as systemic in 113 patients and cutaneous in 26 patients. The prevalence of MC mediator-related systemic symptoms was as follows: cutaneous (71%), gastro-intestinal (48%), cardio-vascular (36%), musculoskeletal (26.6%), fatigue (24%), urinary (14.4%) and respiratory (10%). Headaches and vertigo were noted in respectively 55% and 32% of patients. Irritability, episodes of memory loss and difficulty concentrating were reported in 54%, 52% and 40% of cases, respectively. Sexual impairment was noted in 24% of patients. No associations were found between neuropsychiatric/cognitive impairment and age, gender, diagnostic delay, disease form, the presence of cutaneous lesions, the level of serum and bone marrow tryptase and the presence of KIT mutation in bone marrow and/or skin. Depression was noted in 49% of patients. One in four patients reported a negative impact of the disease on their professional lives. Conclusion This current study provides some insights regarding symptoms related to mastocytosis and their ...

الإتاحة: https://doi.org/10.1186/s13023-021-01747-yTest

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4

دورية أكاديمية

Dermatose à IgA linéaire sévère compliquée d’une aspergillose invasive

المؤلفون: Guédon, Claire, Fradet, Marion, Nicol, Perrine, Dusart, Charlotte, Joly, Pascal, Grolleau, Jean-Louis, Jendoubi, Fatma, Borjesson, Clothilde, Fortenfant, Françoise, Bulai-Livideanu, Cristina, Paul, Carle, Konstantinou, Maria Polina

المصدر: La Presse Médicale Formation ; volume 2, issue 3, page 303-306 ; ISSN 2666-4798

مصطلحات موضوعية: General Medicine

الإتاحة: https://doi.org/10.1016/j.lpmfor.2021.05.001Test
https://api.elsevier.com/content/article/PII:S2666479821000859?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S2666479821000859?httpAccept=text/plainTest

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5

دورية أكاديمية

Efficacity and safety of dupilumab in bullous pemphigoid: a retrospective multicentric study of 36 patients

المساهمون: Pathogenesis and Control of Chronic and Emerging Infections (PCCEI), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université des Antilles (UA)-Etablissement français du don du sang Montpellier -Université de Montpellier (UM), Epidemiology in Dermatology and Evaluation in Therapeutics (EpiDermE), Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12)

المصدر: ISSN: 0007-0963.

مصطلحات موضوعية: [SDV.MHEP.DERM]Life Sciences [q-bio]/Human health and pathology/Dermatology

الوصف: International audience ; Bullous pemphigoid (BP) is the most common auto immune blistering disease in Europe and its treatment can be challenging. Several published cases reported dupilumab efficiency in refractory patients. We conducted a retrospective multicentric study including 36 patients to evaluate real-life efficiency of dupilumab in BP. Our results suggest that dupilumab in association with high potency topical steroids could be rapidly effective in various clinical forms of BP and seems to be well tolerated in elderly population.

العلاقة: hal-04094942; https://hal.science/hal-04094942Test

الإتاحة: https://doi.org/10.1093/bjd/ljad136Test
https://hal.science/hal-04094942Test

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6

دورية أكاديمية

Intracellular Streptococcal Uptake and Persistence: A Potential Cause of Erysipelas Recurrence.

المؤلفون: Jendoubi, Fatma, Rohde, M, Prinz, Jörg Christoph

المساهمون: HZI,Helmholtz-Zentrum für Infektionsforschung GmbH, Inhoffenstr. 7,38124 Braunschweig, Germany.

المصدر: Frontiers in medicine

مصطلحات موضوعية: cellulitis, erysipelas, intracellular streptococcal persistence, intracellular streptococcal uptake, penicillin prophylaxis, relapse, risk factors, treatment

الوصف: Erysipelas is a severe streptococcal infection of the skin primarily spreading through the lymphatic vessels. Penicillin is the treatment of choice. The most common complication consists in relapses which occur in up to 40% or more of patients despite appropriate antibiotic treatment. They cause lymphatic damage resulting in irreversible lymphedema and ultimately elephantiasis nostras and lead to major health restrictions and high socio-medical costs. Prevention of relapses is an unmet need, because even long-term prophylactic penicillin application does eventually not reduce the risk of recurrence. In this article we assess risk factors and causes of erysipelas recurrence. A systematic literature search for clinical studies addressing potential causes and measures for prevention of erysipelas recurrence was combined with a review of experimental and clinical data assessing the ability and clinical relevance of streptococci for intracellular uptake and persistence. The literature review found that venous insufficiency, lymphedema, and intertrigo from fungal infections are considered to be major risk factors for recurrence of erysipelas but cannot adequately explain the high recurrence rate. As hitherto unrecognized likely cause of erysipelas relapses we identify the ability of streptococci for intracellular uptake into and persistence within epithelial and endothelial cells and macrophages. This creates intracellular streptococcal reservoirs out of reach of penicillins which do not reach sufficient bactericidal intracellular concentrations. Incomplete streptococcal elimination due to intracellular streptococcal persistence has been observed in various deep tissue infections and is considered as cause of relapsing streptococcal pharyngitis despite proper antibiotic treatment. It may also serves as endogenous infectious source of erysipelas relapses. We conclude that the current antibiotic treatment strategies and elimination of conventional risk factors employed in erysipelas management are insufficient to ...

العلاقة: Front Med (Lausanne). 2019 Jan 29;6:6. doi:10.3389/fmed.2019.00006. eCollection 2019.; http://hdl.handle.net/10033/621703Test

الإتاحة: https://doi.org/10.3389/fmed.2019.00006Test
http://hdl.handle.net/10033/621703Test

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النص الكامل

7

دورية أكاديمية

Nail Involvement in Psoriatic Patients and Association with Onychomycosis: Results from a Cross-Sectional Study Performed in a Military Hospital in Tunisia

المؤلفون: Jendoubi, Fatma, Ben Lagha, Imene, Rabhi, Faten, Doss, Nejib, Mrabet, Ali, Jaber, Kahena, Dhaoui, Mohamed Raouf

المصدر: Skin Appendage Disorders ; volume 5, issue 5, page 299-303 ; ISSN 2296-9195 2296-9160

الوصف: Nail psoriasis has variable prevalence and heterogeneous aspects. Many of them could mimic onychomycosis (OM). It has been suggested that patients with nail psoriasis are at high risk of OM. The aim of our study was to determine the epidemiological and clinical characteristics of nail psoriasis and to estimate the frequency and the factors associated with OM in psoriatic patients. The studied group included 163 patients with psoriasis aged 18 years or older. Epidemiological and clinical data, as well as the severity of skin and nails disease by evaluating the Psoriasis Area Severity Index (PASI) and Nail Area Psoriasis Severity Index (NAPSI) scores were specified. Mycological testing was performed for patients with nail alterations. Nail involvement was found in 71.2% of patients. The most common nail alterations were subungual hyperkeratosis and onycholysis. The mean NAPSI score was 11.6. Mycological testing was performed in 104 patients with onychodystrophy. OM was diagnosed in 53% of the cases. Dermatophytes were the most isolated pathogens. OM was associated with male gender, but not with age, NAPSI, or PASI score. Psoriasis is one of the dermatoses that most commonly affect the nail. Available data about the association between nail psoriasis and OM are controversial. However, mycological testing should be routinely performed on psoriatic nails.

الإتاحة: https://doi.org/10.1159/000497825Test
https://www.karger.com/Article/Pdf/497825Test

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